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Cytomegalovirus retinitis

MedGen UID:
61532
•Concept ID:
C0206178
•
Disease or Syndrome
Synonyms: Cytomegaloviral Retinitis; Cytomegalovirus Retinitis; Retinitis, Cytomegaloviral; Retinitis, Cytomegalovirus
SNOMED CT: Cytomegalovirus retinitis (22455005); CMV - Cytomegalovirus retinitis (22455005); Cytomegaloviral retinitis (22455005); CMV retinitis (22455005)
 
Monarch Initiative: MONDO:0000878

Definition

Inflammation of the retina due to cytomegalovirus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCytomegalovirus retinitis

Professional guidelines

PubMed

Classification Criteria for Cytomegalovirus Retinitis.
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:245-254. Epub 2021 May 11 doi: 10.1016/j.ajo.2021.03.051. PMID: 33845015Free PMC Article
Viral retinitis: diagnosis and management in the era of biologic immunosuppression: A review.
Wu XN, Lightman S, Tomkins-Netzer O
Clin Exp Ophthalmol 2019 Apr;47(3):381-395. doi: 10.1111/ceo.13500. PMID: 30859706
Cytomegalovirus retinitis in HIV-negative patients - associated conditions, clinical presentation, diagnostic methods and treatment strategy.
Shapira Y, Mimouni M, Vishnevskia-Dai V
Acta Ophthalmol 2018 Nov;96(7):e761-e767. Epub 2017 Oct 25 doi: 10.1111/aos.13553. PMID: 29068151

Recent clinical studies

Etiology

Classification Criteria for Cytomegalovirus Retinitis.
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:245-254. Epub 2021 May 11 doi: 10.1016/j.ajo.2021.03.051. PMID: 33845015Free PMC Article
Chorioretinitis in infants.
Modrzejewska M, Lachowicz E, Karczewicz D, Zdanowska A
Klin Oczna 2011;113(10-12):352-6. PMID: 22384654
Cytomegalovirus.
Taylor GH
Am Fam Physician 2003 Feb 1;67(3):519-24. PMID: 12588074
Fomivirsen.
Perry CM, Balfour JA
Drugs 1999 Mar;57(3):375-80; discussion 381. doi: 10.2165/00003495-199957030-00010. PMID: 10193689
CMV retinitis.
Ballinger R
Optom Vis Sci 1995 May;72(5):305-9. doi: 10.1097/00006324-199505000-00006. PMID: 7667006

Diagnosis

Cytomegalovirus retinitis.
Muelas-Fernandez M, Quintas-Marcos H, Ruiz-Pombo M
Med Clin (Barc) 2022 Apr 8;158(7):350. Epub 2021 Dec 21 doi: 10.1016/j.medcli.2021.11.003. PMID: 34952713
HIV-induced Retinitis.
Wons J, Kempen J, Garweg JG
Ocul Immunol Inflamm 2020 Nov 16;28(8):1259-1268. Epub 2020 Sep 23 doi: 10.1080/09273948.2020.1808225. PMID: 32966142
Cytomegalovirus Retinitis: A Review.
Port AD, Orlin A, Kiss S, Patel S, D'Amico DJ, Gupta MP
J Ocul Pharmacol Ther 2017 May;33(4):224-234. Epub 2017 Mar 29 doi: 10.1089/jop.2016.0140. PMID: 28355091
Metastatic endophthalmitis.
Hussain B, Lynn W, Lightman SL
Br J Hosp Med (Lond) 2007 Aug;68(8):424-8. doi: 10.12968/hmed.2007.68.8.24494. PMID: 17847685
Fomivirsen.
Perry CM, Balfour JA
Drugs 1999 Mar;57(3):375-80; discussion 381. doi: 10.2165/00003495-199957030-00010. PMID: 10193689

Therapy

Cytomegalovirus retinitis.
Muelas-Fernandez M, Quintas-Marcos H, Ruiz-Pombo M
Med Clin (Barc) 2022 Apr 8;158(7):350. Epub 2021 Dec 21 doi: 10.1016/j.medcli.2021.11.003. PMID: 34952713
Valganciclovir.
Curran M, Noble S
Drugs 2001;61(8):1145-50 ; discussion 1151-2. doi: 10.2165/00003495-200161080-00013. PMID: 11465875
Fomivirsen.
Perry CM, Balfour JA
Drugs 1999 Mar;57(3):375-80; discussion 381. doi: 10.2165/00003495-199957030-00010. PMID: 10193689
Cytomegalovirus retinitis.
Harooni M, Lashkari K, Freilich JM, Schepens CL
Int Ophthalmol Clin 1996 Summer;36(3):131-40. doi: 10.1097/00004397-199603630-00012. PMID: 8989605
Cidofovir.
Lea AP, Bryson HM
Drugs 1996 Aug;52(2):225-230; discussion 231. doi: 10.2165/00003495-199652020-00006. PMID: 8841740

Prognosis

Clinical features of Cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome and efficacy of the current therapy.
Zhao Q, Li NN, Chen YX, Zhao XY
Front Cell Infect Microbiol 2023;13:1107237. Epub 2023 May 26 doi: 10.3389/fcimb.2023.1107237. PMID: 37305416Free PMC Article
High Blood Cytomegalovirus Load Suggests Cytomegalovirus Retinitis in HIV/AIDS Patients: A Cross-Sectional Study.
Du KF, Huang XJ, Chen C, Kong WJ, Xie LY, Dong HW, Wei WB
Ocul Immunol Inflamm 2022 Oct-Nov;30(7-8):1559-1563. Epub 2021 Jun 14 doi: 10.1080/09273948.2021.1905857. PMID: 34125650
Herpetic retinitis.
Cordero-Coma M, Anzaar F, Yilmaz T, Foster CS
Herpes 2007 Jun;14(1):4-10. PMID: 17848212
Metastatic endophthalmitis.
Hussain B, Lynn W, Lightman SL
Br J Hosp Med (Lond) 2007 Aug;68(8):424-8. doi: 10.12968/hmed.2007.68.8.24494. PMID: 17847685
HIV/AIDS and blindness.
Kestelyn PG, Cunningham ET Jr
Bull World Health Organ 2001;79(3):208-13. PMID: 11285664Free PMC Article

Clinical prediction guides

Clinical features of Cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome and efficacy of the current therapy.
Zhao Q, Li NN, Chen YX, Zhao XY
Front Cell Infect Microbiol 2023;13:1107237. Epub 2023 May 26 doi: 10.3389/fcimb.2023.1107237. PMID: 37305416Free PMC Article
High Blood Cytomegalovirus Load Suggests Cytomegalovirus Retinitis in HIV/AIDS Patients: A Cross-Sectional Study.
Du KF, Huang XJ, Chen C, Kong WJ, Xie LY, Dong HW, Wei WB
Ocul Immunol Inflamm 2022 Oct-Nov;30(7-8):1559-1563. Epub 2021 Jun 14 doi: 10.1080/09273948.2021.1905857. PMID: 34125650
Review of cytomegalovirus coinfection in HIV-infected individuals in Africa.
Grønborg HL, Jespersen S, Hønge BL, Jensen-Fangel S, Wejse C
Rev Med Virol 2017 Jan;27(1) Epub 2016 Oct 7 doi: 10.1002/rmv.1907. PMID: 27714898
Chorioretinitis in infants.
Modrzejewska M, Lachowicz E, Karczewicz D, Zdanowska A
Klin Oczna 2011;113(10-12):352-6. PMID: 22384654
Development of the 25-item National Eye Institute Visual Function Questionnaire.
Mangione CM, Lee PP, Gutierrez PR, Spritzer K, Berry S, Hays RD; National Eye Institute Visual Function Questionnaire Field Test Investigators
Arch Ophthalmol 2001 Jul;119(7):1050-8. doi: 10.1001/archopht.119.7.1050. PMID: 11448327

Recent systematic reviews

Cytomegalovirus retinitis in children and adolescents with acute leukemia following allogeneic hematopoietic stem cell transplantation.
Zöllner SK, Herbrüggen H, Kolve H, Mihailovic N, Schubert F, Reicherts C, Rössig C, Groll AH
Transpl Infect Dis 2019 Oct;21(5):e13089. Epub 2019 Aug 13 doi: 10.1111/tid.13089. PMID: 30972869
Review of cytomegalovirus coinfection in HIV-infected individuals in Africa.
Grønborg HL, Jespersen S, Hønge BL, Jensen-Fangel S, Wejse C
Rev Med Virol 2017 Jan;27(1) Epub 2016 Oct 7 doi: 10.1002/rmv.1907. PMID: 27714898
Observer bias in randomized clinical trials with time-to-event outcomes: systematic review of trials with both blinded and non-blinded outcome assessors.
Hróbjartsson A, Thomsen AS, Emanuelsson F, Tendal B, Rasmussen JV, Hilden J, Boutron I, Ravaud P, Brorson S
Int J Epidemiol 2014 Jun;43(3):937-48. Epub 2014 Jan 21 doi: 10.1093/ije/dyt270. PMID: 24448109
Burden of HIV-related cytomegalovirus retinitis in resource-limited settings: a systematic review.
Ford N, Shubber Z, Saranchuk P, Pathai S, Durier N, O'Brien DP, Mills EJ, Pascual F, Hoen E', Holland GN, Heiden D
Clin Infect Dis 2013 Nov;57(9):1351-61. Epub 2013 Jul 29 doi: 10.1093/cid/cit494. PMID: 23899681
Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis.
Müller M, Wandel S, Colebunders R, Attia S, Furrer H, Egger M; IeDEA Southern and Central Africa
Lancet Infect Dis 2010 Apr;10(4):251-61. doi: 10.1016/S1473-3099(10)70026-8. PMID: 20334848Free PMC Article

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