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Toxic myopathy

MedGen UID:
509650
•Concept ID:
C0154769
•
Disease or Syndrome
Synonyms: Myopathy, Toxic; Myotoxicities; Myotoxicity; Toxic Myopathies; Toxic Myopathy
SNOMED CT: Toxic myopathy (66952001)

Definition

Damage to the muscle or its function secondary to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVToxic myopathy

Professional guidelines

PubMed

The Management of Hypercholesterolemia in Patients with Neuromuscular Disorder.
Loh WJ, Watts GF
Curr Atheroscler Rep 2023 Feb;25(2):43-53. Epub 2023 Jan 7 doi: 10.1007/s11883-022-01077-9. PMID: 36609642
Colchicine Drug Interaction Errors and Misunderstandings: Recommendations for Improved Evidence-Based Management.
Hansten PD, Tan MS, Horn JR, Gomez-Lumbreras A, Villa-Zapata L, Boyce RD, Subbian V, Romero A, Gephart S, Malone DC
Drug Saf 2023 Mar;46(3):223-242. Epub 2022 Dec 15 doi: 10.1007/s40264-022-01265-1. PMID: 36522578Free PMC Article
Proximal myopathy: diagnostic approach and initial management.
Suresh E, Wimalaratna S
Postgrad Med J 2013 Aug;89(1054):470-7. Epub 2013 Apr 17 doi: 10.1136/postgradmedj-2013-131752. PMID: 23596213

Recent clinical studies

Etiology

Toxic Myopathies.
Doughty CT, Amato AA
Continuum (Minneap Minn) 2019 Dec;25(6):1712-1731. doi: 10.1212/CON.0000000000000806. PMID: 31794468
Statin-associated immune-mediated myopathy: biology and clinical implications.
Christopher-Stine L, Basharat P
Curr Opin Lipidol 2017 Apr;28(2):186-192. doi: 10.1097/MOL.0000000000000399. PMID: 28207435
Statin myopathy.
Radcliffe KA, Campbell WW
Curr Neurol Neurosci Rep 2008 Jan;8(1):66-72. doi: 10.1007/s11910-008-0011-4. PMID: 18367041
Rhabdomyolysis: an evaluation of 475 hospitalized patients.
Melli G, Chaudhry V, Cornblath DR
Medicine (Baltimore) 2005 Nov;84(6):377-385. doi: 10.1097/01.md.0000188565.48918.41. PMID: 16267412
Toxic neuropathies and myopathies.
Kuncl RW, George EB
Curr Opin Neurol 1993 Oct;6(5):695-704. doi: 10.1097/00019052-199310000-00004. PMID: 8293140

Diagnosis

Drug-induced Myopathies.
Steinmeyer J, Flechtenmacher J
Z Orthop Unfall 2023 Apr;161(2):175-181. Epub 2021 Jul 28 doi: 10.1055/a-1488-6912. PMID: 34320661
Other Myopathies.
Hussain Y, Miller S
Neurol Clin 2020 Aug;38(3):619-635. doi: 10.1016/j.ncl.2020.04.002. PMID: 32703473
Inflammatory and toxic myopathy.
Teener JW
Semin Neurol 2012 Nov;32(5):491-9. Epub 2013 May 15 doi: 10.1055/s-0033-1334467. PMID: 23677656
Statin myopathy.
Radcliffe KA, Campbell WW
Curr Neurol Neurosci Rep 2008 Jan;8(1):66-72. doi: 10.1007/s11910-008-0011-4. PMID: 18367041
Rhabdomyolysis: an evaluation of 475 hospitalized patients.
Melli G, Chaudhry V, Cornblath DR
Medicine (Baltimore) 2005 Nov;84(6):377-385. doi: 10.1097/01.md.0000188565.48918.41. PMID: 16267412

Therapy

Drug-induced Myopathies.
Steinmeyer J, Flechtenmacher J
Z Orthop Unfall 2023 Apr;161(2):175-181. Epub 2021 Jul 28 doi: 10.1055/a-1488-6912. PMID: 34320661
Inflammatory and toxic myopathy.
Teener JW
Semin Neurol 2012 Nov;32(5):491-9. Epub 2013 May 15 doi: 10.1055/s-0033-1334467. PMID: 23677656
Toxic and drug-induced myopathies.
Dalakas MC
J Neurol Neurosurg Psychiatry 2009 Aug;80(8):832-8. doi: 10.1136/jnnp.2008.168294. PMID: 19608783
Statin myopathy.
Radcliffe KA, Campbell WW
Curr Neurol Neurosci Rep 2008 Jan;8(1):66-72. doi: 10.1007/s11910-008-0011-4. PMID: 18367041
Rhabdomyolysis: an evaluation of 475 hospitalized patients.
Melli G, Chaudhry V, Cornblath DR
Medicine (Baltimore) 2005 Nov;84(6):377-385. doi: 10.1097/01.md.0000188565.48918.41. PMID: 16267412

Prognosis

Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs.
Madden L, Juhas M, Kraus WE, Truskey GA, Bursac N
Elife 2015 Jan 9;4:e04885. doi: 10.7554/eLife.04885. PMID: 25575180Free PMC Article
The spectrum of statin myopathy.
Mohassel P, Mammen AL
Curr Opin Rheumatol 2013 Nov;25(6):747-52. doi: 10.1097/01.bor.0000434673.85515.89. PMID: 24061077
Drug-related myopathies of which the clinician should be aware.
Valiyil R, Christopher-Stine L
Curr Rheumatol Rep 2010 Jun;12(3):213-20. doi: 10.1007/s11926-010-0104-3. PMID: 20425521Free PMC Article
Agents and mechanisms of toxic myopathy.
Kuncl RW
Curr Opin Neurol 2009 Oct;22(5):506-15. doi: 10.1097/WCO.0b013e32833045a0. PMID: 19680127
Rhabdomyolysis: an evaluation of 475 hospitalized patients.
Melli G, Chaudhry V, Cornblath DR
Medicine (Baltimore) 2005 Nov;84(6):377-385. doi: 10.1097/01.md.0000188565.48918.41. PMID: 16267412

Clinical prediction guides

Toxic myopathy with multiple deletions in mitochondrial DNA associated with long-term use of oral anti-viral drugs for hepatitis B: A case study.
Fujii T, Takase KI, Honda H, Kawamura N, Yamasaki R, Urata M, Uchiumi T, Iwaki T, Kira JI
Neuropathology 2019 Apr;39(2):162-167. Epub 2019 Mar 7 doi: 10.1111/neup.12548. PMID: 30847961
Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs.
Madden L, Juhas M, Kraus WE, Truskey GA, Bursac N
Elife 2015 Jan 9;4:e04885. doi: 10.7554/eLife.04885. PMID: 25575180Free PMC Article
Acute quadriplegic myopathy with loss of thick (myosin) filaments following heart transplantation.
Perea M, Picón M, Miró O, Orús J, Roig E, Grau JM
J Heart Lung Transplant 2001 Oct;20(10):1136-41. doi: 10.1016/s1053-2498(01)00300-x. PMID: 11595571
Drugs and toxins associated with myopathies.
Pascuzzi RM
Curr Opin Rheumatol 1998 Nov;10(6):511-20. doi: 10.1097/00002281-199811000-00003. PMID: 9812211

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