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Palpebral nevus

MedGen UID:
65985
•Concept ID:
C0239460
•
Neoplastic Process
Synonyms: Eyelid nevus; Eyelid Nevus; eyelid nevus; melanocytic nevus of skin of eyelid; Nevus of eyelid; Nevus of Eyelid; nevus of eyelid; Nevus of the Eyelid; nevus of the eyelid; palpebral nevus; skin of eyelid melanocytic nevus
SNOMED CT: Eyelid nevus (231827008); Nevus of eyelid (231827008)
 
Monarch Initiative: MONDO:0020179

Definition

A benign nevus occurring in the eyelid. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPalpebral nevus
Follow this link to review classifications for Palpebral nevus in Orphanet.

Professional guidelines

PubMed

Current Management of Conjunctival Melanoma Part 1: Clinical Features, Diagnosis and Histopathology.
Koç İ, Kıratlı H
Turk J Ophthalmol 2020 Oct 30;50(5):293-303. doi: 10.4274/tjo.galenos.2020.38096. PMID: 33342197Free PMC Article
Pathophysiology, diagnosis, and management of glaucoma associated with Sturge-Weber syndrome.
Javaid U, Ali MH, Jamal S, Butt NH
Int Ophthalmol 2018 Feb;38(1):409-416. Epub 2017 Jan 7 doi: 10.1007/s10792-016-0412-3. PMID: 28064423
Laser treatment of periocular skin conditions.
Yates B, Que SK, D'Souza L, Suchecki J, Finch JJ
Clin Dermatol 2015 Mar-Apr;33(2):197-206. doi: 10.1016/j.clindermatol.2014.10.011. PMID: 25704939

Recent clinical studies

Etiology

Treatments of palpebral congenital melanocytic nevus: a systematic review.
Camargo CP, Saliba M, Saad EA, Milan M, Caldera JM
Acta Cir Bras 2023;38:e384823. Epub 2023 Dec 1 doi: 10.1590/acb384823. PMID: 38055392Free PMC Article
Pigmented lesions of the conjunctiva: The sheep and the wolf.
Christy MC, Honavar SG, Mulay K, Talloju SS
Indian J Ophthalmol 2023 Jul;71(7):2927. doi: 10.4103/IJO.IJO_1367_23. PMID: 37417160Free PMC Article
Cosmetically Challenging Congenital Melanocytic Nevi.
Fahradyan A, Wolfswinkel EM, Tsuha M, Reinisch JF, Magee W 3rd, Hammoudeh JA, Urata MM, Howell LK
Ann Plast Surg 2019 May;82(5S Suppl 4):S306-S309. doi: 10.1097/SAP.0000000000001766. PMID: 30973837
Laser treatment of periocular skin conditions.
Yates B, Que SK, D'Souza L, Suchecki J, Finch JJ
Clin Dermatol 2015 Mar-Apr;33(2):197-206. doi: 10.1016/j.clindermatol.2014.10.011. PMID: 25704939
Inflamed conjunctival nevi: histopathological criteria.
Choi EK, Chévez-Barrios P
Arch Pathol Lab Med 2014 Sep;138(9):1242-6. doi: 10.5858/arpa.2013-0245-RS. PMID: 25171709

Diagnosis

Pigmented lesions of the conjunctiva: The sheep and the wolf.
Christy MC, Honavar SG, Mulay K, Talloju SS
Indian J Ophthalmol 2023 Jul;71(7):2927. doi: 10.4103/IJO.IJO_1367_23. PMID: 37417160Free PMC Article
Solitary Intratarsal Blue Nevus.
Charles NC, Kim ET
Ophthalmic Plast Reconstr Surg 2023 Mar-Apr 01;39(2):e33-e35. Epub 2022 Sep 22 doi: 10.1097/IOP.0000000000002284. PMID: 36136733
Diagnostic Algorithm for Conjunctival Melanocytic Lesions.
Dębicka-Kumela M, Romanowska-Dixon B, Karska-Basta I, Kowal J, Pociej-Marciak W, Markiewicz A
Anticancer Res 2021 Jun;41(6):3161-3167. doi: 10.21873/anticanres.15102. PMID: 34083311
Pathophysiology, diagnosis, and management of glaucoma associated with Sturge-Weber syndrome.
Javaid U, Ali MH, Jamal S, Butt NH
Int Ophthalmol 2018 Feb;38(1):409-416. Epub 2017 Jan 7 doi: 10.1007/s10792-016-0412-3. PMID: 28064423
Inflamed conjunctival nevi: histopathological criteria.
Choi EK, Chévez-Barrios P
Arch Pathol Lab Med 2014 Sep;138(9):1242-6. doi: 10.5858/arpa.2013-0245-RS. PMID: 25171709

Therapy

Treatment of Divided Eyelid Nevus With Orbicularis Oculi Myocutaneous Flap: Report of 17 Cases.
Liu J, Sun J, Wang Z, Guo L, Guo N
Ann Plast Surg 2020 Dec;85(6):626-630. doi: 10.1097/SAP.0000000000002507. PMID: 32756248
Staged Mosaic Punching Excision of a Kissing Nevus on the Eyelid.
Cho HJ, Lee W, Jeon MK, Park JO, Yang EJ
Aesthetic Plast Surg 2019 Jun;43(3):652-657. Epub 2019 Apr 1 doi: 10.1007/s00266-019-01362-0. PMID: 30937473
Divided nevus of the eyelid: successful treatment with CO2 laser.
Zeng Y
J Dermatolog Treat 2014 Aug;25(4):358-9. Epub 2013 Feb 24 doi: 10.3109/09546634.2012.756970. PMID: 23216296
Patterns of prenatal alcohol exposure and associated non-characteristic minor structural malformations: a prospective study.
Feldman HS, Jones KL, Lindsay S, Slymen D, Klonoff-Cohen H, Kao K, Rao S, Chambers C
Am J Med Genet A 2011 Dec;155A(12):2949-55. Epub 2011 Oct 14 doi: 10.1002/ajmg.a.34276. PMID: 22002918
Analysis of 602 Chinese cases of nevus of Ota and the treatment results treated by Q-switched alexandrite laser.
Wang HW, Liu YH, Zhang GK, Jin HZ, Zuo YG, Jiang GT, Wang JB
Dermatol Surg 2007 Apr;33(4):455-60. doi: 10.1111/j.1524-4725.2007.33093.x. PMID: 17430380

Prognosis

Indocyanine Green Angiographic Assessment of Conjunctival Melanocytic Disorders.
Palme C, Wanner A, Romano V, Franchi A, Haas G, Kaye SB, Steger B
Cornea 2021 Dec 1;40(12):1519-1524. doi: 10.1097/ICO.0000000000002681. PMID: 33591034
Current Management of Conjunctival Melanoma Part 1: Clinical Features, Diagnosis and Histopathology.
Koç İ, Kıratlı H
Turk J Ophthalmol 2020 Oct 30;50(5):293-303. doi: 10.4274/tjo.galenos.2020.38096. PMID: 33342197Free PMC Article
Laser treatment of periocular skin conditions.
Yates B, Que SK, D'Souza L, Suchecki J, Finch JJ
Clin Dermatol 2015 Mar-Apr;33(2):197-206. doi: 10.1016/j.clindermatol.2014.10.011. PMID: 25704939
Inflamed conjunctival nevi: histopathological criteria.
Choi EK, Chévez-Barrios P
Arch Pathol Lab Med 2014 Sep;138(9):1242-6. doi: 10.5858/arpa.2013-0245-RS. PMID: 25171709
Pigmented lesions of the conjunctiva.
Farber M, Schutzer P, Mihm MC Jr
J Dermatol 1996 Nov;23(11):746-50. doi: 10.1111/j.1346-8138.1996.tb02696.x. PMID: 8990696

Clinical prediction guides

Pigmented lesions of the conjunctiva: The sheep and the wolf.
Christy MC, Honavar SG, Mulay K, Talloju SS
Indian J Ophthalmol 2023 Jul;71(7):2927. doi: 10.4103/IJO.IJO_1367_23. PMID: 37417160Free PMC Article
The surgical management and outcomes of kissing nevi of the eyelids.
Zloto O, Landau Prat D, Katowitz JA, Katowitz WR, Ben Simon G, Verity DH
Eye (Lond) 2023 Oct;37(14):3015-3019. Epub 2023 Mar 11 doi: 10.1038/s41433-023-02463-6. PMID: 36906696Free PMC Article
Progress of Bulbar Conjunctival Microcirculation Alterations in the Diagnosis of Ocular Diseases.
Sun Z, Li Y, Liu R, Ma B, Zhou Y, Duan H, Bian L, Li W, Qi H
Dis Markers 2022;2022:4046809. Epub 2022 Aug 28 doi: 10.1155/2022/4046809. PMID: 36072898Free PMC Article
"Kissing" basaloid follicular hamartomas of the eyelid.
Ezemma O, Ragi SD, Ruiz R, Robinson-Bostom L, Enzer Y, DiMarco C
J Cutan Pathol 2022 Oct;49(10):881-884. Epub 2022 Jul 5 doi: 10.1111/cup.14273. PMID: 35699643
Diagnostic Algorithm for Conjunctival Melanocytic Lesions.
Dębicka-Kumela M, Romanowska-Dixon B, Karska-Basta I, Kowal J, Pociej-Marciak W, Markiewicz A
Anticancer Res 2021 Jun;41(6):3161-3167. doi: 10.21873/anticanres.15102. PMID: 34083311

Recent systematic reviews

Treatments of palpebral congenital melanocytic nevus: a systematic review.
Camargo CP, Saliba M, Saad EA, Milan M, Caldera JM
Acta Cir Bras 2023;38:e384823. Epub 2023 Dec 1 doi: 10.1590/acb384823. PMID: 38055392Free PMC Article
Pathophysiology, diagnosis, and management of glaucoma associated with Sturge-Weber syndrome.
Javaid U, Ali MH, Jamal S, Butt NH
Int Ophthalmol 2018 Feb;38(1):409-416. Epub 2017 Jan 7 doi: 10.1007/s10792-016-0412-3. PMID: 28064423
Divided nevus of the eyelid: review of embryology, pathology and treatment.
Desai SC, Walen S, Holds JB, Branham G
Am J Otolaryngol 2013 May-Jun;34(3):223-9. Epub 2013 Feb 4 doi: 10.1016/j.amjoto.2013.01.004. PMID: 23380310

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