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Herpes simplex virus keratitis

MedGen UID:
5534
•Concept ID:
C0019357
•
Disease or Syndrome
Synonyms: Herpes Simplex Keratitides; Herpes Simplex Keratitis; Herpes Simplex, Ocular; Herpetic Keratitides; Herpetic Keratitis; Keratitides, Herpes Simplex; Keratitides, Herpetic; Keratitis, Herpes Simplex; Keratitis, Herpetic; Ocular Herpes Simplex
SNOMED CT: Herpes simplex keratitis (9389005); Herpetic keratitis (9389005); HSV keratitis (9389005); Ophthalmic herpes simplex (186542001); Herpes simplex ophthalmicus (186542001)
 
Monarch Initiative: MONDO:0015288

Definition

A superficial, epithelial Herpesvirus hominis infection of the cornea, characterized by the presence of small vesicles which may break down and coalesce to form dendritic ulcers (keratitis, dendritic). (Dictionary of Visual Science, 3d ed) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHerpes simplex virus keratitis

Professional guidelines

PubMed

Management of Herpes Simplex Virus Keratitis in the Pediatric Population.
Vadoothker S, Andrews L, Jeng BH, Levin MR
Pediatr Infect Dis J 2018 Sep;37(9):949-951. doi: 10.1097/INF.0000000000002114. PMID: 29794647
Update on the Management of Infectious Keratitis.
Austin A, Lietman T, Rose-Nussbaumer J
Ophthalmology 2017 Nov;124(11):1678-1689. Epub 2017 Sep 21 doi: 10.1016/j.ophtha.2017.05.012. PMID: 28942073Free PMC Article
Evidence-based treatment of herpes simplex virus keratitis: a systematic review.
Guess S, Stone DU, Chodosh J
Ocul Surf 2007 Jul;5(3):240-50. doi: 10.1016/s1542-0124(12)70614-6. PMID: 17660897

Recent clinical studies

Etiology

Clinical Features of Pediatric Age Herpes Simplex Virus Keratitis.
Ulman EA, Selver OB, Biler ED, Palamar M
Cornea 2023 Sep 1;42(9):1099-1103. Epub 2023 Mar 7 doi: 10.1097/ICO.0000000000003264. PMID: 36921273
INCIDENCE OF HERPES SIMPLEX VIRUS KERATITIS AND OTHER OCULAR DISEASE: GLOBAL REVIEW AND ESTIMATES.
McCormick I, James C, Welton NJ, Mayaud P, Turner KME, Gottlieb SL, Foster A, Looker KJ
Ophthalmic Epidemiol 2022 Aug;29(4):353-362. Epub 2021 Oct 8 doi: 10.1080/09286586.2021.1962919. PMID: 34622738Free PMC Article
The Role of C21orf91 in Herpes Simplex Virus Keratitis.
Danileviciene V, Zemaitiene R, Gintauskiene VM, Nedzelskiene I, Zaliuniene D
Medicina (Kaunas) 2019 Nov 20;55(12) doi: 10.3390/medicina55120753. PMID: 31757016Free PMC Article
Management of Herpes Simplex Virus Keratitis in the Pediatric Population.
Vadoothker S, Andrews L, Jeng BH, Levin MR
Pediatr Infect Dis J 2018 Sep;37(9):949-951. doi: 10.1097/INF.0000000000002114. PMID: 29794647
Herpes simplex virus keratitis in children.
Chong EM, Wilhelmus KR, Matoba AY, Jones DB, Coats DK, Paysse EA
Am J Ophthalmol 2004 Sep;138(3):474-5. doi: 10.1016/j.ajo.2004.04.027. PMID: 15364233

Diagnosis

Clinical Features of Pediatric Age Herpes Simplex Virus Keratitis.
Ulman EA, Selver OB, Biler ED, Palamar M
Cornea 2023 Sep 1;42(9):1099-1103. Epub 2023 Mar 7 doi: 10.1097/ICO.0000000000003264. PMID: 36921273
Herpes Simplex Virus Keratitis.
Harris KD
Home Healthc Now 2019 Sep/Oct;37(5):281-284. doi: 10.1097/NHH.0000000000000791. PMID: 31483360
Management of Herpes Simplex Virus Keratitis in the Pediatric Population.
Vadoothker S, Andrews L, Jeng BH, Levin MR
Pediatr Infect Dis J 2018 Sep;37(9):949-951. doi: 10.1097/INF.0000000000002114. PMID: 29794647
Update on the Management of Infectious Keratitis.
Austin A, Lietman T, Rose-Nussbaumer J
Ophthalmology 2017 Nov;124(11):1678-1689. Epub 2017 Sep 21 doi: 10.1016/j.ophtha.2017.05.012. PMID: 28942073Free PMC Article
Herpes simplex virus keratitis in children.
Chong EM, Wilhelmus KR, Matoba AY, Jones DB, Coats DK, Paysse EA
Am J Ophthalmol 2004 Sep;138(3):474-5. doi: 10.1016/j.ajo.2004.04.027. PMID: 15364233

Therapy

Adoption of Innovation in Herpes Simplex Virus Keratitis.
Chodosh J, Ung L
Cornea 2020 Nov;39 Suppl 1(1):S7-S18. doi: 10.1097/ICO.0000000000002425. PMID: 32732703Free PMC Article
Herpes Simplex Virus Keratitis.
Harris KD
Home Healthc Now 2019 Sep/Oct;37(5):281-284. doi: 10.1097/NHH.0000000000000791. PMID: 31483360
Management of Herpes Simplex Virus Keratitis in the Pediatric Population.
Vadoothker S, Andrews L, Jeng BH, Levin MR
Pediatr Infect Dis J 2018 Sep;37(9):949-951. doi: 10.1097/INF.0000000000002114. PMID: 29794647
Update on the Management of Infectious Keratitis.
Austin A, Lietman T, Rose-Nussbaumer J
Ophthalmology 2017 Nov;124(11):1678-1689. Epub 2017 Sep 21 doi: 10.1016/j.ophtha.2017.05.012. PMID: 28942073Free PMC Article
Aciclovir-resistant herpes keratitis.
Choong K, Walker NJ, Apel AJ, Whitby M
Clin Exp Ophthalmol 2010 Apr;38(3):309-13. doi: 10.1111/j.1442-9071.2010.02209.x. PMID: 20447128

Prognosis

Clinical Features of Pediatric Age Herpes Simplex Virus Keratitis.
Ulman EA, Selver OB, Biler ED, Palamar M
Cornea 2023 Sep 1;42(9):1099-1103. Epub 2023 Mar 7 doi: 10.1097/ICO.0000000000003264. PMID: 36921273
INCIDENCE OF HERPES SIMPLEX VIRUS KERATITIS AND OTHER OCULAR DISEASE: GLOBAL REVIEW AND ESTIMATES.
McCormick I, James C, Welton NJ, Mayaud P, Turner KME, Gottlieb SL, Foster A, Looker KJ
Ophthalmic Epidemiol 2022 Aug;29(4):353-362. Epub 2021 Oct 8 doi: 10.1080/09286586.2021.1962919. PMID: 34622738Free PMC Article
Management of Herpes Simplex Virus Keratitis in the Pediatric Population.
Vadoothker S, Andrews L, Jeng BH, Levin MR
Pediatr Infect Dis J 2018 Sep;37(9):949-951. doi: 10.1097/INF.0000000000002114. PMID: 29794647
Incidence of Herpes Simplex Virus Keratitis in HIV/AIDS patients compared with the general population.
Burcea M, Gheorghe A, Pop M
J Med Life 2015 Jan-Mar;8(1):62-3. PMID: 25914741Free PMC Article
Herpes simplex virus keratitis: histopathologic inflammation and corneal allograft rejection.
Shtein RM, Garcia DD, Musch DC, Elner VM
Ophthalmology 2009 Jul;116(7):1301-5. doi: 10.1016/j.ophtha.2009.03.031. PMID: 19576497Free PMC Article

Clinical prediction guides

Herpes simplex virus keratitis: electronic medical records driven big data analytics report from a tertiary eye institute of South India.
Das AV, Satyashree G, Joseph J, Bagga B
Int Ophthalmol 2023 Dec;43(12):4669-4676. Epub 2023 Sep 5 doi: 10.1007/s10792-023-02866-0. PMID: 37668848
Herpes Simplex Virus Keratitis in a University Tertiary Referral Centre - Clinical Features and Surgical Approaches.
Alfaro Rangel R, Lepper S, Szentmáry N, Langenbucher A, Seitz B
Klin Monbl Augenheilkd 2021 Sep;238(9):989-995. Epub 2021 Feb 19 doi: 10.1055/a-1306-0896. PMID: 33607690
Herpes simplex virus keratitis: histopathologic neovascularization and corneal allograft failure.
Garcia DD, Shtein RM, Musch DC, Elner VM
Cornea 2009 Oct;28(9):963-5. doi: 10.1097/ICO.0b013e31819c4e55. PMID: 19724220Free PMC Article
Herpes simplex virus keratitis: histopathologic inflammation and corneal allograft rejection.
Shtein RM, Garcia DD, Musch DC, Elner VM
Ophthalmology 2009 Jul;116(7):1301-5. doi: 10.1016/j.ophtha.2009.03.031. PMID: 19576497Free PMC Article
Classification of herpes simplex virus keratitis.
Holland EJ, Schwartz GS
Cornea 1999 Mar;18(2):144-54. doi: 10.1097/00003226-199903000-00002. PMID: 10090359

Recent systematic reviews

Evidence-based treatment of herpes simplex virus keratitis: a systematic review.
Guess S, Stone DU, Chodosh J
Ocul Surf 2007 Jul;5(3):240-50. doi: 10.1016/s1542-0124(12)70614-6. PMID: 17660897

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