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Toxic myopathy

MedGen UID:
509650
•Concept ID:
C0154769
•
Disease or Syndrome
Synonyms: Myopathy, Toxic; Myotoxicities; Myotoxicity; Toxic Myopathies; Toxic Myopathy
SNOMED CT: Toxic myopathy (66952001)

Definition

Damage to the muscle or its function secondary to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVToxic myopathy

Professional guidelines

PubMed

NOTCH2NLC-related disorders: the widening spectrum and genotype-phenotype correlation.
Fan Y, Xu Y, Shi C
J Med Genet 2022 Jan;59(1):1-9. Epub 2021 Oct 21 doi: 10.1136/jmedgenet-2021-107883. PMID: 34675123
Consensus Statement Regarding the Efficacy and Safety of Long-Term Low-Dose Colchicine in Gout and Cardiovascular Disease.
Robinson PC, Terkeltaub R, Pillinger MH, Shah B, Karalis V, Karatza E, Liew D, Imazio M, Cornel JH, Thompson PL, Nidorf M
Am J Med 2022 Jan;135(1):32-38. Epub 2021 Aug 18 doi: 10.1016/j.amjmed.2021.07.025. PMID: 34416165Free PMC Article
Proximal myopathy: diagnostic approach and initial management.
Suresh E, Wimalaratna S
Postgrad Med J 2013 Aug;89(1054):470-7. Epub 2013 Apr 17 doi: 10.1136/postgradmedj-2013-131752. PMID: 23596213

Recent clinical studies

Etiology

Toxic Myopathies.
Doughty CT, Amato AA
Continuum (Minneap Minn) 2019 Dec;25(6):1712-1731. doi: 10.1212/CON.0000000000000806. PMID: 31794468
Statin-associated immune-mediated myopathy: biology and clinical implications.
Christopher-Stine L, Basharat P
Curr Opin Lipidol 2017 Apr;28(2):186-192. doi: 10.1097/MOL.0000000000000399. PMID: 28207435
Statin myopathy.
Radcliffe KA, Campbell WW
Curr Neurol Neurosci Rep 2008 Jan;8(1):66-72. doi: 10.1007/s11910-008-0011-4. PMID: 18367041
Statin myopathy: an update.
Christopher-Stine L
Curr Opin Rheumatol 2006 Nov;18(6):647-53. doi: 10.1097/01.bor.0000245730.25383.97. PMID: 17053514
Rhabdomyolysis: an evaluation of 475 hospitalized patients.
Melli G, Chaudhry V, Cornblath DR
Medicine (Baltimore) 2005 Nov;84(6):377-385. doi: 10.1097/01.md.0000188565.48918.41. PMID: 16267412

Diagnosis

Drug-induced Myopathies.
Steinmeyer J, Flechtenmacher J
Z Orthop Unfall 2023 Apr;161(2):175-181. Epub 2021 Jul 28 doi: 10.1055/a-1488-6912. PMID: 34320661
Other Myopathies.
Hussain Y, Miller S
Neurol Clin 2020 Aug;38(3):619-635. doi: 10.1016/j.ncl.2020.04.002. PMID: 32703473
Inflammatory and toxic myopathy.
Teener JW
Semin Neurol 2012 Nov;32(5):491-9. Epub 2013 May 15 doi: 10.1055/s-0033-1334467. PMID: 23677656
Statin myopathy.
Radcliffe KA, Campbell WW
Curr Neurol Neurosci Rep 2008 Jan;8(1):66-72. doi: 10.1007/s11910-008-0011-4. PMID: 18367041
Rhabdomyolysis: an evaluation of 475 hospitalized patients.
Melli G, Chaudhry V, Cornblath DR
Medicine (Baltimore) 2005 Nov;84(6):377-385. doi: 10.1097/01.md.0000188565.48918.41. PMID: 16267412

Therapy

Drug-induced Myopathies.
Steinmeyer J, Flechtenmacher J
Z Orthop Unfall 2023 Apr;161(2):175-181. Epub 2021 Jul 28 doi: 10.1055/a-1488-6912. PMID: 34320661
Inflammatory and toxic myopathy.
Teener JW
Semin Neurol 2012 Nov;32(5):491-9. Epub 2013 May 15 doi: 10.1055/s-0033-1334467. PMID: 23677656
Statin myopathy.
Radcliffe KA, Campbell WW
Curr Neurol Neurosci Rep 2008 Jan;8(1):66-72. doi: 10.1007/s11910-008-0011-4. PMID: 18367041
Rhabdomyolysis: an evaluation of 475 hospitalized patients.
Melli G, Chaudhry V, Cornblath DR
Medicine (Baltimore) 2005 Nov;84(6):377-385. doi: 10.1097/01.md.0000188565.48918.41. PMID: 16267412
Toxic myopathies.
Walsh RJ, Amato AA
Neurol Clin 2005 May;23(2):397-428. doi: 10.1016/j.ncl.2004.12.014. PMID: 15757791

Prognosis

The spectrum of statin myopathy.
Mohassel P, Mammen AL
Curr Opin Rheumatol 2013 Nov;25(6):747-52. doi: 10.1097/01.bor.0000434673.85515.89. PMID: 24061077
Drug-related myopathies of which the clinician should be aware.
Valiyil R, Christopher-Stine L
Curr Rheumatol Rep 2010 Jun;12(3):213-20. doi: 10.1007/s11926-010-0104-3. PMID: 20425521Free PMC Article
Agents and mechanisms of toxic myopathy.
Kuncl RW
Curr Opin Neurol 2009 Oct;22(5):506-15. doi: 10.1097/WCO.0b013e32833045a0. PMID: 19680127
Toxic myopathies: muscle biopsy features.
Scola RH, Pereira ER, Lorenzoni PJ, Werneck LC
Arq Neuropsiquiatr 2007 Mar;65(1):82-6. doi: 10.1590/s0004-282x2007000100018. PMID: 17420833
Rhabdomyolysis: an evaluation of 475 hospitalized patients.
Melli G, Chaudhry V, Cornblath DR
Medicine (Baltimore) 2005 Nov;84(6):377-385. doi: 10.1097/01.md.0000188565.48918.41. PMID: 16267412

Clinical prediction guides

Toxic myopathy with multiple deletions in mitochondrial DNA associated with long-term use of oral anti-viral drugs for hepatitis B: A case study.
Fujii T, Takase KI, Honda H, Kawamura N, Yamasaki R, Urata M, Uchiumi T, Iwaki T, Kira JI
Neuropathology 2019 Apr;39(2):162-167. Epub 2019 Mar 7 doi: 10.1111/neup.12548. PMID: 30847961
Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs.
Madden L, Juhas M, Kraus WE, Truskey GA, Bursac N
Elife 2015 Jan 9;4:e04885. doi: 10.7554/eLife.04885. PMID: 25575180Free PMC Article
Acute quadriplegic myopathy with loss of thick (myosin) filaments following heart transplantation.
Perea M, Picón M, Miró O, Orús J, Roig E, Grau JM
J Heart Lung Transplant 2001 Oct;20(10):1136-41. doi: 10.1016/s1053-2498(01)00300-x. PMID: 11595571
Drugs and toxins associated with myopathies.
Pascuzzi RM
Curr Opin Rheumatol 1998 Nov;10(6):511-20. doi: 10.1097/00002281-199811000-00003. PMID: 9812211

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