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Vertical transmission

MedGen UID:
66943
•Concept ID:
C0242648
•
Pathologic Function
Synonyms: Infection Transmission, Vertical; Infectious Disease Transmission, Vertical; Pathogen Transmission, Vertical; Transmission, Vertical Infection; Transmission, Vertical Pathogen; Vertical Infection Transmission; Vertical Infectious Disease Transmission; Vertical Pathogen Transmission; Vertical Transmission of Infectious Disease
SNOMED CT: Vertical transmission (1290740005)

Definition

The passage of a substance or infectious agent from the mother to the fetus or newborn. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVertical transmission

Professional guidelines

PubMed

Treatment and prevention of viral hepatitis in pregnancy.
Dionne-Odom J, Cozzi GD, Franco RA, Njei B, Tita ATN
Am J Obstet Gynecol 2022 Mar;226(3):335-346. Epub 2021 Sep 10 doi: 10.1016/j.ajog.2021.09.002. PMID: 34516961Free PMC Article
Cytomegalovirus Infection in Pregnancy: Prevention, Presentation, Management and Neonatal Outcomes.
Pesch MH, Saunders NA, Abdelnabi S
J Midwifery Womens Health 2021 May;66(3):397-402. Epub 2021 May 24 doi: 10.1111/jmwh.13228. PMID: 34031974
Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice.
Dunay IR, Gajurel K, Dhakal R, Liesenfeld O, Montoya JG
Clin Microbiol Rev 2018 Oct;31(4) Epub 2018 Sep 12 doi: 10.1128/CMR.00057-17. PMID: 30209035Free PMC Article

Recent clinical studies

Etiology

The effect of valacyclovir on secondary prevention of congenital cytomegalovirus infection, following primary maternal infection acquired periconceptionally or in the first trimester of pregnancy. An individual patient data meta-analysis.
Chatzakis C, Shahar-Nissan K, Faure-Bardon V, Picone O, Hadar E, Amir J, Egloff C, Vivanti A, Sotiriadis A, Leruez-Ville M, Ville Y
Am J Obstet Gynecol 2024 Feb;230(2):109-117.e2. Epub 2023 Jul 18 doi: 10.1016/j.ajog.2023.07.022. PMID: 37473793
Prevention of the Vertical Transmission of HIV; A Recap of the Journey so Far.
Cardenas MC, Farnan S, Hamel BL, Mejia Plazas MC, Sintim-Aboagye E, Littlefield DR, Behl S, Punia S, Enninga EAL, Johnson E, Temesgen Z, Theiler R, Gray CM, Chakraborty R
Viruses 2023 Mar 26;15(4) doi: 10.3390/v15040849. PMID: 37112830Free PMC Article
Human papillomavirus in cancer: Infection, disease transmission, and progress in vaccines.
Oyouni AAA
J Infect Public Health 2023 Apr;16(4):626-631. Epub 2023 Feb 21 doi: 10.1016/j.jiph.2023.02.014. PMID: 36868166
Prevention of vertical transmission of hepatitis B virus infection.
Veronese P, Dodi I, Esposito S, Indolfi G
World J Gastroenterol 2021 Jul 14;27(26):4182-4193. doi: 10.3748/wjg.v27.i26.4182. PMID: 34326618Free PMC Article
Herpes simplex virus infection in pregnancy - An update.
Hammad WAB, Konje JC
Eur J Obstet Gynecol Reprod Biol 2021 Apr;259:38-45. Epub 2021 Feb 4 doi: 10.1016/j.ejogrb.2021.01.055. PMID: 33581405

Diagnosis

Prevention of vertical transmission of hepatitis B virus infection.
Veronese P, Dodi I, Esposito S, Indolfi G
World J Gastroenterol 2021 Jul 14;27(26):4182-4193. doi: 10.3748/wjg.v27.i26.4182. PMID: 34326618Free PMC Article
Herpes simplex virus infection in pregnancy - An update.
Hammad WAB, Konje JC
Eur J Obstet Gynecol Reprod Biol 2021 Apr;259:38-45. Epub 2021 Feb 4 doi: 10.1016/j.ejogrb.2021.01.055. PMID: 33581405
Cytomegalovirus infection in pregnancy - An update.
Navti OB, Al-Belushi M, Konje JC; FRCOG
Eur J Obstet Gynecol Reprod Biol 2021 Mar;258:216-222. Epub 2020 Dec 11 doi: 10.1016/j.ejogrb.2020.12.006. PMID: 33454510
Congenital syphilis, the great imitator-case report and review.
Keuning MW, Kamp GA, Schonenberg-Meinema D, Dorigo-Zetsma JW, van Zuiden JM, Pajkrt D
Lancet Infect Dis 2020 Jul;20(7):e173-e179. Epub 2020 Jun 2 doi: 10.1016/S1473-3099(20)30268-1. PMID: 32502432
Syphilis.
Arando Lasagabaster M, Otero Guerra L
Enferm Infecc Microbiol Clin (Engl Ed) 2019 Jun-Jul;37(6):398-404. Epub 2019 Feb 7 doi: 10.1016/j.eimc.2018.12.009. PMID: 30738716

Therapy

Prevention of the Vertical Transmission of HIV; A Recap of the Journey so Far.
Cardenas MC, Farnan S, Hamel BL, Mejia Plazas MC, Sintim-Aboagye E, Littlefield DR, Behl S, Punia S, Enninga EAL, Johnson E, Temesgen Z, Theiler R, Gray CM, Chakraborty R
Viruses 2023 Mar 26;15(4) doi: 10.3390/v15040849. PMID: 37112830Free PMC Article
Effectiveness and safety of prenatal valacyclovir for congenital cytomegalovirus infection: systematic review and meta-analysis.
D'Antonio F, Marinceu D, Prasad S, Khalil A
Ultrasound Obstet Gynecol 2023 Apr;61(4):436-444. doi: 10.1002/uog.26136. PMID: 36484439
Prevention of vertical transmission of hepatitis B virus infection.
Veronese P, Dodi I, Esposito S, Indolfi G
World J Gastroenterol 2021 Jul 14;27(26):4182-4193. doi: 10.3748/wjg.v27.i26.4182. PMID: 34326618Free PMC Article
Herpes simplex virus infection in pregnancy - An update.
Hammad WAB, Konje JC
Eur J Obstet Gynecol Reprod Biol 2021 Apr;259:38-45. Epub 2021 Feb 4 doi: 10.1016/j.ejogrb.2021.01.055. PMID: 33581405
Valaciclovir to prevent vertical transmission of cytomegalovirus after maternal primary infection during pregnancy: a randomised, double-blind, placebo-controlled trial.
Shahar-Nissan K, Pardo J, Peled O, Krause I, Bilavsky E, Wiznitzer A, Hadar E, Amir J
Lancet 2020 Sep 12;396(10253):779-785. doi: 10.1016/S0140-6736(20)31868-7. PMID: 32919517

Prognosis

Impact of COVID-19 on maternal and neonatal outcomes: a systematic review and meta-analysis.
Di Toro F, Gjoka M, Di Lorenzo G, De Santo D, De Seta F, Maso G, Risso FM, Romano F, Wiesenfeld U, Levi-D'Ancona R, Ronfani L, Ricci G
Clin Microbiol Infect 2021 Jan;27(1):36-46. Epub 2020 Nov 2 doi: 10.1016/j.cmi.2020.10.007. PMID: 33148440Free PMC Article
Congenital syphilis.
Cooper JM, Sánchez PJ
Semin Perinatol 2018 Apr;42(3):176-184. Epub 2018 Apr 5 doi: 10.1053/j.semperi.2018.02.005. PMID: 29627075
Update on syphilis and pregnancy.
Tsimis ME, Sheffield JS
Birth Defects Res 2017 Mar 15;109(5):347-352. doi: 10.1002/bdra.23562. PMID: 28398683
Neonatal infections.
Greenough A
Curr Opin Pediatr 1996 Feb;8(1):6-10. doi: 10.1097/00008480-199602000-00003. PMID: 8680517
Longitudinal follow-up studies.
Peckham C, Newell ML
Acta Paediatr Suppl 1994 Aug;400:78-80. doi: 10.1111/j.1651-2227.1994.tb13341.x. PMID: 7833568

Clinical prediction guides

Mild/asymptomatic COVID-19 in unvaccinated pregnant mothers impairs neonatal immune responses.
Doratt BM, Sureshchandra S, True H, Rincon M, Marshall NE, Messaoudi I
JCI Insight 2023 Sep 12;8(19) doi: 10.1172/jci.insight.172658. PMID: 37698937Free PMC Article
Maternal and perinatal risk factors associated with congenital syphilis.
Pascoal LB, Carellos EVM, Tarabai BHM, Vieira CC, Rezende LG, Salgado BSF, de Castro Romanelli RM
Trop Med Int Health 2023 Jun;28(6):442-453. Epub 2023 May 8 doi: 10.1111/tmi.13881. PMID: 37156513
Monkeypox and Pregnancy: Latest Updates.
Cuérel A, Favre G, Vouga M, Pomar L
Viruses 2022 Nov 14;14(11) doi: 10.3390/v14112520. PMID: 36423129Free PMC Article
Impact of COVID-19 on maternal and neonatal outcomes: a systematic review and meta-analysis.
Di Toro F, Gjoka M, Di Lorenzo G, De Santo D, De Seta F, Maso G, Risso FM, Romano F, Wiesenfeld U, Levi-D'Ancona R, Ronfani L, Ricci G
Clin Microbiol Infect 2021 Jan;27(1):36-46. Epub 2020 Nov 2 doi: 10.1016/j.cmi.2020.10.007. PMID: 33148440Free PMC Article
Timing of primary maternal cytomegalovirus infection and rates of vertical transmission and fetal consequences.
Chatzakis C, Ville Y, Makrydimas G, Dinas K, Zavlanos A, Sotiriadis A
Am J Obstet Gynecol 2020 Dec;223(6):870-883.e11. Epub 2020 May 24 doi: 10.1016/j.ajog.2020.05.038. PMID: 32460972

Recent systematic reviews

Effectiveness and safety of prenatal valacyclovir for congenital cytomegalovirus infection: systematic review and meta-analysis.
D'Antonio F, Marinceu D, Prasad S, Khalil A
Ultrasound Obstet Gynecol 2023 Apr;61(4):436-444. doi: 10.1002/uog.26136. PMID: 36484439
A systematic review of pregnant women with COVID-19 and their neonates.
Mirbeyk M, Saghazadeh A, Rezaei N
Arch Gynecol Obstet 2021 Jul;304(1):5-38. Epub 2021 Apr 2 doi: 10.1007/s00404-021-06049-z. PMID: 33797605Free PMC Article
Impact of COVID-19 on maternal and neonatal outcomes: a systematic review and meta-analysis.
Di Toro F, Gjoka M, Di Lorenzo G, De Santo D, De Seta F, Maso G, Risso FM, Romano F, Wiesenfeld U, Levi-D'Ancona R, Ronfani L, Ricci G
Clin Microbiol Infect 2021 Jan;27(1):36-46. Epub 2020 Nov 2 doi: 10.1016/j.cmi.2020.10.007. PMID: 33148440Free PMC Article
Congenital Zika syndrome: A systematic review.
Freitas DA, Souza-Santos R, Carvalho LMA, Barros WB, Neves LM, Brasil P, Wakimoto MD
PLoS One 2020;15(12):e0242367. Epub 2020 Dec 15 doi: 10.1371/journal.pone.0242367. PMID: 33320867Free PMC Article
Congenital toxoplasmosis.
Kravetz J
BMJ Clin Evid 2013 Aug 29;2013 PMID: 23987732Free PMC Article

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