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Hand paresthesia

MedGen UID:
536934
Concept ID:
C0239836
Sign or Symptom
Synonyms: Hand tingling; Paresthesia of hand
SNOMED CT: Paresthesia of hand (309086004)
 
HPO: HP:0033660

Definition

Tingling (often refered to as a pins and needles feeling) and numbness in the hand. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHand paresthesia

Conditions with this feature

Hereditary liability to pressure palsies
MedGen UID:
98291
Concept ID:
C0393814
Disease or Syndrome
Hereditary neuropathy with liability to pressure palsies (HNPP) is characterized by recurrent acute sensory and motor neuropathy in a single or multiple nerves. The most common initial manifestation is the acute onset of a non-painful focal sensory and motor neuropathy in a single nerve (mononeuropathy). The first attack usually occurs in the second or third decade but earlier onset is possible. Neuropathic pain is increasingly recognized as a common manifestation. Recovery from acute neuropathy is usually complete; when recovery is not complete, the resulting disability is mild. Some affected individuals also demonstrate a mild-to-moderate peripheral neuropathy.
Neuropathy, hereditary sensory and autonomic, type 1C
MedGen UID:
462246
Concept ID:
C3150896
Disease or Syndrome
Hereditary sensory and autonomic neuropathy type IC (HSAN1C) is an autosomal dominant neurologic disorder characterized by sensory neuropathy with variable autonomic and motor involvement. Most patients have adult onset of slowly progressive distal sensory impairment manifest as numbness, tingling, or pain, as well as distal muscle atrophy. Complications include ulceration and osteomyelitis. Some patients may have a more severe phenotype with onset in childhood. Electrophysiologic studies show a predominantly axonal neuropathy with some demyelinating features. Some patients may have evidence of central nervous system involvement, including macular telangiectasia type 2 and/or pyramidal signs. Affected individuals have increased levels of plasma 1-deoxysphingolipids (1-deoxySLs), which are thought to be neurotoxic. (summary by Rotthier et al., 2010, Gantner et al., 2019, and Triplett et al., 2019). Oral supplementation with serine decreases 1-deoxySL and may offer some clinical benefits (Fridman et al., 2019). For a discussion of genetic heterogeneity of HSAN, see HSAN1A (162400).
Carpal tunnel syndrome 2
MedGen UID:
1725962
Concept ID:
C5436916
Disease or Syndrome
Carpal tunnel syndrome-2 (CTS2) is characterized by the relatively early onset of symptoms of median nerve compression in the wrist. Patients experience pain and numbness in the thumb, index, and middle fingers, correlating with the median nerve distribution in the hand. In addition to thickening of the tendons and ligaments of the wrist, thickening of other tendons has been observed (Li et al., 2020). For a general phenotypic description and discussion of genetic heterogeneity of carpal tunnel syndrome, see CTS1 (115430).

Professional guidelines

Recent clinical studies

Etiology

Kunc V, Edelmann K, Bába V, Debnar M, Kmeť P, Kučera K, Kunc V, Mišičko R, Kopp L
Rozhl Chir 2021 Summer;100(8):384-389. doi: 10.33699/PIS.2021.100.8.384-389. PMID: 34649445
Zubiaur P, Del Peso-Casado M, Ochoa D, Enrique-Benedito T, Mejía-Abril G, Navares M, Villapalos-García G, Román M, Abad-Santos F, Ovejero-Benito MC
Biomed Pharmacother 2021 Oct;142:112083. Epub 2021 Aug 24 doi: 10.1016/j.biopha.2021.112083. PMID: 34463270
Marins LR, da Rocha Oppermann ML
J Obstet Gynaecol Res 2021 May;47(5):1898-1902. Epub 2021 Mar 14 doi: 10.1111/jog.14717. PMID: 33719122
Balderman J, Holzem K, Field BJ, Bottros MM, Abuirqeba AA, Vemuri C, Thompson RW
J Vasc Surg 2017 Aug;66(2):533-544.e2. doi: 10.1016/j.jvs.2017.03.419. PMID: 28735950
Styczynski A, Tran C, Dirlikov E, Zapata MR, Ryff K, Petersen B, Sanchez AC, Mayshack M, Martinez LC, Condori R, Ellison J, Orciari L, Yager P, Peña RG, Sanabria D, Velázquez JC, Thomas D, García BR
MMWR Morb Mortal Wkly Rep 2017 Jan 6;65(52):1474-1476. doi: 10.15585/mmwr.mm6552a4. PMID: 28056006

Diagnosis

Rahbar M, Dolatkhah N
J Med Case Rep 2023 Mar 6;17(1):84. doi: 10.1186/s13256-023-03801-8. PMID: 36872340Free PMC Article
Marins LR, da Rocha Oppermann ML
J Obstet Gynaecol Res 2021 May;47(5):1898-1902. Epub 2021 Mar 14 doi: 10.1111/jog.14717. PMID: 33719122
Pallaver A, Schibli S, Fridén J
Spinal Cord Ser Cases 2021 Feb 3;7(1):9. doi: 10.1038/s41394-020-00379-x. PMID: 33536426Free PMC Article
Byon JH, Park EH, Lee CH
World Neurosurg 2020 Aug;140:119-121. Epub 2020 May 17 doi: 10.1016/j.wneu.2020.05.080. PMID: 32434017
Styczynski A, Tran C, Dirlikov E, Zapata MR, Ryff K, Petersen B, Sanchez AC, Mayshack M, Martinez LC, Condori R, Ellison J, Orciari L, Yager P, Peña RG, Sanabria D, Velázquez JC, Thomas D, García BR
MMWR Morb Mortal Wkly Rep 2017 Jan 6;65(52):1474-1476. doi: 10.15585/mmwr.mm6552a4. PMID: 28056006

Therapy

Zubiaur P, Del Peso-Casado M, Ochoa D, Enrique-Benedito T, Mejía-Abril G, Navares M, Villapalos-García G, Román M, Abad-Santos F, Ovejero-Benito MC
Biomed Pharmacother 2021 Oct;142:112083. Epub 2021 Aug 24 doi: 10.1016/j.biopha.2021.112083. PMID: 34463270
Byon JH, Park EH, Lee CH
World Neurosurg 2020 Aug;140:119-121. Epub 2020 May 17 doi: 10.1016/j.wneu.2020.05.080. PMID: 32434017
Nourbakhsh MR, Bell TJ, Martin JB, Arab AM
J Altern Complement Med 2016 Nov;22(11):911-920. Epub 2016 Aug 3 doi: 10.1089/acm.2016.0083. PMID: 27487406Free PMC Article
Babaei-Ghazani A, Eftekharsadat B
J Back Musculoskelet Rehabil 2016 Apr 27;29(2):381-385. doi: 10.3233/BMR-150625. PMID: 26406204

Prognosis

Marins LR, da Rocha Oppermann ML
J Obstet Gynaecol Res 2021 May;47(5):1898-1902. Epub 2021 Mar 14 doi: 10.1111/jog.14717. PMID: 33719122
Balderman J, Holzem K, Field BJ, Bottros MM, Abuirqeba AA, Vemuri C, Thompson RW
J Vasc Surg 2017 Aug;66(2):533-544.e2. doi: 10.1016/j.jvs.2017.03.419. PMID: 28735950
Styczynski A, Tran C, Dirlikov E, Zapata MR, Ryff K, Petersen B, Sanchez AC, Mayshack M, Martinez LC, Condori R, Ellison J, Orciari L, Yager P, Peña RG, Sanabria D, Velázquez JC, Thomas D, García BR
MMWR Morb Mortal Wkly Rep 2017 Jan 6;65(52):1474-1476. doi: 10.15585/mmwr.mm6552a4. PMID: 28056006

Clinical prediction guides

Zhang DY, Pearce JJ, Mazza J, Petrosyan E, Borghei A, Patel N, Sani S
Stereotact Funct Neurosurg 2023;101(2):101-111. Epub 2023 Mar 2 doi: 10.1159/000528925. PMID: 36863325
Zubiaur P, Del Peso-Casado M, Ochoa D, Enrique-Benedito T, Mejía-Abril G, Navares M, Villapalos-García G, Román M, Abad-Santos F, Ovejero-Benito MC
Biomed Pharmacother 2021 Oct;142:112083. Epub 2021 Aug 24 doi: 10.1016/j.biopha.2021.112083. PMID: 34463270
Pallaver A, Schibli S, Fridén J
Spinal Cord Ser Cases 2021 Feb 3;7(1):9. doi: 10.1038/s41394-020-00379-x. PMID: 33536426Free PMC Article
Balderman J, Holzem K, Field BJ, Bottros MM, Abuirqeba AA, Vemuri C, Thompson RW
J Vasc Surg 2017 Aug;66(2):533-544.e2. doi: 10.1016/j.jvs.2017.03.419. PMID: 28735950
Zanette G, Marani S, Tamburin S
J Peripher Nerv Syst 2007 Jun;12(2):91-7. doi: 10.1111/j.1529-8027.2007.00127.x. PMID: 17565533

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