U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Acute hepatitis C

MedGen UID:
586482
Concept ID:
C0400914
Disease or Syndrome
Synonym: Acute Hepatitis C Infection
SNOMED CT: Acute hepatitis C (235866006)

Definition

A new infection by the hepatitis C virus, which can be detected in blood. Signs and symptoms may include right upper quadrant abdominal pain, jaundice, dark urine, white stools and nausea. Approximately 15%-25% individuals clear the virus from their bodies without treatment. 75%-85% individuals develop chronic hepatitis C. There are possible treatments depending on individual characteristics. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute hepatitis C

Professional guidelines

PubMed

Ambrosioni J, Levi L, Alagaratnam J, Van Bremen K, Mastrangelo A, Waalewijn H, Molina JM, Guaraldi G, Winston A, Boesecke C, Cinque P, Bamford A, Calmy A, Marzolini C, Martínez E, Oprea C, Welch S, Koval A, Mendao L, Rockstroh JK; EACS Governing Board
HIV Med 2023 Nov;24(11):1126-1136. Epub 2023 Oct 18 doi: 10.1111/hiv.13542. PMID: 37849432
Misra S, Dieterich DT, Saberi B, Kushner T
Expert Rev Anti Infect Ther 2018 Aug;16(8):599-610. Epub 2018 Aug 1 doi: 10.1080/14787210.2018.1505502. PMID: 30067402
Maheshwari A, Thuluvath PJ
Clin Liver Dis 2010 Feb;14(1):169-76; x. doi: 10.1016/j.cld.2009.11.007. PMID: 20123448

Recent clinical studies

Etiology

GBD 2019 Europe Hepatitis B & C Collaborators
Lancet Public Health 2023 Sep;8(9):e701-e716. doi: 10.1016/S2468-2667(23)00149-4. PMID: 37633679
Zakrzewska K, Stępień M, Rosińska M
Przegl Epidemiol 2022;76(2):233-242. doi: 10.32394/pe.76.23. PMID: 36218178
Page EE, Nelson M
Clin Med (Lond) 2016 Apr;16(2):189-92. doi: 10.7861/clinmedicine.16-2-189. PMID: 27037392Free PMC Article
Hullegie SJ, Arends JE, Rijnders BJ, Irving WL, Salmon D, Prins M, Wensing AM, Klenerman P, Leblebicioglu H, Boesecke C, Rockstroh JK, Hoepelman AI
Clin Microbiol Infect 2015 Aug;21(8):797.e9-797.e17. Epub 2015 Apr 16 doi: 10.1016/j.cmi.2015.03.026. PMID: 25892133
Maheshwari A, Ray S, Thuluvath PJ
Lancet 2008 Jul 26;372(9635):321-32. doi: 10.1016/S0140-6736(08)61116-2. PMID: 18657711

Diagnosis

Ambrosioni J, Levi L, Alagaratnam J, Van Bremen K, Mastrangelo A, Waalewijn H, Molina JM, Guaraldi G, Winston A, Boesecke C, Cinque P, Bamford A, Calmy A, Marzolini C, Martínez E, Oprea C, Welch S, Koval A, Mendao L, Rockstroh JK; EACS Governing Board
HIV Med 2023 Nov;24(11):1126-1136. Epub 2023 Oct 18 doi: 10.1111/hiv.13542. PMID: 37849432
Liu CH, Kao JH
Clin Mol Hepatol 2023 Jul;29(3):623-642. Epub 2023 Feb 20 doi: 10.3350/cmh.2022.0349. PMID: 36800699Free PMC Article
Page EE, Nelson M
Clin Med (Lond) 2016 Apr;16(2):189-92. doi: 10.7861/clinmedicine.16-2-189. PMID: 27037392Free PMC Article
Maheshwari A, Ray S, Thuluvath PJ
Lancet 2008 Jul 26;372(9635):321-32. doi: 10.1016/S0140-6736(08)61116-2. PMID: 18657711
Orland JR, Wright TL, Cooper S
Hepatology 2001 Feb;33(2):321-7. doi: 10.1053/jhep.2001.22112. PMID: 11172332

Therapy

Ambrosioni J, Levi L, Alagaratnam J, Van Bremen K, Mastrangelo A, Waalewijn H, Molina JM, Guaraldi G, Winston A, Boesecke C, Cinque P, Bamford A, Calmy A, Marzolini C, Martínez E, Oprea C, Welch S, Koval A, Mendao L, Rockstroh JK; EACS Governing Board
HIV Med 2023 Nov;24(11):1126-1136. Epub 2023 Oct 18 doi: 10.1111/hiv.13542. PMID: 37849432
Liu CH, Kao JH
Clin Mol Hepatol 2023 Jul;29(3):623-642. Epub 2023 Feb 20 doi: 10.3350/cmh.2022.0349. PMID: 36800699Free PMC Article
Hullegie SJ, Arends JE, Rijnders BJ, Irving WL, Salmon D, Prins M, Wensing AM, Klenerman P, Leblebicioglu H, Boesecke C, Rockstroh JK, Hoepelman AI
Clin Microbiol Infect 2015 Aug;21(8):797.e9-797.e17. Epub 2015 Apr 16 doi: 10.1016/j.cmi.2015.03.026. PMID: 25892133
Maheshwari A, Ray S, Thuluvath PJ
Lancet 2008 Jul 26;372(9635):321-32. doi: 10.1016/S0140-6736(08)61116-2. PMID: 18657711
Orland JR, Wright TL, Cooper S
Hepatology 2001 Feb;33(2):321-7. doi: 10.1053/jhep.2001.22112. PMID: 11172332

Prognosis

Liu CH, Kao JH
Clin Mol Hepatol 2023 Jul;29(3):623-642. Epub 2023 Feb 20 doi: 10.3350/cmh.2022.0349. PMID: 36800699Free PMC Article
Zakrzewska K, Stępień M, Rosińska M
Przegl Epidemiol 2021;75(3):379-389. doi: 10.32394/pe.75.35. PMID: 35170294
Hullegie SJ, Arends JE, Rijnders BJ, Irving WL, Salmon D, Prins M, Wensing AM, Klenerman P, Leblebicioglu H, Boesecke C, Rockstroh JK, Hoepelman AI
Clin Microbiol Infect 2015 Aug;21(8):797.e9-797.e17. Epub 2015 Apr 16 doi: 10.1016/j.cmi.2015.03.026. PMID: 25892133
Maheshwari A, Ray S, Thuluvath PJ
Lancet 2008 Jul 26;372(9635):321-32. doi: 10.1016/S0140-6736(08)61116-2. PMID: 18657711
Orland JR, Wright TL, Cooper S
Hepatology 2001 Feb;33(2):321-7. doi: 10.1053/jhep.2001.22112. PMID: 11172332

Clinical prediction guides

GBD 2019 Europe Hepatitis B & C Collaborators
Lancet Public Health 2023 Sep;8(9):e701-e716. doi: 10.1016/S2468-2667(23)00149-4. PMID: 37633679
Zakrzewska K, Stępień M, Rosińska M
Przegl Epidemiol 2022;76(2):233-242. doi: 10.32394/pe.76.23. PMID: 36218178
Zakrzewska K, Stępień M, Rosińska M
Przegl Epidemiol 2021;75(3):379-389. doi: 10.32394/pe.75.35. PMID: 35170294
Floreani A
World J Gastroenterol 2013 Oct 28;19(40):6714-20. doi: 10.3748/wjg.v19.i40.6714. PMID: 24187446Free PMC Article
Fabris P, Fleming VM, Giordani MT, Barnes E
Curr Pharm Des 2008;14(17):1661-5. doi: 10.2174/138161208784746789. PMID: 18673189

Recent systematic reviews

Kalafateli M, Buzzetti E, Thorburn D, Davidson BR, Tsochatzis E, Gurusamy KS
Cochrane Database Syst Rev 2018 Dec 3;12(12):CD011644. doi: 10.1002/14651858.CD011644.pub3. PMID: 30521693Free PMC Article
Kalafateli M, Buzzetti E, Thorburn D, Davidson BR, Tsochatzis E, Gurusamy KS
Cochrane Database Syst Rev 2017 Mar 13;3(3):CD011644. doi: 10.1002/14651858.CD011644.pub2. PMID: 28285495Free PMC Article
Yaphe S, Bozinoff N, Kyle R, Shivkumar S, Pai NP, Klein M
Sex Transm Infect 2012 Nov;88(7):558-64. Epub 2012 Aug 2 doi: 10.1136/sextrans-2012-050566. PMID: 22859499
Hajarizadeh B, Grebely J, Dore GJ
J Hepatol 2012 Dec;57(6):1349-60. Epub 2012 Jul 14 doi: 10.1016/j.jhep.2012.07.007. PMID: 22796896
Kamal SM
Am J Gastroenterol 2008 May;103(5):1283-97; quiz 1298. doi: 10.1111/j.1572-0241.2008.01825.x. PMID: 18477352

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...