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Testicular embryonal carcinoma

MedGen UID:
66771
•Concept ID:
C0238448
•
Neoplastic Process
Synonyms: Embryonal Carcinoma of Testis; embryonal carcinoma of testis; Embryonal Carcinoma of the Testis; embryonal carcinoma of the testis; embryonal testis carcinoma; Testicular Embryonal Carcinoma; testicular embryonal carcinoma; testis embryonal carcinoma
 
Monarch Initiative: MONDO:0006446

Definition

A malignant germ cell neoplasm arising from the testis. It is composed of primitive epithelial cells arranged in solid, papillary, and glandular configurations. Most patients present with a testicular mass, which may be associated with pain. More than half of the patients have metastatic disease at diagnosis. The form of treatment following radical orchiectomy is stage dependent. [from NCI]

Professional guidelines

PubMed

Diagnosis and Treatment of Early Stage Testicular Cancer: AUA Guideline.
Stephenson A, Eggener SE, Bass EB, Chelnick DM, Daneshmand S, Feldman D, Gilligan T, Karam JA, Leibovich B, Liauw SL, Masterson TA, Meeks JJ, Pierorazio PM, Sharma R, Sheinfeld J
J Urol 2019 Aug;202(2):272-281. Epub 2019 Jul 8 doi: 10.1097/JU.0000000000000318. PMID: 31059667
Testicular germ-cell tumours and penile squamous cell carcinoma: Appropriate management makes the difference.
Nicolai N, Biasoni D, Catanzaro MA, Colecchia M, Trama A; RARECAREnet Working Group
Eur J Surg Oncol 2019 Jan;45(1):60-66. Epub 2018 Feb 14 doi: 10.1016/j.ejso.2018.02.006. PMID: 29526370
Testicular microlithiasis and carcinoma in situ overview and proposed clinical guideline.
van Casteren NJ, Looijenga LH, Dohle GR
Int J Androl 2009 Aug;32(4):279-87. Epub 2008 Dec 22 doi: 10.1111/j.1365-2605.2008.00937.x. PMID: 19207616

Recent clinical studies

Etiology

Overexpression of SerpinB9 in non-seminomatous germ cell tumors.
Anami T, Ibe Y, Li L, Komohara Y, Hirao H, Harada M, Yano H, Fujiwara Y, Motoshima T, Yatsuda J, Hibi T, Kamba T
Med Mol Morphol 2024 Mar;57(1):68-75. Epub 2023 Nov 22 doi: 10.1007/s00795-023-00374-9. PMID: 37991604
Paradoxical Expression of R-10G-reactive Antigen in Human Testicular Embryonal Carcinoma.
Muramoto A, Inamura S, Hoshino H, Terada N, Kobayashi M
J Histochem Cytochem 2023 Oct;71(10):555-563. Epub 2023 Sep 7 doi: 10.1369/00221554231199134. PMID: 37675782Free PMC Article
Hypermethylation of genes in testicular embryonal carcinomas.
Cheung HH, Yang Y, Lee TL, Rennert O, Chan WY
Br J Cancer 2016 Jan 19;114(2):230-6. Epub 2015 Dec 1 doi: 10.1038/bjc.2015.408. PMID: 26625006Free PMC Article
Transcription factors Sp1 and p73 control the expression of the proapoptotic protein NOXA in the response of testicular embryonal carcinoma cells to cisplatin.
Grande L, Bretones G, Rosa-Garrido M, Garrido-Martin EM, Hernandez T, Fraile S, Botella L, de Alava E, Vidal A, Garcia del Muro X, Villanueva A, Delgado MD, Fernandez-Luna JL
J Biol Chem 2012 Aug 3;287(32):26495-505. Epub 2012 Jun 20 doi: 10.1074/jbc.M112.376319. PMID: 22718761Free PMC Article
Lectin histochemistry of embryonal carcinoma.
Malmi R, Söderström KO
APMIS 1991 Mar;99(3):233-43. doi: 10.1111/j.1699-0463.1991.tb05144.x. PMID: 1902111

Diagnosis

Mediastinal Presentation of Testicular Embryonal Carcinoma.
Chandra S, McKean H
S D Med 2023 Aug;76(8):342-344. PMID: 37734076
Paradoxical Expression of R-10G-reactive Antigen in Human Testicular Embryonal Carcinoma.
Muramoto A, Inamura S, Hoshino H, Terada N, Kobayashi M
J Histochem Cytochem 2023 Oct;71(10):555-563. Epub 2023 Sep 7 doi: 10.1369/00221554231199134. PMID: 37675782Free PMC Article
Long noncoding RNA HOTTIP is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation.
Su Y, Zhou LL, Zhang YQ, Ni LY
Mol Genet Genomic Med 2019 Sep;7(9):e870. Epub 2019 Jul 21 doi: 10.1002/mgg3.870. PMID: 31328440Free PMC Article
Gonadotrophin-independent precocious puberty associated with later diagnosis of testicular embryonal carcinoma.
Senniappan S, Wood D, Hakeem V, Stoneham S, Freeman A, Dattani M
Horm Res Paediatr 2014;82(4):272-7. Epub 2014 Jul 5 doi: 10.1159/000362187. PMID: 25012595
Testicular embryonal carcinoma: a morphologic study of 180 cases highlighting unusual and unemphasized aspects.
Kao CS, Ulbright TM, Young RH, Idrees MT
Am J Surg Pathol 2014 May;38(5):689-97. doi: 10.1097/PAS.0000000000000171. PMID: 24503753

Therapy

Gonadotrophin-independent precocious puberty associated with later diagnosis of testicular embryonal carcinoma.
Senniappan S, Wood D, Hakeem V, Stoneham S, Freeman A, Dattani M
Horm Res Paediatr 2014;82(4):272-7. Epub 2014 Jul 5 doi: 10.1159/000362187. PMID: 25012595
Cisplatin induces resistance by triggering differentiation of testicular embryonal carcinoma cells.
Abada PB, Howell SB
PLoS One 2014;9(1):e87444. Epub 2014 Jan 27 doi: 10.1371/journal.pone.0087444. PMID: 24475288Free PMC Article
Transcription factors Sp1 and p73 control the expression of the proapoptotic protein NOXA in the response of testicular embryonal carcinoma cells to cisplatin.
Grande L, Bretones G, Rosa-Garrido M, Garrido-Martin EM, Hernandez T, Fraile S, Botella L, de Alava E, Vidal A, Garcia del Muro X, Villanueva A, Delgado MD, Fernandez-Luna JL
J Biol Chem 2012 Aug 3;287(32):26495-505. Epub 2012 Jun 20 doi: 10.1074/jbc.M112.376319. PMID: 22718761Free PMC Article
Mono-(2-ethylhexyl) phthalate (MEHP) promotes invasion and migration of human testicular embryonal carcinoma cells.
Yao PL, Lin YC, Richburg JH
Biol Reprod 2012 May;86(5):160, 1-10. Epub 2012 May 31 doi: 10.1095/biolreprod.111.097295. PMID: 22321834Free PMC Article
Cis-diamminedichloroplatinum (NSC-119875) in childhood malignancies: a Southwest Oncology Group study.
Nitschke R, Starling KA, Vats T, Bryan H
Med Pediatr Oncol 1978;4(2):127-32. doi: 10.1002/mpo.2950040208. PMID: 275532

Prognosis

Transcription factors Sp1 and p73 control the expression of the proapoptotic protein NOXA in the response of testicular embryonal carcinoma cells to cisplatin.
Grande L, Bretones G, Rosa-Garrido M, Garrido-Martin EM, Hernandez T, Fraile S, Botella L, de Alava E, Vidal A, Garcia del Muro X, Villanueva A, Delgado MD, Fernandez-Luna JL
J Biol Chem 2012 Aug 3;287(32):26495-505. Epub 2012 Jun 20 doi: 10.1074/jbc.M112.376319. PMID: 22718761Free PMC Article
Screening for germline DND1 mutations in testicular cancer patients.
Sijmons RH, Vos YJ, Herkert JC, Bos KK, Lutke Holzik MF, Hoekstra-Weebers JE, Hofstra RM, Hoekstra HJ
Fam Cancer 2010 Sep;9(3):439-42. doi: 10.1007/s10689-010-9340-y. PMID: 20411342Free PMC Article
MdmX is a substrate for the deubiquitinating enzyme USP2a.
Allende-Vega N, Sparks A, Lane DP, Saville MK
Oncogene 2010 Jan 21;29(3):432-41. Epub 2009 Oct 19 doi: 10.1038/onc.2009.330. PMID: 19838211
Non-palpable testicular embryonal carcinoma diagnosed by ultrasound: a case report.
Ishida M, Hasegawa M, Kanao K, Oyama M, Nakajima Y
Jpn J Clin Oncol 2009 Feb;39(2):124-6. Epub 2008 Dec 9 doi: 10.1093/jjco/hyn141. PMID: 19066212
Metastatic mature teratoma in lung following testicular embryonal carcinoma and teratocarcinoma.
Moran CA, Travis WD, Carter D, Koss MN
Arch Pathol Lab Med 1993 Jun;117(6):641-4. PMID: 8135909

Clinical prediction guides

Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms.
Yao PL, Chen LP, Dobrzański TP, Phillips DA, Zhu B, Kang BH, Gonzalez FJ, Peters JM
Oncotarget 2015 Nov 3;6(34):36319-37. doi: 10.18632/oncotarget.5415. PMID: 26431381Free PMC Article
MicroRNA-302a sensitizes testicular embryonal carcinoma cells to cisplatin-induced cell death.
Liu L, Lian J, Zhang H, Tian H, Liang M, Yin M, Sun F
J Cell Physiol 2013 Dec;228(12):2294-304. doi: 10.1002/jcp.24394. PMID: 23625774
Transcription factors Sp1 and p73 control the expression of the proapoptotic protein NOXA in the response of testicular embryonal carcinoma cells to cisplatin.
Grande L, Bretones G, Rosa-Garrido M, Garrido-Martin EM, Hernandez T, Fraile S, Botella L, de Alava E, Vidal A, Garcia del Muro X, Villanueva A, Delgado MD, Fernandez-Luna JL
J Biol Chem 2012 Aug 3;287(32):26495-505. Epub 2012 Jun 20 doi: 10.1074/jbc.M112.376319. PMID: 22718761Free PMC Article
Non-palpable testicular embryonal carcinoma diagnosed by ultrasound: a case report.
Ishida M, Hasegawa M, Kanao K, Oyama M, Nakajima Y
Jpn J Clin Oncol 2009 Feb;39(2):124-6. Epub 2008 Dec 9 doi: 10.1093/jjco/hyn141. PMID: 19066212
Tissue specificity of enhancer and promoter activities of a HERV-K(HML-2) LTR.
Ruda VM, Akopov SB, Trubetskoy DO, Manuylov NL, Vetchinova AS, Zavalova LL, Nikolaev LG, Sverdlov ED
Virus Res 2004 Aug;104(1):11-6. doi: 10.1016/j.virusres.2004.02.036. PMID: 15177887

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