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Urethral diverticulum

MedGen UID:
57776
•Concept ID:
C0152443
•
Disease or Syndrome
Synonym: Urethral Diverticulum
SNOMED CT: Urethral diverticulum (90531003)
 
HPO: HP:0008722

Definition

The presence of a diverticulum (sac or pouch) in the wall of the urethra. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUrethral diverticulum

Conditions with this feature

Cardiac valvular defect, developmental
MedGen UID:
1823949
•Concept ID:
C5774175
•
Disease or Syndrome
Cardiac valvular dysplasia-1 (CVDP1) is characterized by congenital malformations of the pulmonic, tricuspid, and mitral valves. Structural cardiac defects, including atrial and ventricular septal defects, single left ventricle, and hypoplastic right ventricle have also been observed in affected individuals (Ta-Shma et al., 2017). Genetic Heterogeneity of Cardiac Valvular Dysplasia CVDP2 (620067) is caused by mutation in the ADAMTS19 gene (607513) on chromosome 5q23.
See: Condition Record
Cardiac valvular defect, developmental

Professional guidelines

PubMed

Role of urodynamics in management of urethral diverticulum in females.
Lin KJ, Fan YH, Lin AT
J Chin Med Assoc 2017 Nov;80(11):712-716. Epub 2017 Aug 12 doi: 10.1016/j.jcma.2017.07.003. PMID: 28807625
Female Urethral Diverticulum: Current Diagnosis and Management.
Crescenze IM, Goldman HB
Curr Urol Rep 2015 Oct;16(10):71. doi: 10.1007/s11934-015-0540-8. PMID: 26267225
Differential diagnosis of chronic pelvic pain in women: the urologist's approach.
Fletcher SG, Zimmern PE
Nat Rev Urol 2009 Oct;6(10):557-62. Epub 2009 Sep 1 doi: 10.1038/nrurol.2009.178. PMID: 19724247

Recent clinical studies

Etiology

Congenital anterior urethral valves and diverticulum: A case series and association with posterior urethral valves.
Menon P, Rao KLN
J Pediatr Urol 2022 Oct;18(5):663.e1-663.e9. Epub 2022 Sep 5 doi: 10.1016/j.jpurol.2022.08.024. PMID: 36123286
Analysis in the influence factors of urethroplasty in DSD.
Yu J, Sun N, Song H, Li M, Li L, Gong C, Zhang W
BMC Urol 2022 Aug 10;22(1):124. doi: 10.1186/s12894-022-01080-x. PMID: 35948888Free PMC Article
Characterization of urethral diverticula in males.
Olson K, Vaidya R, Khan A
Can J Urol 2022 Apr;29(2):11046-11051. PMID: 35429421
Characterization of Urethral Diverticula in Women.
Vaidya RV, Olson K, Wolter C, Khan A
Female Pelvic Med Reconstr Surg 2022 Jan 1;28(1):54-56. doi: 10.1097/SPV.0000000000001060. PMID: 34978545
Urethral diverticulum in the female: a meta-analysis of modern series.
Cameron AP
Minerva Ginecol 2016 Apr;68(2):186-210. Epub 2015 Nov 6 PMID: 26545036

Diagnosis

Female Urethral Reconstruction: Urethral Diverticulectomy, Urethral Strictures, Vesicovaginal Fistula.
Alvarez de Toledo I, DeLong J
Urol Clin North Am 2022 Aug;49(3):393-402. Epub 2022 Jun 27 doi: 10.1016/j.ucl.2022.04.004. PMID: 35931432
Characterization of Urethral Diverticula in Women.
Vaidya RV, Olson K, Wolter C, Khan A
Female Pelvic Med Reconstr Surg 2022 Jan 1;28(1):54-56. doi: 10.1097/SPV.0000000000001060. PMID: 34978545
Urethral Masses.
Serrell EC, McAchran SE
Obstet Gynecol Clin North Am 2021 Sep;48(3):599-616. doi: 10.1016/j.ogc.2021.05.011. PMID: 34416940
Robotic assisted proximal dorsal urethral diverticulectomy.
Mozafarpour S, Nwaoha N, Pucheril D, De EJB
Int Urogynecol J 2021 Oct;32(10):2863-2866. Epub 2021 Feb 26 doi: 10.1007/s00192-021-04716-y. PMID: 33635350
Female Urethral Diverticulum: Current Diagnosis and Management.
Crescenze IM, Goldman HB
Curr Urol Rep 2015 Oct;16(10):71. doi: 10.1007/s11934-015-0540-8. PMID: 26267225

Therapy

Analysis in the influence factors of urethroplasty in DSD.
Yu J, Sun N, Song H, Li M, Li L, Gong C, Zhang W
BMC Urol 2022 Aug 10;22(1):124. doi: 10.1186/s12894-022-01080-x. PMID: 35948888Free PMC Article
Urethral Diverticulum following Polypropylene Mesh Midurethral Slings: A Literature Review.
Pacer E, Duenas-Garcia OF, Hota L, Hornsby K, Shapiro R
Biomed Res Int 2020;2020:6761581. Epub 2020 May 11 doi: 10.1155/2020/6761581. PMID: 32462011Free PMC Article
Radiographic Misdiagnoses After Periurethral Bulking Agents.
Gaines N, Gupta P, Khourdaji AS, Ehlert M, Parikh K, Kohli H, Sirls LT
Female Pelvic Med Reconstr Surg 2018 Jul/Aug;24(4):312-314. doi: 10.1097/SPV.0000000000000440. PMID: 28657999
Surgical management of urethral diverticula in women: a systematic review.
Bodner-Adler B, Halpern K, Hanzal E
Int Urogynecol J 2016 Jul;27(7):993-1001. Epub 2015 Nov 13 doi: 10.1007/s00192-015-2862-y. PMID: 26564222
Female urethral diverticula.
Patel AK, Chapple CR
Curr Opin Urol 2006 Jul;16(4):248-54. doi: 10.1097/01.mou.0000232045.80180.2f. PMID: 16770123

Prognosis

Diagnosis of female urethral diverticulum using pelvic floor ultrasound and comparison with voiding cystourethrogram (imaging study).
Barakat B, Gauger U, Rehme C, Hadaschik B, Wolff I, Hijazi S
Int Urogynecol J 2023 Feb;34(2):563-569. Epub 2022 Sep 13 doi: 10.1007/s00192-022-05340-0. PMID: 36098788
Congenital anterior urethral valves and diverticulum: A case series and association with posterior urethral valves.
Menon P, Rao KLN
J Pediatr Urol 2022 Oct;18(5):663.e1-663.e9. Epub 2022 Sep 5 doi: 10.1016/j.jpurol.2022.08.024. PMID: 36123286
Robotic assisted proximal dorsal urethral diverticulectomy.
Mozafarpour S, Nwaoha N, Pucheril D, De EJB
Int Urogynecol J 2021 Oct;32(10):2863-2866. Epub 2021 Feb 26 doi: 10.1007/s00192-021-04716-y. PMID: 33635350
Surgical management of urethral diverticula in women: a systematic review.
Bodner-Adler B, Halpern K, Hanzal E
Int Urogynecol J 2016 Jul;27(7):993-1001. Epub 2015 Nov 13 doi: 10.1007/s00192-015-2862-y. PMID: 26564222
Clear cell adenocarcinoma of the urethra: review of the literature.
Venyo AK
Int J Surg Oncol 2015;2015:790235. Epub 2015 Jan 20 doi: 10.1155/2015/790235. PMID: 25685552Free PMC Article

Clinical prediction guides

Diagnosis of female urethral diverticulum using pelvic floor ultrasound and comparison with voiding cystourethrogram (imaging study).
Barakat B, Gauger U, Rehme C, Hadaschik B, Wolff I, Hijazi S
Int Urogynecol J 2023 Feb;34(2):563-569. Epub 2022 Sep 13 doi: 10.1007/s00192-022-05340-0. PMID: 36098788
Urethral Masses.
Serrell EC, McAchran SE
Obstet Gynecol Clin North Am 2021 Sep;48(3):599-616. doi: 10.1016/j.ogc.2021.05.011. PMID: 34416940
Robotic assisted proximal dorsal urethral diverticulectomy.
Mozafarpour S, Nwaoha N, Pucheril D, De EJB
Int Urogynecol J 2021 Oct;32(10):2863-2866. Epub 2021 Feb 26 doi: 10.1007/s00192-021-04716-y. PMID: 33635350
Translabial ultrasound imaging of urethral diverticula.
Gillor M, Dietz HP
Ultrasound Obstet Gynecol 2019 Oct;54(4):552-556. doi: 10.1002/uog.20305. PMID: 31038237
Correlation of MRI features of urethral diverticulum and pre- and post-operative stress urinary incontinence.
Seth JH, Naaseri S, Solomon E, Pakzad M, Hamid R, Ockrim J, Greenwell TJ
Neurourol Urodyn 2019 Jan;38(1):180-186. Epub 2018 Nov 9 doi: 10.1002/nau.23820. PMID: 30411812

Recent systematic reviews

Should endoscopic laser excision be offered as the first-line management for patients with eroded mesh? Outcomes of a systematic review of literature.
Ripa F, Enikeev D, Talyshinskii A, Juliebø-Jones P, Tzelves L, Kallidonis P, Somani B
Curr Opin Urol 2024 Mar 1;34(2):135-144. Epub 2023 Nov 6 doi: 10.1097/MOU.0000000000001146. PMID: 37933676
Meta-analysis comparing the outcomes of single stage (foreskin pedicled tube) versus two stage (foreskin free graft & foreskin pedicled flap) repair for proximal hypospadias in the last decade.
Babu R, Chandrasekharam VVS
J Pediatr Urol 2021 Oct;17(5):681-689. Epub 2021 May 17 doi: 10.1016/j.jpurol.2021.05.014. PMID: 34099397
Postoperative "complications" following laparoscopic-assisted anorectoplasty: A systematic review.
Pathak M, Saxena AK
Pediatr Surg Int 2020 Nov;36(11):1299-1307. Epub 2020 Sep 26 doi: 10.1007/s00383-020-04748-3. PMID: 32980932
Surgical management of urethral diverticula in women: a systematic review.
Bodner-Adler B, Halpern K, Hanzal E
Int Urogynecol J 2016 Jul;27(7):993-1001. Epub 2015 Nov 13 doi: 10.1007/s00192-015-2862-y. PMID: 26564222

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