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Sterile abscess

MedGen UID:
639046
Concept ID:
C0541754
Acquired Abnormality
SNOMED CT: Sterile abscess (129124008)
 
HPO: HP:0025616

Definition

An abscess not caused by infection with pyogenic bacteria. Operationally, a sterile abscess is inferred if investigations of an abscess fail to reveal evidence of pathogenic organisms. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSterile abscess

Conditions with this feature

Pyogenic arthritis-pyoderma gangrenosum-acne syndrome
MedGen UID:
346801
Concept ID:
C1858361
Disease or Syndrome
A rare pleiotropic auto-inflammatory disorder of childhood, primarily affecting the joints and skin. The first affected family contained ten affected members from three generations and manifested variable expression of a pauciarticular, nonaxial, arthritis that began in childhood; pyoderma gangrenosum; and severe cystic acne in adolescence and beyond. Recurrent sterile arthritis usually occurs after minor trauma, but can also occur spontaneously. PAPA syndrome is a self-limiting disease, but it can lead to severe joint destruction. The gene responsible for the syndrome is the proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1).
Hyper-IgE recurrent infection syndrome 3, autosomal recessive
MedGen UID:
1648483
Concept ID:
C4748969
Disease or Syndrome
Hyper-IgE syndrome-3 with recurrent infections (HIES3) is an autosomal recessive immunologic disorder characterized by childhood onset of atopic dermatitis, skin infections particularly with Staphylococcus aureus, recurrent sinopulmonary infections, and increased serum IgE and IgG. Patients are susceptible to bacterial and fungal infections, including chronic mucocutaneous candidiasis. Immunologic workup shows impaired differentiation of CD4+ T cells into T-helper 17 cells, decreased memory B cells, and often decreased NK cells (summary by Beziat et al., 2018). For a discussion of genetic heterogeneity of hyper-IgE syndrome, see HIES1 (147060).
Warburg-cinotti syndrome
MedGen UID:
1677486
Concept ID:
C5193019
Disease or Syndrome
Warburg-Cinotti syndrome (WRCN) is characterized by progressive corneal neovascularization, keloid formation, chronic skin ulcers, wasting of subcutaneous tissue, flexion contractures of the fingers, and acroosteolysis (Xu et al., 2018).

Professional guidelines

PubMed

Munhoz G, Cavallieri FA, de Almeida Balassiano LK, Tembra MF, Cunha JMT, Silveira ACO, Moreira MVR, Ramos-E-Silva M
J Cosmet Dermatol 2022 Nov;21(11):5562-5568. Epub 2022 Jul 19 doi: 10.1111/jocd.15135. PMID: 35638403
Sutherland AE, Curtin J, Bradley V, Bush O, Presswood M, Hedges V, Naessens K
BMJ Support Palliat Care 2018 Jun;8(2):129-135. Epub 2017 Jul 22 doi: 10.1136/bmjspcare-2016-001261. PMID: 28735270
Tonini G, Lazzerini M
J Pediatr Endocrinol Metab 2000 Jul;13 Suppl 1:795-803. doi: 10.1515/jpem.2000.13.s1.795. PMID: 10969924

Recent clinical studies

Etiology

Izadi S, Mohammadi M, Sartipi M, Karami M, Karimi H
East Mediterr Health J 2023 Jan 19;29(1):6-14. doi: 10.26719/emhj.23.002. PMID: 36710609
Dyson ME, Orangi M, Goldberg LH, Kimyai-Asadi A
Dermatol Surg 2019 Oct;45(10):1222-1227. doi: 10.1097/DSS.0000000000001799. PMID: 30672858
Akıncı D, Ergun O, Topel Ç, Çiftçi T, Akhan O
Diagn Interv Radiol 2018 May-Jun;24(3):146-152. doi: 10.5152/dir.2018.16500. PMID: 29770767Free PMC Article
Wong FK, Adams S, Hudson DA, Ozaki W
J Craniofac Surg 2017 May;28(3):635-637. doi: 10.1097/SCS.0000000000003413. PMID: 28468138
Sweat SD, Lightner DJ
J Urol 1999 Jan;161(1):93-6. PMID: 10037377

Diagnosis

Munhoz G, Cavallieri FA, de Almeida Balassiano LK, Tembra MF, Cunha JMT, Silveira ACO, Moreira MVR, Ramos-E-Silva M
J Cosmet Dermatol 2022 Nov;21(11):5562-5568. Epub 2022 Jul 19 doi: 10.1111/jocd.15135. PMID: 35638403
Mezei T, Hajdu M, Czigléczki G, Lotz G, Kocsis J, Kulka J, Horváth A
BMC Cancer 2020 Jul 1;20(1):615. doi: 10.1186/s12885-020-07114-7. PMID: 32611325Free PMC Article
Polat AV, Bekci T, Dabak N, Ulu EM, Selcuk MB
Skeletal Radiol 2015 Dec;44(12):1849-52. Epub 2015 Aug 26 doi: 10.1007/s00256-015-2242-1. PMID: 26306390
Sweat SD, Lightner DJ
J Urol 1999 Jan;161(1):93-6. PMID: 10037377
Hayes CS, Heinrich SD, Craver R, MacEwen GD
Orthopedics 1990 Mar;13(3):363-6. doi: 10.3928/0147-7447-19900301-18. PMID: 2179915

Therapy

Munhoz G, Cavallieri FA, de Almeida Balassiano LK, Tembra MF, Cunha JMT, Silveira ACO, Moreira MVR, Ramos-E-Silva M
J Cosmet Dermatol 2022 Nov;21(11):5562-5568. Epub 2022 Jul 19 doi: 10.1111/jocd.15135. PMID: 35638403
Mezei T, Hajdu M, Czigléczki G, Lotz G, Kocsis J, Kulka J, Horváth A
BMC Cancer 2020 Jul 1;20(1):615. doi: 10.1186/s12885-020-07114-7. PMID: 32611325Free PMC Article
Sutherland AE, Curtin J, Bradley V, Bush O, Presswood M, Hedges V, Naessens K
BMJ Support Palliat Care 2018 Jun;8(2):129-135. Epub 2017 Jul 22 doi: 10.1136/bmjspcare-2016-001261. PMID: 28735270
Tonini G, Lazzerini M
J Pediatr Endocrinol Metab 2000 Jul;13 Suppl 1:795-803. doi: 10.1515/jpem.2000.13.s1.795. PMID: 10969924
Sweat SD, Lightner DJ
J Urol 1999 Jan;161(1):93-6. PMID: 10037377

Prognosis

Mezei T, Hajdu M, Czigléczki G, Lotz G, Kocsis J, Kulka J, Horváth A
BMC Cancer 2020 Jul 1;20(1):615. doi: 10.1186/s12885-020-07114-7. PMID: 32611325Free PMC Article
Wong FK, Adams S, Hudson DA, Ozaki W
J Craniofac Surg 2017 May;28(3):635-637. doi: 10.1097/SCS.0000000000003413. PMID: 28468138
Pierannunzii L, Fossali A, De Lucia O, Guarino A
J Orthop Traumatol 2015 Mar;16(1):59-65. Epub 2014 Jun 11 doi: 10.1007/s10195-014-0300-4. PMID: 24916148Free PMC Article
Nell AS, D'lom E, Bouic P, Sabaté M, Bosser R, Picas J, Amat M, Churchyard G, Cardona PJ
PLoS One 2014;9(2):e89612. Epub 2014 Feb 26 doi: 10.1371/journal.pone.0089612. PMID: 24586912Free PMC Article
Ho VH, Wilson MW, Fleming JC, Haik BG
Ophthalmic Plast Reconstr Surg 2004 May;20(3):232-6. doi: 10.1097/01.iop.0000129014.94384.e6. PMID: 15167733

Clinical prediction guides

Izadi S, Mohammadi M, Sartipi M, Karami M, Karimi H
East Mediterr Health J 2023 Jan 19;29(1):6-14. doi: 10.26719/emhj.23.002. PMID: 36710609
Kaya A, Kaya SY
BMC Infect Dis 2021 Jan 12;21(1):53. doi: 10.1186/s12879-020-05756-3. PMID: 33430802Free PMC Article
Mezei T, Hajdu M, Czigléczki G, Lotz G, Kocsis J, Kulka J, Horváth A
BMC Cancer 2020 Jul 1;20(1):615. doi: 10.1186/s12885-020-07114-7. PMID: 32611325Free PMC Article
Akıncı D, Ergun O, Topel Ç, Çiftçi T, Akhan O
Diagn Interv Radiol 2018 May-Jun;24(3):146-152. doi: 10.5152/dir.2018.16500. PMID: 29770767Free PMC Article
Sutherland AE, Curtin J, Bradley V, Bush O, Presswood M, Hedges V, Naessens K
BMJ Support Palliat Care 2018 Jun;8(2):129-135. Epub 2017 Jul 22 doi: 10.1136/bmjspcare-2016-001261. PMID: 28735270

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