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Acute hepatitis C

MedGen UID:
586482
•Concept ID:
C0400914
•
Disease or Syndrome
Synonym: Acute Hepatitis C Infection
SNOMED CT: Acute hepatitis C (235866006)

Definition

A new infection by the hepatitis C virus, which can be detected in blood. Signs and symptoms may include right upper quadrant abdominal pain, jaundice, dark urine, white stools and nausea. Approximately 15%-25% individuals clear the virus from their bodies without treatment. 75%-85% individuals develop chronic hepatitis C. There are possible treatments depending on individual characteristics. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute hepatitis C

Professional guidelines

PubMed

Major revision version 12.0 of the European AIDS Clinical Society guidelines 2023.
Ambrosioni J, Levi L, Alagaratnam J, Van Bremen K, Mastrangelo A, Waalewijn H, Molina JM, Guaraldi G, Winston A, Boesecke C, Cinque P, Bamford A, Calmy A, Marzolini C, Martínez E, Oprea C, Welch S, Koval A, Mendao L, Rockstroh JK; EACS Governing Board
HIV Med 2023 Nov;24(11):1126-1136. Epub 2023 Oct 18 doi: 10.1111/hiv.13542. PMID: 37849432
Direct-acting antiviral treatment of acute hepatitis C virus infections.
Misra S, Dieterich DT, Saberi B, Kushner T
Expert Rev Anti Infect Ther 2018 Aug;16(8):599-610. Epub 2018 Aug 1 doi: 10.1080/14787210.2018.1505502. PMID: 30067402
Management of acute hepatitis C.
Maheshwari A, Thuluvath PJ
Clin Liver Dis 2010 Feb;14(1):169-76; x. doi: 10.1016/j.cld.2009.11.007. PMID: 20123448

Recent clinical studies

Etiology

Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019.
GBD 2019 Europe Hepatitis B & C Collaborators
Lancet Public Health 2023 Sep;8(9):e701-e716. doi: 10.1016/S2468-2667(23)00149-4. PMID: 37633679
Direct-acting antiviral treatment of acute hepatitis C virus infections.
Misra S, Dieterich DT, Saberi B, Kushner T
Expert Rev Anti Infect Ther 2018 Aug;16(8):599-610. Epub 2018 Aug 1 doi: 10.1080/14787210.2018.1505502. PMID: 30067402
Enhancing the detection and management of acute hepatitis C virus infection.
Martinello M, Matthews GV
Int J Drug Policy 2015 Oct;26(10):899-910. Epub 2015 Jul 16 doi: 10.1016/j.drugpo.2015.07.003. PMID: 26254495
Current knowledge and future perspectives on acute hepatitis C infection.
Hullegie SJ, Arends JE, Rijnders BJ, Irving WL, Salmon D, Prins M, Wensing AM, Klenerman P, Leblebicioglu H, Boesecke C, Rockstroh JK, Hoepelman AI
Clin Microbiol Infect 2015 Aug;21(8):797.e9-797.e17. Epub 2015 Apr 16 doi: 10.1016/j.cmi.2015.03.026. PMID: 25892133
Acute hepatitis C.
Maheshwari A, Ray S, Thuluvath PJ
Lancet 2008 Jul 26;372(9635):321-32. doi: 10.1016/S0140-6736(08)61116-2. PMID: 18657711

Diagnosis

Major revision version 12.0 of the European AIDS Clinical Society guidelines 2023.
Ambrosioni J, Levi L, Alagaratnam J, Van Bremen K, Mastrangelo A, Waalewijn H, Molina JM, Guaraldi G, Winston A, Boesecke C, Cinque P, Bamford A, Calmy A, Marzolini C, Martínez E, Oprea C, Welch S, Koval A, Mendao L, Rockstroh JK; EACS Governing Board
HIV Med 2023 Nov;24(11):1126-1136. Epub 2023 Oct 18 doi: 10.1111/hiv.13542. PMID: 37849432
Acute hepatitis C virus infection: clinical update and remaining challenges.
Liu CH, Kao JH
Clin Mol Hepatol 2023 Jul;29(3):623-642. Epub 2023 Feb 20 doi: 10.3350/cmh.2022.0349. PMID: 36800699Free PMC Article
Current knowledge and future perspectives on acute hepatitis C infection.
Hullegie SJ, Arends JE, Rijnders BJ, Irving WL, Salmon D, Prins M, Wensing AM, Klenerman P, Leblebicioglu H, Boesecke C, Rockstroh JK, Hoepelman AI
Clin Microbiol Infect 2015 Aug;21(8):797.e9-797.e17. Epub 2015 Apr 16 doi: 10.1016/j.cmi.2015.03.026. PMID: 25892133
Acute hepatitis C.
Maheshwari A, Ray S, Thuluvath PJ
Lancet 2008 Jul 26;372(9635):321-32. doi: 10.1016/S0140-6736(08)61116-2. PMID: 18657711
Acute hepatitis C.
Orland JR, Wright TL, Cooper S
Hepatology 2001 Feb;33(2):321-7. doi: 10.1053/jhep.2001.22112. PMID: 11172332

Therapy

Major revision version 12.0 of the European AIDS Clinical Society guidelines 2023.
Ambrosioni J, Levi L, Alagaratnam J, Van Bremen K, Mastrangelo A, Waalewijn H, Molina JM, Guaraldi G, Winston A, Boesecke C, Cinque P, Bamford A, Calmy A, Marzolini C, Martínez E, Oprea C, Welch S, Koval A, Mendao L, Rockstroh JK; EACS Governing Board
HIV Med 2023 Nov;24(11):1126-1136. Epub 2023 Oct 18 doi: 10.1111/hiv.13542. PMID: 37849432
Acute hepatitis C virus infection: clinical update and remaining challenges.
Liu CH, Kao JH
Clin Mol Hepatol 2023 Jul;29(3):623-642. Epub 2023 Feb 20 doi: 10.3350/cmh.2022.0349. PMID: 36800699Free PMC Article
Direct-acting antiviral treatment of acute hepatitis C virus infections.
Misra S, Dieterich DT, Saberi B, Kushner T
Expert Rev Anti Infect Ther 2018 Aug;16(8):599-610. Epub 2018 Aug 1 doi: 10.1080/14787210.2018.1505502. PMID: 30067402
Acute hepatitis C.
Maheshwari A, Ray S, Thuluvath PJ
Lancet 2008 Jul 26;372(9635):321-32. doi: 10.1016/S0140-6736(08)61116-2. PMID: 18657711
Acute hepatitis C.
Orland JR, Wright TL, Cooper S
Hepatology 2001 Feb;33(2):321-7. doi: 10.1053/jhep.2001.22112. PMID: 11172332

Prognosis

Acute hepatitis C virus infection: clinical update and remaining challenges.
Liu CH, Kao JH
Clin Mol Hepatol 2023 Jul;29(3):623-642. Epub 2023 Feb 20 doi: 10.3350/cmh.2022.0349. PMID: 36800699Free PMC Article
Hepatitis C in Poland in 2019.
Zakrzewska K, Stępień M, Rosińska M
Przegl Epidemiol 2021;75(3):379-389. doi: 10.32394/pe.75.35. PMID: 35170294
Current knowledge and future perspectives on acute hepatitis C infection.
Hullegie SJ, Arends JE, Rijnders BJ, Irving WL, Salmon D, Prins M, Wensing AM, Klenerman P, Leblebicioglu H, Boesecke C, Rockstroh JK, Hoepelman AI
Clin Microbiol Infect 2015 Aug;21(8):797.e9-797.e17. Epub 2015 Apr 16 doi: 10.1016/j.cmi.2015.03.026. PMID: 25892133
Acute hepatitis C.
Maheshwari A, Ray S, Thuluvath PJ
Lancet 2008 Jul 26;372(9635):321-32. doi: 10.1016/S0140-6736(08)61116-2. PMID: 18657711
Acute hepatitis C.
Orland JR, Wright TL, Cooper S
Hepatology 2001 Feb;33(2):321-7. doi: 10.1053/jhep.2001.22112. PMID: 11172332

Clinical prediction guides

Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019.
GBD 2019 Europe Hepatitis B & C Collaborators
Lancet Public Health 2023 Sep;8(9):e701-e716. doi: 10.1016/S2468-2667(23)00149-4. PMID: 37633679
Hepatitis C in Poland in 2020.
Zakrzewska K, Stępień M, Rosińska M
Przegl Epidemiol 2022;76(2):233-242. doi: 10.32394/pe.76.23. PMID: 36218178
Hepatitis C in Poland in 2019.
Zakrzewska K, Stępień M, Rosińska M
Przegl Epidemiol 2021;75(3):379-389. doi: 10.32394/pe.75.35. PMID: 35170294
Hepatitis C and pregnancy.
Floreani A
World J Gastroenterol 2013 Oct 28;19(40):6714-20. doi: 10.3748/wjg.v19.i40.6714. PMID: 24187446Free PMC Article
Acute hepatitis C: clinical aspects, diagnosis, and outcome of acute HCV infection.
Fabris P, Fleming VM, Giordani MT, Barnes E
Curr Pharm Des 2008;14(17):1661-5. doi: 10.2174/138161208784746789. PMID: 18673189

Recent systematic reviews

Pharmacological interventions for acute hepatitis C infection.
Kalafateli M, Buzzetti E, Thorburn D, Davidson BR, Tsochatzis E, Gurusamy KS
Cochrane Database Syst Rev 2018 Dec 3;12(12):CD011644. doi: 10.1002/14651858.CD011644.pub3. PMID: 30521693Free PMC Article
Pharmacological interventions for acute hepatitis C infection: an attempted network meta-analysis.
Kalafateli M, Buzzetti E, Thorburn D, Davidson BR, Tsochatzis E, Gurusamy KS
Cochrane Database Syst Rev 2017 Mar 13;3(3):CD011644. doi: 10.1002/14651858.CD011644.pub2. PMID: 28285495Free PMC Article
Case definitions for acute hepatitis C virus infection: a systematic review.
Hajarizadeh B, Grebely J, Dore GJ
J Hepatol 2012 Dec;57(6):1349-60. Epub 2012 Jul 14 doi: 10.1016/j.jhep.2012.07.007. PMID: 22796896
Acute hepatitis C: a systematic review.
Kamal SM
Am J Gastroenterol 2008 May;103(5):1283-97; quiz 1298. doi: 10.1111/j.1572-0241.2008.01825.x. PMID: 18477352
Spontaneous viral clearance following acute hepatitis C infection: a systematic review of longitudinal studies.
Micallef JM, Kaldor JM, Dore GJ
J Viral Hepat 2006 Jan;13(1):34-41. doi: 10.1111/j.1365-2893.2005.00651.x. PMID: 16364080

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