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Adverse drug response

MedGen UID:
22562
•Concept ID:
C0041755
•
Pathologic Function
Synonyms: Adverse Drug Event; Adverse Drug Events; Adverse Drug Reaction; Adverse Drug Reactions; Drug Event, Adverse; Drug Events, Adverse; Drug Reaction, Adverse; Drug Reactions, Adverse; Drug Related Side Effects and Adverse Reaction; Drug Related Side Effects and Adverse Reactions; Drug Side Effect; Drug Side Effects; Drug-Related Side Effects and Adverse Reaction; Drug-Related Side Effects and Adverse Reactions; Effects, Drug Side; Reactions, Adverse Drug; Side Effect, Drug; Side Effects of Drugs; Side Effects, Drug
SNOMED CT: Drug reaction (62014003); Adverse drug effect (62014003); Adverse drug reaction (62014003); Adverse reaction caused by drug (62014003); Drug reaction (264519003); Adverse reaction to drug (62014003); ADR - Adverse drug reaction (62014003); Adverse reaction to medication (62014003)
 
HPO: HP:0020172

Definition

An unpleasant or harmful reaction resulting from treatment with a drug. [from HPO]

Professional guidelines

PubMed

A Novel PCR-RFLP Method for Detection of POR*28 Polymorphism and its Genotype/Allele Frequencies in a Turkish Population.
Ozdemir F, Oz MD, Suzen HS
Curr Drug Metab 2019;20(10):845-851. doi: 10.2174/1389200220666190913121052. PMID: 31518218
In Vitro Drug-Induced Liver Injury Prediction: Criteria Optimization of Efflux Transporter IC50 and Physicochemical Properties.
Yucha RW, He K, Shi Q, Cai L, Nakashita Y, Xia CQ, Liao M
Toxicol Sci 2017 Jun 1;157(2):487-499. doi: 10.1093/toxsci/kfx060. PMID: 28369588
Human leukocyte antigen genotypes in carbamazepine-induced severe cutaneous adverse drug response in Japanese patients.
Kashiwagi M, Aihara M, Takahashi Y, Yamazaki E, Yamane Y, Song Y, Muramatsu M, Ikezawa Z
J Dermatol 2008 Oct;35(10):683-5. doi: 10.1111/j.1346-8138.2008.00548.x. PMID: 19017052

Recent clinical studies

Etiology

Pharmacogenes (PGx-genes): Current understanding and future directions.
Katara P, Yadav A
Gene 2019 Nov 15;718:144050. Epub 2019 Aug 16 doi: 10.1016/j.gene.2019.144050. PMID: 31425740
Mouse Population-Based Approaches to Investigate Adverse Drug Reactions.
Mosedale M
Drug Metab Dispos 2018 Nov;46(11):1787-1795. Epub 2018 Jul 25 doi: 10.1124/dmd.118.082834. PMID: 30045843
Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response.
Brackman DJ, Giacomini KM
Clin Pharmacol Ther 2018 Feb;103(2):233-242. Epub 2017 Nov 28 doi: 10.1002/cpt.903. PMID: 29023674Free PMC Article
Female gender as a susceptibility factor for drug-induced liver injury.
Amacher DE
Hum Exp Toxicol 2014 Sep;33(9):928-39. Epub 2013 Dec 3 doi: 10.1177/0960327113512860. PMID: 24299907
Regulation of drug metabolism and disposition during inflammation and infection.
Renton KW
Expert Opin Drug Metab Toxicol 2005 Dec;1(4):629-40. doi: 10.1517/17425255.1.4.629. PMID: 16863429

Diagnosis

A Routine over the Counter Phenylephrine Causing Rarer Drug Eruption as Adverse Drug Reaction - A Case Report.
Yella SST, Krishna Sasanka KSBS, Singh H, Meena B
Curr Drug Saf 2024;19(2):291-294. doi: 10.2174/1574886318666230601162144. PMID: 37264618
Mouse Population-Based Approaches to Investigate Adverse Drug Reactions.
Mosedale M
Drug Metab Dispos 2018 Nov;46(11):1787-1795. Epub 2018 Jul 25 doi: 10.1124/dmd.118.082834. PMID: 30045843
Evaluation of Batch Variations in Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes from 2 Major Suppliers.
Huo J, Kamalakar A, Yang X, Word B, Stockbridge N, Lyn-Cook B, Pang L
Toxicol Sci 2017 Mar 1;156(1):25-38. doi: 10.1093/toxsci/kfw235. PMID: 28031415
Genetic variants influencing fluoropyrimidine based-therapy and available methods to detect them.
Di Francia R, Cimino L, Berretta M
Eur Rev Med Pharmacol Sci 2012 Mar;16(3):285-98. PMID: 22530343
Genetics of migraine and pharmacogenomics: some considerations.
Piane M, Lulli P, Farinelli I, Simeoni S, De Filippis S, Patacchioli FR, Martelletti P
J Headache Pain 2007 Dec;8(6):334-9. Epub 2007 Dec 5 doi: 10.1007/s10194-007-0427-2. PMID: 18058067Free PMC Article

Therapy

Pharmacogenomics of GPCR Drug Targets.
Hauser AS, Chavali S, Masuho I, Jahn LJ, Martemyanov KA, Gloriam DE, Babu MM
Cell 2018 Jan 11;172(1-2):41-54.e19. Epub 2017 Dec 14 doi: 10.1016/j.cell.2017.11.033. PMID: 29249361Free PMC Article
Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response.
Brackman DJ, Giacomini KM
Clin Pharmacol Ther 2018 Feb;103(2):233-242. Epub 2017 Nov 28 doi: 10.1002/cpt.903. PMID: 29023674Free PMC Article
Expectations, validity, and reality in pharmacogenetics.
Limdi NA, Veenstra DL
J Clin Epidemiol 2010 Sep;63(9):960-9. Epub 2009 Dec 7 doi: 10.1016/j.jclinepi.2009.09.006. PMID: 19995676Free PMC Article
Understanding drug-induced torsades de pointes: a genetic stance.
Kannankeril PJ
Expert Opin Drug Saf 2008 May;7(3):231-9. doi: 10.1517/14740338.7.3.231. PMID: 18462182
Genetics of migraine and pharmacogenomics: some considerations.
Piane M, Lulli P, Farinelli I, Simeoni S, De Filippis S, Patacchioli FR, Martelletti P
J Headache Pain 2007 Dec;8(6):334-9. Epub 2007 Dec 5 doi: 10.1007/s10194-007-0427-2. PMID: 18058067Free PMC Article

Prognosis

Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3.
Zou L, Matsson P, Stecula A, Ngo HX, Zur AA, Giacomini KM
J Pharm Sci 2021 Jan;110(1):347-353. Epub 2020 Sep 7 doi: 10.1016/j.xphs.2020.09.004. PMID: 32910949Free PMC Article
Evaluation of Batch Variations in Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes from 2 Major Suppliers.
Huo J, Kamalakar A, Yang X, Word B, Stockbridge N, Lyn-Cook B, Pang L
Toxicol Sci 2017 Mar 1;156(1):25-38. doi: 10.1093/toxsci/kfw235. PMID: 28031415
Advances in human cytochrome p450 and personalized medicine.
Chen Q, Zhang T, Wang JF, Wei DQ
Curr Drug Metab 2011 Jun;12(5):436-44. doi: 10.2174/138920011795495259. PMID: 21453272
Expectations, validity, and reality in pharmacogenetics.
Limdi NA, Veenstra DL
J Clin Epidemiol 2010 Sep;63(9):960-9. Epub 2009 Dec 7 doi: 10.1016/j.jclinepi.2009.09.006. PMID: 19995676Free PMC Article
Understanding drug-induced torsades de pointes: a genetic stance.
Kannankeril PJ
Expert Opin Drug Saf 2008 May;7(3):231-9. doi: 10.1517/14740338.7.3.231. PMID: 18462182

Clinical prediction guides

Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3.
Zou L, Matsson P, Stecula A, Ngo HX, Zur AA, Giacomini KM
J Pharm Sci 2021 Jan;110(1):347-353. Epub 2020 Sep 7 doi: 10.1016/j.xphs.2020.09.004. PMID: 32910949Free PMC Article
Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response.
Brackman DJ, Giacomini KM
Clin Pharmacol Ther 2018 Feb;103(2):233-242. Epub 2017 Nov 28 doi: 10.1002/cpt.903. PMID: 29023674Free PMC Article
Advances in human cytochrome p450 and personalized medicine.
Chen Q, Zhang T, Wang JF, Wei DQ
Curr Drug Metab 2011 Jun;12(5):436-44. doi: 10.2174/138920011795495259. PMID: 21453272
Expectations, validity, and reality in pharmacogenetics.
Limdi NA, Veenstra DL
J Clin Epidemiol 2010 Sep;63(9):960-9. Epub 2009 Dec 7 doi: 10.1016/j.jclinepi.2009.09.006. PMID: 19995676Free PMC Article
Understanding drug-induced torsades de pointes: a genetic stance.
Kannankeril PJ
Expert Opin Drug Saf 2008 May;7(3):231-9. doi: 10.1517/14740338.7.3.231. PMID: 18462182

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