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Vertical transmission

MedGen UID:
66943
•Concept ID:
C0242648
•
Pathologic Function
Synonyms: Infection Transmission, Vertical; Infectious Disease Transmission, Vertical; Pathogen Transmission, Vertical; Transmission, Vertical Infection; Transmission, Vertical Pathogen; Vertical Infection Transmission; Vertical Infectious Disease Transmission; Vertical Pathogen Transmission; Vertical Transmission of Infectious Disease
SNOMED CT: Vertical transmission (1290740005)

Definition

The passage of a substance or infectious agent from the mother to the fetus or newborn. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVertical transmission

Professional guidelines

PubMed

Treatment and prevention of viral hepatitis in pregnancy.
Dionne-Odom J, Cozzi GD, Franco RA, Njei B, Tita ATN
Am J Obstet Gynecol 2022 Mar;226(3):335-346. Epub 2021 Sep 10 doi: 10.1016/j.ajog.2021.09.002. PMID: 34516961Free PMC Article
Cytomegalovirus Infection in Pregnancy: Prevention, Presentation, Management and Neonatal Outcomes.
Pesch MH, Saunders NA, Abdelnabi S
J Midwifery Womens Health 2021 May;66(3):397-402. Epub 2021 May 24 doi: 10.1111/jmwh.13228. PMID: 34031974
Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice.
Dunay IR, Gajurel K, Dhakal R, Liesenfeld O, Montoya JG
Clin Microbiol Rev 2018 Oct;31(4) Epub 2018 Sep 12 doi: 10.1128/CMR.00057-17. PMID: 30209035Free PMC Article

Recent clinical studies

Etiology

The effect of valacyclovir on secondary prevention of congenital cytomegalovirus infection, following primary maternal infection acquired periconceptionally or in the first trimester of pregnancy. An individual patient data meta-analysis.
Chatzakis C, Shahar-Nissan K, Faure-Bardon V, Picone O, Hadar E, Amir J, Egloff C, Vivanti A, Sotiriadis A, Leruez-Ville M, Ville Y
Am J Obstet Gynecol 2024 Feb;230(2):109-117.e2. Epub 2023 Jul 18 doi: 10.1016/j.ajog.2023.07.022. PMID: 37473793
Prevention of the Vertical Transmission of HIV; A Recap of the Journey so Far.
Cardenas MC, Farnan S, Hamel BL, Mejia Plazas MC, Sintim-Aboagye E, Littlefield DR, Behl S, Punia S, Enninga EAL, Johnson E, Temesgen Z, Theiler R, Gray CM, Chakraborty R
Viruses 2023 Mar 26;15(4) doi: 10.3390/v15040849. PMID: 37112830Free PMC Article
Human papillomavirus in cancer: Infection, disease transmission, and progress in vaccines.
Oyouni AAA
J Infect Public Health 2023 Apr;16(4):626-631. Epub 2023 Feb 21 doi: 10.1016/j.jiph.2023.02.014. PMID: 36868166
Prevention of vertical transmission of hepatitis B virus infection.
Veronese P, Dodi I, Esposito S, Indolfi G
World J Gastroenterol 2021 Jul 14;27(26):4182-4193. doi: 10.3748/wjg.v27.i26.4182. PMID: 34326618Free PMC Article
Herpes simplex virus infection in pregnancy - An update.
Hammad WAB, Konje JC
Eur J Obstet Gynecol Reprod Biol 2021 Apr;259:38-45. Epub 2021 Feb 4 doi: 10.1016/j.ejogrb.2021.01.055. PMID: 33581405

Diagnosis

Effectiveness and safety of prenatal valacyclovir for congenital cytomegalovirus infection: systematic review and meta-analysis.
D'Antonio F, Marinceu D, Prasad S, Khalil A
Ultrasound Obstet Gynecol 2023 Apr;61(4):436-444. doi: 10.1002/uog.26136. PMID: 36484439
Prevention of vertical transmission of hepatitis B virus infection.
Veronese P, Dodi I, Esposito S, Indolfi G
World J Gastroenterol 2021 Jul 14;27(26):4182-4193. doi: 10.3748/wjg.v27.i26.4182. PMID: 34326618Free PMC Article
Herpes simplex virus infection in pregnancy - An update.
Hammad WAB, Konje JC
Eur J Obstet Gynecol Reprod Biol 2021 Apr;259:38-45. Epub 2021 Feb 4 doi: 10.1016/j.ejogrb.2021.01.055. PMID: 33581405
Congenital syphilis, the great imitator-case report and review.
Keuning MW, Kamp GA, Schonenberg-Meinema D, Dorigo-Zetsma JW, van Zuiden JM, Pajkrt D
Lancet Infect Dis 2020 Jul;20(7):e173-e179. Epub 2020 Jun 2 doi: 10.1016/S1473-3099(20)30268-1. PMID: 32502432
Syphilis.
Arando Lasagabaster M, Otero Guerra L
Enferm Infecc Microbiol Clin (Engl Ed) 2019 Jun-Jul;37(6):398-404. Epub 2019 Feb 7 doi: 10.1016/j.eimc.2018.12.009. PMID: 30738716

Therapy

Prevention of the Vertical Transmission of HIV; A Recap of the Journey so Far.
Cardenas MC, Farnan S, Hamel BL, Mejia Plazas MC, Sintim-Aboagye E, Littlefield DR, Behl S, Punia S, Enninga EAL, Johnson E, Temesgen Z, Theiler R, Gray CM, Chakraborty R
Viruses 2023 Mar 26;15(4) doi: 10.3390/v15040849. PMID: 37112830Free PMC Article
Effectiveness and safety of prenatal valacyclovir for congenital cytomegalovirus infection: systematic review and meta-analysis.
D'Antonio F, Marinceu D, Prasad S, Khalil A
Ultrasound Obstet Gynecol 2023 Apr;61(4):436-444. doi: 10.1002/uog.26136. PMID: 36484439
Prevention of vertical transmission of hepatitis B virus infection.
Veronese P, Dodi I, Esposito S, Indolfi G
World J Gastroenterol 2021 Jul 14;27(26):4182-4193. doi: 10.3748/wjg.v27.i26.4182. PMID: 34326618Free PMC Article
Herpes simplex virus infection in pregnancy - An update.
Hammad WAB, Konje JC
Eur J Obstet Gynecol Reprod Biol 2021 Apr;259:38-45. Epub 2021 Feb 4 doi: 10.1016/j.ejogrb.2021.01.055. PMID: 33581405
Valaciclovir to prevent vertical transmission of cytomegalovirus after maternal primary infection during pregnancy: a randomised, double-blind, placebo-controlled trial.
Shahar-Nissan K, Pardo J, Peled O, Krause I, Bilavsky E, Wiznitzer A, Hadar E, Amir J
Lancet 2020 Sep 12;396(10253):779-785. doi: 10.1016/S0140-6736(20)31868-7. PMID: 32919517

Prognosis

Evaluation of pregnancy outcomes in mothers with COVID-19 infection: a systematic review and meta-analysis.
Simbar M, Nazarpour S, Sheidaei A
J Obstet Gynaecol 2023 Dec;43(1):2162867. doi: 10.1080/01443615.2022.2162867. PMID: 36651606
A systematic review of pregnant women with COVID-19 and their neonates.
Mirbeyk M, Saghazadeh A, Rezaei N
Arch Gynecol Obstet 2021 Jul;304(1):5-38. Epub 2021 Apr 2 doi: 10.1007/s00404-021-06049-z. PMID: 33797605Free PMC Article
Impact of COVID-19 on maternal and neonatal outcomes: a systematic review and meta-analysis.
Di Toro F, Gjoka M, Di Lorenzo G, De Santo D, De Seta F, Maso G, Risso FM, Romano F, Wiesenfeld U, Levi-D'Ancona R, Ronfani L, Ricci G
Clin Microbiol Infect 2021 Jan;27(1):36-46. Epub 2020 Nov 2 doi: 10.1016/j.cmi.2020.10.007. PMID: 33148440Free PMC Article
Congenital syphilis.
Cooper JM, Sánchez PJ
Semin Perinatol 2018 Apr;42(3):176-184. Epub 2018 Apr 5 doi: 10.1053/j.semperi.2018.02.005. PMID: 29627075
Neonatal infections.
Greenough A
Curr Opin Pediatr 1996 Feb;8(1):6-10. doi: 10.1097/00008480-199602000-00003. PMID: 8680517

Clinical prediction guides

Monkeypox and Pregnancy: Latest Updates.
Cuérel A, Favre G, Vouga M, Pomar L
Viruses 2022 Nov 14;14(11) doi: 10.3390/v14112520. PMID: 36423129Free PMC Article
Comprehensive analysis of COVID-19 during pregnancy.
Moore KM, Suthar MS
Biochem Biophys Res Commun 2021 Jan 29;538:180-186. Epub 2020 Dec 24 doi: 10.1016/j.bbrc.2020.12.064. PMID: 33384142Free PMC Article
Impact of COVID-19 on maternal and neonatal outcomes: a systematic review and meta-analysis.
Di Toro F, Gjoka M, Di Lorenzo G, De Santo D, De Seta F, Maso G, Risso FM, Romano F, Wiesenfeld U, Levi-D'Ancona R, Ronfani L, Ricci G
Clin Microbiol Infect 2021 Jan;27(1):36-46. Epub 2020 Nov 2 doi: 10.1016/j.cmi.2020.10.007. PMID: 33148440Free PMC Article
Timing of primary maternal cytomegalovirus infection and rates of vertical transmission and fetal consequences.
Chatzakis C, Ville Y, Makrydimas G, Dinas K, Zavlanos A, Sotiriadis A
Am J Obstet Gynecol 2020 Dec;223(6):870-883.e11. Epub 2020 May 24 doi: 10.1016/j.ajog.2020.05.038. PMID: 32460972
Assisted reproduction in hepatitis carrier couples.
Mak JSM, Lao TT
Best Pract Res Clin Obstet Gynaecol 2020 Oct;68:103-108. Epub 2020 Mar 7 doi: 10.1016/j.bpobgyn.2020.02.013. PMID: 32278628

Recent systematic reviews

Effectiveness and safety of prenatal valacyclovir for congenital cytomegalovirus infection: systematic review and meta-analysis.
D'Antonio F, Marinceu D, Prasad S, Khalil A
Ultrasound Obstet Gynecol 2023 Apr;61(4):436-444. doi: 10.1002/uog.26136. PMID: 36484439
A systematic review of pregnant women with COVID-19 and their neonates.
Mirbeyk M, Saghazadeh A, Rezaei N
Arch Gynecol Obstet 2021 Jul;304(1):5-38. Epub 2021 Apr 2 doi: 10.1007/s00404-021-06049-z. PMID: 33797605Free PMC Article
Impact of COVID-19 on maternal and neonatal outcomes: a systematic review and meta-analysis.
Di Toro F, Gjoka M, Di Lorenzo G, De Santo D, De Seta F, Maso G, Risso FM, Romano F, Wiesenfeld U, Levi-D'Ancona R, Ronfani L, Ricci G
Clin Microbiol Infect 2021 Jan;27(1):36-46. Epub 2020 Nov 2 doi: 10.1016/j.cmi.2020.10.007. PMID: 33148440Free PMC Article
Congenital Zika syndrome: A systematic review.
Freitas DA, Souza-Santos R, Carvalho LMA, Barros WB, Neves LM, Brasil P, Wakimoto MD
PLoS One 2020;15(12):e0242367. Epub 2020 Dec 15 doi: 10.1371/journal.pone.0242367. PMID: 33320867Free PMC Article
Congenital toxoplasmosis.
Kravetz J
BMJ Clin Evid 2013 Aug 29;2013 PMID: 23987732Free PMC Article

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