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Iron deficiency

MedGen UID:
66001
•Concept ID:
C0240066
•
Disease or Syndrome
Synonyms: Deficiencies, Iron; Deficiency, Iron; Iron Deficiencies; Iron Deficiency; Sideropenia; Sideropenias
SNOMED CT: Iron deficiency (35240004)

Definition

Subnormal concentrations of iron resulting from low iron intake, inefficient iron absorption in the gastrointestinal tract, or increased iron loss. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIron deficiency

Professional guidelines

PubMed

Iron deficiency anaemia: pathophysiology, assessment, practical management.
Kumar A, Sharma E, Marley A, Samaan MA, Brookes MJ
BMJ Open Gastroenterol 2022 Jan;9(1) doi: 10.1136/bmjgast-2021-000759. PMID: 34996762Free PMC Article
Restless Legs Syndrome: Contemporary Diagnosis and Treatment.
Gossard TR, Trotti LM, Videnovic A, St Louis EK
Neurotherapeutics 2021 Jan;18(1):140-155. Epub 2021 Apr 20 doi: 10.1007/s13311-021-01019-4. PMID: 33880737Free PMC Article
ACG Clinical Guideline: Treatment of Helicobacter pylori Infection.
Chey WD, Leontiadis GI, Howden CW, Moss SF
Am J Gastroenterol 2017 Feb;112(2):212-239. Epub 2017 Jan 10 doi: 10.1038/ajg.2016.563. PMID: 28071659

Recent clinical studies

Etiology

Iron Deficiency Anemia: An Updated Review.
Leung AKC, Lam JM, Wong AHC, Hon KL, Li X
Curr Pediatr Rev 2024;20(3):339-356. doi: 10.2174/1573396320666230727102042. PMID: 37497686
Iron deficiency anaemia revisited.
Cappellini MD, Musallam KM, Taher AT
J Intern Med 2020 Feb;287(2):153-170. Epub 2019 Nov 12 doi: 10.1111/joim.13004. PMID: 31665543
Iron deficiency anemia: clinical and etiological features.
Bellakhal S, Ouertani S, Antit S, Abdelaali I, Teyeb Z, Dougui MH
Tunis Med 2019 Dec;97(12):1389-1398. PMID: 32173810
Iron deficiency.
Camaschella C
Blood 2019 Jan 3;133(1):30-39. Epub 2018 Nov 6 doi: 10.1182/blood-2018-05-815944. PMID: 30401704
Iron deficiency anaemia.
Lopez A, Cacoub P, Macdougall IC, Peyrin-Biroulet L
Lancet 2016 Feb 27;387(10021):907-16. Epub 2015 Aug 24 doi: 10.1016/S0140-6736(15)60865-0. PMID: 26314490

Diagnosis

Iron deficiency anemia: Impact on women's reproductive health.
Petraglia F, Dolmans MM
Fertil Steril 2022 Oct;118(4):605-606. doi: 10.1016/j.fertnstert.2022.08.850. PMID: 36182259
Iron metabolism and iron deficiency anemia in women.
Cappellini MD, Santini V, Braxs C, Shander A
Fertil Steril 2022 Oct;118(4):607-614. Epub 2022 Sep 6 doi: 10.1016/j.fertnstert.2022.08.014. PMID: 36075747
Iron deficiency anaemia: pathophysiology, assessment, practical management.
Kumar A, Sharma E, Marley A, Samaan MA, Brookes MJ
BMJ Open Gastroenterol 2022 Jan;9(1) doi: 10.1136/bmjgast-2021-000759. PMID: 34996762Free PMC Article
Iron deficiency anaemia revisited.
Cappellini MD, Musallam KM, Taher AT
J Intern Med 2020 Feb;287(2):153-170. Epub 2019 Nov 12 doi: 10.1111/joim.13004. PMID: 31665543
Iron Deficiency Anemia.
DeLoughery TG
Med Clin North Am 2017 Mar;101(2):319-332. Epub 2016 Dec 8 doi: 10.1016/j.mcna.2016.09.004. PMID: 28189173

Therapy

The effects of oral ferrous bisglycinate supplementation on hemoglobin and ferritin concentrations in adults and children: a systematic review and meta-analysis of randomized controlled trials.
Fischer JAJ, Cherian AM, Bone JN, Karakochuk CD
Nutr Rev 2023 Jul 10;81(8):904-920. doi: 10.1093/nutrit/nuac106. PMID: 36728680Free PMC Article
Iron deficiency and common neurodevelopmental disorders-A scoping review.
McWilliams S, Singh I, Leung W, Stockler S, Ipsiroglu OS
PLoS One 2022;17(9):e0273819. Epub 2022 Sep 29 doi: 10.1371/journal.pone.0273819. PMID: 36173945Free PMC Article
Effectiveness of Dietary Interventions in Prevention and Treatment of Iron-Deficiency Anemia in Pregnant Women: A Systematic Review of Randomized Controlled Trials.
Skolmowska D, Głąbska D, Kołota A, Guzek D
Nutrients 2022 Jul 23;14(15) doi: 10.3390/nu14153023. PMID: 35893877Free PMC Article
Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: Two Randomized Clinical Trials.
Wolf M, Rubin J, Achebe M, Econs MJ, Peacock M, Imel EA, Thomsen LL, Carpenter TO, Weber T, Brandenburg V, Zoller H
JAMA 2020 Feb 4;323(5):432-443. doi: 10.1001/jama.2019.22450. PMID: 32016310Free PMC Article
Iron Deficiency Anemia in Chronic Kidney Disease.
Gafter-Gvili A, Schechter A, Rozen-Zvi B
Acta Haematol 2019;142(1):44-50. Epub 2019 Apr 10 doi: 10.1159/000496492. PMID: 30970355

Prognosis

The incidence, complications, and treatment of iron deficiency in pregnancy.
Benson AE, Shatzel JJ, Ryan KS, Hedges MA, Martens K, Aslan JE, Lo JO
Eur J Haematol 2022 Dec;109(6):633-642. Epub 2022 Oct 4 doi: 10.1111/ejh.13870. PMID: 36153674Free PMC Article
Physiologically based serum ferritin thresholds for iron deficiency in children and non-pregnant women: a US National Health and Nutrition Examination Surveys (NHANES) serial cross-sectional study.
Mei Z, Addo OY, Jefferds ME, Sharma AJ, Flores-Ayala RC, Brittenham GM
Lancet Haematol 2021 Aug;8(8):e572-e582. doi: 10.1016/S2352-3026(21)00168-X. PMID: 34329578Free PMC Article
Prevention of iron deficiency anemia in infants and toddlers.
Sundararajan S, Rabe H
Pediatr Res 2021 Jan;89(1):63-73. Epub 2020 Apr 24 doi: 10.1038/s41390-020-0907-5. PMID: 32330927
Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.
GBD 2016 Disease and Injury Incidence and Prevalence Collaborators
Lancet 2017 Sep 16;390(10100):1211-1259. doi: 10.1016/S0140-6736(17)32154-2. PMID: 28919117Free PMC Article
Common sleep disorders in children.
Carter KA, Hathaway NE, Lettieri CF
Am Fam Physician 2014 Mar 1;89(5):368-77. PMID: 24695508

Clinical prediction guides

Intravenous iron for heart failure, iron deficiency definitions, and clinical response: the IRONMAN trial.
Cleland JGF, Kalra PA, Pellicori P, Graham FJ, Foley PWX, Squire IB, Cowburn PJ, Seed A, Clark AL, Szwejkowski B, Banerjee P, Cooke J, Francis M, Clifford P, Wong A, Petrie C, McMurray JJV, Thomson EA, Wetherall K, Robertson M, Ford I, Kalra PR; IRONMAN Study Group
Eur Heart J 2024 Apr 21;45(16):1410-1426. doi: 10.1093/eurheartj/ehae086. PMID: 38446126Free PMC Article
Iron deficiency in pulmonary vascular disease: pathophysiological and clinical implications.
Martens P, Yu S, Larive B, Borlaug BA, Erzurum SC, Farha S, Finet JE, Grunig G, Hemnes AR, Hill NS, Horn EM, Jacob M, Kwon DH, Park MM, Rischard FP, Rosenzweig EB, Wilcox JD, Tang WHW; PVDOMICS Study Group
Eur Heart J 2023 Jun 9;44(22):1979-1991. doi: 10.1093/eurheartj/ehad149. PMID: 36879444Free PMC Article
2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America.
Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Colvin MM, Drazner MH, Filippatos GS, Fonarow GC, Givertz MM, Hollenberg SM, Lindenfeld J, Masoudi FA, McBride PE, Peterson PN, Stevenson LW, Westlake C
Circulation 2017 Aug 8;136(6):e137-e161. Epub 2017 Apr 28 doi: 10.1161/CIR.0000000000000509. PMID: 28455343
Evaluation of Anemia.
Kujovich JL
Obstet Gynecol Clin North Am 2016 Jun;43(2):247-64. Epub 2016 Mar 18 doi: 10.1016/j.ogc.2016.01.009. PMID: 27212091
Enterolithiasis.
Gurvits GE, Lan G
World J Gastroenterol 2014 Dec 21;20(47):17819-29. doi: 10.3748/wjg.v20.i47.17819. PMID: 25548480Free PMC Article

Recent systematic reviews

Relationship between Iron Deficiency and Thyroid Function: A Systematic Review and Meta-Analysis.
Garofalo V, Condorelli RA, Cannarella R, Aversa A, Calogero AE, La Vignera S
Nutrients 2023 Nov 15;15(22) doi: 10.3390/nu15224790. PMID: 38004184Free PMC Article
The effects of oral ferrous bisglycinate supplementation on hemoglobin and ferritin concentrations in adults and children: a systematic review and meta-analysis of randomized controlled trials.
Fischer JAJ, Cherian AM, Bone JN, Karakochuk CD
Nutr Rev 2023 Jul 10;81(8):904-920. doi: 10.1093/nutrit/nuac106. PMID: 36728680Free PMC Article
Effectiveness of Dietary Interventions in Prevention and Treatment of Iron-Deficiency Anemia in Pregnant Women: A Systematic Review of Randomized Controlled Trials.
Skolmowska D, Głąbska D, Kołota A, Guzek D
Nutrients 2022 Jul 23;14(15) doi: 10.3390/nu14153023. PMID: 35893877Free PMC Article
Diagnosis and treatment of iron-deficiency anemia in gastrointestinal bleeding: A systematic review.
Cotter J, Baldaia C, Ferreira M, Macedo G, Pedroto I
World J Gastroenterol 2020 Dec 7;26(45):7242-7257. doi: 10.3748/wjg.v26.i45.7242. PMID: 33362380Free PMC Article
ESPEN guideline: Clinical nutrition in inflammatory bowel disease.
Forbes A, Escher J, Hébuterne X, Kłęk S, Krznaric Z, Schneider S, Shamir R, Stardelova K, Wierdsma N, Wiskin AE, Bischoff SC
Clin Nutr 2017 Apr;36(2):321-347. Epub 2016 Dec 31 doi: 10.1016/j.clnu.2016.12.027. PMID: 28131521

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