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Fatty streak

MedGen UID:
569155
•Concept ID:
C0333484
•
Finding
Synonyms: Fatty dots; Fatty streaks; Lipid streaks; Sudanophilic lesion; Yellow dots; Yellow streaks
SNOMED CT: Fatty streaks (53151000); Lipid streaks (53151000); Yellow streaks (53151000); Yellow dots (53151000); Fatty dots (53151000)
 
HPO: HP:0031011

Definition

Yellow-colored streaks, patches, or spots on the intimal surface of arteries. Fatty streaks stain red with Sudan III or Sudan IV. [from HPO]

Professional guidelines

PubMed

Recent Advances in Understanding the Pathogenesis of Cardiovascular Diseases and Development of Treatment Modalities.
Mittal R, Jhaveri VM, Kay SS, Greer A, Sutherland KJ, McMurry HS, Lin N, Mittal J, Malhotra AK, Patel AP
Cardiovasc Hematol Disord Drug Targets 2019;19(1):19-32. doi: 10.2174/1871529X18666180508111353. PMID: 29737266
A review of the peri-operative risk stratification assessment tools used for the prediction of cardiovascular complications in non-cardiac surgery.
Magapu P, Haskard D, Fisher M
Perfusion 2016 Jul;31(5):358-65. Epub 2015 Nov 12 doi: 10.1177/0267659115615207. PMID: 26567135
Hypertension treatment and prevention of new atherosclerotic plaque formation.
Rafflenbeul W
Drugs 1994;48 Suppl 1:11-5. doi: 10.2165/00003495-199400481-00005. PMID: 7533701

Recent clinical studies

Etiology

Dyslipidemia in pregnancy and maternal-fetal outcome.
Nasioudis D, Doulaveris G, Kanninen TT
Minerva Ginecol 2019 Apr;71(2):155-162. Epub 2018 Oct 11 doi: 10.23736/S0026-4784.18.04330-7. PMID: 30318877
Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease.
Maguire EM, Pearce SWA, Xiao Q
Vascul Pharmacol 2019 Jan;112:54-71. Epub 2018 Aug 14 doi: 10.1016/j.vph.2018.08.002. PMID: 30115528
PPARgamma and atherosclerosis.
Staels B
Curr Med Res Opin 2005;21 Suppl 1:S13-20. doi: 10.1185/030079905X36440. PMID: 15811195
Atherosclerosis and inflammation.
Farmer JA, Torre-Amione G
Curr Atheroscler Rep 2002 Mar;4(2):92-8. doi: 10.1007/s11883-002-0031-5. PMID: 11822971
Atherosclerosis and hypertension.
Matova EE, Vihert AM
Bull World Health Organ 1976;53(5-6):539-46. PMID: 1087193Free PMC Article

Diagnosis

Inflammation, atherosclerosis, and psoriasis.
Siegel D, Devaraj S, Mitra A, Raychaudhuri SP, Raychaudhuri SK, Jialal I
Clin Rev Allergy Immunol 2013 Apr;44(2):194-204. doi: 10.1007/s12016-012-8308-0. PMID: 22359071
Inflammation in atherosclerosis: a cause or a result of vascular disorders?
Manduteanu I, Simionescu M
J Cell Mol Med 2012 Sep;16(9):1978-90. doi: 10.1111/j.1582-4934.2012.01552.x. PMID: 22348535Free PMC Article
Mechanisms of LDL oxidation.
Yoshida H, Kisugi R
Clin Chim Acta 2010 Dec 14;411(23-24):1875-82. Epub 2010 Sep 9 doi: 10.1016/j.cca.2010.08.038. PMID: 20816951
Biomarkers of atherosclerosis and the potential of MRI for the diagnosis of vulnerable plaque.
Canet-Soulas E, Letourneur D
MAGMA 2007 Jun;20(3):129-42. Epub 2007 Jun 29 doi: 10.1007/s10334-007-0078-y. PMID: 17605060
Atherosclerosis and inflammation.
Farmer JA, Torre-Amione G
Curr Atheroscler Rep 2002 Mar;4(2):92-8. doi: 10.1007/s11883-002-0031-5. PMID: 11822971

Therapy

Keep recycling going: New approaches to reduce LDL-C.
Klein-Szanto AJP, Bassi DE
Biochem Pharmacol 2019 Jun;164:336-341. Epub 2019 Apr 4 doi: 10.1016/j.bcp.2019.04.003. PMID: 30953636
Diet effects on atherosclerosis in mice.
Temel RE, Rudel LL
Curr Drug Targets 2007 Nov;8(11):1150-60. doi: 10.2174/138945007782403847. PMID: 18045093
PPARgamma and atherosclerosis.
Staels B
Curr Med Res Opin 2005;21 Suppl 1:S13-20. doi: 10.1185/030079905X36440. PMID: 15811195
Amlodipine and atorvastatin in atherosclerosis: a review of the potential of combination therapy.
Jukema JW, van der Hoorn JW
Expert Opin Pharmacother 2004 Feb;5(2):459-68. doi: 10.1517/14656566.5.2.459. PMID: 14996641
Oxidized LDL and antioxidants.
Jialal I, Fuller CJ
Clin Cardiol 1993 Apr;16(4 Suppl 1):I6-9. doi: 10.1002/clc.4960161304. PMID: 8472396

Prognosis

How do elevated triglycerides and low HDL-cholesterol affect inflammation and atherothrombosis?
Welty FK
Curr Cardiol Rep 2013 Sep;15(9):400. doi: 10.1007/s11886-013-0400-4. PMID: 23881582Free PMC Article
Inflammation, atherosclerosis, and psoriasis.
Siegel D, Devaraj S, Mitra A, Raychaudhuri SP, Raychaudhuri SK, Jialal I
Clin Rev Allergy Immunol 2013 Apr;44(2):194-204. doi: 10.1007/s12016-012-8308-0. PMID: 22359071
C-reactive protein and atherogenesis: from fatty streak to clinical event.
Bisoendial RJ, Kastelein JJ, Stroes ES
Atherosclerosis 2007 Dec;195(2):e10-8. Epub 2007 Jul 31 doi: 10.1016/j.atherosclerosis.2007.04.053. PMID: 17669411
Atherosclerosis and inflammation.
Farmer JA, Torre-Amione G
Curr Atheroscler Rep 2002 Mar;4(2):92-8. doi: 10.1007/s11883-002-0031-5. PMID: 11822971
Is it wise to restrict fat in the diets of children?
Olson RE
J Am Diet Assoc 2000 Jan;100(1):28-32. doi: 10.1016/S0002-8223(00)00012-2. PMID: 10645998

Clinical prediction guides

Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease.
Maguire EM, Pearce SWA, Xiao Q
Vascul Pharmacol 2019 Jan;112:54-71. Epub 2018 Aug 14 doi: 10.1016/j.vph.2018.08.002. PMID: 30115528
How do elevated triglycerides and low HDL-cholesterol affect inflammation and atherothrombosis?
Welty FK
Curr Cardiol Rep 2013 Sep;15(9):400. doi: 10.1007/s11886-013-0400-4. PMID: 23881582Free PMC Article
Inflammation, atherosclerosis, and psoriasis.
Siegel D, Devaraj S, Mitra A, Raychaudhuri SP, Raychaudhuri SK, Jialal I
Clin Rev Allergy Immunol 2013 Apr;44(2):194-204. doi: 10.1007/s12016-012-8308-0. PMID: 22359071
CRP and the risk of atherosclerotic events.
Calabrò P, Golia E, Yeh ET
Semin Immunopathol 2009 Jun;31(1):79-94. Epub 2009 May 5 doi: 10.1007/s00281-009-0149-4. PMID: 19415283
Atherosclerosis and inflammation.
Farmer JA, Torre-Amione G
Curr Atheroscler Rep 2002 Mar;4(2):92-8. doi: 10.1007/s11883-002-0031-5. PMID: 11822971

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