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Abnormality of the urethra

MedGen UID:
871336
•Concept ID:
C4025826
•
Anatomical Abnormality
Synonym: Urethra issue
 
HPO: HP:0000795

Definition

An abnormality of the urethra, i.e., of the tube which connects the urinary bladder to the outside of the body. [from HPO]

Professional guidelines

PubMed

The current state of tissue engineering in the management of hypospadias.
Chan YY, Bury MI, Yura EM, Hofer MD, Cheng EY, Sharma AK
Nat Rev Urol 2020 Mar;17(3):162-175. Epub 2020 Feb 5 doi: 10.1038/s41585-020-0281-4. PMID: 32024995
Evaluation and Management of Neurogenic Bladder: What Is New in China?
Liao L
Int J Mol Sci 2015 Aug 10;16(8):18580-600. doi: 10.3390/ijms160818580. PMID: 26266405Free PMC Article
Duration of follow-up to diagnose hypospadias urethroplasty complications.
Snodgrass W, Villanueva C, Bush NC
J Pediatr Urol 2014 Apr;10(2):208-11. Epub 2013 Dec 7 doi: 10.1016/j.jpurol.2013.11.011. PMID: 24439629

Recent clinical studies

Etiology

Spectrum and classification of megameatus anomalies.
Baky Fahmy MA, Shebl SE, Gad D, Othman D, Elsadek M
Int J Urol 2023 Jun;30(6):526-531. Epub 2023 Mar 5 doi: 10.1111/iju.15173. PMID: 36872075
Hypospadias, all there is to know.
van der Horst HJ, de Wall LL
Eur J Pediatr 2017 Apr;176(4):435-441. Epub 2017 Feb 11 doi: 10.1007/s00431-017-2864-5. PMID: 28190103Free PMC Article
Female epispadias.
Shetty MV, Bhaskaran A, Sen TK
Afr J Paediatr Surg 2011 May-Aug;8(2):215-7. doi: 10.4103/0189-6725.86066. PMID: 22005369
Hypospadias reoperations.
Söylet Y, Gundogdu G, Yesildag E, Emir H
Eur J Pediatr Surg 2004 Jun;14(3):188-92. doi: 10.1055/s-2004-820969. PMID: 15211410
Midshaft hypospadias.
Upadhyay J, Shekarriz B, Khoury AE
Urol Clin North Am 2002 May;29(2):299-310. doi: 10.1016/s0094-0143(02)00049-6. PMID: 12371222

Diagnosis

Congenital Urethrocutaneous Fistula.
Suman BK, Singh RJ, Sinha AK, Kumar B
Afr J Paediatr Surg 2024 Jan 1;21(1):73-74. Epub 2023 Jul 20 doi: 10.4103/ajps.ajps_97_22. PMID: 38259026Free PMC Article
Hypospadias.
Mole RJ, Nash S, MacKenzie DN
BMJ 2020 Jun 17;369:m2070. doi: 10.1136/bmj.m2070. PMID: 32554436
Hypospadias, all there is to know.
van der Horst HJ, de Wall LL
Eur J Pediatr 2017 Apr;176(4):435-441. Epub 2017 Feb 11 doi: 10.1007/s00431-017-2864-5. PMID: 28190103Free PMC Article
What Is Hypospadias?
Baskin L
Clin Pediatr (Phila) 2017 May;56(5):409-418. Epub 2017 Jan 12 doi: 10.1177/0009922816684613. PMID: 28081624
Posterior urethral valve.
Nasir AA, Ameh EA, Abdur-Rahman LO, Adeniran JO, Abraham MK
World J Pediatr 2011 Aug;7(3):205-16. Epub 2011 Aug 7 doi: 10.1007/s12519-011-0289-1. PMID: 21822988

Therapy

The current state of tissue engineering in the management of hypospadias.
Chan YY, Bury MI, Yura EM, Hofer MD, Cheng EY, Sharma AK
Nat Rev Urol 2020 Mar;17(3):162-175. Epub 2020 Feb 5 doi: 10.1038/s41585-020-0281-4. PMID: 32024995
Genitourinary Complications of Gender-Affirming Surgery.
Bryson C, Honig SC
Curr Urol Rep 2019 Apr 30;20(6):31. doi: 10.1007/s11934-019-0894-4. PMID: 31041616
Hypospadias.
Macedo A Jr, Rondon A, Ortiz V
Curr Opin Urol 2012 Nov;22(6):447-52. doi: 10.1097/MOU.0b013e328357bc62. PMID: 23026892
Hypospadias.
Shukla AR, Patel RP, Canning DA
Urol Clin North Am 2004 Aug;31(3):445-60, viii. doi: 10.1016/j.ucl.2004.04.020. PMID: 15313054
Incontinence.
Edwards LE
Practitioner 1975 Jan;214(1279):46-55. PMID: 1096112

Prognosis

Posterior urethral valve in thai boys.
Ekarat P, Attawettayanon W, Limratchapong C, Sophark P, Vachvanichsanong P
BMC Pediatr 2023 Sep 7;23(1):445. doi: 10.1186/s12887-023-04281-x. PMID: 37679663Free PMC Article
Ingrafts in hypospadias surgery: Longer-term outcomes.
Loloi J, Harrington S, Boltz S, Decter RM
J Pediatr Urol 2020 Oct;16(5):555.e1-555.e5. Epub 2020 May 7 doi: 10.1016/j.jpurol.2020.04.030. PMID: 32471708
Female epispadias.
Shetty MV, Bhaskaran A, Sen TK
Afr J Paediatr Surg 2011 May-Aug;8(2):215-7. doi: 10.4103/0189-6725.86066. PMID: 22005369
Posterior urethral valve.
Nasir AA, Ameh EA, Abdur-Rahman LO, Adeniran JO, Abraham MK
World J Pediatr 2011 Aug;7(3):205-16. Epub 2011 Aug 7 doi: 10.1007/s12519-011-0289-1. PMID: 21822988
Congenital megalourethra.
Wakhlu AK, Wakhlu A, Tandon RK, Kureel SN
J Pediatr Surg 1996 Mar;31(3):441-3. doi: 10.1016/s0022-3468(96)90758-7. PMID: 8708923

Clinical prediction guides

Expression of Rab25 is down-regulated in the foreskin of children with hypospadias.
Zhang Q, Zhang Z, He X, Liu Z, Shen L, Long C, Wei G, Liu X
J Pediatr Urol 2023 Oct;19(5):581.e1-581.e6. Epub 2023 May 13 doi: 10.1016/j.jpurol.2023.05.006. PMID: 37246119
An objective hypospadias classification system.
Abbas TO
J Pediatr Urol 2022 Aug;18(4):481.e1-481.e8. Epub 2022 May 11 doi: 10.1016/j.jpurol.2022.05.001. PMID: 35644790
Ingrafts in hypospadias surgery: Longer-term outcomes.
Loloi J, Harrington S, Boltz S, Decter RM
J Pediatr Urol 2020 Oct;16(5):555.e1-555.e5. Epub 2020 May 7 doi: 10.1016/j.jpurol.2020.04.030. PMID: 32471708
Epispadias and the associated embryopathies: genetic and developmental basis.
Suzuki K, Matsumaru D, Matsushita S, Murashima A, Ludwig M, Reutter H, Yamada G
Clin Genet 2017 Feb;91(2):247-253. Epub 2016 Oct 10 doi: 10.1111/cge.12871. PMID: 27649475
Recurrent hypospadias surgery.
Barbagli G, Sansalone S, Djinovic R, Lazzeri M
Arch Esp Urol 2014 Jan-Feb;67(1):54-60. PMID: 24531672

Recent systematic reviews

What are the factors affecting glanular dehiscence after hypospadias surgery?
Karabulut R, Turkyilmaz Z, Atan A, Kaya C, Sonmez K
Actas Urol Esp (Engl Ed) 2022 Jan-Feb;46(1):4-15. Epub 2021 Nov 24 doi: 10.1016/j.acuroe.2020.11.013. PMID: 34838491
Are there any benefits of using an inlay graft in the treatment of primary hypospadias in children? A systematic review and metanalysis.
Silay MS, 't Hoen L, Bhatt N, Quaedackers J, Bogaert G, Dogan HS, Nijman RJM, Rawashdeh Y, Stein R, Tekgul S, Radmayr C
J Pediatr Urol 2021 Jun;17(3):303-315. Epub 2021 Feb 19 doi: 10.1016/j.jpurol.2021.02.013. PMID: 33691984
State-of-the-Art Renal Imaging in Children.
Viteri B, Calle-Toro JS, Furth S, Darge K, Hartung EA, Otero H
Pediatrics 2020 Feb;145(2) Epub 2020 Jan 8 doi: 10.1542/peds.2019-0829. PMID: 31915193Free PMC Article
Systematic review and meta-analysis of studies comparing the perimeatal-based flap and tubularized incised-plate techniques for primary hypospadias repair.
Wang F, Xu Y, Zhong H
Pediatr Surg Int 2013 Aug;29(8):811-21. Epub 2013 Jun 21 doi: 10.1007/s00383-013-3335-3. PMID: 23793987
A systematic review on renal and bladder dysfunction after endoscopic treatment of infravesical obstruction in boys.
Hennus PM, van der Heijden GJ, Bosch JL, de Jong TP, de Kort LM
PLoS One 2012;7(9):e44663. Epub 2012 Sep 13 doi: 10.1371/journal.pone.0044663. PMID: 23028576Free PMC Article

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