U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Disorder of tonsil (palatine tonsil)

MedGen UID:
544010
•Concept ID:
C0272380
•
Disease or Syndrome
Synonyms: Disorder of palatine tonsil; Disorder of tonsil; Tonsillar Disorder
SNOMED CT: Disorder of tonsil (palatine tonsil) (23023009); Disorder of palatine tonsil (23023009); Disorder of tonsil (23023009)

Definition

A non-neoplastic or neoplastic disorder that affects the tonsils. [from NCI]

Professional guidelines

PubMed

Guideline for the management of acute sore throat.
ESCMID Sore Throat Guideline Group, Pelucchi C, Grigoryan L, Galeone C, Esposito S, Huovinen P, Little P, Verheij T
Clin Microbiol Infect 2012 Apr;18 Suppl 1:1-28. doi: 10.1111/j.1469-0691.2012.03766.x. PMID: 22432746
Comment on validation of diagnostic criteria for variant Creutzfeldt-Jakob disease.
Lukic A, Mead S, Rudge P, Collinge J
Ann Neurol 2011 Jan;69(1):212; author reply 212-3. doi: 10.1002/ana.22273. PMID: 21280094
Aspiration treatment of peritonsillar abscess.
KING JT
J Med Assoc Ga 1961 Jan;50:18-9. PMID: 13756087

Recent clinical studies

Etiology

Is Helicobacter pylori colonization associated with chronic tonsillitis? - A meta-analysis and systematic review.
Wu X, Wang W, Fang L, Shi L, Rao X
Am J Otolaryngol 2022 Sep-Oct;43(5):103515. Epub 2022 Jun 6 doi: 10.1016/j.amjoto.2022.103515. PMID: 35687938
Adult obstructive sleep apnoea.
Jordan AS, McSharry DG, Malhotra A
Lancet 2014 Feb 22;383(9918):736-47. Epub 2013 Aug 2 doi: 10.1016/S0140-6736(13)60734-5. PMID: 23910433Free PMC Article
Guideline for the management of acute sore throat.
ESCMID Sore Throat Guideline Group, Pelucchi C, Grigoryan L, Galeone C, Esposito S, Huovinen P, Little P, Verheij T
Clin Microbiol Infect 2012 Apr;18 Suppl 1:1-28. doi: 10.1111/j.1469-0691.2012.03766.x. PMID: 22432746
Otorhinolaryngology-related tuberculosis.
Ricciardiello F, Martufi S, Cardone M, Cavaliere M, D'Errico P, Iengo M
Acta Otorhinolaryngol Ital 2006 Feb;26(1):38-42. PMID: 18383756Free PMC Article
Acute epiglottitis: MRI.
Ozanne A, Marsot-Dupuch K, Ducreux D, Meyer B, Lasjaunias P
Neuroradiology 2004 Feb;46(2):153-5. Epub 2004 Jan 16 doi: 10.1007/s00234-003-1094-x. PMID: 14726983

Diagnosis

Is Helicobacter pylori colonization associated with chronic tonsillitis? - A meta-analysis and systematic review.
Wu X, Wang W, Fang L, Shi L, Rao X
Am J Otolaryngol 2022 Sep-Oct;43(5):103515. Epub 2022 Jun 6 doi: 10.1016/j.amjoto.2022.103515. PMID: 35687938
Adult obstructive sleep apnoea.
Jordan AS, McSharry DG, Malhotra A
Lancet 2014 Feb 22;383(9918):736-47. Epub 2013 Aug 2 doi: 10.1016/S0140-6736(13)60734-5. PMID: 23910433Free PMC Article
Acute tonsillitis.
Sidell D, Shapiro NL
Infect Disord Drug Targets 2012 Aug;12(4):271-6. doi: 10.2174/187152612801319230. PMID: 22338587
Tonsillar carcinoma.
Guay ME, Lavertu P
Eur Arch Otorhinolaryngol 1995;252(5):259-64. doi: 10.1007/BF00185386. PMID: 7576581
Unilateral tonsillar enlargement.
Cortez EA, Mattox DE, Holt GR, Gates GA
Otolaryngol Head Neck Surg (1979) 1979 Nov-Dec;87(6):707-16. doi: 10.1177/019459987908700603. PMID: 530694

Therapy

Posttonsillectomy pain in children.
Sutters KA, Isaacson G
Am J Nurs 2014 Feb;114(2):36-42; quiz 43. doi: 10.1097/01.NAJ.0000443769.04764.65. PMID: 24445532
Adult obstructive sleep apnoea.
Jordan AS, McSharry DG, Malhotra A
Lancet 2014 Feb 22;383(9918):736-47. Epub 2013 Aug 2 doi: 10.1016/S0140-6736(13)60734-5. PMID: 23910433Free PMC Article
Guideline for the management of acute sore throat.
ESCMID Sore Throat Guideline Group, Pelucchi C, Grigoryan L, Galeone C, Esposito S, Huovinen P, Little P, Verheij T
Clin Microbiol Infect 2012 Apr;18 Suppl 1:1-28. doi: 10.1111/j.1469-0691.2012.03766.x. PMID: 22432746
Otorhinolaryngology-related tuberculosis.
Ricciardiello F, Martufi S, Cardone M, Cavaliere M, D'Errico P, Iengo M
Acta Otorhinolaryngol Ital 2006 Feb;26(1):38-42. PMID: 18383756Free PMC Article
Adenotonsillar disease.
Zalzal GH
J Med Liban 1994;42(4):230-4. PMID: 8558584

Prognosis

Low usefulness of reporting tonsillar PCR Ct-values in pharyngeal infections with Fusobacterium necrophorum.
Nygren D, Wasserstrom L, Torisson G, Holm K
Anaerobe 2024 Apr;86:102831. Epub 2024 Feb 16 doi: 10.1016/j.anaerobe.2024.102831. PMID: 38369049
The prognostic effect of anatomic subsite in HPV-positive oropharyngeal squamous cell carcinoma.
Tham T, Wotman M, Roche A, Kraus D, Costantino P
Am J Otolaryngol 2019 Jul-Aug;40(4):567-572. Epub 2019 May 15 doi: 10.1016/j.amjoto.2019.05.006. PMID: 31113681
Single-cell RNA-Seq of follicular lymphoma reveals malignant B-cell types and coexpression of T-cell immune checkpoints.
Andor N, Simonds EF, Czerwinski DK, Chen J, Grimes SM, Wood-Bouwens C, Zheng GXY, Kubit MA, Greer S, Weiss WA, Levy R, Ji HP
Blood 2019 Mar 7;133(10):1119-1129. Epub 2018 Dec 27 doi: 10.1182/blood-2018-08-862292. PMID: 30591526Free PMC Article
Acute epiglottitis: MRI.
Ozanne A, Marsot-Dupuch K, Ducreux D, Meyer B, Lasjaunias P
Neuroradiology 2004 Feb;46(2):153-5. Epub 2004 Jan 16 doi: 10.1007/s00234-003-1094-x. PMID: 14726983
Tonsillar carcinoma.
Guay ME, Lavertu P
Eur Arch Otorhinolaryngol 1995;252(5):259-64. doi: 10.1007/BF00185386. PMID: 7576581

Clinical prediction guides

Conservative management versus tonsillectomy in adults with recurrent acute tonsillitis in the UK (NATTINA): a multicentre, open-label, randomised controlled trial.
Wilson JA, O'Hara J, Fouweather T, Homer T, Stocken DD, Vale L, Haighton C, Rousseau N, Wilson R, McSweeney L, Wilkes S, Morrison J, MacKenzie K, Ah-See K, Carrie S, Hopkins C, Howe N, Hussain M, Mehanna H, Raine C, Sullivan F, von Wilamowitz-Moellendorff A, Teare MD
Lancet 2023 Jun 17;401(10393):2051-2059. Epub 2023 May 17 doi: 10.1016/S0140-6736(23)00519-6. PMID: 37209706
Single-cell RNA-Seq of follicular lymphoma reveals malignant B-cell types and coexpression of T-cell immune checkpoints.
Andor N, Simonds EF, Czerwinski DK, Chen J, Grimes SM, Wood-Bouwens C, Zheng GXY, Kubit MA, Greer S, Weiss WA, Levy R, Ji HP
Blood 2019 Mar 7;133(10):1119-1129. Epub 2018 Dec 27 doi: 10.1182/blood-2018-08-862292. PMID: 30591526Free PMC Article
Guideline for the management of acute sore throat.
ESCMID Sore Throat Guideline Group, Pelucchi C, Grigoryan L, Galeone C, Esposito S, Huovinen P, Little P, Verheij T
Clin Microbiol Infect 2012 Apr;18 Suppl 1:1-28. doi: 10.1111/j.1469-0691.2012.03766.x. PMID: 22432746
Immunopathological alterations in tonsillar disease.
Brandtzaeg P
Acta Otolaryngol Suppl 1988;454:64-9. doi: 10.3109/00016488809125007. PMID: 3146863
Chronic bacterial tonsillitis: fact or fiction.
Sasaki CT, Koss N
Otolaryngology 1978 Nov-Dec;86(6 Pt 1):ORL-858-64. doi: 10.1177/019459987808600604. PMID: 113743

Recent systematic reviews

Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Association of Unilateral Radiotherapy With Contralateral Lymph Node Failure Among Patients With Squamous Cell Carcinoma of the Tonsil: A Systematic Review and Meta-analysis.
Razavian NB, D'Agostino RB Jr, Steber CR, Helis CA, Hughes RT
JAMA Netw Open 2023 Feb 1;6(2):e2255209. doi: 10.1001/jamanetworkopen.2022.55209. PMID: 36753275Free PMC Article
Is Helicobacter pylori colonization associated with chronic tonsillitis? - A meta-analysis and systematic review.
Wu X, Wang W, Fang L, Shi L, Rao X
Am J Otolaryngol 2022 Sep-Oct;43(5):103515. Epub 2022 Jun 6 doi: 10.1016/j.amjoto.2022.103515. PMID: 35687938
A systematic review of the clinical evidence and biomarkers linking allergy to adeno-tonsillar disease.
De Corso E, Galli J, Di Cesare T, Lucidi D, Ottaviano G, Seccia V, Bussu F, Passali GC, Paludetti G, Cantone E
Int J Pediatr Otorhinolaryngol 2021 Aug;147:110799. Epub 2021 Jun 12 doi: 10.1016/j.ijporl.2021.110799. PMID: 34153930
Growth and growth biomarker changes after adenotonsillectomy: systematic review and meta-analysis.
Bonuck KA, Freeman K, Henderson J
Arch Dis Child 2009 Feb;94(2):83-91. Epub 2008 Aug 6 doi: 10.1136/adc.2008.141192. PMID: 18684748

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...