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Lymphoid nodular hyperplasia

MedGen UID:
569500
•Concept ID:
C0333998
•
Disease or Syndrome
Synonyms: Lymphonodular hyperplasia of the colon; Nodular lymphoid hyperplasia
SNOMED CT: Nodular lymphoid hyperplasia (43961000)
 
HPO: HP:0032203

Definition

Lymphoid nodular hyperplasia (LNH) of the terminal ileum and colon has been considered a mucosal response to nonspecific stimuli, most often infections, and consequently has been regarded as a pathophysiologic phenomenon during infancy and childhood. LNH can be ascertained by colonoscopy, whereby a lymphoid nodule is defined as an extruding follicle with a diameter of not more than 2 mm, and LNH is defined as a cluster of not more than 10 of such extruding lymphoid nodules (see Figure 1 of PMID:17368236). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphoid nodular hyperplasia

Professional guidelines

PubMed

Management of small bowel polyps: A literature review.
de Latour RA, Kilaru SM, Gross SA
Best Pract Res Clin Gastroenterol 2017 Aug;31(4):401-408. Epub 2017 Jun 27 doi: 10.1016/j.bpg.2017.06.003. PMID: 28842049
Primary Pulmonary Lymphoid Lesions: Radiologic and Pathologic Findings.
Sirajuddin A, Raparia K, Lewis VA, Franks TJ, Dhand S, Galvin JR, White CS
Radiographics 2016 Jan-Feb;36(1):53-70. doi: 10.1148/rg.2016140339. PMID: 26761531
Diagnosis and treatment of gastrointestinal disorders in patients with primary immunodeficiency.
Agarwal S, Mayer L
Clin Gastroenterol Hepatol 2013 Sep;11(9):1050-63. Epub 2013 Mar 13 doi: 10.1016/j.cgh.2013.02.024. PMID: 23501398Free PMC Article

Recent clinical studies

Etiology

Intestinal lymphoid nodular hyperplasia in children: the relationship to food allergy.
Lucarelli S, Lastrucci G, Di Nardo G, D'Alfonso Y, Aloi M, Oliva S, Frediani S, Rossetti D, Frediani T
Pediatr Allergy Immunol 2015 Feb;26(1):18-24. doi: 10.1111/pai.12328. PMID: 25684674
Lymphoid nodular hyperplasia of the terminal ileum can mimic active crohn disease on MR enterography.
Plumb AA, Pendsé DA, McCartney S, Punwani S, Halligan S, Taylor SA
AJR Am J Roentgenol 2014 Oct;203(4):W400-7. doi: 10.2214/AJR.13.12055. PMID: 25247969
Colonic lymphoid nodular hyperplasia in childhood: causes of familial Mediterranean fever need extra attention.
Gurkan OE, Yilmaz G, Aksu AU, Demirtas Z, Akyol G, Dalgic B
J Pediatr Gastroenterol Nutr 2013 Dec;57(6):817-21. doi: 10.1097/MPG.0b013e3182a9083b. PMID: 24280993
Colon in food allergy.
Troncone R, Discepolo V
J Pediatr Gastroenterol Nutr 2009 Apr;48 Suppl 2:S89-91. doi: 10.1097/MPG.0b013e3181a15d1a. PMID: 19300136
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children.
Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Harvey P, Valentine A, Davies SE, Walker-Smith JA
Lancet 1998 Feb 28;351(9103):637-41. doi: 10.1016/s0140-6736(97)11096-0. PMID: 9500320

Diagnosis

Appendiceal Lymphoid Nodular Hyperplasia.
Gaspar R, Rodrigues-Pinto E, Macedo G
Am J Gastroenterol 2018 Jan;113(1):11. doi: 10.1038/ajg.2017.381. PMID: 29311725
Intestinal lymphoid nodular hyperplasia in children: the relationship to food allergy.
Lucarelli S, Lastrucci G, Di Nardo G, D'Alfonso Y, Aloi M, Oliva S, Frediani S, Rossetti D, Frediani T
Pediatr Allergy Immunol 2015 Feb;26(1):18-24. doi: 10.1111/pai.12328. PMID: 25684674
Lymphoid nodular hyperplasia of the terminal ileum can mimic active crohn disease on MR enterography.
Plumb AA, Pendsé DA, McCartney S, Punwani S, Halligan S, Taylor SA
AJR Am J Roentgenol 2014 Oct;203(4):W400-7. doi: 10.2214/AJR.13.12055. PMID: 25247969
Review article: intestinal lymphoid nodular hyperplasia in children--the relationship to food hypersensitivity.
Mansueto P, Iacono G, Seidita A, D'Alcamo A, Sprini D, Carroccio A
Aliment Pharmacol Ther 2012 May;35(9):1000-9. Epub 2012 Mar 20 doi: 10.1111/j.1365-2036.2012.05062.x. PMID: 22428565
Food-induced eosinophilic proctocolitis.
Lake AM
J Pediatr Gastroenterol Nutr 2000;30 Suppl:S58-60. doi: 10.1097/00005176-200001001-00009. PMID: 10634300

Therapy

Intestinal lymphoid nodular hyperplasia in children: the relationship to food allergy.
Lucarelli S, Lastrucci G, Di Nardo G, D'Alfonso Y, Aloi M, Oliva S, Frediani S, Rossetti D, Frediani T
Pediatr Allergy Immunol 2015 Feb;26(1):18-24. doi: 10.1111/pai.12328. PMID: 25684674
Review article: intestinal lymphoid nodular hyperplasia in children--the relationship to food hypersensitivity.
Mansueto P, Iacono G, Seidita A, D'Alcamo A, Sprini D, Carroccio A
Aliment Pharmacol Ther 2012 May;35(9):1000-9. Epub 2012 Mar 20 doi: 10.1111/j.1365-2036.2012.05062.x. PMID: 22428565
Colon in food allergy.
Troncone R, Discepolo V
J Pediatr Gastroenterol Nutr 2009 Apr;48 Suppl 2:S89-91. doi: 10.1097/MPG.0b013e3181a15d1a. PMID: 19300136
Food-induced eosinophilic proctocolitis.
Lake AM
J Pediatr Gastroenterol Nutr 2000;30 Suppl:S58-60. doi: 10.1097/00005176-200001001-00009. PMID: 10634300
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children.
Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Harvey P, Valentine A, Davies SE, Walker-Smith JA
Lancet 1998 Feb 28;351(9103):637-41. doi: 10.1016/s0140-6736(97)11096-0. PMID: 9500320

Prognosis

Intestinal lymphoid nodular hyperplasia in children: the relationship to food allergy.
Lucarelli S, Lastrucci G, Di Nardo G, D'Alfonso Y, Aloi M, Oliva S, Frediani S, Rossetti D, Frediani T
Pediatr Allergy Immunol 2015 Feb;26(1):18-24. doi: 10.1111/pai.12328. PMID: 25684674
Colon in food allergy.
Troncone R, Discepolo V
J Pediatr Gastroenterol Nutr 2009 Apr;48 Suppl 2:S89-91. doi: 10.1097/MPG.0b013e3181a15d1a. PMID: 19300136
Colonic lymphoid nodular hyperplasia in children: relationship to food hypersensitivity.
Iacono G, Ravelli A, Di Prima L, Scalici C, Bolognini S, Chiappa S, Pirrone G, Licastri G, Carroccio A
Clin Gastroenterol Hepatol 2007 Mar;5(3):361-6. doi: 10.1016/j.cgh.2006.12.010. PMID: 17368236
Sigmoidoscopy in children with chronic lower gastrointestinal bleeding.
Mandhan P
J Paediatr Child Health 2004 Jul;40(7):365-8. doi: 10.1111/j.1440-1754.2004.00403.x. PMID: 15228564
Food-induced eosinophilic proctocolitis.
Lake AM
J Pediatr Gastroenterol Nutr 2000;30 Suppl:S58-60. doi: 10.1097/00005176-200001001-00009. PMID: 10634300

Clinical prediction guides

Intestinal lymphoid nodular hyperplasia in children: the relationship to food allergy.
Lucarelli S, Lastrucci G, Di Nardo G, D'Alfonso Y, Aloi M, Oliva S, Frediani S, Rossetti D, Frediani T
Pediatr Allergy Immunol 2015 Feb;26(1):18-24. doi: 10.1111/pai.12328. PMID: 25684674
Lymphoid nodular hyperplasia of the terminal ileum can mimic active crohn disease on MR enterography.
Plumb AA, Pendsé DA, McCartney S, Punwani S, Halligan S, Taylor SA
AJR Am J Roentgenol 2014 Oct;203(4):W400-7. doi: 10.2214/AJR.13.12055. PMID: 25247969
Colonic lymphoid nodular hyperplasia in childhood: causes of familial Mediterranean fever need extra attention.
Gurkan OE, Yilmaz G, Aksu AU, Demirtas Z, Akyol G, Dalgic B
J Pediatr Gastroenterol Nutr 2013 Dec;57(6):817-21. doi: 10.1097/MPG.0b013e3182a9083b. PMID: 24280993
Review article: intestinal lymphoid nodular hyperplasia in children--the relationship to food hypersensitivity.
Mansueto P, Iacono G, Seidita A, D'Alcamo A, Sprini D, Carroccio A
Aliment Pharmacol Ther 2012 May;35(9):1000-9. Epub 2012 Mar 20 doi: 10.1111/j.1365-2036.2012.05062.x. PMID: 22428565
Colonic lymphoid nodular hyperplasia in children: relationship to food hypersensitivity.
Iacono G, Ravelli A, Di Prima L, Scalici C, Bolognini S, Chiappa S, Pirrone G, Licastri G, Carroccio A
Clin Gastroenterol Hepatol 2007 Mar;5(3):361-6. doi: 10.1016/j.cgh.2006.12.010. PMID: 17368236

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