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Labyrinthitis

MedGen UID:
5991
•Concept ID:
C0022893
•
Disease or Syndrome
Synonyms: Labyrinthitides; Otitis Interna
SNOMED CT: Labyrinthitis (23919004)
 
Monarch Initiative: MONDO:0002008

Definition

Inflammation of the anatomical structures of the inner ear secondary to an infectious process. Symptoms include severe vertigo, nausea, vomiting, anxiety, and pain. Viral etiology is most common, and recent history of an upper respiratory infection is common. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLabyrinthitis

Professional guidelines

PubMed

Vertigo and dizziness in childhood - update on diagnosis and treatment.
Jahn K, Langhagen T, Schroeder AS, Heinen F
Neuropediatrics 2011 Aug;42(4):129-34. Epub 2011 Jul 15 doi: 10.1055/s-0031-1283158. PMID: 21766267
Treatment of vertigo.
Swartz R, Longwell P
Am Fam Physician 2005 Mar 15;71(6):1115-22. PMID: 15791890
CT diagnosis and differential diagnosis of otodystrophic lesions of the temporal bone.
d'Archambeau O, Parizel PM, Koekelkoren E, Van de Heyning P, De Schepper AM
Eur J Radiol 1990 Jul-Aug;11(1):22-30. doi: 10.1016/0720-048x(90)90098-v. PMID: 2397727

Recent clinical studies

Etiology

Acute mastoiditis in children.
Cassano P, Ciprandi G, Passali D
Acta Biomed 2020 Feb 17;91(1-S):54-59. doi: 10.23750/abm.v91i1-S.9259. PMID: 32073562Free PMC Article
Deterioration of Vestibular Cells in Labyrinthitis.
Kaya S, Schachern PA, Tsuprun V, Paparella MM, Cureoglu S
Ann Otol Rhinol Laryngol 2017 Feb;126(2):89-95. Epub 2016 Nov 24 doi: 10.1177/0003489416675356. PMID: 27881797
Inferior vestibular neuritis.
Kim JS, Kim HJ
J Neurol 2012 Aug;259(8):1553-60. Epub 2012 Jan 4 doi: 10.1007/s00415-011-6375-4. PMID: 22215238
Mastoidectomy in the elderly.
Migirov L, Weissburd S, Wolf M
ORL J Otorhinolaryngol Relat Spec 2010;72(2):80-3. Epub 2010 May 1 doi: 10.1159/000296137. PMID: 20431317
Human cytomegalovirus labyrinthitis.
Strauss M
Am J Otolaryngol 1990 Sep-Oct;11(5):292-8. doi: 10.1016/0196-0709(90)90057-3. PMID: 2176062

Diagnosis

Dizziness demystified.
Welgampola MS, Young AS, Pogson JM, Bradshaw AP, Halmagyi GM
Pract Neurol 2019 Dec;19(6):492-501. Epub 2019 Jul 20 doi: 10.1136/practneurol-2019-002199. PMID: 31326945
Dizziness.
Whitman GT
Am J Med 2018 Dec;131(12):1431-1437. Epub 2018 Jun 1 doi: 10.1016/j.amjmed.2018.05.014. PMID: 29859806
An approach to vertigo in general practice.
Dommaraju S, Perera E
Aust Fam Physician 2016 Apr;45(4):190-4. PMID: 27052132
Dizziness and vertigo.
Wipperman J
Prim Care 2014 Mar;41(1):115-31. doi: 10.1016/j.pop.2013.10.004. PMID: 24439886
Dizziness: a diagnostic approach.
Post RE, Dickerson LM
Am Fam Physician 2010 Aug 15;82(4):361-8, 369. PMID: 20704166

Therapy

Acute mastoiditis in children.
Cassano P, Ciprandi G, Passali D
Acta Biomed 2020 Feb 17;91(1-S):54-59. doi: 10.23750/abm.v91i1-S.9259. PMID: 32073562Free PMC Article
Contemporary surgical issues in paediatric cochlear implantation.
Wasson JD, Briggs RJ
Int J Audiol 2016;55 Suppl 2:S77-87. Epub 2016 Jun 7 doi: 10.1080/14992027.2016.1184765. PMID: 27266370
Nitrogen and oxygen molecules in meningitis-associated labyrinthitis and hearing impairment.
Klein M, Koedel U, Kastenbauer S, Pfister HW
Infection 2008 Feb;36(1):2-14. Epub 2007 Dec 14 doi: 10.1007/s15010-007-7153-1. PMID: 18084715
Tuberculous petrous apicitis.
Kearns DB, Coker NJ, Pitcock JK, Jenkins HA
Arch Otolaryngol 1985 Jun;111(6):406-8. doi: 10.1001/archotol.1985.00800080092014. PMID: 4004640
Pathophysiology of endolymphatic hydrops.
Schuknecht HF
Arch Otorhinolaryngol 1976 Sep 16;212(4):253-62. doi: 10.1007/BF00453673. PMID: 1086664

Prognosis

Idiopathic Labyrinthitis: Symptoms, Clinical Characteristics, and Prognosis.
Oussoren FK, Schermer TR, Bruintjes TD, Leeuwen RBV
J Int Adv Otol 2023 Nov;19(6):478-484. doi: 10.5152/iao.2023.231096. PMID: 38088320Free PMC Article
Non-Syndromic Sensorineural Hearing Loss in Children.
Robson CD, Lewis M, D'Arco F
Neuroimaging Clin N Am 2023 Nov;33(4):531-542. Epub 2023 Jul 11 doi: 10.1016/j.nic.2023.05.005. PMID: 37741656
Acute mastoiditis in children.
Cassano P, Ciprandi G, Passali D
Acta Biomed 2020 Feb 17;91(1-S):54-59. doi: 10.23750/abm.v91i1-S.9259. PMID: 32073562Free PMC Article
Positional dizziness.
Fife TD
Continuum (Minneap Minn) 2012 Oct;18(5 Neuro-otology):1060-85. doi: 10.1212/01.CON.0000418376.80099.24. PMID: 23042060
Mastoidectomy in the elderly.
Migirov L, Weissburd S, Wolf M
ORL J Otorhinolaryngol Relat Spec 2010;72(2):80-3. Epub 2010 May 1 doi: 10.1159/000296137. PMID: 20431317

Clinical prediction guides

Idiopathic Labyrinthitis: Symptoms, Clinical Characteristics, and Prognosis.
Oussoren FK, Schermer TR, Bruintjes TD, Leeuwen RBV
J Int Adv Otol 2023 Nov;19(6):478-484. doi: 10.5152/iao.2023.231096. PMID: 38088320Free PMC Article
Spontaneous Labyrinthine Hemorrhage: A Case Series.
Vivas EX, Panella NJ, Baugnon KL
Otolaryngol Head Neck Surg 2018 Nov;159(5):908-913. Epub 2018 Jul 3 doi: 10.1177/0194599818785900. PMID: 29966483
Significance of spiral ligament fibrocytes with cochlear inflammation.
Ichimiya I, Yoshida K, Hirano T, Suzuki M, Mogi G
Int J Pediatr Otorhinolaryngol 2000 Nov 30;56(1):45-51. doi: 10.1016/s0165-5876(00)00408-0. PMID: 11074115
Human cytomegalovirus labyrinthitis.
Strauss M
Am J Otolaryngol 1990 Sep-Oct;11(5):292-8. doi: 10.1016/0196-0709(90)90057-3. PMID: 2176062
Congenital cytomegalovirus and hearing loss: clinical and experimental observations.
Davis GL
Laryngoscope 1979 Oct;89(10 Pt 1):1681-8. doi: 10.1002/lary.5540891017. PMID: 228136

Recent systematic reviews

Association of Vestibular Disorders and Cognitive Function: A Systematic Review.
Li J, Xu X, Deng X, Li S, Guo T, Xie H
Laryngoscope 2024 Dec;134(12):4858-4872. Epub 2024 Jul 17 doi: 10.1002/lary.31646. PMID: 39016124
Plectranthus Species with Anti-Inflammatory and Analgesic Potential: A Systematic Review on Ethnobotanical and Pharmacological Findings.
Barbosa MO, Wilairatana P, Leite GML, Delmondes GA, Silva LYSD, Júnior SCA, Dantas LBR, Bezerra DS, Beltrão ICSL, Dias DQ, Ribeiro-Filho J, Felipe CFB, Coutinho HDM, Menezes IRA, Kerntopf Mendonça MR
Molecules 2023 Jul 26;28(15) doi: 10.3390/molecules28155653. PMID: 37570622Free PMC Article
Aetiology of Ludwig van Beethoven's hearing impairment: hypotheses over the past 100 years - A systematic review.
Thomas JP, Dazert S, Prescher A, Voelter C
Eur Arch Otorhinolaryngol 2021 Aug;278(8):2703-2712. Epub 2020 Nov 23 doi: 10.1007/s00405-020-06467-w. PMID: 33230590Free PMC Article
Cochlear implantation versus auditory brainstem implantation in bilateral total deafness after head trauma: personal experience and review of the literature.
Medina M, Di Lella F, Di Trapani G, Prasad SC, Bacciu A, Aristegui M, Russo A, Sanna M
Otol Neurotol 2014 Feb;35(2):260-70. doi: 10.1097/MAO.0000000000000235. PMID: 24448286
Antibiotic prophylaxis in clean and clean-contaminated ear surgery.
Verschuur HP, de Wever WW, van Benthem PP
Cochrane Database Syst Rev 2004;2004(3):CD003996. doi: 10.1002/14651858.CD003996.pub2. PMID: 15266512Free PMC Article

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