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Hodgkin lymphoma, mixed cellularity

MedGen UID:
57521
•Concept ID:
C0152266
•
Neoplastic Process
Synonyms: Classic Hodgkin lymphoma, mixed cellularity type; Hodgkin's lymphoma, mixed cellularity
SNOMED CT: Hodgkin's disease, mixed cellularity (clinical) (118609008); Classical Hodgkin lymphoma, mixed cellularity (41529000); Hodgkin lymphoma, mixed cellularity (41529000); Hodgkin's disease, mixed cellularity (118609008); Hodgkin disease, mixed cellularity (118609008); Hodgkin mixed cellularity lymphoma (118609008); Hodgkin's disease, mixed cellularity (41529000)
 
Monarch Initiative: MONDO:0004633
Orphanet: ORPHA98844

Definition

A subtype of classic Hodgkin lymphoma with scattered Reed-Sternberg and Hodgkin cells in a diffuse or vaguely nodular mixed inflammatory background without nodular sclerosing fibrosis. (WHO, 2008) [from NCI]

Professional guidelines

PubMed

Hodgkin lymphoma: 2023 update on diagnosis, risk-stratification, and management.
Ansell SM
Am J Hematol 2022 Nov;97(11):1478-1488. Epub 2022 Sep 19 doi: 10.1002/ajh.26717. PMID: 36215668
Lymphoma: Diagnosis and Treatment.
Lewis WD, Lilly S, Jones KL
Am Fam Physician 2020 Jan 1;101(1):34-41. PMID: 31894937
Hodgkin Lymphoma: Diagnosis and Treatment.
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251

Recent clinical studies

Etiology

Disparities in the Concentrations of Essential/Toxic Elements in the Blood and Scalp Hair of Lymphoma Patients and Healthy Subjects.
Qayyum MA, Shah MH
Sci Rep 2019 Oct 25;9(1):15363. doi: 10.1038/s41598-019-51973-5. PMID: 31653974Free PMC Article
Expression of PAX-5 in B Cell Hodgkin and Non Hodgkin Lymphoma.
Khan MR, Ahmad A, Kayani N, Minhas K
Asian Pac J Cancer Prev 2018 Dec 25;19(12):3463-3466. doi: 10.31557/APJCP.2018.19.12.3463. PMID: 30583670Free PMC Article
Secondary Hodgkin Lymphoma and Myelodysplastic Syndrome (MDS) After Paclitaxel-Carboplatin Treatment in a Patient with Small Cell Lung Cancer.
Petrusevska M, Stavridis IP, Mladenovska K, Petrushevska G
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec 1;38(3):97-103. doi: 10.2478/prilozi-2018-0010. PMID: 29668470
PD-1, a follicular T-cell marker useful for recognizing nodular lymphocyte-predominant Hodgkin lymphoma.
Nam-Cha SH, Roncador G, Sanchez-Verde L, Montes-Moreno S, Acevedo A, Domínguez-Franjo P, Piris MA
Am J Surg Pathol 2008 Aug;32(8):1252-7. doi: 10.1097/PAS.0b013e318165b0d6. PMID: 18594468
Cytomorphology of some uncommon tumors of childhood and adolescence.
Singh UR, Gupta K, Arora VK, Gupta S, Bhatia A
Indian J Pediatr 1996 Jul-Aug;63(4):539-47. doi: 10.1007/BF02905730. PMID: 10832475

Diagnosis

Primary Hodgkin's Lymphoma of bone in 7-year-old- an exceptional case report of youngest child in literature.
Siddiqui DE, Akbar HF, Sadiq H, Iftikhar N, Khan MR, Raza MR
Cancer Treat Res Commun 2021;29:100448. Epub 2021 Aug 19 doi: 10.1016/j.ctarc.2021.100448. PMID: 34488186
Disparities in the Concentrations of Essential/Toxic Elements in the Blood and Scalp Hair of Lymphoma Patients and Healthy Subjects.
Qayyum MA, Shah MH
Sci Rep 2019 Oct 25;9(1):15363. doi: 10.1038/s41598-019-51973-5. PMID: 31653974Free PMC Article
Expression of PAX-5 in B Cell Hodgkin and Non Hodgkin Lymphoma.
Khan MR, Ahmad A, Kayani N, Minhas K
Asian Pac J Cancer Prev 2018 Dec 25;19(12):3463-3466. doi: 10.31557/APJCP.2018.19.12.3463. PMID: 30583670Free PMC Article
Secondary Hodgkin Lymphoma and Myelodysplastic Syndrome (MDS) After Paclitaxel-Carboplatin Treatment in a Patient with Small Cell Lung Cancer.
Petrusevska M, Stavridis IP, Mladenovska K, Petrushevska G
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec 1;38(3):97-103. doi: 10.2478/prilozi-2018-0010. PMID: 29668470
PD-1, a follicular T-cell marker useful for recognizing nodular lymphocyte-predominant Hodgkin lymphoma.
Nam-Cha SH, Roncador G, Sanchez-Verde L, Montes-Moreno S, Acevedo A, Domínguez-Franjo P, Piris MA
Am J Surg Pathol 2008 Aug;32(8):1252-7. doi: 10.1097/PAS.0b013e318165b0d6. PMID: 18594468

Therapy

Secondary Hodgkin Lymphoma and Myelodysplastic Syndrome (MDS) After Paclitaxel-Carboplatin Treatment in a Patient with Small Cell Lung Cancer.
Petrusevska M, Stavridis IP, Mladenovska K, Petrushevska G
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec 1;38(3):97-103. doi: 10.2478/prilozi-2018-0010. PMID: 29668470

Prognosis

Primary Hodgkin's Lymphoma of bone in 7-year-old- an exceptional case report of youngest child in literature.
Siddiqui DE, Akbar HF, Sadiq H, Iftikhar N, Khan MR, Raza MR
Cancer Treat Res Commun 2021;29:100448. Epub 2021 Aug 19 doi: 10.1016/j.ctarc.2021.100448. PMID: 34488186
PD-1, a follicular T-cell marker useful for recognizing nodular lymphocyte-predominant Hodgkin lymphoma.
Nam-Cha SH, Roncador G, Sanchez-Verde L, Montes-Moreno S, Acevedo A, Domínguez-Franjo P, Piris MA
Am J Surg Pathol 2008 Aug;32(8):1252-7. doi: 10.1097/PAS.0b013e318165b0d6. PMID: 18594468
Cytomorphology of some uncommon tumors of childhood and adolescence.
Singh UR, Gupta K, Arora VK, Gupta S, Bhatia A
Indian J Pediatr 1996 Jul-Aug;63(4):539-47. doi: 10.1007/BF02905730. PMID: 10832475

Clinical prediction guides

PD-1, a follicular T-cell marker useful for recognizing nodular lymphocyte-predominant Hodgkin lymphoma.
Nam-Cha SH, Roncador G, Sanchez-Verde L, Montes-Moreno S, Acevedo A, Domínguez-Franjo P, Piris MA
Am J Surg Pathol 2008 Aug;32(8):1252-7. doi: 10.1097/PAS.0b013e318165b0d6. PMID: 18594468

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