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Fibroadenomas

MedGen UID:
61650
•Concept ID:
C0206650
•
Neoplastic Process
Synonym: Fibroadenoma

Definition

An adenoma containing fibrous tissue. It should be differentiated from ADENOFIBROMA which is a tumor composed of connective tissue (fibroma) containing glandular (adeno-) structures. (From Dorland, 27th ed) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFibroadenomas

Professional guidelines

PubMed

Metastatic and Malignant Phyllodes Tumors of the Breast: An Update for Current Management.
Goodwin B, Oyinlola AF, Palhang M, Lehman D, Platoff R, Atabek U, Spitz F, Hong Y
Am Surg 2023 Dec;89(12):6190-6196. Epub 2023 Aug 23 doi: 10.1177/00031348231198114. PMID: 37611540
Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.
Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875
The diagnosis and management of breast problems during pregnancy and lactation.
Scott-Conner CE, Schorr SJ
Am J Surg 1995 Oct;170(4):401-5. doi: 10.1016/s0002-9610(99)80313-4. PMID: 7573738

Recent clinical studies

Etiology

Benign Breast Disease in Women.
Stachs A, Stubert J, Reimer T, Hartmann S
Dtsch Arztebl Int 2019 Aug 9;116(33-34):565-574. doi: 10.3238/arztebl.2019.0565. PMID: 31554551Free PMC Article
Genetics and genomics of breast fibroadenomas.
Loke BN, Md Nasir ND, Thike AA, Lee JYH, Lee CS, Teh BT, Tan PH
J Clin Pathol 2018 May;71(5):381-387. Epub 2017 Dec 16 doi: 10.1136/jclinpath-2017-204838. PMID: 29248888
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications.
Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Lønning PE, Børresen-Dale AL
Proc Natl Acad Sci U S A 2001 Sep 11;98(19):10869-74. doi: 10.1073/pnas.191367098. PMID: 11553815Free PMC Article
Mastodynia.
BeLieu RM
Obstet Gynecol Clin North Am 1994 Sep;21(3):461-77. PMID: 7816407

Diagnosis

Fibroepithelial tumours of the breast-a review.
Lerwill MF, Lee AHS, Tan PH
Virchows Arch 2022 Jan;480(1):45-63. Epub 2021 Sep 10 doi: 10.1007/s00428-021-03175-6. PMID: 34505197
Breast fibroadenomas: a review in the light of current literature.
Salati SA
Pol Przegl Chir 2020 Dec 7;93(1):40-48. doi: 10.5604/01.3001.0014.5676. PMID: 33729177
Benign Breast Disease in Women.
Stachs A, Stubert J, Reimer T, Hartmann S
Dtsch Arztebl Int 2019 Aug 9;116(33-34):565-574. doi: 10.3238/arztebl.2019.0565. PMID: 31554551Free PMC Article
Phyllodes tumours.
Parker SJ, Harries SA
Postgrad Med J 2001 Jul;77(909):428-35. doi: 10.1136/pmj.77.909.428. PMID: 11423590Free PMC Article
Mastodynia.
BeLieu RM
Obstet Gynecol Clin North Am 1994 Sep;21(3):461-77. PMID: 7816407

Therapy

Feasibility and efficacy of ultrasound-guided high-intensity focused ultrasound of breast fibroadenoma.
Liang M, Zhang Z, Zhang C, Chen R, Xiao Y, Li Z, Li T, Liu Y, Ling L, Xie H, Chen L, Liu X, Wang S, Xia T
Int J Hyperthermia 2023;40(1):2240548. doi: 10.1080/02656736.2023.2240548. PMID: 37544652
Single cell profiling of female breast fibroadenoma reveals distinct epithelial cell compositions and therapeutic targets.
Chen Z, Zhang Y, Li W, Gao C, Huang F, Cheng L, Jin M, Xu X, Huang J
Nat Commun 2023 Jun 16;14(1):3469. doi: 10.1038/s41467-023-39059-3. PMID: 37328469Free PMC Article
Management of Stromal Lesions.
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Mastodynia.
BeLieu RM
Obstet Gynecol Clin North Am 1994 Sep;21(3):461-77. PMID: 7816407
Ethinyloestradiol.
IARC Monogr Eval Carcinog Risk Chem Hum 1979 Dec;21:233-55. PMID: 120833

Prognosis

Fibroepithelial tumours of the breast-a review.
Lerwill MF, Lee AHS, Tan PH
Virchows Arch 2022 Jan;480(1):45-63. Epub 2021 Sep 10 doi: 10.1007/s00428-021-03175-6. PMID: 34505197
Genetics and genomics of breast fibroadenomas.
Loke BN, Md Nasir ND, Thike AA, Lee JYH, Lee CS, Teh BT, Tan PH
J Clin Pathol 2018 May;71(5):381-387. Epub 2017 Dec 16 doi: 10.1136/jclinpath-2017-204838. PMID: 29248888
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications.
Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Lønning PE, Børresen-Dale AL
Proc Natl Acad Sci U S A 2001 Sep 11;98(19):10869-74. doi: 10.1073/pnas.191367098. PMID: 11553815Free PMC Article
Mastodynia.
BeLieu RM
Obstet Gynecol Clin North Am 1994 Sep;21(3):461-77. PMID: 7816407

Clinical prediction guides

Single cell profiling of female breast fibroadenoma reveals distinct epithelial cell compositions and therapeutic targets.
Chen Z, Zhang Y, Li W, Gao C, Huang F, Cheng L, Jin M, Xu X, Huang J
Nat Commun 2023 Jun 16;14(1):3469. doi: 10.1038/s41467-023-39059-3. PMID: 37328469Free PMC Article
Breast fibroadenomas: a review in the light of current literature.
Salati SA
Pol Przegl Chir 2020 Dec 7;93(1):40-48. doi: 10.5604/01.3001.0014.5676. PMID: 33729177
Fibroepithelial lesions; The WHO spectrum.
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
Mastodynia.
BeLieu RM
Obstet Gynecol Clin North Am 1994 Sep;21(3):461-77. PMID: 7816407

Recent systematic reviews

Metastatic and Malignant Phyllodes Tumors of the Breast: An Update for Current Management.
Goodwin B, Oyinlola AF, Palhang M, Lehman D, Platoff R, Atabek U, Spitz F, Hong Y
Am Surg 2023 Dec;89(12):6190-6196. Epub 2023 Aug 23 doi: 10.1177/00031348231198114. PMID: 37611540
Pediatric Breast Fibroadenomas: A Systematic Review and Algorithm for Treatment.
Brownstone ND, Celie KB, Spigland NA, Otterburn DM
Ann Plast Surg 2019 Nov;83(5):601-605. doi: 10.1097/SAP.0000000000001717. PMID: 30628932

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