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Phototoxic dermatitis

MedGen UID:
58188
Concept ID:
C0162830
Disease or Syndrome
Synonyms: Contact Dermatitides, Phototoxic; Contact Dermatitis, Phototoxic; Dermatitides, Phototoxic; Dermatitides, Phototoxic Contact; Dermatitis, Contact, Phototoxic; Dermatitis, Phototoxic; Dermatitis, Phototoxic Contact; Phototoxic Contact Dermatitides; Phototoxic Contact Dermatitis; Phototoxic Dermatitides; Phototoxic Dermatitis
SNOMED CT: Photosensitization reaction (84326006); Phototoxic eczema (53597009); Phototoxic reaction (53597009); Photosensitive dermatitis (84326006); Phototoxic dermatitis (53597009)
 
Monarch Initiative: MONDO:0006598

Definition

Dermatitis caused or precipitated by exposure to ultraviolet sunlight, or by mediating phototoxic or photoallergic material in response to ultraviolet sunlight. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPhototoxic dermatitis

Professional guidelines

PubMed

Dickey AK, Naik H, Keel SB, Levy C, Beaven SW, Elmariah SB, Erwin AL, Goddu RJ, Hedstrom K, Leaf RK, Kazamel M, Mazepa M, Philpotts LL, Quigley J, Raef H, Rudnick SR, Saberi B, Thapar M, Ungar J, Wang B, Balwani M; Porphyrias Consortium of the Rare Diseases Clinical Research Network
J Am Acad Dermatol 2023 Dec;89(6):1227-1237. Epub 2022 Aug 27 doi: 10.1016/j.jaad.2022.08.036. PMID: 36041558Free PMC Article
Balwani M
Mol Genet Metab 2019 Nov;128(3):298-303. Epub 2019 Jan 24 doi: 10.1016/j.ymgme.2019.01.020. PMID: 30704898Free PMC Article
Bylaite M, Grigaitiene J, Lapinskaite GS
Br J Dermatol 2009 Nov;161 Suppl 3:61-8. doi: 10.1111/j.1365-2133.2009.09451.x. PMID: 19775359

Recent clinical studies

Etiology

Hofmann GA, Weber B
J Dtsch Dermatol Ges 2021 Jan;19(1):19-29. doi: 10.1111/ddg.14314. PMID: 33491908Free PMC Article
Blakely KM, Drucker AM, Rosen CF
Drug Saf 2019 Jul;42(7):827-847. doi: 10.1007/s40264-019-00806-5. PMID: 30888626
Gutierrez D, Gaulding JV, Motta Beltran AF, Lim HW, Pritchett EN
J Eur Acad Dermatol Venereol 2018 Nov;32(11):1879-1886. Epub 2018 Jul 15 doi: 10.1111/jdv.15115. PMID: 29888465
Kutlubay Z, Sevim A, Engin B, Tüzün Y
Clin Dermatol 2014 Jan-Feb;32(1):73-9. doi: 10.1016/j.clindermatol.2013.05.027. PMID: 24314379
Nair B
Int J Toxicol 2001;20 Suppl 3:23-50. doi: 10.1080/10915810152630729. PMID: 11766131

Diagnosis

Dickey AK, Naik H, Keel SB, Levy C, Beaven SW, Elmariah SB, Erwin AL, Goddu RJ, Hedstrom K, Leaf RK, Kazamel M, Mazepa M, Philpotts LL, Quigley J, Raef H, Rudnick SR, Saberi B, Thapar M, Ungar J, Wang B, Balwani M; Porphyrias Consortium of the Rare Diseases Clinical Research Network
J Am Acad Dermatol 2023 Dec;89(6):1227-1237. Epub 2022 Aug 27 doi: 10.1016/j.jaad.2022.08.036. PMID: 36041558Free PMC Article
Sibaud V
J Eur Acad Dermatol Venereol 2022 Jun;36 Suppl 6(Suppl 6):51-58. doi: 10.1111/jdv.18200. PMID: 35738806Free PMC Article
Montgomery S, Worswick S
Clin Dermatol 2022 Jan-Feb;40(1):57-63. Epub 2021 Aug 8 doi: 10.1016/j.clindermatol.2021.08.014. PMID: 35190066
Ellis CR, Elston DM
Dermatitis 2021 May-Jun 01;32(3):140-143. doi: 10.1097/DER.0000000000000691. PMID: 33273237
Blakely KM, Drucker AM, Rosen CF
Drug Saf 2019 Jul;42(7):827-847. doi: 10.1007/s40264-019-00806-5. PMID: 30888626

Therapy

Belcadi J, Oulad Ali S, Senouci K
Dermatitis 2024 Sep-Oct;35(5):429-430. Epub 2024 Feb 22 doi: 10.1089/derm.2024.0017. PMID: 38387001
Montgomery S, Worswick S
Clin Dermatol 2022 Jan-Feb;40(1):57-63. Epub 2021 Aug 8 doi: 10.1016/j.clindermatol.2021.08.014. PMID: 35190066
Ellis CR, Elston DM
Dermatitis 2021 May-Jun 01;32(3):140-143. doi: 10.1097/DER.0000000000000691. PMID: 33273237
Blakely KM, Drucker AM, Rosen CF
Drug Saf 2019 Jul;42(7):827-847. doi: 10.1007/s40264-019-00806-5. PMID: 30888626
Sasseville D
J Cutan Med Surg 1999 Jul;3(5):263-79. doi: 10.1177/120347549900300510. PMID: 10438232

Prognosis

Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA Jr, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S
Food Chem Toxicol 2020 Oct 15;144 Suppl 1:111658. Epub 2020 Aug 21 doi: 10.1016/j.fct.2020.111658. PMID: 32835729
Gutierrez D, Gaulding JV, Motta Beltran AF, Lim HW, Pritchett EN
J Eur Acad Dermatol Venereol 2018 Nov;32(11):1879-1886. Epub 2018 Jul 15 doi: 10.1111/jdv.15115. PMID: 29888465
Onoue S, Seto Y, Sato H, Nishida H, Hirota M, Ashikaga T, Api AM, Basketter D, Tokura Y
J Dermatol Sci 2017 Jan;85(1):4-11. Epub 2016 Aug 6 doi: 10.1016/j.jdermsci.2016.08.005. PMID: 27528585
Santoro FA, Lim HW
Semin Cutan Med Surg 2011 Dec;30(4):229-38. doi: 10.1016/j.sder.2011.07.007. PMID: 22123421
Deleo VA
Dermatol Ther 2004;17(4):279-88. doi: 10.1111/j.1396-0296.2004.04026.x. PMID: 15327473

Clinical prediction guides

Kessel D
Photochem Photobiol 2023 Mar;99(2):199-203. Epub 2022 Mar 24 doi: 10.1111/php.13616. PMID: 35290667
Sibaud V
J Eur Acad Dermatol Venereol 2022 Jun;36 Suppl 6(Suppl 6):51-58. doi: 10.1111/jdv.18200. PMID: 35738806Free PMC Article
Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA Jr, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S
Food Chem Toxicol 2020 Oct 15;144 Suppl 1:111658. Epub 2020 Aug 21 doi: 10.1016/j.fct.2020.111658. PMID: 32835729
Doan HQ, Hu MI, Goldstein J, Piha-Paul SA, Subbiah V, Patel AB
Cutis 2019 May;103(5):E24-E29. PMID: 31233590
Onoue S, Seto Y, Sato H, Nishida H, Hirota M, Ashikaga T, Api AM, Basketter D, Tokura Y
J Dermatol Sci 2017 Jan;85(1):4-11. Epub 2016 Aug 6 doi: 10.1016/j.jdermsci.2016.08.005. PMID: 27528585

Recent systematic reviews

Kim WB, Shelley AJ, Novice K, Joo J, Lim HW, Glassman SJ
J Am Acad Dermatol 2018 Dec;79(6):1069-1075. Epub 2018 Jul 10 doi: 10.1016/j.jaad.2018.06.061. PMID: 30003982
Sousa J, Alves G, Fortuna A, Falcão A
Curr Drug Saf 2014;9(2):89-105. doi: 10.2174/1574886308666140106154754. PMID: 24410307

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