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Phototoxic dermatitis

MedGen UID:
58188
•Concept ID:
C0162830
•
Disease or Syndrome
Synonyms: Contact Dermatitides, Phototoxic; Contact Dermatitis, Phototoxic; Dermatitides, Phototoxic; Dermatitides, Phototoxic Contact; Dermatitis, Contact, Phototoxic; Dermatitis, Phototoxic; Dermatitis, Phototoxic Contact; Phototoxic Contact Dermatitides; Phototoxic Contact Dermatitis; Phototoxic Dermatitides; Phototoxic Dermatitis
SNOMED CT: Photosensitization reaction (84326006); Phototoxic eczema (53597009); Phototoxic reaction (53597009); Photosensitive dermatitis (84326006); Phototoxic dermatitis (53597009)
 
Monarch Initiative: MONDO:0006598

Definition

Dermatitis caused or precipitated by exposure to ultraviolet sunlight, or by mediating phototoxic or photoallergic material in response to ultraviolet sunlight. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPhototoxic dermatitis

Professional guidelines

PubMed

Evidence-based consensus guidelines for the diagnosis and management of erythropoietic protoporphyria and X-linked protoporphyria.
Dickey AK, Naik H, Keel SB, Levy C, Beaven SW, Elmariah SB, Erwin AL, Goddu RJ, Hedstrom K, Leaf RK, Kazamel M, Mazepa M, Philpotts LL, Quigley J, Raef H, Rudnick SR, Saberi B, Thapar M, Ungar J, Wang B, Balwani M; Porphyrias Consortium of the Rare Diseases Clinical Research Network
J Am Acad Dermatol 2023 Dec;89(6):1227-1237. Epub 2022 Aug 27 doi: 10.1016/j.jaad.2022.08.036. PMID: 36041558Free PMC Article
Erythropoietic Protoporphyria and X-Linked Protoporphyria: pathophysiology, genetics, clinical manifestations, and management.
Balwani M
Mol Genet Metab 2019 Nov;128(3):298-303. Epub 2019 Jan 24 doi: 10.1016/j.ymgme.2019.01.020. PMID: 30704898Free PMC Article
Cutaneous allergic drug reactions: update on pathophysiology, diagnostic procedures and differential diagnosic.
Balakirski G, Merk HF
Cutan Ocul Toxicol 2017 Dec;36(4):307-316. Epub 2017 Apr 27 doi: 10.1080/15569527.2017.1319379. PMID: 28412864

Recent clinical studies

Etiology

Drug-induced photosensitivity: culprit drugs, potential mechanisms and clinical consequences.
Hofmann GA, Weber B
J Dtsch Dermatol Ges 2021 Jan;19(1):19-29. doi: 10.1111/ddg.14314. PMID: 33491908Free PMC Article
Drug-Induced Photosensitivity-An Update: Culprit Drugs, Prevention and Management.
Blakely KM, Drucker AM, Rosen CF
Drug Saf 2019 Jul;42(7):827-847. doi: 10.1007/s40264-019-00806-5. PMID: 30888626
Photodermatoses in skin of colour.
Gutierrez D, Gaulding JV, Motta Beltran AF, Lim HW, Pritchett EN
J Eur Acad Dermatol Venereol 2018 Nov;32(11):1879-1886. Epub 2018 Jul 15 doi: 10.1111/jdv.15115. PMID: 29888465
Photocontact dermatitis.
Deleo VA
Dermatol Ther 2004;17(4):279-88. doi: 10.1111/j.1396-0296.2004.04026.x. PMID: 15327473
Final report on the safety assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate.
Nair B
Int J Toxicol 2001;20 Suppl 3:23-50. doi: 10.1080/10915810152630729. PMID: 11766131

Diagnosis

Photosensitizing drug reactions.
Montgomery S, Worswick S
Clin Dermatol 2022 Jan-Feb;40(1):57-63. Epub 2021 Aug 8 doi: 10.1016/j.clindermatol.2021.08.014. PMID: 35190066
Psoralen-Induced Phytophotodermatitis.
Ellis CR, Elston DM
Dermatitis 2021 May-Jun 01;32(3):140-143. doi: 10.1097/DER.0000000000000691. PMID: 33273237
Drug-Induced Photosensitivity-An Update: Culprit Drugs, Prevention and Management.
Blakely KM, Drucker AM, Rosen CF
Drug Saf 2019 Jul;42(7):827-847. doi: 10.1007/s40264-019-00806-5. PMID: 30888626
Photocontact dermatitis.
Deleo VA
Dermatol Ther 2004;17(4):279-88. doi: 10.1111/j.1396-0296.2004.04026.x. PMID: 15327473
Drug-induced photosensitivity.
Allen JE
Clin Pharm 1993 Aug;12(8):580-7. PMID: 8222522

Therapy

Photosensitizing drug reactions.
Montgomery S, Worswick S
Clin Dermatol 2022 Jan-Feb;40(1):57-63. Epub 2021 Aug 8 doi: 10.1016/j.clindermatol.2021.08.014. PMID: 35190066
Psoralen-Induced Phytophotodermatitis.
Ellis CR, Elston DM
Dermatitis 2021 May-Jun 01;32(3):140-143. doi: 10.1097/DER.0000000000000691. PMID: 33273237
Drug-Induced Photosensitivity-An Update: Culprit Drugs, Prevention and Management.
Blakely KM, Drucker AM, Rosen CF
Drug Saf 2019 Jul;42(7):827-847. doi: 10.1007/s40264-019-00806-5. PMID: 30888626
Photocontact dermatitis.
Deleo VA
Dermatol Ther 2004;17(4):279-88. doi: 10.1111/j.1396-0296.2004.04026.x. PMID: 15327473
Phytodermatitis.
Sasseville D
J Cutan Med Surg 1999 Jul;3(5):263-79. doi: 10.1177/120347549900300510. PMID: 10438232

Prognosis

Photodermatoses in skin of colour.
Gutierrez D, Gaulding JV, Motta Beltran AF, Lim HW, Pritchett EN
J Eur Acad Dermatol Venereol 2018 Nov;32(11):1879-1886. Epub 2018 Jul 15 doi: 10.1111/jdv.15115. PMID: 29888465
Molecular mechanisms of drug photodegradation and photosensitization.
Zaheer MR, Gupta A, Iqbal J, Zia Q, Ahmad A, Roohi, Owais M, Hashlamon A, Mohd Setapar SH, Ashraf GM, Aliev G
Curr Pharm Des 2016;22(7):768-82. doi: 10.2174/1381612822666151209151408. PMID: 26675230
Exploratory and regulatory assessments on photosafety of new drug entities.
Seto Y, Hosoi K, Takagi H, Nakamura K, Kojima H, Yamada S, Onoue S
Curr Drug Saf 2012 Apr;7(2):140-8. doi: 10.2174/157488612802715726. PMID: 22873498
Update on photodermatoses.
Santoro FA, Lim HW
Semin Cutan Med Surg 2011 Dec;30(4):229-38. doi: 10.1016/j.sder.2011.07.007. PMID: 22123421
Photocontact dermatitis.
Deleo VA
Dermatol Ther 2004;17(4):279-88. doi: 10.1111/j.1396-0296.2004.04026.x. PMID: 15327473

Clinical prediction guides

Photodynamic Therapy: Critical PDT Theory.
Kessel D
Photochem Photobiol 2023 Mar;99(2):199-203. Epub 2022 Mar 24 doi: 10.1111/php.13616. PMID: 35290667
Anticancer treatments and photosensitivity.
Sibaud V
J Eur Acad Dermatol Venereol 2022 Jun;36 Suppl 6(Suppl 6):51-58. doi: 10.1111/jdv.18200. PMID: 35738806Free PMC Article
Vandetanib photoinduced cutaneous toxicities.
Doan HQ, Hu MI, Goldstein J, Piha-Paul SA, Subbiah V, Patel AB
Cutis 2019 May;103(5):E24-E29. PMID: 31233590
Chemical photoallergy: photobiochemical mechanisms, classification, and risk assessments.
Onoue S, Seto Y, Sato H, Nishida H, Hirota M, Ashikaga T, Api AM, Basketter D, Tokura Y
J Dermatol Sci 2017 Jan;85(1):4-11. Epub 2016 Aug 6 doi: 10.1016/j.jdermsci.2016.08.005. PMID: 27528585
Exploratory and regulatory assessments on photosafety of new drug entities.
Seto Y, Hosoi K, Takagi H, Nakamura K, Kojima H, Yamada S, Onoue S
Curr Drug Saf 2012 Apr;7(2):140-8. doi: 10.2174/157488612802715726. PMID: 22873498

Recent systematic reviews

Dermatitis versus nonaccidental trauma: A systematic review of initial pediatric misdiagnoses.
King A, Pope E
Pediatr Dermatol 2024 Mar-Apr;41(2):215-220. Epub 2024 Feb 24 doi: 10.1111/pde.15556. PMID: 38400817
Drug-induced phototoxicity: A systematic review.
Kim WB, Shelley AJ, Novice K, Joo J, Lim HW, Glassman SJ
J Am Acad Dermatol 2018 Dec;79(6):1069-1075. Epub 2018 Jul 10 doi: 10.1016/j.jaad.2018.06.061. PMID: 30003982
Third and fourth generation fluoroquinolone antibacterials: a systematic review of safety and toxicity profiles.
Sousa J, Alves G, Fortuna A, Falcão A
Curr Drug Saf 2014;9(2):89-105. doi: 10.2174/1574886308666140106154754. PMID: 24410307

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