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Bradyphrenia

MedGen UID:
640666
Concept ID:
C0554976
Mental or Behavioral Dysfunction
Synonyms: Mental slowness; Slowed thinking; Slowed thoughts; Slowness of thought
SNOMED CT: Bradyphrenia (285242009)
 
HPO: HP:0031843

Definition

Abnormal slowness of thought processes. [from HPO]

Term Hierarchy

Conditions with this feature

Intellectual disability, autosomal dominant 56
MedGen UID:
1638835
Concept ID:
C4693389
Mental or Behavioral Dysfunction

Professional guidelines

PubMed

Heinonen EH, Rinne UK
Acta Neurol Scand Suppl 1989;126:103-11. doi: 10.1111/j.1600-0404.1989.tb01789.x. PMID: 2515715

Recent clinical studies

Etiology

Schönecker S, Palleis C, Franzmeier N, Katzdobler S, Ferschmann C, Schuster S, Finze A, Scheifele M, Prix C, Fietzek U, Weidinger E, Nübling G, Vöglein J, Patt M, Barthel H, Sabri O, Danek A, Höglinger GU, Brendel M, Levin J; for German Imaging Initiative for Tauopathies GII4T
Neuroimage Clin 2023;38:103402. Epub 2023 Apr 11 doi: 10.1016/j.nicl.2023.103402. PMID: 37087820Free PMC Article
Arroyo A, Periáñez JA, Ríos-Lago M, Lubrini G, Andreo J, Benito-León J, Louis ED, Romero JP
Brain Behav 2021 Mar;11(3):e02031. Epub 2021 Jan 15 doi: 10.1002/brb3.2031. PMID: 33452724Free PMC Article
Piot I, Schweyer K, Respondek G, Stamelou M; DescribePSP study group; ProPSP study group; MDS-endorsed PSP study group, Sckopke P, Schenk T, Goetz CG, Stebbins GT, Höglinger GU
Mov Disord 2020 Apr;35(4):650-661. Epub 2020 Jan 17 doi: 10.1002/mds.27964. PMID: 31951049
Bonelli RM, Cummings JL
Neurologist 2008 Mar;14(2):100-7. doi: 10.1097/NRL.0b013e31815b0de2. PMID: 18332839
Mayeux R, Stern Y, Sano M, Cote L, Williams JB
Neurology 1987 Jul;37(7):1130-4. doi: 10.1212/wnl.37.7.1130. PMID: 2439947

Diagnosis

Zhang C, Reeves S, David AS, Costello H, Rogers J
Cogn Neuropsychiatry 2023 Jul;28(4):243-252. Epub 2023 May 12 doi: 10.1080/13546805.2023.2212151. PMID: 37170593
Schönecker S, Palleis C, Franzmeier N, Katzdobler S, Ferschmann C, Schuster S, Finze A, Scheifele M, Prix C, Fietzek U, Weidinger E, Nübling G, Vöglein J, Patt M, Barthel H, Sabri O, Danek A, Höglinger GU, Brendel M, Levin J; for German Imaging Initiative for Tauopathies GII4T
Neuroimage Clin 2023;38:103402. Epub 2023 Apr 11 doi: 10.1016/j.nicl.2023.103402. PMID: 37087820Free PMC Article
Piot I, Schweyer K, Respondek G, Stamelou M; DescribePSP study group; ProPSP study group; MDS-endorsed PSP study group, Sckopke P, Schenk T, Goetz CG, Stebbins GT, Höglinger GU
Mov Disord 2020 Apr;35(4):650-661. Epub 2020 Jan 17 doi: 10.1002/mds.27964. PMID: 31951049
Johnson DK, Langford Z, Garnier-Villarreal M, Morris JC, Galvin JE
Alzheimer Dis Assoc Disord 2016 Apr-Jun;30(2):127-33. doi: 10.1097/WAD.0000000000000088. PMID: 25850732Free PMC Article
DeSousa EA, Albert RH, Kalman B
Am J Alzheimers Dis Other Demen 2002 Jan-Feb;17(1):23-9. doi: 10.1177/153331750201700104. PMID: 11831417Free PMC Article

Therapy

Piot I, Schweyer K, Respondek G, Stamelou M; DescribePSP study group; ProPSP study group; MDS-endorsed PSP study group, Sckopke P, Schenk T, Goetz CG, Stebbins GT, Höglinger GU
Mov Disord 2020 Apr;35(4):650-661. Epub 2020 Jan 17 doi: 10.1002/mds.27964. PMID: 31951049
Kehagia AA, Barker RA, Robbins TW
Lancet Neurol 2010 Dec;9(12):1200-1213. Epub 2010 Sep 27 doi: 10.1016/S1474-4422(10)70212-X. PMID: 20880750
Cheong R, Wilson RK, Cortese IC, Newman-Toker DE
Subst Abus 2006 Dec;27(4):63-7. doi: 10.1300/j465v27n04_08. PMID: 17347127
Duncombe ME, Bradshaw JL, Iansek R, Phillips JG
Neuropsychologia 1994 Nov;32(11):1383-96. doi: 10.1016/0028-3932(94)00071-9. PMID: 7877746
Rogers D, Lees AJ, Smith E, Trimble M, Stern GM
Brain 1987 Jun;110 ( Pt 3):761-76. doi: 10.1093/brain/110.3.761. PMID: 3107750

Prognosis

Schönecker S, Palleis C, Franzmeier N, Katzdobler S, Ferschmann C, Schuster S, Finze A, Scheifele M, Prix C, Fietzek U, Weidinger E, Nübling G, Vöglein J, Patt M, Barthel H, Sabri O, Danek A, Höglinger GU, Brendel M, Levin J; for German Imaging Initiative for Tauopathies GII4T
Neuroimage Clin 2023;38:103402. Epub 2023 Apr 11 doi: 10.1016/j.nicl.2023.103402. PMID: 37087820Free PMC Article
Vlagsma TT, Koerts J, Tucha O, Dijkstra HT, Duits AA, van Laar T, Spikman JM
J Clin Exp Neuropsychol 2016 Oct;38(8):844-52. Epub 2016 May 1 doi: 10.1080/13803395.2016.1167840. PMID: 27132647
Kertesz A, McMonagle P
J Neurol Sci 2010 Feb 15;289(1-2):138-43. Epub 2009 Sep 5 doi: 10.1016/j.jns.2009.08.036. PMID: 19733862
DeSousa EA, Albert RH, Kalman B
Am J Alzheimers Dis Other Demen 2002 Jan-Feb;17(1):23-9. doi: 10.1177/153331750201700104. PMID: 11831417Free PMC Article
Paulsen JS, Salmon DP, Thal LJ, Romero R, Weisstein-Jenkins C, Galasko D, Hofstetter CR, Thomas R, Grant I, Jeste DV
Neurology 2000 May 23;54(10):1965-71. doi: 10.1212/wnl.54.10.1965. PMID: 10822438

Clinical prediction guides

Schönecker S, Palleis C, Franzmeier N, Katzdobler S, Ferschmann C, Schuster S, Finze A, Scheifele M, Prix C, Fietzek U, Weidinger E, Nübling G, Vöglein J, Patt M, Barthel H, Sabri O, Danek A, Höglinger GU, Brendel M, Levin J; for German Imaging Initiative for Tauopathies GII4T
Neuroimage Clin 2023;38:103402. Epub 2023 Apr 11 doi: 10.1016/j.nicl.2023.103402. PMID: 37087820Free PMC Article
Piot I, Schweyer K, Respondek G, Stamelou M; DescribePSP study group; ProPSP study group; MDS-endorsed PSP study group, Sckopke P, Schenk T, Goetz CG, Stebbins GT, Höglinger GU
Mov Disord 2020 Apr;35(4):650-661. Epub 2020 Jan 17 doi: 10.1002/mds.27964. PMID: 31951049
Vlagsma TT, Koerts J, Tucha O, Dijkstra HT, Duits AA, van Laar T, Spikman JM
J Clin Exp Neuropsychol 2016 Oct;38(8):844-52. Epub 2016 May 1 doi: 10.1080/13803395.2016.1167840. PMID: 27132647
Kertesz A, McMonagle P
J Neurol Sci 2010 Feb 15;289(1-2):138-43. Epub 2009 Sep 5 doi: 10.1016/j.jns.2009.08.036. PMID: 19733862
Paulsen JS, Salmon DP, Thal LJ, Romero R, Weisstein-Jenkins C, Galasko D, Hofstetter CR, Thomas R, Grant I, Jeste DV
Neurology 2000 May 23;54(10):1965-71. doi: 10.1212/wnl.54.10.1965. PMID: 10822438

Recent systematic reviews

Verbraeken R, Luykx JJ
BMC Psychiatry 2018 Oct 29;18(1):350. doi: 10.1186/s12888-018-1935-0. PMID: 30373550Free PMC Article

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