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Frailty

MedGen UID:
603303
Concept ID:
C0424594
Finding
Synonyms: Frailness; Frailties
SNOMED CT: Frailty (248279007)
 
HPO: HP:0033675

Definition

A clinically recognizable state of increased vulnerability resulting from a decline in reserve and function across multiple physiologic systems such that the ability to cope with everyday or acute stressors is compromised. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFrailty

Professional guidelines

PubMed

Ott C, Schmieder RE
Kidney Int 2022 Jan;101(1):36-46. Epub 2021 Oct 29 doi: 10.1016/j.kint.2021.09.026. PMID: 34757122
Izquierdo M, Merchant RA, Morley JE, Anker SD, Aprahamian I, Arai H, Aubertin-Leheudre M, Bernabei R, Cadore EL, Cesari M, Chen LK, de Souto Barreto P, Duque G, Ferrucci L, Fielding RA, García-Hermoso A, Gutiérrez-Robledo LM, Harridge SDR, Kirk B, Kritchevsky S, Landi F, Lazarus N, Martin FC, Marzetti E, Pahor M, Ramírez-Vélez R, Rodriguez-Mañas L, Rolland Y, Ruiz JG, Theou O, Villareal DT, Waters DL, Won Won C, Woo J, Vellas B, Fiatarone Singh M
J Nutr Health Aging 2021;25(7):824-853. doi: 10.1007/s12603-021-1665-8. PMID: 34409961
Dhillon RJ, Hasni S
Clin Geriatr Med 2017 Feb;33(1):17-26. doi: 10.1016/j.cger.2016.08.002. PMID: 27886695Free PMC Article

Recent clinical studies

Etiology

Wang X, Hu J, Wu D
Medicine (Baltimore) 2022 Aug 26;101(34):e30169. doi: 10.1097/MD.0000000000030169. PMID: 36042657Free PMC Article
Sugimoto T, Arai H, Sakurai T
Geriatr Gerontol Int 2022 Feb;22(2):99-109. Epub 2021 Dec 9 doi: 10.1111/ggi.14322. PMID: 34882939
Lee H, Lee E, Jang IY
J Korean Med Sci 2020 Jan 20;35(3):e16. doi: 10.3346/jkms.2020.35.e16. PMID: 31950775Free PMC Article
Proietti M, Cesari M
Adv Exp Med Biol 2020;1216:1-7. doi: 10.1007/978-3-030-33330-0_1. PMID: 31894541
Hoogendijk EO, Afilalo J, Ensrud KE, Kowal P, Onder G, Fried LP
Lancet 2019 Oct 12;394(10206):1365-1375. doi: 10.1016/S0140-6736(19)31786-6. PMID: 31609228

Diagnosis

Proietti M, Cesari M
Adv Exp Med Biol 2020;1216:1-7. doi: 10.1007/978-3-030-33330-0_1. PMID: 31894541
Dent E, Martin FC, Bergman H, Woo J, Romero-Ortuno R, Walston JD
Lancet 2019 Oct 12;394(10206):1376-1386. doi: 10.1016/S0140-6736(19)31785-4. PMID: 31609229
Khan KT, Hemati K, Donovan AL
Anesthesiol Clin 2019 Sep;37(3):453-474. Epub 2019 Jun 18 doi: 10.1016/j.anclin.2019.04.006. PMID: 31337478
Arai H, Satake S, Kozaki K
Clin Geriatr Med 2018 Nov;34(4):667-675. Epub 2018 Aug 16 doi: 10.1016/j.cger.2018.06.011. PMID: 30336994
Walston J, Buta B, Xue QL
Clin Geriatr Med 2018 Feb;34(1):25-38. doi: 10.1016/j.cger.2017.09.004. PMID: 29129215Free PMC Article

Therapy

Martínez-Velilla N, Casas-Herrero A, Zambom-Ferraresi F, Sáez de Asteasu ML, Lucia A, Galbete A, García-Baztán A, Alonso-Renedo J, González-Glaría B, Gonzalo-Lázaro M, Apezteguía Iráizoz I, Gutiérrez-Valencia M, Rodríguez-Mañas L, Izquierdo M
JAMA Intern Med 2019 Jan 1;179(1):28-36. doi: 10.1001/jamainternmed.2018.4869. PMID: 30419096Free PMC Article
Marzetti E, Calvani R, Tosato M, Cesari M, Di Bari M, Cherubini A, Broccatelli M, Savera G, D'Elia M, Pahor M, Bernabei R, Landi F; SPRINTT Consortium
Aging Clin Exp Res 2017 Feb;29(1):35-42. Epub 2017 Feb 8 doi: 10.1007/s40520-016-0705-4. PMID: 28181204
de Labra C, Guimaraes-Pinheiro C, Maseda A, Lorenzo T, Millán-Calenti JC
BMC Geriatr 2015 Dec 2;15:154. doi: 10.1186/s12877-015-0155-4. PMID: 26626157Free PMC Article
Landi F, Marzetti E, Martone AM, Bernabei R, Onder G
Curr Opin Clin Nutr Metab Care 2014 Jan;17(1):25-31. doi: 10.1097/MCO.0000000000000018. PMID: 24310054
Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL
J Clin Invest 2013 Mar;123(3):966-72. Epub 2013 Mar 1 doi: 10.1172/JCI64098. PMID: 23454759Free PMC Article

Prognosis

Jayanama K, Theou O, Godin J, Cahill L, Shivappa N, Hébert JR, Wirth MD, Park YM, Fung TT, Rockwood K
BMC Med 2021 Mar 16;19(1):64. doi: 10.1186/s12916-021-01918-5. PMID: 33722232Free PMC Article
Dugravot A, Fayosse A, Dumurgier J, Bouillon K, Rayana TB, Schnitzler A, Kivimaki M, Sabia S, Singh-Manoux A
Lancet Public Health 2020 Jan;5(1):e42-e50. Epub 2019 Dec 16 doi: 10.1016/S2468-2667(19)30226-9. PMID: 31837974Free PMC Article
Azoulay E, Mokart D, Kouatchet A, Demoule A, Lemiale V
Lancet Respir Med 2019 Feb;7(2):173-186. Epub 2018 Dec 7 doi: 10.1016/S2213-2600(18)30345-X. PMID: 30529232Free PMC Article
Hanlon P, Nicholl BI, Jani BD, Lee D, McQueenie R, Mair FS
Lancet Public Health 2018 Jul;3(7):e323-e332. Epub 2018 Jun 14 doi: 10.1016/S2468-2667(18)30091-4. PMID: 29908859Free PMC Article
Lai JC, Covinsky KE, Dodge JL, Boscardin WJ, Segev DL, Roberts JP, Feng S
Hepatology 2017 Aug;66(2):564-574. Epub 2017 Jun 28 doi: 10.1002/hep.29219. PMID: 28422306Free PMC Article

Clinical prediction guides

Motta F, Sica A, Selmi C
Front Immunol 2020;11:576134. Epub 2020 Oct 29 doi: 10.3389/fimmu.2020.576134. PMID: 33193369Free PMC Article
Richards SJG, Frizelle FA, Geddes JA, Eglinton TW, Hampton MB
Int J Colorectal Dis 2018 Dec;33(12):1657-1666. Epub 2018 Sep 14 doi: 10.1007/s00384-018-3163-y. PMID: 30218144
Kojima G, Iliffe S, Walters K
Age Ageing 2018 Mar 1;47(2):193-200. doi: 10.1093/ageing/afx162. PMID: 29040347
Vermeiren S, Vella-Azzopardi R, Beckwée D, Habbig AK, Scafoglieri A, Jansen B, Bautmans I; Gerontopole Brussels Study group
J Am Med Dir Assoc 2016 Dec 1;17(12):1163.e1-1163.e17. doi: 10.1016/j.jamda.2016.09.010. PMID: 27886869
Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, Mitnitski A
CMAJ 2005 Aug 30;173(5):489-95. doi: 10.1503/cmaj.050051. PMID: 16129869Free PMC Article

Recent systematic reviews

Wang X, Hu J, Wu D
Medicine (Baltimore) 2022 Aug 26;101(34):e30169. doi: 10.1097/MD.0000000000030169. PMID: 36042657Free PMC Article
Picca A, Coelho-Junior HJ, Calvani R, Marzetti E, Vetrano DL
Ageing Res Rev 2022 Jan;73:101530. Epub 2021 Nov 25 doi: 10.1016/j.arr.2021.101530. PMID: 34839041
Veronese N, Custodero C, Cella A, Demurtas J, Zora S, Maggi S, Barbagallo M, Sabbà C, Ferrucci L, Pilotto A
Ageing Res Rev 2021 Dec;72:101498. Epub 2021 Oct 23 doi: 10.1016/j.arr.2021.101498. PMID: 34700009
Gutiérrez-Valencia M, Izquierdo M, Cesari M, Casas-Herrero Á, Inzitari M, Martínez-Velilla N
Br J Clin Pharmacol 2018 Jul;84(7):1432-1444. Epub 2018 May 3 doi: 10.1111/bcp.13590. PMID: 29575094Free PMC Article
Lin HS, Watts JN, Peel NM, Hubbard RE
BMC Geriatr 2016 Aug 31;16(1):157. doi: 10.1186/s12877-016-0329-8. PMID: 27580947Free PMC Article

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