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Hemolytic disease of fetus OR newborn due to ABO immunization

MedGen UID:
542596
•Concept ID:
C0270202
•
Disease or Syndrome
Synonyms: ABO HDN - ABO hemolytic disease of the newborn; ABO Hemolytic Disease of the Newborn; ABO hemolytic disease of the newborn; ABO isoimmunization of the newborn; Anemia due to ABO incompatibility in the newborn; Erythroblastosis fetalis due to ABO isoimmunization; Hemolytic disease due to ABO isoimmunization; Jaundice due to ABO isoimmunization of the newborn
SNOMED CT: ABO HDN - ABO hemolytic disease of the newborn (32858009); Hemolytic disease of fetus OR newborn due to ABO immunization (32858009); Hemolytic disease due to ABO isoimmunization (32858009); Erythroblastosis fetalis due to ABO isoimmunization (32858009); Anemia due to ABO incompatibility in the newborn (32858009); Jaundice due to ABO isoimmunization of the newborn (32858009); ABO isoimmunization of the newborn (32858009); ABO hemolytic disease of the newborn (32858009)

Definition

A condition of the newborn characterized by the destruction of red blood cells initiated by the transmission of anti-A or anti-B antibodies from a mother to the child via the placenta against A or B antigens of the newborn''s blood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemolytic disease of fetus OR newborn due to ABO immunization

Professional guidelines

PubMed

Fetal anemia: Diagnosis and management.
Prefumo F, Fichera A, Fratelli N, Sartori E
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:2-14. Epub 2019 Jan 9 doi: 10.1016/j.bpobgyn.2019.01.001. PMID: 30718211
ACOG Practice Bulletin No. 192: Management of Alloimmunization During Pregnancy.
Obstet Gynecol 2018 Mar;131(3):e82-e90. doi: 10.1097/AOG.0000000000002528. PMID: 29470342
Practice Bulletin No. 181: Prevention of Rh D Alloimmunization.
Obstet Gynecol 2017 Aug;130(2):e57-e70. doi: 10.1097/AOG.0000000000002232. PMID: 28742673

Recent clinical studies

Etiology

Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D
BMC Pregnancy Childbirth 2023 Jan 7;23(1):12. doi: 10.1186/s12884-022-05329-z. PMID: 36611144Free PMC Article
History and current standard of postnatal management in hemolytic disease of the fetus and newborn.
De Winter DP, Hulzebos C, Van 't Oever RM, De Haas M, Verweij EJ, Lopriore E
Eur J Pediatr 2023 Feb;182(2):489-500. Epub 2022 Dec 5 doi: 10.1007/s00431-022-04724-0. PMID: 36469119
Fetal-maternal incompatibility in the Rh system. Rh isoimmunization associated with hereditary spherocytosis: case presentation and review of the literature.
Neamţu SD, Novac MB, Neamţu AV, Stanca ID, Boldeanu MV, Gluhovschi A, Stanca L, Dijmărescu AL, Manolea MM, Trăistaru MR, Mateescu GO, Siminel MA
Rom J Morphol Embryol 2022 Jan-Mar;63(1):229-235. doi: 10.47162/RJME.63.1.26. PMID: 36074689Free PMC Article
Hemolytic disease in fetuses and newborns due to antibodies against the M-antigen.
Páez M, Jiménez M, Corredor A
Biomedica 2021 Dec 15;41(4):643-650. doi: 10.7705/biomedica.5930. PMID: 34936250Free PMC Article
Hemolytic disease of the fetus and newborn: managing the mother, fetus, and newborn.
Delaney M, Matthews DC
Hematology Am Soc Hematol Educ Program 2015;2015:146-51. doi: 10.1182/asheducation-2015.1.146. PMID: 26637714

Diagnosis

Hemolytic Disease of the Fetus and Newborn: Historical and Current State.
Jackson ME, Baker JM
Clin Lab Med 2021 Mar;41(1):133-151. Epub 2020 Dec 24 doi: 10.1016/j.cll.2020.10.009. PMID: 33494881
Fetal anemia: Diagnosis and management.
Prefumo F, Fichera A, Fratelli N, Sartori E
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:2-14. Epub 2019 Jan 9 doi: 10.1016/j.bpobgyn.2019.01.001. PMID: 30718211
ACOG Practice Bulletin No. 192: Management of Alloimmunization During Pregnancy.
Obstet Gynecol 2018 Mar;131(3):e82-e90. doi: 10.1097/AOG.0000000000002528. PMID: 29470342
Haemolytic disease of the fetus and newborn.
de Haas M, Thurik FF, Koelewijn JM, van der Schoot CE
Vox Sang 2015 Aug;109(2):99-113. Epub 2015 Apr 20 doi: 10.1111/vox.12265. PMID: 25899660
Alpha-thalassaemia.
Harteveld CL, Higgs DR
Orphanet J Rare Dis 2010 May 28;5:13. doi: 10.1186/1750-1172-5-13. PMID: 20507641Free PMC Article

Therapy

New developments in fetal and neonatal alloimmune thrombocytopenia.
Bussel JB, Vander Haar EL, Berkowitz RL
Am J Obstet Gynecol 2021 Aug;225(2):120-127. Epub 2021 Apr 8 doi: 10.1016/j.ajog.2021.04.211. PMID: 33839095
Hemolytic disease of the fetus and newborn due to Rh(D) incompatibility: A preventable disease that still produces significant morbidity and mortality in children.
Pegoraro V, Urbinati D, Visser GHA, Di Renzo GC, Zipursky A, Stotler BA, Spitalnik SL
PLoS One 2020;15(7):e0235807. Epub 2020 Jul 20 doi: 10.1371/journal.pone.0235807. PMID: 32687543Free PMC Article
Transfusion-related red blood cell alloantibodies: induction and consequences.
Tormey CA, Hendrickson JE
Blood 2019 Apr 25;133(17):1821-1830. Epub 2019 Feb 26 doi: 10.1182/blood-2018-08-833962. PMID: 30808636Free PMC Article
Fetal anemia: Diagnosis and management.
Prefumo F, Fichera A, Fratelli N, Sartori E
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:2-14. Epub 2019 Jan 9 doi: 10.1016/j.bpobgyn.2019.01.001. PMID: 30718211
Practice Bulletin No. 181: Prevention of Rh D Alloimmunization.
Obstet Gynecol 2017 Aug;130(2):e57-e70. doi: 10.1097/AOG.0000000000002232. PMID: 28742673

Prognosis

Perinatal Hemolytic Disorders and Identification Using End Tidal Breath Carbon Monoxide.
Christensen RD, Bahr TM, Pakdeeto S, Supapannachart S, Zhang H
Curr Pediatr Rev 2023;19(4):376-387. doi: 10.2174/1573396319666221220095522. PMID: 36545740
Eculizumab in pregnancy: a narrative overview.
Sarno L, Tufano A, Maruotti GM, Martinelli P, Balletta MM, Russo D
J Nephrol 2019 Feb;32(1):17-25. Epub 2018 Aug 29 doi: 10.1007/s40620-018-0517-z. PMID: 30159857
Hemolytic Disease of the Fetus and Newborn: Modern Practice and Future Investigations.
Hendrickson JE, Delaney M
Transfus Med Rev 2016 Oct;30(4):159-64. Epub 2016 May 26 doi: 10.1016/j.tmrv.2016.05.008. PMID: 27397673
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360
Maternal CW alloimmunization.
Bowman JM, Pollock J
Vox Sang 1993;64(4):226-30. PMID: 8517051

Clinical prediction guides

Hemolytic disease of the fetus and newborn: rapid review of postnatal care and outcomes.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D, Lopriore E
BMC Pregnancy Childbirth 2023 Oct 18;23(1):738. doi: 10.1186/s12884-023-06061-y. PMID: 37853331Free PMC Article
Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D
BMC Pregnancy Childbirth 2023 Jan 7;23(1):12. doi: 10.1186/s12884-022-05329-z. PMID: 36611144Free PMC Article
Fetal-maternal incompatibility in the Rh system. Rh isoimmunization associated with hereditary spherocytosis: case presentation and review of the literature.
Neamţu SD, Novac MB, Neamţu AV, Stanca ID, Boldeanu MV, Gluhovschi A, Stanca L, Dijmărescu AL, Manolea MM, Trăistaru MR, Mateescu GO, Siminel MA
Rom J Morphol Embryol 2022 Jan-Mar;63(1):229-235. doi: 10.47162/RJME.63.1.26. PMID: 36074689Free PMC Article
Hemolytic disease in fetuses and newborns due to antibodies against the M-antigen.
Páez M, Jiménez M, Corredor A
Biomedica 2021 Dec 15;41(4):643-650. doi: 10.7705/biomedica.5930. PMID: 34936250Free PMC Article
Alpha-thalassaemia.
Harteveld CL, Higgs DR
Orphanet J Rare Dis 2010 May 28;5:13. doi: 10.1186/1750-1172-5-13. PMID: 20507641Free PMC Article

Recent systematic reviews

Intravenous immunoglobulin for the treatment of severe maternal alloimmunization: individual patient data meta-analysis.
Mustafa HJ, Sambatur EV, Pagani G, D'Antonio F, Maisonneuve E, Maurice P, Zwiers C, Verweij JEJT, Flood A, Shamshirsaz AA, Jouannic JM, Khalil A
Am J Obstet Gynecol 2024 Oct;231(4):417-429.e21. Epub 2024 Apr 7 doi: 10.1016/j.ajog.2024.03.044. PMID: 38588966
Misclassification of RhD variants among pregnant women: a systematic review.
Owaidah AY, Yamani LZ
J Med Life 2023 Jul;16(7):981-989. doi: 10.25122/jml-2023-0004. PMID: 37900088Free PMC Article
Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D
BMC Pregnancy Childbirth 2023 Jan 7;23(1):12. doi: 10.1186/s12884-022-05329-z. PMID: 36611144Free PMC Article
Non-Invasive Prenatal Fetal Blood Group Genotype and Its Application in the Management of Hemolytic Disease of Fetus and Newborn: Systematic Review and Meta-Analysis.
Alshehri AA, Jackson DE
Transfus Med Rev 2021 Apr;35(2):85-94. Epub 2021 Mar 1 doi: 10.1016/j.tmrv.2021.02.001. PMID: 33781630
Intramuscular versus intravenous anti-D for preventing Rhesus alloimmunization during pregnancy.
Okwundu CI, Afolabi BB
Cochrane Database Syst Rev 2013 Jan 31;(1):CD007885. doi: 10.1002/14651858.CD007885.pub2. PMID: 23440818

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