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Toxic myopathy

MedGen UID:
509650
•Concept ID:
C0154769
•
Disease or Syndrome
Synonyms: Myopathy, Toxic; Myotoxicities; Myotoxicity; Toxic Myopathies; Toxic Myopathy
SNOMED CT: Toxic myopathy (66952001)

Definition

Damage to the muscle or its function secondary to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVToxic myopathy

Professional guidelines

PubMed

Statin-associated muscle symptoms: A comprehensive exploration of epidemiology, pathophysiology, diagnosis, and clinical management strategies.
Shah M, Shrestha K, Tseng CW, Goyal A, Liewluck T, Gupta L
Int J Rheum Dis 2024 Sep;27(9):e15337. doi: 10.1111/1756-185X.15337. PMID: 39285637
Glucocorticoid-Induced Myopathy: Typology, Pathogenesis, Diagnosis, and Treatment.
Wu M, Liu C, Sun D
Horm Metab Res 2024 May;56(5):341-349. Epub 2024 Jan 15 doi: 10.1055/a-2246-2900. PMID: 38224966

Recent clinical studies

Etiology

Toxic Myopathies.
Doughty CT, Amato AA
Continuum (Minneap Minn) 2019 Dec;25(6):1712-1731. doi: 10.1212/CON.0000000000000806. PMID: 31794468
Statin-associated immune-mediated myopathy: biology and clinical implications.
Christopher-Stine L, Basharat P
Curr Opin Lipidol 2017 Apr;28(2):186-192. doi: 10.1097/MOL.0000000000000399. PMID: 28207435
Statin myopathy.
Radcliffe KA, Campbell WW
Curr Neurol Neurosci Rep 2008 Jan;8(1):66-72. doi: 10.1007/s11910-008-0011-4. PMID: 18367041
Rhabdomyolysis: an evaluation of 475 hospitalized patients.
Melli G, Chaudhry V, Cornblath DR
Medicine (Baltimore) 2005 Nov;84(6):377-385. doi: 10.1097/01.md.0000188565.48918.41. PMID: 16267412
Toxic neuropathies and myopathies.
Kuncl RW, George EB
Curr Opin Neurol 1993 Oct;6(5):695-704. doi: 10.1097/00019052-199310000-00004. PMID: 8293140

Diagnosis

Challenges in diagnosing hydroxychloroquine myopathy during the COVID-19 pandemic.
Pamphlett R, Wang MX, Chan RC
Intern Med J 2020 Dec;50(12):1559-1562. doi: 10.1111/imj.15092. PMID: 33354884
Detecting Toxic Myopathies as Medication Side Effect.
Gerena-Maldonado E
Phys Med Rehabil Clin N Am 2018 Nov;29(4):659-667. Epub 2018 Sep 5 doi: 10.1016/j.pmr.2018.06.002. PMID: 30293621
Is statin-induced myositis part of the polymyositis disease spectrum?
Albayda J, Mammen AL
Curr Rheumatol Rep 2014 Aug;16(8):433. doi: 10.1007/s11926-014-0433-8. PMID: 24996782
Drug-related myopathies of which the clinician should be aware.
Valiyil R, Christopher-Stine L
Curr Rheumatol Rep 2010 Jun;12(3):213-20. doi: 10.1007/s11926-010-0104-3. PMID: 20425521Free PMC Article
Statin myopathy.
Radcliffe KA, Campbell WW
Curr Neurol Neurosci Rep 2008 Jan;8(1):66-72. doi: 10.1007/s11910-008-0011-4. PMID: 18367041

Therapy

Drug-induced Myopathies.
Steinmeyer J, Flechtenmacher J
Z Orthop Unfall 2023 Apr;161(2):175-181. Epub 2021 Jul 28 doi: 10.1055/a-1488-6912. PMID: 34320661
Challenges in diagnosing hydroxychloroquine myopathy during the COVID-19 pandemic.
Pamphlett R, Wang MX, Chan RC
Intern Med J 2020 Dec;50(12):1559-1562. doi: 10.1111/imj.15092. PMID: 33354884
Is statin-induced myositis part of the polymyositis disease spectrum?
Albayda J, Mammen AL
Curr Rheumatol Rep 2014 Aug;16(8):433. doi: 10.1007/s11926-014-0433-8. PMID: 24996782
Steroid myopathy: some unresolved issues.
Minetto MA, Lanfranco F, Motta G, Allasia S, Arvat E, D'Antona G
J Endocrinol Invest 2011 May;34(5):370-5. doi: 10.1007/BF03347462. PMID: 21677507
Labetalol-induced toxic myopathy.
Teicher A, Rosenthal T, Kissin E, Sarova I
Br Med J (Clin Res Ed) 1981 Jun 6;282(6279):1824-5. doi: 10.1136/bmj.282.6279.1824. PMID: 6786636Free PMC Article

Prognosis

Nerve, muscle and heart acute toxicity following oxaliplatin and capecitabine treatment.
Orsucci D, Pizzanelli C, Alì G, Calabrese R, Ricci G, Lenzi P, Petrozzi L, Moretti P, Siciliano G
Neuromuscul Disord 2012 Aug;22(8):767-70. Epub 2012 May 29 doi: 10.1016/j.nmd.2012.04.004. PMID: 22652078
Drug-related myopathies of which the clinician should be aware.
Valiyil R, Christopher-Stine L
Curr Rheumatol Rep 2010 Jun;12(3):213-20. doi: 10.1007/s11926-010-0104-3. PMID: 20425521Free PMC Article
Hydroxychloroquine-induced toxic myopathy causing respiratory failure.
Siddiqui AK, Huberfeld SI, Weidenheim KM, Einberg KR, Efferen LS
Chest 2007 Feb;131(2):588-90. doi: 10.1378/chest.06-1146. PMID: 17296665
Rhabdomyolysis: an evaluation of 475 hospitalized patients.
Melli G, Chaudhry V, Cornblath DR
Medicine (Baltimore) 2005 Nov;84(6):377-385. doi: 10.1097/01.md.0000188565.48918.41. PMID: 16267412
Inhaled nitric oxide in advanced paraquat intoxication.
Köppel C, von Wissmann C, Barckow D, Rossaint R, Falke K, Stoltenburg-Didinger G, Schnoy N
J Toxicol Clin Toxicol 1994;32(2):205-14. doi: 10.3109/15563659409000452. PMID: 8145361

Clinical prediction guides

Statin-associated muscle symptoms: A comprehensive exploration of epidemiology, pathophysiology, diagnosis, and clinical management strategies.
Shah M, Shrestha K, Tseng CW, Goyal A, Liewluck T, Gupta L
Int J Rheum Dis 2024 Sep;27(9):e15337. doi: 10.1111/1756-185X.15337. PMID: 39285637
Toxic myopathy with multiple deletions in mitochondrial DNA associated with long-term use of oral anti-viral drugs for hepatitis B: A case study.
Fujii T, Takase KI, Honda H, Kawamura N, Yamasaki R, Urata M, Uchiumi T, Iwaki T, Kira JI
Neuropathology 2019 Apr;39(2):162-167. Epub 2019 Mar 7 doi: 10.1111/neup.12548. PMID: 30847961
Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs.
Madden L, Juhas M, Kraus WE, Truskey GA, Bursac N
Elife 2015 Jan 9;4:e04885. doi: 10.7554/eLife.04885. PMID: 25575180Free PMC Article
Acute quadriplegic myopathy with loss of thick (myosin) filaments following heart transplantation.
Perea M, Picón M, Miró O, Orús J, Roig E, Grau JM
J Heart Lung Transplant 2001 Oct;20(10):1136-41. doi: 10.1016/s1053-2498(01)00300-x. PMID: 11595571
Drugs and toxins associated with myopathies.
Pascuzzi RM
Curr Opin Rheumatol 1998 Nov;10(6):511-20. doi: 10.1097/00002281-199811000-00003. PMID: 9812211

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