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Nipple tenderness

MedGen UID:
536988
•Concept ID:
C0240521
•
Sign or Symptom
SNOMED CT: Nipple tenderness (225574009)
 
HPO: HP:0020226

Definition

Pain or discomfort produced by touching the nipple. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNipple tenderness

Professional guidelines

PubMed

CLOMIPHENE CITRATE IN THE TREATMENT OF IDIOPATHIC OR FUNCTIONAL HYPOGONADOTROPIC HYPOGONADISM IN MEN: A CASE SERIES AND REVIEW OF THE LITERATURE.
Liel Y
Endocr Pract 2017 Mar;23(3):279-287. Epub 2016 Nov 16 doi: 10.4158/EP161543.OR. PMID: 27849376
Provider management and support for breastfeeding pain.
Strong GD
J Obstet Gynecol Neonatal Nurs 2011 Nov-Dec;40(6):753-64. doi: 10.1111/j.1552-6909.2011.01303.x. PMID: 22273451
Activity of the herbal combination, PC-SPES, in the treatment of patients with androgen-independent prostate cancer.
Oh WK, George DJ, Hackmann K, Manola J, Kantoff PW
Urology 2001 Jan;57(1):122-6. doi: 10.1016/s0090-4295(00)00986-9. PMID: 11164156

Recent clinical studies

Etiology

Clinical and immunologic impact of short-course enzalutamide alone and with immunotherapy in non-metastatic castration sensitive prostate cancer.
Madan RA, Karzai F, Donahue RN, Al-Harthy M, Bilusic M, Rosner II, Singh H, Arlen PM, Theoret MR, Marté JL, Cordes L, Couvillon A, Hankin A, Williams M, Owens H, Lochrin SE, Chau CH, Steinberg S, Figg WD, Dahut W, Schlom J, Gulley JL
J Immunother Cancer 2021 Mar;9(3) doi: 10.1136/jitc-2020-001556. PMID: 33664086Free PMC Article
CLOMIPHENE CITRATE IN THE TREATMENT OF IDIOPATHIC OR FUNCTIONAL HYPOGONADOTROPIC HYPOGONADISM IN MEN: A CASE SERIES AND REVIEW OF THE LITERATURE.
Liel Y
Endocr Pract 2017 Mar;23(3):279-287. Epub 2016 Nov 16 doi: 10.4158/EP161543.OR. PMID: 27849376
Provider management and support for breastfeeding pain.
Strong GD
J Obstet Gynecol Neonatal Nurs 2011 Nov-Dec;40(6):753-64. doi: 10.1111/j.1552-6909.2011.01303.x. PMID: 22273451
Clomiphene citrate effects on testosterone/estrogen ratio in male hypogonadism.
Shabsigh A, Kang Y, Shabsign R, Gonzalez M, Liberson G, Fisch H, Goluboff E
J Sex Med 2005 Sep;2(5):716-21. doi: 10.1111/j.1743-6109.2005.00075.x. PMID: 16422830
Oestradiol improves arterial endothelial function in healthy men receiving testosterone.
Sader MA, McCredie RJ, Griffiths KA, Wishart SM, Handelsman DJ, Celermajer DS
Clin Endocrinol (Oxf) 2001 Feb;54(2):175-81. doi: 10.1046/j.1365-2265.2001.01176.x. PMID: 11207631

Diagnosis

Clinical and immunologic impact of short-course enzalutamide alone and with immunotherapy in non-metastatic castration sensitive prostate cancer.
Madan RA, Karzai F, Donahue RN, Al-Harthy M, Bilusic M, Rosner II, Singh H, Arlen PM, Theoret MR, Marté JL, Cordes L, Couvillon A, Hankin A, Williams M, Owens H, Lochrin SE, Chau CH, Steinberg S, Figg WD, Dahut W, Schlom J, Gulley JL
J Immunother Cancer 2021 Mar;9(3) doi: 10.1136/jitc-2020-001556. PMID: 33664086Free PMC Article
Provider management and support for breastfeeding pain.
Strong GD
J Obstet Gynecol Neonatal Nurs 2011 Nov-Dec;40(6):753-64. doi: 10.1111/j.1552-6909.2011.01303.x. PMID: 22273451
Long-term effectiveness of luteinizing hormone-releasing hormone agonist or antiandrogen monotherapy in elderly men with localized prostate cancer (T1-2): a retrospective study.
Raina R, Pahalajani G, Agarwal A, Zippe C
Asian J Androl 2007 Mar;9(2):253-8. doi: 10.1111/j.1745-7262.2007.00074.x. PMID: 17334592
Herbal therapy PC-SPES: in vitro effects and evaluation of its efficacy in 69 patients with prostate cancer.
de la Taille A, Buttyan R, Hayek O, Bagiella E, Shabsigh A, Burchardt M, Burchardt T, Chopin DK, Katz AE
J Urol 2000 Oct;164(4):1229-34. doi: 10.1097/00005392-200010000-00021. PMID: 10992371
Effects of a phytotherapeutic agent, PC-SPES, on prostate cancer: a preliminary investigation on human cell lines and patients.
de la Taille A, Hayek OR, Buttyan R, Bagiella E, Burchardt M, Katz AE
BJU Int 1999 Nov;84(7):845-50. doi: 10.1046/j.1464-410x.1999.00285.x. PMID: 10532984

Therapy

Clinical and immunologic impact of short-course enzalutamide alone and with immunotherapy in non-metastatic castration sensitive prostate cancer.
Madan RA, Karzai F, Donahue RN, Al-Harthy M, Bilusic M, Rosner II, Singh H, Arlen PM, Theoret MR, Marté JL, Cordes L, Couvillon A, Hankin A, Williams M, Owens H, Lochrin SE, Chau CH, Steinberg S, Figg WD, Dahut W, Schlom J, Gulley JL
J Immunother Cancer 2021 Mar;9(3) doi: 10.1136/jitc-2020-001556. PMID: 33664086Free PMC Article
A Dose-Escalating Study With the Fetal Estrogen Estetrol in Healthy Men.
Coelingh Bennink HJT, Zimmerman Y, Verhoeven C, Dutman AE, Mensinga T, Kluft C, Reisman Y, Debruyne FMJ
J Clin Endocrinol Metab 2018 Sep 1;103(9):3239-3249. doi: 10.1210/jc.2018-00147. PMID: 29931320
Provider management and support for breastfeeding pain.
Strong GD
J Obstet Gynecol Neonatal Nurs 2011 Nov-Dec;40(6):753-64. doi: 10.1111/j.1552-6909.2011.01303.x. PMID: 22273451
PC-SPES: herbal formulation for prostate cancer.
Marks LS, DiPaola RS, Nelson P, Chen S, Heber D, Belldegrun AS, Lowe FC, Fan J, Leaders FE Jr, Pantuck AJ, Tyler VE
Urology 2002 Sep;60(3):369-75; discussion 376-7. doi: 10.1016/s0090-4295(02)01913-1. PMID: 12350462
Tamoxifen for flutamide/finasteride-induced gynecomastia.
Staiman VR, Lowe FC
Urology 1997 Dec;50(6):929-33. doi: 10.1016/S0090-4295(97)00457-3. PMID: 9426725

Prognosis

Clinical and immunologic impact of short-course enzalutamide alone and with immunotherapy in non-metastatic castration sensitive prostate cancer.
Madan RA, Karzai F, Donahue RN, Al-Harthy M, Bilusic M, Rosner II, Singh H, Arlen PM, Theoret MR, Marté JL, Cordes L, Couvillon A, Hankin A, Williams M, Owens H, Lochrin SE, Chau CH, Steinberg S, Figg WD, Dahut W, Schlom J, Gulley JL
J Immunother Cancer 2021 Mar;9(3) doi: 10.1136/jitc-2020-001556. PMID: 33664086Free PMC Article
Provider management and support for breastfeeding pain.
Strong GD
J Obstet Gynecol Neonatal Nurs 2011 Nov-Dec;40(6):753-64. doi: 10.1111/j.1552-6909.2011.01303.x. PMID: 22273451
Clomiphene citrate effects on testosterone/estrogen ratio in male hypogonadism.
Shabsigh A, Kang Y, Shabsign R, Gonzalez M, Liberson G, Fisch H, Goluboff E
J Sex Med 2005 Sep;2(5):716-21. doi: 10.1111/j.1743-6109.2005.00075.x. PMID: 16422830
Activity of the herbal combination, PC-SPES, in the treatment of patients with androgen-independent prostate cancer.
Oh WK, George DJ, Hackmann K, Manola J, Kantoff PW
Urology 2001 Jan;57(1):122-6. doi: 10.1016/s0090-4295(00)00986-9. PMID: 11164156

Clinical prediction guides

Clinical and immunologic impact of short-course enzalutamide alone and with immunotherapy in non-metastatic castration sensitive prostate cancer.
Madan RA, Karzai F, Donahue RN, Al-Harthy M, Bilusic M, Rosner II, Singh H, Arlen PM, Theoret MR, Marté JL, Cordes L, Couvillon A, Hankin A, Williams M, Owens H, Lochrin SE, Chau CH, Steinberg S, Figg WD, Dahut W, Schlom J, Gulley JL
J Immunother Cancer 2021 Mar;9(3) doi: 10.1136/jitc-2020-001556. PMID: 33664086Free PMC Article
CLOMIPHENE CITRATE IN THE TREATMENT OF IDIOPATHIC OR FUNCTIONAL HYPOGONADOTROPIC HYPOGONADISM IN MEN: A CASE SERIES AND REVIEW OF THE LITERATURE.
Liel Y
Endocr Pract 2017 Mar;23(3):279-287. Epub 2016 Nov 16 doi: 10.4158/EP161543.OR. PMID: 27849376
A double-blind, placebo-controlled, randomized clinical trial of recombinant human chorionic gonadotropin on muscle strength and physical function and activity in older men with partial age-related androgen deficiency.
Liu PY, Wishart SM, Handelsman DJ
J Clin Endocrinol Metab 2002 Jul;87(7):3125-35. doi: 10.1210/jcem.87.7.8630. PMID: 12107212
Activity of the herbal combination, PC-SPES, in the treatment of patients with androgen-independent prostate cancer.
Oh WK, George DJ, Hackmann K, Manola J, Kantoff PW
Urology 2001 Jan;57(1):122-6. doi: 10.1016/s0090-4295(00)00986-9. PMID: 11164156
Effects of a phytotherapeutic agent, PC-SPES, on prostate cancer: a preliminary investigation on human cell lines and patients.
de la Taille A, Hayek OR, Buttyan R, Bagiella E, Burchardt M, Katz AE
BJU Int 1999 Nov;84(7):845-50. doi: 10.1046/j.1464-410x.1999.00285.x. PMID: 10532984

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