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Megaesophagus

MedGen UID:
6286
•Concept ID:
C0025164
•
Disease or Syndrome
Synonym: megaesophagus
SNOMED CT: Megaesophagus (70667005)
 
Monarch Initiative: MONDO:0001656

Definition

An abnormal dilation of the esophagus not due to obstruction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMegaesophagus

Professional guidelines

PubMed

Surgical Treatment of Esophageal Achalasia in the Era of Minimally Invasive Surgery.
Andrási L, Paszt A, Simonka Z, Ábrahám S, Erdős M, Rosztóczy A, Ollé G, Lázár G
JSLS 2021 Jan-Mar;25(1) doi: 10.4293/JSLS.2020.00099. PMID: 33879995Free PMC Article
Management of Esophageal Dysphagia in Chagas Disease.
Dantas RO
Dysphagia 2021 Jun;36(3):517-522. Epub 2021 Apr 14 doi: 10.1007/s00455-021-10297-1. PMID: 33855597
Management of achalasia: surgery or pneumatic dilation.
Richter JE, Boeckxstaens GE
Gut 2011 Jun;60(6):869-76. Epub 2011 Feb 8 doi: 10.1136/gut.2010.212423. PMID: 21303915

Recent clinical studies

Etiology

Suspected Fluoroquinolone-Induced Exacerbation of Myasthenia Gravis in Dogs.
Guzman KMH, Harkin K
J Am Anim Hosp Assoc 2023 Sep 1;59(5):249-254. doi: 10.5326/JAAHA-MS-7353. PMID: 37708471
Management of Esophageal Dysphagia in Chagas Disease.
Dantas RO
Dysphagia 2021 Jun;36(3):517-522. Epub 2021 Apr 14 doi: 10.1007/s00455-021-10297-1. PMID: 33855597
Surgical treatment of relapsed megaesophagus.
Costa LCDS, Braga JGR, Tercioti Junior V, Coelho Neto JS, Ferrer JAP, Lopes LR, Andreollo NA
Rev Col Bras Cir 2020;47:e20202444. Epub 2020 Jun 8 doi: 10.1590/0100-6991e-20202444. PMID: 32520130
Isosorbide and nifedipine for Chagas' megaesophagus: A systematic review and meta-analysis.
Borges Migliavaca C, Stein C, Colpani V, René Pinto de Sousa Miguel S, Nascimento Cruz L, Oliveira Dantas R, Falavigna M
PLoS Negl Trop Dis 2018 Sep;12(9):e0006836. Epub 2018 Sep 28 doi: 10.1371/journal.pntd.0006836. PMID: 30265663Free PMC Article
Chagas disease in Europe: A review for the internist in the globalized world.
Antinori S, Galimberti L, Bianco R, Grande R, Galli M, Corbellino M
Eur J Intern Med 2017 Sep;43:6-15. Epub 2017 May 11 doi: 10.1016/j.ejim.2017.05.001. PMID: 28502864

Diagnosis

Suspected Fluoroquinolone-Induced Exacerbation of Myasthenia Gravis in Dogs.
Guzman KMH, Harkin K
J Am Anim Hosp Assoc 2023 Sep 1;59(5):249-254. doi: 10.5326/JAAHA-MS-7353. PMID: 37708471
Surgical Options for End-Stage Achalasia.
DeSouza M
Curr Gastroenterol Rep 2023 Nov;25(11):267-274. Epub 2023 Aug 30 doi: 10.1007/s11894-023-00889-2. PMID: 37646894
Achalasia with megaesophagus.
Yang CF, Chua C
CMAJ 2023 May 15;195(19):E684. doi: 10.1503/cmaj.230111. PMID: 37188374Free PMC Article
An Unbelievable Esophagus.
Miranda LEC, Miranda ACG, Lima DL
Gastroenterology 2020 Oct;159(4):e11-e12. Epub 2020 Apr 18 doi: 10.1053/j.gastro.2020.03.077. PMID: 32311355
Chagasic enteropathy.
Meneghelli UG
Rev Soc Bras Med Trop 2004 May-Jun;37(3):252-60. doi: 10.1590/s0037-86822004000300012. PMID: 15330067

Therapy

Suspected Fluoroquinolone-Induced Exacerbation of Myasthenia Gravis in Dogs.
Guzman KMH, Harkin K
J Am Anim Hosp Assoc 2023 Sep 1;59(5):249-254. doi: 10.5326/JAAHA-MS-7353. PMID: 37708471
Myotomy in sigmoid megaesophagus: is it applicable? A systematic review and meta-analysis.
Orlandini MF, Serafim MCA, Datrino LN, Tavares G, Tristão LS, Dos Santos CL, Bernardo WM, Tustumi F
Dis Esophagus 2021 Oct 11;34(10) doi: 10.1093/dote/doab053. PMID: 34355243
Peroral endoscopic myotomy for advanced achalasia with megaesophagus.
Ueda C, Abe H, Tanaka S, Kawara F, Toyonaga T, Ariyoshi R, Sako T, Sakaguchi H, Ikezawa N, Urakami S, Nakai T, Kodama Y
Esophagus 2021 Oct;18(4):922-931. Epub 2021 Apr 10 doi: 10.1007/s10388-021-00833-1. PMID: 33837865
Isosorbide and nifedipine for Chagas' megaesophagus: A systematic review and meta-analysis.
Borges Migliavaca C, Stein C, Colpani V, René Pinto de Sousa Miguel S, Nascimento Cruz L, Oliveira Dantas R, Falavigna M
PLoS Negl Trop Dis 2018 Sep;12(9):e0006836. Epub 2018 Sep 28 doi: 10.1371/journal.pntd.0006836. PMID: 30265663Free PMC Article
Management of achalasia: surgery or pneumatic dilation.
Richter JE, Boeckxstaens GE
Gut 2011 Jun;60(6):869-76. Epub 2011 Feb 8 doi: 10.1136/gut.2010.212423. PMID: 21303915

Prognosis

Hospitalizations due to gastrointestinal Chagas disease: National registry.
Bierrenbach AL, Quintino ND, Moreira CHV, Damasceno RF, Nunes MDCP, Baldoni NR, de Oliveira da Silva LC, Ferreira AM, Cardoso CS, Haikal DS, Sabino EC, Ribeiro ALP, Oliveira CDL
PLoS Negl Trop Dis 2022 Sep;16(9):e0010796. Epub 2022 Sep 19 doi: 10.1371/journal.pntd.0010796. PMID: 36121897Free PMC Article
Preservation of the vagus nerves in subtotal esophagectomy without thoracotomy.
Crema E, Terra Júnior JA, Borges MC, Queiroz CAS, Soares LA, Silva AAD
Acta Cir Bras 2018 Sep;33(9):834-841. doi: 10.1590/s0102-865020180090000012. PMID: 30328916
Management of achalasia: surgery or pneumatic dilation.
Richter JE, Boeckxstaens GE
Gut 2011 Jun;60(6):869-76. Epub 2011 Feb 8 doi: 10.1136/gut.2010.212423. PMID: 21303915
The determinants of Chagas disease: connecting parasite and host genetics.
Campbell DA, Westenberger SJ, Sturm NR
Curr Mol Med 2004 Sep;4(6):549-62. doi: 10.2174/1566524043360249. PMID: 15357207
Resection for achalasia of the esophagus.
Pinotti HW, Cecconello I, da Rocha JM, Zilberstein B
Hepatogastroenterology 1991 Dec;38(6):470-3. PMID: 1778572

Clinical prediction guides

Peroral endoscopic myotomy for advanced achalasia with megaesophagus.
Ueda C, Abe H, Tanaka S, Kawara F, Toyonaga T, Ariyoshi R, Sako T, Sakaguchi H, Ikezawa N, Urakami S, Nakai T, Kodama Y
Esophagus 2021 Oct;18(4):922-931. Epub 2021 Apr 10 doi: 10.1007/s10388-021-00833-1. PMID: 33837865
Surgical treatment of relapsed megaesophagus.
Costa LCDS, Braga JGR, Tercioti Junior V, Coelho Neto JS, Ferrer JAP, Lopes LR, Andreollo NA
Rev Col Bras Cir 2020;47:e20202444. Epub 2020 Jun 8 doi: 10.1590/0100-6991e-20202444. PMID: 32520130
Isosorbide and nifedipine for Chagas' megaesophagus: A systematic review and meta-analysis.
Borges Migliavaca C, Stein C, Colpani V, René Pinto de Sousa Miguel S, Nascimento Cruz L, Oliveira Dantas R, Falavigna M
PLoS Negl Trop Dis 2018 Sep;12(9):e0006836. Epub 2018 Sep 28 doi: 10.1371/journal.pntd.0006836. PMID: 30265663Free PMC Article
Infectious diseases causing autonomic dysfunction.
Carod-Artal FJ
Clin Auton Res 2018 Feb;28(1):67-81. Epub 2017 Jul 20 doi: 10.1007/s10286-017-0452-4. PMID: 28730326
Chagas disease in Europe: A review for the internist in the globalized world.
Antinori S, Galimberti L, Bianco R, Grande R, Galli M, Corbellino M
Eur J Intern Med 2017 Sep;43:6-15. Epub 2017 May 11 doi: 10.1016/j.ejim.2017.05.001. PMID: 28502864

Recent systematic reviews

ADVANCED MEGAESOPHAGUS TREATMENT: WHICH TECHNIQUE OFFERS THE BEST RESULTS? A SYSTEMATIC REVIEW.
Chaib PS, Tedrus GA, Aquino JLB, Mendonça JA
Arq Bras Cir Dig 2024;37:e1809. Epub 2024 Jul 1 doi: 10.1590/0102-6720202400016e1809. PMID: 38958345Free PMC Article
Gastrointestinal Manifestations of Chagas Disease: A Systematic Review with Meta-Analysis.
Baldoni NR, de Oliveira-da Silva LC, Gonçalves ACO, Quintino ND, Ferreira AM, Bierrenbach AL, Padilha da Silva JL, Pereira Nunes MC, Ribeiro ALP, Oliveira CDL, Sabino EC, Cardoso CS
Am J Trop Med Hyg 2024 Jan 3;110(1):10-19. Epub 2023 Dec 4 doi: 10.4269/ajtmh.23-0323. PMID: 38052078Free PMC Article
Myotomy in sigmoid megaesophagus: is it applicable? A systematic review and meta-analysis.
Orlandini MF, Serafim MCA, Datrino LN, Tavares G, Tristão LS, Dos Santos CL, Bernardo WM, Tustumi F
Dis Esophagus 2021 Oct 11;34(10) doi: 10.1093/dote/doab053. PMID: 34355243
Isosorbide and nifedipine for Chagas' megaesophagus: A systematic review and meta-analysis.
Borges Migliavaca C, Stein C, Colpani V, René Pinto de Sousa Miguel S, Nascimento Cruz L, Oliveira Dantas R, Falavigna M
PLoS Negl Trop Dis 2018 Sep;12(9):e0006836. Epub 2018 Sep 28 doi: 10.1371/journal.pntd.0006836. PMID: 30265663Free PMC Article

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