U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hemolytic disease of fetus OR newborn due to isoimmunization

MedGen UID:
4530
•Concept ID:
C0014761
•
Disease or Syndrome
Synonyms: Fetal erythroblastosis; Hemolytic Disease of the Newborn
SNOMED CT: Hemolytic disease of fetus OR newborn due to isoimmunization (387705004); EF - Erythroblastosis fetalis (387705004); Erythroblastosis fetalis (387705004); Alloimmune hemolytic disease of newborn (387705004); Isoimmunization of newborn (387705004); HDN - Hemolytic disease of the newborn (387705004); Hemolytic disease of the newborn (387705004); Hemolytic disease of fetus OR newborn (387705004)
 
Monarch Initiative: MONDO:0006760

Definition

A disorder of the fetus or newborn that occurs when fetal cells that are coated with IgG alloantibodies from the mother attack antigens inherited from the father. Severity can range from absence of symptoms to death. [from NCI]

Professional guidelines

PubMed

Fetal anemia: Diagnosis and management.
Prefumo F, Fichera A, Fratelli N, Sartori E
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:2-14. Epub 2019 Jan 9 doi: 10.1016/j.bpobgyn.2019.01.001. PMID: 30718211
ACOG Practice Bulletin No. 192: Management of Alloimmunization During Pregnancy.
Obstet Gynecol 2018 Mar;131(3):e82-e90. doi: 10.1097/AOG.0000000000002528. PMID: 29470342
Practice Bulletin No. 181: Prevention of Rh D Alloimmunization.
Obstet Gynecol 2017 Aug;130(2):e57-e70. doi: 10.1097/AOG.0000000000002232. PMID: 28742673

Recent clinical studies

Etiology

Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D
BMC Pregnancy Childbirth 2023 Jan 7;23(1):12. doi: 10.1186/s12884-022-05329-z. PMID: 36611144Free PMC Article
History and current standard of postnatal management in hemolytic disease of the fetus and newborn.
De Winter DP, Hulzebos C, Van 't Oever RM, De Haas M, Verweij EJ, Lopriore E
Eur J Pediatr 2023 Feb;182(2):489-500. Epub 2022 Dec 5 doi: 10.1007/s00431-022-04724-0. PMID: 36469119
Hemolytic disease in fetuses and newborns due to antibodies against the M-antigen.
Páez M, Jiménez M, Corredor A
Biomedica 2021 Dec 15;41(4):643-650. doi: 10.7705/biomedica.5930. PMID: 34936250Free PMC Article
How I manage children with neutropenia.
Dale DC
Br J Haematol 2017 Aug;178(3):351-363. Epub 2017 Apr 17 doi: 10.1111/bjh.14677. PMID: 28419427
Hemolytic disease of the fetus and newborn: managing the mother, fetus, and newborn.
Delaney M, Matthews DC
Hematology Am Soc Hematol Educ Program 2015;2015:146-51. doi: 10.1182/asheducation-2015.1.146. PMID: 26637714

Diagnosis

Mirror syndrome: a systematic literature review.
Biswas S, Gomez J, Horgan R, Sibai BM, Saad A, Powel JE, Al-Kouatly HB
Am J Obstet Gynecol MFM 2023 Sep;5(9):101067. Epub 2023 Jun 28 doi: 10.1016/j.ajogmf.2023.101067. PMID: 37385374
History and current standard of postnatal management in hemolytic disease of the fetus and newborn.
De Winter DP, Hulzebos C, Van 't Oever RM, De Haas M, Verweij EJ, Lopriore E
Eur J Pediatr 2023 Feb;182(2):489-500. Epub 2022 Dec 5 doi: 10.1007/s00431-022-04724-0. PMID: 36469119
Hemolytic Disease of the Fetus and Newborn: Historical and Current State.
Jackson ME, Baker JM
Clin Lab Med 2021 Mar;41(1):133-151. Epub 2020 Dec 24 doi: 10.1016/j.cll.2020.10.009. PMID: 33494881
Fetal anemia: Diagnosis and management.
Prefumo F, Fichera A, Fratelli N, Sartori E
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:2-14. Epub 2019 Jan 9 doi: 10.1016/j.bpobgyn.2019.01.001. PMID: 30718211
How I manage children with neutropenia.
Dale DC
Br J Haematol 2017 Aug;178(3):351-363. Epub 2017 Apr 17 doi: 10.1111/bjh.14677. PMID: 28419427

Therapy

Nipocalimab in Early-Onset Severe Hemolytic Disease of the Fetus and Newborn.
Moise KJ Jr, Ling LE, Oepkes D, Tiblad E, Verweij EJTJ, Lopriore E, Smoleniec J, Sachs UJ, Bein G, Kilby MD, Miller RS, Devlieger R, Audibert F, Emery SP, Markham K, Norton ME, Ocón-Hernández O, Pandya P, Pereira L, Silver RM, Windrim R, Streisand JB, Leu JH, Mirza A, Smith V, Schwartz LB, Tjoa ML, Saeed-Khawaja S, Komatsu Y, Bussel JB; UNITY Study Group
N Engl J Med 2024 Aug 8;391(6):526-537. doi: 10.1056/NEJMoa2314466. PMID: 39115062
Transfusion-related red blood cell alloantibodies: induction and consequences.
Tormey CA, Hendrickson JE
Blood 2019 Apr 25;133(17):1821-1830. Epub 2019 Feb 26 doi: 10.1182/blood-2018-08-833962. PMID: 30808636Free PMC Article
Fetal anemia: Diagnosis and management.
Prefumo F, Fichera A, Fratelli N, Sartori E
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:2-14. Epub 2019 Jan 9 doi: 10.1016/j.bpobgyn.2019.01.001. PMID: 30718211
Practice Bulletin No. 181: Prevention of Rh D Alloimmunization.
Obstet Gynecol 2017 Aug;130(2):e57-e70. doi: 10.1097/AOG.0000000000002232. PMID: 28742673
How I manage children with neutropenia.
Dale DC
Br J Haematol 2017 Aug;178(3):351-363. Epub 2017 Apr 17 doi: 10.1111/bjh.14677. PMID: 28419427

Prognosis

Eculizumab in pregnancy: a narrative overview.
Sarno L, Tufano A, Maruotti GM, Martinelli P, Balletta MM, Russo D
J Nephrol 2019 Feb;32(1):17-25. Epub 2018 Aug 29 doi: 10.1007/s40620-018-0517-z. PMID: 30159857
Hemolytic Disease of the Fetus and Newborn: Modern Practice and Future Investigations.
Hendrickson JE, Delaney M
Transfus Med Rev 2016 Oct;30(4):159-64. Epub 2016 May 26 doi: 10.1016/j.tmrv.2016.05.008. PMID: 27397673
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360
Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses.
Mari G, Deter RL, Carpenter RL, Rahman F, Zimmerman R, Moise KJ Jr, Dorman KF, Ludomirsky A, Gonzalez R, Gomez R, Oz U, Detti L, Copel JA, Bahado-Singh R, Berry S, Martinez-Poyer J, Blackwell SC
N Engl J Med 2000 Jan 6;342(1):9-14. doi: 10.1056/NEJM200001063420102. PMID: 10620643
Nonimmune hydrops fetalis.
Sosa ME
J Perinat Neonatal Nurs 1999 Dec;13(3):33-44. doi: 10.1097/00005237-199912000-00004. PMID: 10818859

Clinical prediction guides

Hemolytic disease of the fetus and newborn: rapid review of postnatal care and outcomes.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D, Lopriore E
BMC Pregnancy Childbirth 2023 Oct 18;23(1):738. doi: 10.1186/s12884-023-06061-y. PMID: 37853331Free PMC Article
Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D
BMC Pregnancy Childbirth 2023 Jan 7;23(1):12. doi: 10.1186/s12884-022-05329-z. PMID: 36611144Free PMC Article
Hemolytic disease in fetuses and newborns due to antibodies against the M-antigen.
Páez M, Jiménez M, Corredor A
Biomedica 2021 Dec 15;41(4):643-650. doi: 10.7705/biomedica.5930. PMID: 34936250Free PMC Article
How I manage children with neutropenia.
Dale DC
Br J Haematol 2017 Aug;178(3):351-363. Epub 2017 Apr 17 doi: 10.1111/bjh.14677. PMID: 28419427
Alpha-thalassaemia.
Harteveld CL, Higgs DR
Orphanet J Rare Dis 2010 May 28;5:13. doi: 10.1186/1750-1172-5-13. PMID: 20507641Free PMC Article

Recent systematic reviews

Misclassification of RhD variants among pregnant women: a systematic review.
Owaidah AY, Yamani LZ
J Med Life 2023 Jul;16(7):981-989. doi: 10.25122/jml-2023-0004. PMID: 37900088Free PMC Article
Mirror syndrome: a systematic literature review.
Biswas S, Gomez J, Horgan R, Sibai BM, Saad A, Powel JE, Al-Kouatly HB
Am J Obstet Gynecol MFM 2023 Sep;5(9):101067. Epub 2023 Jun 28 doi: 10.1016/j.ajogmf.2023.101067. PMID: 37385374
Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D
BMC Pregnancy Childbirth 2023 Jan 7;23(1):12. doi: 10.1186/s12884-022-05329-z. PMID: 36611144Free PMC Article
Non-Invasive Prenatal Fetal Blood Group Genotype and Its Application in the Management of Hemolytic Disease of Fetus and Newborn: Systematic Review and Meta-Analysis.
Alshehri AA, Jackson DE
Transfus Med Rev 2021 Apr;35(2):85-94. Epub 2021 Mar 1 doi: 10.1016/j.tmrv.2021.02.001. PMID: 33781630
Intravenous immunoglobulin in isoimmune haemolytic disease of newborn: an updated systematic review and meta-analysis.
Louis D, More K, Oberoi S, Shah PS
Arch Dis Child Fetal Neonatal Ed 2014 Jul;99(4):F325-31. Epub 2014 Feb 10 doi: 10.1136/archdischild-2013-304878. PMID: 24514437

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...