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Fatty streak

MedGen UID:
569155
•Concept ID:
C0333484
•
Finding
Synonyms: Fatty dots; Fatty streaks; Lipid streaks; Sudanophilic lesion; Yellow dots; Yellow streaks
SNOMED CT: Fatty streaks (53151000); Lipid streaks (53151000); Yellow streaks (53151000); Yellow dots (53151000); Fatty dots (53151000)
 
HPO: HP:0031011

Definition

Yellow-colored streaks, patches, or spots on the intimal surface of arteries. Fatty streaks stain red with Sudan III or Sudan IV. [from HPO]

Professional guidelines

PubMed

Recent Advances in Understanding the Pathogenesis of Cardiovascular Diseases and Development of Treatment Modalities.
Mittal R, Jhaveri VM, Kay SS, Greer A, Sutherland KJ, McMurry HS, Lin N, Mittal J, Malhotra AK, Patel AP
Cardiovasc Hematol Disord Drug Targets 2019;19(1):19-32. doi: 10.2174/1871529X18666180508111353. PMID: 29737266
A review of the peri-operative risk stratification assessment tools used for the prediction of cardiovascular complications in non-cardiac surgery.
Magapu P, Haskard D, Fisher M
Perfusion 2016 Jul;31(5):358-65. Epub 2015 Nov 12 doi: 10.1177/0267659115615207. PMID: 26567135
Hypertension treatment and prevention of new atherosclerotic plaque formation.
Rafflenbeul W
Drugs 1994;48 Suppl 1:11-5. doi: 10.2165/00003495-199400481-00005. PMID: 7533701

Recent clinical studies

Etiology

Inflammatory Biomarkers for Cardiovascular Risk Stratification in Familial Hypercholesterolemia.
Bahrami A, Liberale L, Reiner Ž, Carbone F, Montecucco F, Sahebkar A
Rev Physiol Biochem Pharmacol 2020;177:25-52. doi: 10.1007/112_2020_26. PMID: 32691159
Dyslipidemia in pregnancy and maternal-fetal outcome.
Nasioudis D, Doulaveris G, Kanninen TT
Minerva Ginecol 2019 Apr;71(2):155-162. Epub 2018 Oct 11 doi: 10.23736/S0026-4784.18.04330-7. PMID: 30318877
Imaging of the unstable plaque.
Tan KT, Lip GY
Int J Cardiol 2008 Jul 4;127(2):157-65. Epub 2008 Jan 22 doi: 10.1016/j.ijcard.2007.11.054. PMID: 18207257
Atherosclerosis and inflammation.
Farmer JA, Torre-Amione G
Curr Atheroscler Rep 2002 Mar;4(2):92-8. doi: 10.1007/s11883-002-0031-5. PMID: 11822971
The pathogenesis of atherosclerosis.
Schachter M
Int J Cardiol 1997 Dec 31;62 Suppl 2:S3-7. doi: 10.1016/s0167-5273(97)00235-0. PMID: 9488189

Diagnosis

Imaging of the unstable plaque.
Tan KT, Lip GY
Int J Cardiol 2008 Jul 4;127(2):157-65. Epub 2008 Jan 22 doi: 10.1016/j.ijcard.2007.11.054. PMID: 18207257
The fetal origins of atherosclerosis: maternal hypercholesterolemia, and cholesterol-lowering or antioxidant treatment during pregnancy influence in utero programming and postnatal susceptibility to atherogenesis.
Palinski W, Napoli C
FASEB J 2002 Sep;16(11):1348-60. doi: 10.1096/fj.02-0226rev. PMID: 12205026
Atherosclerosis and inflammation.
Farmer JA, Torre-Amione G
Curr Atheroscler Rep 2002 Mar;4(2):92-8. doi: 10.1007/s11883-002-0031-5. PMID: 11822971
HDL and the inflammatory response induced by LDL-derived oxidized phospholipids.
Navab M, Berliner JA, Subbanagounder G, Hama S, Lusis AJ, Castellani LW, Reddy S, Shih D, Shi W, Watson AD, Van Lenten BJ, Vora D, Fogelman AM
Arterioscler Thromb Vasc Biol 2001 Apr;21(4):481-8. doi: 10.1161/01.atv.21.4.481. PMID: 11304461
Coronary artery calcification: clinical significance and current methods of detection.
Stanford W, Thompson BH, Weiss RM
AJR Am J Roentgenol 1993 Dec;161(6):1139-46. doi: 10.2214/ajr.161.6.8249716. PMID: 8249716

Therapy

The emerging crosstalk between atherosclerosis-related microRNAs and Bermuda triangle of foam cells: Cholesterol influx, trafficking, and efflux.
Achmad H, Almajidi YQ, Adel H, Obaid RF, Romero-Parra RM, Kadhum WR, Almulla AF, Alhachami FR, Gabr GA, Mustafa YF, Mahmoudi R, Hosseini-Fard S
Cell Signal 2023 Jun;106:110632. Epub 2023 Feb 16 doi: 10.1016/j.cellsig.2023.110632. PMID: 36805844
Deletion of P2Y2 receptor reveals a role for lymphotoxin-α in fatty streak formation.
Qian S, Hoggatt A, Jones-Hall YL, Ware CF, Herring P, Seye CI
Vascul Pharmacol 2016 Oct;85:11-20. Epub 2016 Jun 26 doi: 10.1016/j.vph.2016.06.001. PMID: 27355755Free PMC Article
The fetal origins of atherosclerosis: maternal hypercholesterolemia, and cholesterol-lowering or antioxidant treatment during pregnancy influence in utero programming and postnatal susceptibility to atherogenesis.
Palinski W, Napoli C
FASEB J 2002 Sep;16(11):1348-60. doi: 10.1096/fj.02-0226rev. PMID: 12205026
Atherogenesis in children: implications for the prevention of atherosclerosis.
Olson RE
Adv Pediatr 2000;47:55-78. PMID: 10959440
Oxidized LDL and antioxidants.
Jialal I, Fuller CJ
Clin Cardiol 1993 Apr;16(4 Suppl 1):I6-9. doi: 10.1002/clc.4960161304. PMID: 8472396

Prognosis

Inflammatory Biomarkers for Cardiovascular Risk Stratification in Familial Hypercholesterolemia.
Bahrami A, Liberale L, Reiner Ž, Carbone F, Montecucco F, Sahebkar A
Rev Physiol Biochem Pharmacol 2020;177:25-52. doi: 10.1007/112_2020_26. PMID: 32691159
A review of the peri-operative risk stratification assessment tools used for the prediction of cardiovascular complications in non-cardiac surgery.
Magapu P, Haskard D, Fisher M
Perfusion 2016 Jul;31(5):358-65. Epub 2015 Nov 12 doi: 10.1177/0267659115615207. PMID: 26567135
Atherosclerosis and inflammation.
Farmer JA, Torre-Amione G
Curr Atheroscler Rep 2002 Mar;4(2):92-8. doi: 10.1007/s11883-002-0031-5. PMID: 11822971
Lipoprotein trafficking in vascular cells. Molecular Trojan horses and cellular saboteurs.
Hajjar DP, Haberland ME
J Biol Chem 1997 Sep 12;272(37):22975-8. doi: 10.1074/jbc.272.37.22975. PMID: 9287290
Prevention of cardiovascular risk in women. A new concern for the obstetrician/gynecologist.
Kafrissen ME
Acta Obstet Gynecol Scand Suppl 1990;152:13-20. doi: 10.3109/00016349009156501. PMID: 2189280

Clinical prediction guides

Inflammatory Biomarkers for Cardiovascular Risk Stratification in Familial Hypercholesterolemia.
Bahrami A, Liberale L, Reiner Ž, Carbone F, Montecucco F, Sahebkar A
Rev Physiol Biochem Pharmacol 2020;177:25-52. doi: 10.1007/112_2020_26. PMID: 32691159
Characterization of Atherosclerosis Formation in a Murine Model of Type IIa Human Familial Hypercholesterolemia.
Miyajima C, Iwaki T, Umemura K, Ploplis VA, Castellino FJ
Biomed Res Int 2018;2018:1878964. Epub 2018 Jun 7 doi: 10.1155/2018/1878964. PMID: 29977908Free PMC Article
A review of the peri-operative risk stratification assessment tools used for the prediction of cardiovascular complications in non-cardiac surgery.
Magapu P, Haskard D, Fisher M
Perfusion 2016 Jul;31(5):358-65. Epub 2015 Nov 12 doi: 10.1177/0267659115615207. PMID: 26567135
Oxidized lipids as mediators of coronary heart disease.
Navab M, Hama SY, Reddy ST, Ng CJ, Van Lenten BJ, Laks H, Fogelman AM
Curr Opin Lipidol 2002 Aug;13(4):363-72. doi: 10.1097/00041433-200208000-00003. PMID: 12151851
Alcohol consumption and atherosclerosis.
Lifsic AM
Bull World Health Organ 1976;53(5-6):623-30. PMID: 1087205Free PMC Article

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