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Malignant Neoplasm of the Upper Third of the Esophagus

MedGen UID:
57555
•Concept ID:
C0153413
•
Neoplastic Process
Synonyms: Malignant Neoplasm of Proximal Third of Esophagus; Malignant Neoplasm of the Proximal Third of the Esophagus; Malignant neoplasm of upper third of esophagus; Malignant Neoplasm of Upper Third of Esophagus; Malignant Tumor of Proximal Third of Esophagus; Malignant Tumor of the Proximal Third of the Esophagus; Malignant Tumor of the Upper Third of the Esophagus; Malignant tumor of upper third of esophagus; Malignant Tumor of Upper Third of Esophagus
SNOMED CT: Malignant neoplasm of upper third of esophagus (187725002); Malignant tumor of upper third of esophagus (187725002)

Definition

A primary or metastatic malignant neoplasm involving the upper third segment of the esophagus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Neoplasm of the Upper Third of the Esophagus

Professional guidelines

PubMed

Role of endoscopic ultrasonography for differential diagnosis of upper gastrointestinal submucosal lesions.
Su Q, Peng J, Chen X, Xiao Z, Liu R, Wang F
BMC Gastroenterol 2021 Oct 7;21(1):365. doi: 10.1186/s12876-021-01945-9. PMID: 34620107Free PMC Article
The management of mid & proximal oesophageal squamous cell carcinoma.
Wong I, Law S
Best Pract Res Clin Gastroenterol 2018 Oct-Dec;36-37:85-90. Epub 2018 Nov 30 doi: 10.1016/j.bpg.2018.11.012. PMID: 30551861
Differential role of microRNAs in the pathogenesis and treatment of Esophageal cancer.
Hemmatzadeh M, Mohammadi H, Karimi M, Musavishenas MH, Baradaran B
Biomed Pharmacother 2016 Aug;82:509-19. Epub 2016 Jun 4 doi: 10.1016/j.biopha.2016.05.009. PMID: 27470391

Recent clinical studies

Etiology

Cancer Diagnoses After Recent Weight Loss.
Wang QL, Babic A, Rosenthal MH, Lee AA, Zhang Y, Zhang X, Song M, Rezende LFM, Lee DH, Biller L, Ng K, Giannakis M, Chan AT, Meyerhardt JA, Fuchs CS, Eliassen AH, Birmann BM, Stampfer MJ, Giovannucci EL, Kraft P, Nowak JA, Yuan C, Wolpin BM
JAMA 2024 Jan 23;331(4):318-328. doi: 10.1001/jama.2023.25869. PMID: 38261044Free PMC Article
Prebiotics and the Risk of Upper Digestive Tract and Stomach Cancers: The PrebiotiCa Study.
Turati F, Concina F, Bertuccio P, Fiori F, Parpinel M, Garavello W, Crispo A, Libra M, Negri E, Serraino D, La Vecchia C
J Acad Nutr Diet 2023 Dec;123(12):1772-1780. Epub 2023 Jul 17 doi: 10.1016/j.jand.2023.07.008. PMID: 37468063
Diet and cancer of the esophagus and stomach.
Tay SW, Li JW, Fock KM
Curr Opin Gastroenterol 2021 Mar 1;37(2):158-163. doi: 10.1097/MOG.0000000000000700. PMID: 33315794
Submucosal gland neoplasms of the esophagus: an update and review.
Nie L, Li W, Xue L, Wang L, Shen Y, Fan X
Esophagus 2020 Oct;17(4):376-384. Epub 2020 Jul 3 doi: 10.1007/s10388-020-00758-1. PMID: 32621256Free PMC Article
Tobacco smoking and cancer: a brief review of recent epidemiological evidence.
Sasco AJ, Secretan MB, Straif K
Lung Cancer 2004 Aug;45 Suppl 2:S3-9. doi: 10.1016/j.lungcan.2004.07.998. PMID: 15552776

Diagnosis

Cancer Diagnoses After Recent Weight Loss.
Wang QL, Babic A, Rosenthal MH, Lee AA, Zhang Y, Zhang X, Song M, Rezende LFM, Lee DH, Biller L, Ng K, Giannakis M, Chan AT, Meyerhardt JA, Fuchs CS, Eliassen AH, Birmann BM, Stampfer MJ, Giovannucci EL, Kraft P, Nowak JA, Yuan C, Wolpin BM
JAMA 2024 Jan 23;331(4):318-328. doi: 10.1001/jama.2023.25869. PMID: 38261044Free PMC Article
Role of endoscopic ultrasonography for differential diagnosis of upper gastrointestinal submucosal lesions.
Su Q, Peng J, Chen X, Xiao Z, Liu R, Wang F
BMC Gastroenterol 2021 Oct 7;21(1):365. doi: 10.1186/s12876-021-01945-9. PMID: 34620107Free PMC Article
Submucosal gland neoplasms of the esophagus: an update and review.
Nie L, Li W, Xue L, Wang L, Shen Y, Fan X
Esophagus 2020 Oct;17(4):376-384. Epub 2020 Jul 3 doi: 10.1007/s10388-020-00758-1. PMID: 32621256Free PMC Article
Acute esophageal necrosis.
Rodrigues BD, Dos Santos R, da Luz MM, Chaves E Silva F, Reis IG
Clin J Gastroenterol 2016 Dec;9(6):341-344. Epub 2016 Oct 11 doi: 10.1007/s12328-016-0692-1. PMID: 27730597
Thoracoscopic resection of a cervical esophageal duplication cyst in a 3-month-old infant: a case report.
Lee SY, Kim HY, Kim SH, Jung SE, Park KW
J Pediatr Surg 2013 Apr;48(4):873-5. doi: 10.1016/j.jpedsurg.2012.12.046. PMID: 23583149

Therapy

Targeted therapy for upper gastrointestinal tract cancer: current and future prospects.
Rosenbaum MW, Gonzalez RS
Histopathology 2021 Jan;78(1):148-161. doi: 10.1111/his.14244. PMID: 33382497
Targeted therapies for advanced and metastatic adenocarcinoma of the gastroesophageal junction: is there something new?
Pasini F, Fraccon AP, Modena Y, Bencivenga M, Giacopuzzi S, La Russa F, Gusella M, de Manzoni G
Gastric Cancer 2017 Jan;20(1):31-42. Epub 2016 Aug 27 doi: 10.1007/s10120-016-0626-0. PMID: 27568322
Erosion of an esophageal endoprosthesis into the trachea.
Rampado S, Battaglia G, Zaninotto G, Ruol A, Portale G, Ancona E
Ann Thorac Surg 2006 Dec;82(6):2278-80. doi: 10.1016/j.athoracsur.2006.04.043. PMID: 17126153
Tobacco smoking and cancer: a brief review of recent epidemiological evidence.
Sasco AJ, Secretan MB, Straif K
Lung Cancer 2004 Aug;45 Suppl 2:S3-9. doi: 10.1016/j.lungcan.2004.07.998. PMID: 15552776
Radiotherapy.
Jelliffe AM
Postgrad Med J 1974 Apr;50(582):231-2. doi: 10.1136/pgmj.50.582.231. PMID: 4217448Free PMC Article

Prognosis

Cancer Diagnoses After Recent Weight Loss.
Wang QL, Babic A, Rosenthal MH, Lee AA, Zhang Y, Zhang X, Song M, Rezende LFM, Lee DH, Biller L, Ng K, Giannakis M, Chan AT, Meyerhardt JA, Fuchs CS, Eliassen AH, Birmann BM, Stampfer MJ, Giovannucci EL, Kraft P, Nowak JA, Yuan C, Wolpin BM
JAMA 2024 Jan 23;331(4):318-328. doi: 10.1001/jama.2023.25869. PMID: 38261044Free PMC Article
Comprehensive Molecular Characterization of Adenocarcinoma of the Gastroesophageal Junction Between Esophageal and Gastric Adenocarcinomas.
Suh YS, Na D, Lee JS, Chae J, Kim E, Jang G, Lee J, Min J, Ock CY, Kong SH, George J, Zhang C, Lee HJ, Kim JI, Kim SJ, Kim WH, Lee C, Yang HK
Ann Surg 2022 Apr 1;275(4):706-717. doi: 10.1097/SLA.0000000000004303. PMID: 33086305
Diet and cancer of the esophagus and stomach.
Tay SW, Li JW, Fock KM
Curr Opin Gastroenterol 2021 Mar 1;37(2):158-163. doi: 10.1097/MOG.0000000000000700. PMID: 33315794
The management of mid & proximal oesophageal squamous cell carcinoma.
Wong I, Law S
Best Pract Res Clin Gastroenterol 2018 Oct-Dec;36-37:85-90. Epub 2018 Nov 30 doi: 10.1016/j.bpg.2018.11.012. PMID: 30551861
Differential role of microRNAs in the pathogenesis and treatment of Esophageal cancer.
Hemmatzadeh M, Mohammadi H, Karimi M, Musavishenas MH, Baradaran B
Biomed Pharmacother 2016 Aug;82:509-19. Epub 2016 Jun 4 doi: 10.1016/j.biopha.2016.05.009. PMID: 27470391

Clinical prediction guides

Prebiotics and the Risk of Upper Digestive Tract and Stomach Cancers: The PrebiotiCa Study.
Turati F, Concina F, Bertuccio P, Fiori F, Parpinel M, Garavello W, Crispo A, Libra M, Negri E, Serraino D, La Vecchia C
J Acad Nutr Diet 2023 Dec;123(12):1772-1780. Epub 2023 Jul 17 doi: 10.1016/j.jand.2023.07.008. PMID: 37468063
Comprehensive Molecular Characterization of Adenocarcinoma of the Gastroesophageal Junction Between Esophageal and Gastric Adenocarcinomas.
Suh YS, Na D, Lee JS, Chae J, Kim E, Jang G, Lee J, Min J, Ock CY, Kong SH, George J, Zhang C, Lee HJ, Kim JI, Kim SJ, Kim WH, Lee C, Yang HK
Ann Surg 2022 Apr 1;275(4):706-717. doi: 10.1097/SLA.0000000000004303. PMID: 33086305
Diet and cancer of the esophagus and stomach.
Tay SW, Li JW, Fock KM
Curr Opin Gastroenterol 2021 Mar 1;37(2):158-163. doi: 10.1097/MOG.0000000000000700. PMID: 33315794
Differential role of microRNAs in the pathogenesis and treatment of Esophageal cancer.
Hemmatzadeh M, Mohammadi H, Karimi M, Musavishenas MH, Baradaran B
Biomed Pharmacother 2016 Aug;82:509-19. Epub 2016 Jun 4 doi: 10.1016/j.biopha.2016.05.009. PMID: 27470391
Epidemiology of adenocarcinoma of the esophagus, gastric cardia, and upper gastric third.
Vial M, Grande L, Pera M
Recent Results Cancer Res 2010;182:1-17. doi: 10.1007/978-3-540-70579-6_1. PMID: 20676867

Recent systematic reviews

Minimally invasive oesophagectomy in the prone versus lateral decubitus position: a systematic review and meta-analysis.
Schizas D, Papaconstantinou D, Krompa A, Athanasiou A, Triantafyllou T, Tsekrekos A, Ruurda JP, Rouvelas I
Dis Esophagus 2022 Apr 19;35(4) doi: 10.1093/dote/doab042. PMID: 34175947
Prognostic Role of Primary Tumor Location in Non-Metastatic Gastric Cancer: A Systematic Review and Meta-Analysis of 50 Studies.
Petrelli F, Ghidini M, Barni S, Steccanella F, Sgroi G, Passalacqua R, Tomasello G
Ann Surg Oncol 2017 Sep;24(9):2655-2668. Epub 2017 Mar 15 doi: 10.1245/s10434-017-5832-4. PMID: 28299508

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