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Acute hepatitis C

MedGen UID:
586482
•Concept ID:
C0400914
•
Disease or Syndrome
Synonym: Acute Hepatitis C Infection
SNOMED CT: Acute hepatitis C (235866006)

Definition

A new infection by the hepatitis C virus, which can be detected in blood. Signs and symptoms may include right upper quadrant abdominal pain, jaundice, dark urine, white stools and nausea. Approximately 15%-25% individuals clear the virus from their bodies without treatment. 75%-85% individuals develop chronic hepatitis C. There are possible treatments depending on individual characteristics. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute hepatitis C

Professional guidelines

PubMed

Major revision version 12.0 of the European AIDS Clinical Society guidelines 2023.
Ambrosioni J, Levi L, Alagaratnam J, Van Bremen K, Mastrangelo A, Waalewijn H, Molina JM, Guaraldi G, Winston A, Boesecke C, Cinque P, Bamford A, Calmy A, Marzolini C, Martínez E, Oprea C, Welch S, Koval A, Mendao L, Rockstroh JK; EACS Governing Board
HIV Med 2023 Nov;24(11):1126-1136. Epub 2023 Oct 18 doi: 10.1111/hiv.13542. PMID: 37849432
Direct-acting antiviral treatment of acute hepatitis C virus infections.
Misra S, Dieterich DT, Saberi B, Kushner T
Expert Rev Anti Infect Ther 2018 Aug;16(8):599-610. Epub 2018 Aug 1 doi: 10.1080/14787210.2018.1505502. PMID: 30067402
Management of acute hepatitis C.
Maheshwari A, Thuluvath PJ
Clin Liver Dis 2010 Feb;14(1):169-76; x. doi: 10.1016/j.cld.2009.11.007. PMID: 20123448

Recent clinical studies

Etiology

Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019.
GBD 2019 Europe Hepatitis B & C Collaborators
Lancet Public Health 2023 Sep;8(9):e701-e716. doi: 10.1016/S2468-2667(23)00149-4. PMID: 37633679Free PMC Article
Interventions to reduce acute hepatitis C virus in HIV-positive MSM.
Elliott T, Cooke GS, Garvey L
Curr Opin Infect Dis 2020 Feb;33(1):1-9. doi: 10.1097/QCO.0000000000000614. PMID: 31789696
Direct-acting antiviral treatment of acute hepatitis C virus infections.
Misra S, Dieterich DT, Saberi B, Kushner T
Expert Rev Anti Infect Ther 2018 Aug;16(8):599-610. Epub 2018 Aug 1 doi: 10.1080/14787210.2018.1505502. PMID: 30067402
Current knowledge and future perspectives on acute hepatitis C infection.
Hullegie SJ, Arends JE, Rijnders BJ, Irving WL, Salmon D, Prins M, Wensing AM, Klenerman P, Leblebicioglu H, Boesecke C, Rockstroh JK, Hoepelman AI
Clin Microbiol Infect 2015 Aug;21(8):797.e9-797.e17. Epub 2015 Apr 16 doi: 10.1016/j.cmi.2015.03.026. PMID: 25892133
Acute hepatitis C.
Maheshwari A, Ray S, Thuluvath PJ
Lancet 2008 Jul 26;372(9635):321-32. doi: 10.1016/S0140-6736(08)61116-2. PMID: 18657711

Diagnosis

Major revision version 12.0 of the European AIDS Clinical Society guidelines 2023.
Ambrosioni J, Levi L, Alagaratnam J, Van Bremen K, Mastrangelo A, Waalewijn H, Molina JM, Guaraldi G, Winston A, Boesecke C, Cinque P, Bamford A, Calmy A, Marzolini C, Martínez E, Oprea C, Welch S, Koval A, Mendao L, Rockstroh JK; EACS Governing Board
HIV Med 2023 Nov;24(11):1126-1136. Epub 2023 Oct 18 doi: 10.1111/hiv.13542. PMID: 37849432
Acute hepatitis C virus infection: clinical update and remaining challenges.
Liu CH, Kao JH
Clin Mol Hepatol 2023 Jul;29(3):623-642. Epub 2023 Feb 20 doi: 10.3350/cmh.2022.0349. PMID: 36800699Free PMC Article
Hepatitis C in Poland in 2019.
Zakrzewska K, Stępień M, Rosińska M
Przegl Epidemiol 2021;75(3):379-389. doi: 10.32394/pe.75.35. PMID: 35170294
Current knowledge and future perspectives on acute hepatitis C infection.
Hullegie SJ, Arends JE, Rijnders BJ, Irving WL, Salmon D, Prins M, Wensing AM, Klenerman P, Leblebicioglu H, Boesecke C, Rockstroh JK, Hoepelman AI
Clin Microbiol Infect 2015 Aug;21(8):797.e9-797.e17. Epub 2015 Apr 16 doi: 10.1016/j.cmi.2015.03.026. PMID: 25892133
Acute hepatitis C.
Maheshwari A, Ray S, Thuluvath PJ
Lancet 2008 Jul 26;372(9635):321-32. doi: 10.1016/S0140-6736(08)61116-2. PMID: 18657711

Therapy

Major revision version 12.0 of the European AIDS Clinical Society guidelines 2023.
Ambrosioni J, Levi L, Alagaratnam J, Van Bremen K, Mastrangelo A, Waalewijn H, Molina JM, Guaraldi G, Winston A, Boesecke C, Cinque P, Bamford A, Calmy A, Marzolini C, Martínez E, Oprea C, Welch S, Koval A, Mendao L, Rockstroh JK; EACS Governing Board
HIV Med 2023 Nov;24(11):1126-1136. Epub 2023 Oct 18 doi: 10.1111/hiv.13542. PMID: 37849432
Acute hepatitis C virus infection: clinical update and remaining challenges.
Liu CH, Kao JH
Clin Mol Hepatol 2023 Jul;29(3):623-642. Epub 2023 Feb 20 doi: 10.3350/cmh.2022.0349. PMID: 36800699Free PMC Article
Interventions to reduce acute hepatitis C virus in HIV-positive MSM.
Elliott T, Cooke GS, Garvey L
Curr Opin Infect Dis 2020 Feb;33(1):1-9. doi: 10.1097/QCO.0000000000000614. PMID: 31789696
Current knowledge and future perspectives on acute hepatitis C infection.
Hullegie SJ, Arends JE, Rijnders BJ, Irving WL, Salmon D, Prins M, Wensing AM, Klenerman P, Leblebicioglu H, Boesecke C, Rockstroh JK, Hoepelman AI
Clin Microbiol Infect 2015 Aug;21(8):797.e9-797.e17. Epub 2015 Apr 16 doi: 10.1016/j.cmi.2015.03.026. PMID: 25892133
Acute hepatitis C.
Maheshwari A, Ray S, Thuluvath PJ
Lancet 2008 Jul 26;372(9635):321-32. doi: 10.1016/S0140-6736(08)61116-2. PMID: 18657711

Prognosis

Acute hepatitis C virus infection: clinical update and remaining challenges.
Liu CH, Kao JH
Clin Mol Hepatol 2023 Jul;29(3):623-642. Epub 2023 Feb 20 doi: 10.3350/cmh.2022.0349. PMID: 36800699Free PMC Article
Hepatitis C in Poland in 2019.
Zakrzewska K, Stępień M, Rosińska M
Przegl Epidemiol 2021;75(3):379-389. doi: 10.32394/pe.75.35. PMID: 35170294
Interventions to reduce acute hepatitis C virus in HIV-positive MSM.
Elliott T, Cooke GS, Garvey L
Curr Opin Infect Dis 2020 Feb;33(1):1-9. doi: 10.1097/QCO.0000000000000614. PMID: 31789696
Current knowledge and future perspectives on acute hepatitis C infection.
Hullegie SJ, Arends JE, Rijnders BJ, Irving WL, Salmon D, Prins M, Wensing AM, Klenerman P, Leblebicioglu H, Boesecke C, Rockstroh JK, Hoepelman AI
Clin Microbiol Infect 2015 Aug;21(8):797.e9-797.e17. Epub 2015 Apr 16 doi: 10.1016/j.cmi.2015.03.026. PMID: 25892133
Acute hepatitis C.
Maheshwari A, Ray S, Thuluvath PJ
Lancet 2008 Jul 26;372(9635):321-32. doi: 10.1016/S0140-6736(08)61116-2. PMID: 18657711

Clinical prediction guides

Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019.
GBD 2019 Europe Hepatitis B & C Collaborators
Lancet Public Health 2023 Sep;8(9):e701-e716. doi: 10.1016/S2468-2667(23)00149-4. PMID: 37633679Free PMC Article
Hepatitis C in Poland in 2020.
Zakrzewska K, Stępień M, Rosińska M
Przegl Epidemiol 2022;76(2):233-242. doi: 10.32394/pe.76.23. PMID: 36218178
Hepatitis C in Poland in 2019.
Zakrzewska K, Stępień M, Rosińska M
Przegl Epidemiol 2021;75(3):379-389. doi: 10.32394/pe.75.35. PMID: 35170294
Natural history of hepatitis C.
Westbrook RH, Dusheiko G
J Hepatol 2014 Nov;61(1 Suppl):S58-68. Epub 2014 Nov 3 doi: 10.1016/j.jhep.2014.07.012. PMID: 25443346
Hepatitis C and pregnancy.
Floreani A
World J Gastroenterol 2013 Oct 28;19(40):6714-20. doi: 10.3748/wjg.v19.i40.6714. PMID: 24187446Free PMC Article

Recent systematic reviews

Pharmacological interventions for acute hepatitis C infection.
Kalafateli M, Buzzetti E, Thorburn D, Davidson BR, Tsochatzis E, Gurusamy KS
Cochrane Database Syst Rev 2018 Dec 3;12(12):CD011644. doi: 10.1002/14651858.CD011644.pub3. PMID: 30521693Free PMC Article
Pharmacological interventions for acute hepatitis C infection: an attempted network meta-analysis.
Kalafateli M, Buzzetti E, Thorburn D, Davidson BR, Tsochatzis E, Gurusamy KS
Cochrane Database Syst Rev 2017 Mar 13;3(3):CD011644. doi: 10.1002/14651858.CD011644.pub2. PMID: 28285495Free PMC Article
Case definitions for acute hepatitis C virus infection: a systematic review.
Hajarizadeh B, Grebely J, Dore GJ
J Hepatol 2012 Dec;57(6):1349-60. Epub 2012 Jul 14 doi: 10.1016/j.jhep.2012.07.007. PMID: 22796896
Acute hepatitis C: a systematic review.
Kamal SM
Am J Gastroenterol 2008 May;103(5):1283-97; quiz 1298. doi: 10.1111/j.1572-0241.2008.01825.x. PMID: 18477352
Spontaneous viral clearance following acute hepatitis C infection: a systematic review of longitudinal studies.
Micallef JM, Kaldor JM, Dore GJ
J Viral Hepat 2006 Jan;13(1):34-41. doi: 10.1111/j.1365-2893.2005.00651.x. PMID: 16364080

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