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Centrilobular emphysema

MedGen UID:
65133
Concept ID:
C0221227
Disease or Syndrome
Synonyms: Centriacinar Emphysema; Centriacinar Emphysemas; Centrilobular Emphysema; Centrilobular Emphysemas; Emphysema, Centriacinar; Emphysema, Centrilobular; Emphysemas, Centriacinar; Emphysemas, Centrilobular
SNOMED CT: Centriacinar emphysema (68328006); Centrilobular emphysema (68328006)
 
HPO: HP:0032966

Definition

A type of emphysema characterized by destroyed centrilobular alveolar walls and enlargement of respiratory bronchioles and associated alveoli. This is the commonest form of emphysema in cigarette smokers. CT findings are centrilobular areas of decreased attenuation, usually without visible walls, of nonuniform distribution and predominantly located in upper lung zones. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentrilobular emphysema

Professional guidelines

PubMed

Wick MR
Semin Diagn Pathol 2018 Sep;35(5):315-323. Epub 2018 Aug 10 doi: 10.1053/j.semdp.2018.08.002. PMID: 30154023

Recent clinical studies

Etiology

Maetani T, Tanabe N, Shiraishi Y, Shimada T, Terada S, Shima H, Mochizuki F, Sakamoto R, Kaji S, Oguma T, Sato S, Iijima H, Masuda I, Hirai T
Respiration 2023;102(3):194-202. Epub 2023 Jan 23 doi: 10.1159/000529031. PMID: 36689922Free PMC Article
Janssen R, Piscaer I, Franssen FME, Wouters EFM
Expert Rev Respir Med 2019 Apr;13(4):381-397. Epub 2019 Feb 22 doi: 10.1080/17476348.2019.1580575. PMID: 30761929
Bhatt SP, Nath HP, Kim YI, Ramachandran R, Watts JR, Terry NLJ, Sonavane S, Deshmane SP, Woodruff PG, Oelsner EC, Bodduluri S, Han MK, Labaki WW, Michael Wells J, Martinez FJ, Barr RG, Dransfield MT; SPIROMICS investigators
Respir Res 2018 Dec 18;19(1):257. doi: 10.1186/s12931-018-0946-1. PMID: 30563576Free PMC Article
Leung JM, Malagoli A, Santoro A, Besutti G, Ligabue G, Scaglioni R, Dai D, Hague C, Leipsic J, Sin DD, Man SP, Guaraldi G
PLoS One 2016;11(11):e0167247. Epub 2016 Nov 30 doi: 10.1371/journal.pone.0167247. PMID: 27902753Free PMC Article
Ginsburg SB, Zhao J, Humphries S, Jou S, Yagihashi K, Lynch DA, Schroeder JD; COPDGene Investigators
Acad Radiol 2016 Nov;23(11):1349-1358. Epub 2016 Aug 27 doi: 10.1016/j.acra.2016.06.002. PMID: 27575837Free PMC Article

Diagnosis

Booth S, Hsieh A, Mostaco-Guidolin L, Koo HK, Wu K, Aminazadeh F, Yang CX, Quail D, Wei Y, Cooper JD, Paré PD, Hogg JC, Vasilescu DM, Hackett TL
Am J Respir Crit Care Med 2023 Aug 15;208(4):472-486. doi: 10.1164/rccm.202303-0534OC. PMID: 37406359
Klont F, Horvatovich P, Bowler RP, van Rikxoort E, Charbonnier JP, Kwiatkowski M, Lynch DA, Humphries S, Bischoff R, Ten Hacken NHT, Pouwels SD
Respir Res 2022 Jan 24;23(1):15. doi: 10.1186/s12931-022-01934-w. PMID: 35073932Free PMC Article
Janssen R, Piscaer I, Franssen FME, Wouters EFM
Expert Rev Respir Med 2019 Apr;13(4):381-397. Epub 2019 Feb 22 doi: 10.1080/17476348.2019.1580575. PMID: 30761929
Sieminska A, Kuziemski K
Orphanet J Rare Dis 2014 Jul 11;9:106. doi: 10.1186/s13023-014-0106-8. PMID: 25011486Free PMC Article
Foster WL Jr, Gimenez EI, Roubidoux MA, Sherrier RH, Shannon RH, Roggli VL, Pratt PC
Radiographics 1993 Mar;13(2):311-28. doi: 10.1148/radiographics.13.2.8460222. PMID: 8460222

Therapy

Yang X, Wisselink HJ, Vliegenthart R, Heuvelmans MA, Groen HJM, Vonder M, Dorrius MD, de Bock GH
Radiology 2022 Aug;304(2):322-330. Epub 2022 May 3 doi: 10.1148/radiol.212904. PMID: 35503012
Janssen R, Piscaer I, Franssen FME, Wouters EFM
Expert Rev Respir Med 2019 Apr;13(4):381-397. Epub 2019 Feb 22 doi: 10.1080/17476348.2019.1580575. PMID: 30761929
Ginsburg SB, Zhao J, Humphries S, Jou S, Yagihashi K, Lynch DA, Schroeder JD; COPDGene Investigators
Acad Radiol 2016 Nov;23(11):1349-1358. Epub 2016 Aug 27 doi: 10.1016/j.acra.2016.06.002. PMID: 27575837Free PMC Article
Cosio Piqueras MG, Cosio MG
Eur Respir J Suppl 2001 Dec;34:41s-49s. doi: 10.1183/09031936.01.00234601. PMID: 12392034
Saetta M, Kim WD, Izquierdo JL, Ghezzo H, Cosio MG
Eur Respir J 1994 Apr;7(4):664-71. doi: 10.1183/09031936.94.07040664. PMID: 8005246

Prognosis

Klont F, Horvatovich P, Bowler RP, van Rikxoort E, Charbonnier JP, Kwiatkowski M, Lynch DA, Humphries S, Bischoff R, Ten Hacken NHT, Pouwels SD
Respir Res 2022 Jan 24;23(1):15. doi: 10.1186/s12931-022-01934-w. PMID: 35073932Free PMC Article
Tanabe N, Hirai T
Korean J Intern Med 2021 Nov;36(6):1294-1304. Epub 2021 Oct 6 doi: 10.3904/kjim.2021.124. PMID: 34607419Free PMC Article
Tanabe N, Rhee CK, Sato S, Muro S, Shima H, Tanimura K, Jung KS, Yoo KH, Hirai T
COPD 2020 Dec;17(6):627-634. Epub 2020 Nov 23 doi: 10.1080/15412555.2020.1845639. PMID: 33222554
Leung JM, Malagoli A, Santoro A, Besutti G, Ligabue G, Scaglioni R, Dai D, Hague C, Leipsic J, Sin DD, Man SP, Guaraldi G
PLoS One 2016;11(11):e0167247. Epub 2016 Nov 30 doi: 10.1371/journal.pone.0167247. PMID: 27902753Free PMC Article
Sieminska A, Kuziemski K
Orphanet J Rare Dis 2014 Jul 11;9:106. doi: 10.1186/s13023-014-0106-8. PMID: 25011486Free PMC Article

Clinical prediction guides

Booth S, Hsieh A, Mostaco-Guidolin L, Koo HK, Wu K, Aminazadeh F, Yang CX, Quail D, Wei Y, Cooper JD, Paré PD, Hogg JC, Vasilescu DM, Hackett TL
Am J Respir Crit Care Med 2023 Aug 15;208(4):472-486. doi: 10.1164/rccm.202303-0534OC. PMID: 37406359
Shiraishi Y, Tanabe N, Shimizu K, Oguma A, Shima H, Sakamoto R, Yamazaki H, Oguma T, Sato A, Suzuki M, Makita H, Muro S, Nishimura M, Sato S, Konno S, Hirai T
Chest 2023 Aug;164(2):327-338. Epub 2023 Jan 31 doi: 10.1016/j.chest.2023.01.034. PMID: 36736486
Klont F, Horvatovich P, Bowler RP, van Rikxoort E, Charbonnier JP, Kwiatkowski M, Lynch DA, Humphries S, Bischoff R, Ten Hacken NHT, Pouwels SD
Respir Res 2022 Jan 24;23(1):15. doi: 10.1186/s12931-022-01934-w. PMID: 35073932Free PMC Article
Bhatt SP, Nath HP, Kim YI, Ramachandran R, Watts JR, Terry NLJ, Sonavane S, Deshmane SP, Woodruff PG, Oelsner EC, Bodduluri S, Han MK, Labaki WW, Michael Wells J, Martinez FJ, Barr RG, Dransfield MT; SPIROMICS investigators
Respir Res 2018 Dec 18;19(1):257. doi: 10.1186/s12931-018-0946-1. PMID: 30563576Free PMC Article
Gelb AF, Christenson SA, Nadel JA
Curr Opin Pulm Med 2016 Mar;22(2):100-5. doi: 10.1097/MCP.0000000000000236. PMID: 26717511

Recent systematic reviews

Yang X, Wisselink HJ, Vliegenthart R, Heuvelmans MA, Groen HJM, Vonder M, Dorrius MD, de Bock GH
Radiology 2022 Aug;304(2):322-330. Epub 2022 May 3 doi: 10.1148/radiol.212904. PMID: 35503012

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