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Endotheliitis

MedGen UID:
602202
•Concept ID:
C0423262
•
Disease or Syndrome
Synonyms: Corneal endothelialitis; Corneal endotheliitis; Corneal endotheliolitis; endotheliitis; endothelium inflammation; inflammation of endothelium
SNOMED CT: Corneal endotheliolitis (373425009); Corneal endotheliitis (373425009); Corneal endothelialitis (373425009)
 
Monarch Initiative: MONDO:0015292
Orphanet: ORPHA137602

Definition

A rare corneal disorder characterized by inflammation of the corneal endothelium with corneal edema, keratic precipitates, mild to moderate anterior chamber reaction, and subsequent visual disturbances. It is often associated with increased intraocular pressure. Based on the distribution of the lesions, a linear, sectorial, disciform, and diffuse form can be distinguished. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndotheliitis

Professional guidelines

PubMed

Clinical characteristics and treatment outcomes of cytomegalovirus anterior uveitis and endotheliitis: A systematic review and meta-analysis.
La Distia Nora R, Putera I, Mayasari YD, Hikmahwati W, Pertiwi AM, Ridwan AS, Sitompul R, Westcott M, Chee SP, Pavesio C, Thng ZX, Gupta V, Agrawal R
Surv Ophthalmol 2022 Jul-Aug;67(4):1014-1030. Epub 2021 Dec 23 doi: 10.1016/j.survophthal.2021.12.006. PMID: 34954093
Advances in the diagnosis and treatment of disseminated intravascular coagulation in haematological malignancies.
Ikezoe T
Int J Hematol 2021 Jan;113(1):34-44. Epub 2020 Sep 9 doi: 10.1007/s12185-020-02992-w. PMID: 32902759
Coronavirus disease 2019: investigational therapies in the prevention and treatment of hyperinflammation.
Amigues I, Pearlman AH, Patel A, Reid P, Robinson PC, Sinha R, Kim AH, Youngstein T, Jayatilleke A, Konig M
Expert Rev Clin Immunol 2020 Dec;16(12):1185-1204. Epub 2020 Nov 25 doi: 10.1080/1744666X.2021.1847084. PMID: 33146561Free PMC Article

Recent clinical studies

Etiology

Mid-Regional Pro-Adrenomedullin Can Predict Organ Failure and Prognosis in Sepsis?
Spoto S, Basili S, Cangemi R, D'Avanzo G, Lupoi DM, Romiti GF, Argemi J, Yuste JR, Lucena F, Locorriere L, Masini F, Testorio G, Calarco R, Fogolari M, Francesconi M, Battifoglia G, Costantino S, Angeletti S
Int J Mol Sci 2023 Dec 13;24(24) doi: 10.3390/ijms242417429. PMID: 38139258Free PMC Article
Hepatitic Variant of Graft-vs-Host Disease.
Liang TZ, Dong S, Fang M, Gong Y, Yaghmour G, Chopra S
Am J Clin Pathol 2022 Jun 7;157(6):948-955. doi: 10.1093/ajcp/aqab215. PMID: 35038720
COVID-19 and coagulopathy.
Sarkar M, Madabhavi IV, Quy PN, Govindagoudar MB
Clin Respir J 2021 Dec;15(12):1259-1274. Epub 2021 Aug 30 doi: 10.1111/crj.13438. PMID: 34399021Free PMC Article
Coronavirus disease-19: The multi-level, multi-faceted vasculopathy.
Quinaglia T, Shabani M, Breder I, Silber HA, Lima JAC, Sposito AC
Atherosclerosis 2021 Apr;322:39-50. Epub 2021 Feb 15 doi: 10.1016/j.atherosclerosis.2021.02.009. PMID: 33706082Free PMC Article
Review of clinical and basic approaches to corneal endotheliitis.
Inoue Y
Cornea 2014 Nov;33 Suppl 11:S3-8. doi: 10.1097/ICO.0000000000000228. PMID: 25170583

Diagnosis

Overview and update on cytomegalovirus-associated anterior uveitis and glaucoma.
Ye Z, Yang Y, Ke W, Li Y, Wang K, Chen M
Front Public Health 2023;11:1117412. Epub 2023 Mar 1 doi: 10.3389/fpubh.2023.1117412. PMID: 36935679Free PMC Article
Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS).
Haffke M, Freitag H, Rudolf G, Seifert M, Doehner W, Scherbakov N, Hanitsch L, Wittke K, Bauer S, Konietschke F, Paul F, Bellmann-Strobl J, Kedor C, Scheibenbogen C, Sotzny F
J Transl Med 2022 Mar 22;20(1):138. doi: 10.1186/s12967-022-03346-2. PMID: 35317812Free PMC Article
Clinical characteristics and treatment outcomes of cytomegalovirus anterior uveitis and endotheliitis: A systematic review and meta-analysis.
La Distia Nora R, Putera I, Mayasari YD, Hikmahwati W, Pertiwi AM, Ridwan AS, Sitompul R, Westcott M, Chee SP, Pavesio C, Thng ZX, Gupta V, Agrawal R
Surv Ophthalmol 2022 Jul-Aug;67(4):1014-1030. Epub 2021 Dec 23 doi: 10.1016/j.survophthal.2021.12.006. PMID: 34954093
Characterization of liver injury induced by cancer immunotherapy using immune checkpoint inhibitors.
De Martin E, Michot JM, Papouin B, Champiat S, Mateus C, Lambotte O, Roche B, Antonini TM, Coilly A, Laghouati S, Robert C, Marabelle A, Guettier C, Samuel D
J Hepatol 2018 Jun;68(6):1181-1190. Epub 2018 Feb 8 doi: 10.1016/j.jhep.2018.01.033. PMID: 29427729
Review of clinical and basic approaches to corneal endotheliitis.
Inoue Y
Cornea 2014 Nov;33 Suppl 11:S3-8. doi: 10.1097/ICO.0000000000000228. PMID: 25170583

Therapy

Vascular endotheliitis associated with infections: Its pathogenetic role and therapeutic implication.
Hattori Y, Hattori K, Machida T, Matsuda N
Biochem Pharmacol 2022 Mar;197:114909. Epub 2022 Jan 10 doi: 10.1016/j.bcp.2022.114909. PMID: 35021044Free PMC Article
Clinical characteristics and treatment outcomes of cytomegalovirus anterior uveitis and endotheliitis: A systematic review and meta-analysis.
La Distia Nora R, Putera I, Mayasari YD, Hikmahwati W, Pertiwi AM, Ridwan AS, Sitompul R, Westcott M, Chee SP, Pavesio C, Thng ZX, Gupta V, Agrawal R
Surv Ophthalmol 2022 Jul-Aug;67(4):1014-1030. Epub 2021 Dec 23 doi: 10.1016/j.survophthal.2021.12.006. PMID: 34954093
Characterization of liver injury induced by cancer immunotherapy using immune checkpoint inhibitors.
De Martin E, Michot JM, Papouin B, Champiat S, Mateus C, Lambotte O, Roche B, Antonini TM, Coilly A, Laghouati S, Robert C, Marabelle A, Guettier C, Samuel D
J Hepatol 2018 Jun;68(6):1181-1190. Epub 2018 Feb 8 doi: 10.1016/j.jhep.2018.01.033. PMID: 29427729
Review of clinical and basic approaches to corneal endotheliitis.
Inoue Y
Cornea 2014 Nov;33 Suppl 11:S3-8. doi: 10.1097/ICO.0000000000000228. PMID: 25170583
Linear endotheliitis.
Olsen TW, Hardten DR, Meiusi RS, Holland EJ
Am J Ophthalmol 1994 Apr 15;117(4):468-74. doi: 10.1016/s0002-9394(14)70006-6. PMID: 8154528

Prognosis

Mid-Regional Pro-Adrenomedullin Can Predict Organ Failure and Prognosis in Sepsis?
Spoto S, Basili S, Cangemi R, D'Avanzo G, Lupoi DM, Romiti GF, Argemi J, Yuste JR, Lucena F, Locorriere L, Masini F, Testorio G, Calarco R, Fogolari M, Francesconi M, Battifoglia G, Costantino S, Angeletti S
Int J Mol Sci 2023 Dec 13;24(24) doi: 10.3390/ijms242417429. PMID: 38139258Free PMC Article
Hepatitic Variant of Graft-vs-Host Disease.
Liang TZ, Dong S, Fang M, Gong Y, Yaghmour G, Chopra S
Am J Clin Pathol 2022 Jun 7;157(6):948-955. doi: 10.1093/ajcp/aqab215. PMID: 35038720
Coronavirus disease 2019 and stroke.
Leslie-Mazwi TM, Srivatanakul K
Interv Neuroradiol 2021 Oct;27(1_suppl):13-18. Epub 2021 Oct 20 doi: 10.1177/15910199211035920. PMID: 34670419Free PMC Article
COVID-19 and the clinical course of rheumatic manifestations.
Ahmed S, Zimba O, Gasparyan AY
Clin Rheumatol 2021 Jul;40(7):2611-2619. Epub 2021 Mar 17 doi: 10.1007/s10067-021-05691-x. PMID: 33733315Free PMC Article
Myocarditis in COVID-19 patients: current problems.
Mele D, Flamigni F, Rapezzi C, Ferrari R
Intern Emerg Med 2021 Aug;16(5):1123-1129. Epub 2021 Jan 23 doi: 10.1007/s11739-021-02635-w. PMID: 33484452Free PMC Article

Clinical prediction guides

Mid-Regional Pro-Adrenomedullin Can Predict Organ Failure and Prognosis in Sepsis?
Spoto S, Basili S, Cangemi R, D'Avanzo G, Lupoi DM, Romiti GF, Argemi J, Yuste JR, Lucena F, Locorriere L, Masini F, Testorio G, Calarco R, Fogolari M, Francesconi M, Battifoglia G, Costantino S, Angeletti S
Int J Mol Sci 2023 Dec 13;24(24) doi: 10.3390/ijms242417429. PMID: 38139258Free PMC Article
Autopsy-Based Pulmonary and Vascular Pathology: Pulmonary Endotheliitis and Multi-Organ Involvement in COVID-19 Associated Deaths.
Haberecker M, Schwarz EI, Steiger P, Frontzek K, Scholkmann F, Zeng X, Höller S, Moch H, Varga Z
Respiration 2022;101(2):155-165. Epub 2021 Sep 15 doi: 10.1159/000518914. PMID: 34525475Free PMC Article
COVID-19 and the clinical course of rheumatic manifestations.
Ahmed S, Zimba O, Gasparyan AY
Clin Rheumatol 2021 Jul;40(7):2611-2619. Epub 2021 Mar 17 doi: 10.1007/s10067-021-05691-x. PMID: 33733315Free PMC Article
Obesity, Nutrients and the Immune System in the Era of COVID-19.
De Bandt JP, Monin C
Nutrients 2021 Feb 13;13(2) doi: 10.3390/nu13020610. PMID: 33668493Free PMC Article
Bilateral herpetic keratoconjunctivitis.
Souza PM, Holland EJ, Huang AJ
Ophthalmology 2003 Mar;110(3):493-6. doi: 10.1016/S0161-6420(02)01772-4. PMID: 12623810

Recent systematic reviews

Postmortem Histopathologic Findings and SARS-CoV-2 Detection in Autopsy Kidneys of Patients With COVID-19: A Systematic Review and Meta-Analysis.
Mahjani M, Parvin M, Ghobadi S, Jafari A, Ahangar H, Gohari S, Gohari S
Am J Clin Pathol 2023 May 2;159(5):429-436. doi: 10.1093/ajcp/aqad001. PMID: 36869828
COVID-19 Vasculitis and vasculopathy-Distinct immunopathology emerging from the close juxtaposition of Type II Pneumocytes and Pulmonary Endothelial Cells.
Giryes S, Bragazzi NL, Bridgewood C, De Marco G, McGonagle D
Semin Immunopathol 2022 May;44(3):375-390. Epub 2022 Apr 12 doi: 10.1007/s00281-022-00928-6. PMID: 35412072Free PMC Article
Clinical characteristics and treatment outcomes of cytomegalovirus anterior uveitis and endotheliitis: A systematic review and meta-analysis.
La Distia Nora R, Putera I, Mayasari YD, Hikmahwati W, Pertiwi AM, Ridwan AS, Sitompul R, Westcott M, Chee SP, Pavesio C, Thng ZX, Gupta V, Agrawal R
Surv Ophthalmol 2022 Jul-Aug;67(4):1014-1030. Epub 2021 Dec 23 doi: 10.1016/j.survophthal.2021.12.006. PMID: 34954093
Postmortem Findings Associated With SARS-CoV-2: Systematic Review and Meta-analysis.
Satturwar S, Fowkes M, Farver C, Wilson AM, Eccher A, Girolami I, Pujadas E, Bryce C, Salem F, El Jamal SM, Paniz-Mondolfi A, Petersen B, Gordon RE, Reidy J, Fraggetta F, Marshall DA, Pantanowitz L
Am J Surg Pathol 2021 May 1;45(5):587-603. doi: 10.1097/PAS.0000000000001650. PMID: 33481385Free PMC Article

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