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Frailty

MedGen UID:
603303
Concept ID:
C0424594
Finding
Synonyms: Frailness; Frailties
SNOMED CT: Frailty (248279007)
 
HPO: HP:0033675

Definition

A clinically recognizable state of increased vulnerability resulting from a decline in reserve and function across multiple physiologic systems such that the ability to cope with everyday or acute stressors is compromised. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFrailty

Professional guidelines

PubMed

Ott C, Schmieder RE
Kidney Int 2022 Jan;101(1):36-46. Epub 2021 Oct 29 doi: 10.1016/j.kint.2021.09.026. PMID: 34757122
Dent E, Martin FC, Bergman H, Woo J, Romero-Ortuno R, Walston JD
Lancet 2019 Oct 12;394(10206):1376-1386. doi: 10.1016/S0140-6736(19)31785-4. PMID: 31609229
Dhillon RJ, Hasni S
Clin Geriatr Med 2017 Feb;33(1):17-26. doi: 10.1016/j.cger.2016.08.002. PMID: 27886695Free PMC Article

Recent clinical studies

Etiology

Cohen CI, Benyaminov R, Rahman M, Ngu D, Reinhardt M
Med Clin North Am 2023 Jan;107(1):183-197. Epub 2022 Oct 28 doi: 10.1016/j.mcna.2022.04.006. PMID: 36402498
Lee H, Lee E, Jang IY
J Korean Med Sci 2020 Jan 20;35(3):e16. doi: 10.3346/jkms.2020.35.e16. PMID: 31950775Free PMC Article
Proietti M, Cesari M
Adv Exp Med Biol 2020;1216:1-7. doi: 10.1007/978-3-030-33330-0_1. PMID: 31894541
Hoogendijk EO, Afilalo J, Ensrud KE, Kowal P, Onder G, Fried LP
Lancet 2019 Oct 12;394(10206):1365-1375. doi: 10.1016/S0140-6736(19)31786-6. PMID: 31609228
Walston J, Buta B, Xue QL
Clin Geriatr Med 2018 Feb;34(1):25-38. doi: 10.1016/j.cger.2017.09.004. PMID: 29129215Free PMC Article

Diagnosis

Cohen CI, Benyaminov R, Rahman M, Ngu D, Reinhardt M
Med Clin North Am 2023 Jan;107(1):183-197. Epub 2022 Oct 28 doi: 10.1016/j.mcna.2022.04.006. PMID: 36402498
Sugimoto T, Arai H, Sakurai T
Geriatr Gerontol Int 2022 Feb;22(2):99-109. Epub 2021 Dec 9 doi: 10.1111/ggi.14322. PMID: 34882939
Proietti M, Cesari M
Adv Exp Med Biol 2020;1216:1-7. doi: 10.1007/978-3-030-33330-0_1. PMID: 31894541
Dent E, Martin FC, Bergman H, Woo J, Romero-Ortuno R, Walston JD
Lancet 2019 Oct 12;394(10206):1376-1386. doi: 10.1016/S0140-6736(19)31785-4. PMID: 31609229
Walston J, Buta B, Xue QL
Clin Geriatr Med 2018 Feb;34(1):25-38. doi: 10.1016/j.cger.2017.09.004. PMID: 29129215Free PMC Article

Therapy

Huang CY, Mayer PK, Wu MY, Liu DH, Wu PC, Yen HR
Ageing Res Rev 2022 Dec;82:101747. Epub 2022 Oct 9 doi: 10.1016/j.arr.2022.101747. PMID: 36223875
Marzetti E, Calvani R, Tosato M, Cesari M, Di Bari M, Cherubini A, Broccatelli M, Savera G, D'Elia M, Pahor M, Bernabei R, Landi F; SPRINTT Consortium
Aging Clin Exp Res 2017 Feb;29(1):35-42. Epub 2017 Feb 8 doi: 10.1007/s40520-016-0705-4. PMID: 28181204
de Labra C, Guimaraes-Pinheiro C, Maseda A, Lorenzo T, Millán-Calenti JC
BMC Geriatr 2015 Dec 2;15:154. doi: 10.1186/s12877-015-0155-4. PMID: 26626157Free PMC Article
Landi F, Marzetti E, Martone AM, Bernabei R, Onder G
Curr Opin Clin Nutr Metab Care 2014 Jan;17(1):25-31. doi: 10.1097/MCO.0000000000000018. PMID: 24310054
Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL
J Clin Invest 2013 Mar;123(3):966-72. Epub 2013 Mar 1 doi: 10.1172/JCI64098. PMID: 23454759Free PMC Article

Prognosis

Jayanama K, Theou O, Godin J, Cahill L, Shivappa N, Hébert JR, Wirth MD, Park YM, Fung TT, Rockwood K
BMC Med 2021 Mar 16;19(1):64. doi: 10.1186/s12916-021-01918-5. PMID: 33722232Free PMC Article
Azoulay E, Mokart D, Kouatchet A, Demoule A, Lemiale V
Lancet Respir Med 2019 Feb;7(2):173-186. Epub 2018 Dec 7 doi: 10.1016/S2213-2600(18)30345-X. PMID: 30529232Free PMC Article
Hanlon P, Nicholl BI, Jani BD, Lee D, McQueenie R, Mair FS
Lancet Public Health 2018 Jul;3(7):e323-e332. Epub 2018 Jun 14 doi: 10.1016/S2468-2667(18)30091-4. PMID: 29908859Free PMC Article
Afilalo J, Lauck S, Kim DH, Lefèvre T, Piazza N, Lachapelle K, Martucci G, Lamy A, Labinaz M, Peterson MD, Arora RC, Noiseux N, Rassi A, Palacios IF, Généreux P, Lindman BR, Asgar AW, Kim CA, Trnkus A, Morais JA, Langlois Y, Rudski LG, Morin JF, Popma JJ, Webb JG, Perrault LP
J Am Coll Cardiol 2017 Aug 8;70(6):689-700. Epub 2017 Jul 7 doi: 10.1016/j.jacc.2017.06.024. PMID: 28693934
Lai JC, Covinsky KE, Dodge JL, Boscardin WJ, Segev DL, Roberts JP, Feng S
Hepatology 2017 Aug;66(2):564-574. Epub 2017 Jun 28 doi: 10.1002/hep.29219. PMID: 28422306Free PMC Article

Clinical prediction guides

Gilbert T, Neuburger J, Kraindler J, Keeble E, Smith P, Ariti C, Arora S, Street A, Parker S, Roberts HC, Bardsley M, Conroy S
Lancet 2018 May 5;391(10132):1775-1782. Epub 2018 Apr 26 doi: 10.1016/S0140-6736(18)30668-8. PMID: 29706364Free PMC Article
Kojima G, Iliffe S, Walters K
Age Ageing 2018 Mar 1;47(2):193-200. doi: 10.1093/ageing/afx162. PMID: 29040347
Clegg A, Bates C, Young J, Ryan R, Nichols L, Ann Teale E, Mohammed MA, Parry J, Marshall T
Age Ageing 2016 May;45(3):353-60. Epub 2016 Mar 3 doi: 10.1093/ageing/afw039. PMID: 26944937Free PMC Article
Cesari M, Gambassi G, van Kan GA, Vellas B
Age Ageing 2014 Jan;43(1):10-2. Epub 2013 Oct 16 doi: 10.1093/ageing/aft160. PMID: 24132852
Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, Mitnitski A
CMAJ 2005 Aug 30;173(5):489-95. doi: 10.1503/cmaj.050051. PMID: 16129869Free PMC Article

Recent systematic reviews

Wang X, Hu J, Wu D
Medicine (Baltimore) 2022 Aug 26;101(34):e30169. doi: 10.1097/MD.0000000000030169. PMID: 36042657Free PMC Article
Picca A, Coelho-Junior HJ, Calvani R, Marzetti E, Vetrano DL
Ageing Res Rev 2022 Jan;73:101530. Epub 2021 Nov 25 doi: 10.1016/j.arr.2021.101530. PMID: 34839041
Dibello V, Zupo R, Sardone R, Lozupone M, Castellana F, Dibello A, Daniele A, De Pergola G, Bortone I, Lampignano L, Giannelli G, Panza F
Lancet Healthy Longev 2021 Aug;2(8):e507-e520. doi: 10.1016/S2666-7568(21)00143-4. PMID: 36098000
Lorenzo-López L, Maseda A, de Labra C, Regueiro-Folgueira L, Rodríguez-Villamil JL, Millán-Calenti JC
BMC Geriatr 2017 May 15;17(1):108. doi: 10.1186/s12877-017-0496-2. PMID: 28506216Free PMC Article
Collard RM, Boter H, Schoevers RA, Oude Voshaar RC
J Am Geriatr Soc 2012 Aug;60(8):1487-92. Epub 2012 Aug 6 doi: 10.1111/j.1532-5415.2012.04054.x. PMID: 22881367

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