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Filoviridae infectious disease

MedGen UID:
67006
•Concept ID:
C0242917
•
Disease or Syndrome
Synonyms: Filoviridae Infection; Filoviridae Infections; Filovirus Infection; Filovirus Infections; Infection, Filoviridae; Infection, Filovirus; Infections, Filoviridae
SNOMED CT: Disease caused by Filoviridae (198007)
 
Monarch Initiative: MONDO:0005762

Definition

Infections with viruses of the family filoviridae. The infections in humans consist of a variety of clinically similar viral hemorrhagic fevers but the natural reservoir host is unknown. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFiloviridae infectious disease

Professional guidelines

PubMed

Ebola Virus Disease: Epidemiology, Clinical Features, Management, and Prevention.
Nicastri E, Kobinger G, Vairo F, Montaldo C, Mboera LEG, Ansunama R, Zumla A, Ippolito G
Infect Dis Clin North Am 2019 Dec;33(4):953-976. doi: 10.1016/j.idc.2019.08.005. PMID: 31668200
Ebola: history, treatment, and lessons from a new emerging pathogen.
Harrod KS
Am J Physiol Lung Cell Mol Physiol 2015 Feb 15;308(4):L307-13. Epub 2014 Dec 12 doi: 10.1152/ajplung.00354.2014. PMID: 25502503Free PMC Article
Development of treatment strategies to combat Ebola and Marburg viruses.
Paragas J, Geisbert TW
Expert Rev Anti Infect Ther 2006 Feb;4(1):67-76. doi: 10.1586/14787210.4.1.67. PMID: 16441210

Recent clinical studies

Etiology

Perspectives on Advancing Countermeasures for Filovirus Disease: Report From a Multisector Meeting.
Sprecher A, Cross R, Marzi A, Martins KA, Wolfe D, Montgomery JM, Spiropoulou CF, Cihlar T, Ahuka-Mundeke S, Nyhuis T, Teicher C, Crozier I, Strong J, Kobinger G, Woolsey C, Geisbert TW, Feldmann H, Muyembe JJ
J Infect Dis 2023 Nov 13;228(Suppl 7):S474-S478. doi: 10.1093/infdis/jiad354. PMID: 37596837Free PMC Article
Drivers of African Filovirus (Ebola and Marburg) Outbreaks.
Stephens PR, Sundaram M, Ferreira S, Gottdenker N, Nipa KF, Schatz AM, Schmidt JP, Drake JM
Vector Borne Zoonotic Dis 2022 Sep;22(9):478-490. doi: 10.1089/vbz.2022.0020. PMID: 36084314Free PMC Article
Antivirals in medical biodefense.
Bugert JJ, Hucke F, Zanetta P, Bassetto M, Brancale A
Virus Genes 2020 Apr;56(2):150-167. Epub 2020 Feb 19 doi: 10.1007/s11262-020-01737-5. PMID: 32076918Free PMC Article
Will There Be a Cure for Ebola?
Cardile AP, Warren TK, Martins KA, Reisler RB, Bavari S
Annu Rev Pharmacol Toxicol 2017 Jan 6;57:329-348. Epub 2016 Dec 7 doi: 10.1146/annurev-pharmtox-010716-105055. PMID: 27959624
Ebola virus: a clear and present danger.
Burd EM
J Clin Microbiol 2015 Jan;53(1):4-8. Epub 2014 Nov 12 doi: 10.1128/JCM.03115-14. PMID: 25392362Free PMC Article

Diagnosis

Ebola.
Feldmann H, Sprecher A, Geisbert TW
N Engl J Med 2020 May 7;382(19):1832-1842. doi: 10.1056/NEJMra1901594. PMID: 32441897
Ebola virus disease.
Jacob ST, Crozier I, Fischer WA 2nd, Hewlett A, Kraft CS, Vega MA, Soka MJ, Wahl V, Griffiths A, Bollinger L, Kuhn JH
Nat Rev Dis Primers 2020 Feb 20;6(1):13. doi: 10.1038/s41572-020-0147-3. PMID: 32080199Free PMC Article
Ebola Virus Disease: Epidemiology, Clinical Features, Management, and Prevention.
Nicastri E, Kobinger G, Vairo F, Montaldo C, Mboera LEG, Ansunama R, Zumla A, Ippolito G
Infect Dis Clin North Am 2019 Dec;33(4):953-976. doi: 10.1016/j.idc.2019.08.005. PMID: 31668200
Will There Be a Cure for Ebola?
Cardile AP, Warren TK, Martins KA, Reisler RB, Bavari S
Annu Rev Pharmacol Toxicol 2017 Jan 6;57:329-348. Epub 2016 Dec 7 doi: 10.1146/annurev-pharmtox-010716-105055. PMID: 27959624
Ebola virus: a clear and present danger.
Burd EM
J Clin Microbiol 2015 Jan;53(1):4-8. Epub 2014 Nov 12 doi: 10.1128/JCM.03115-14. PMID: 25392362Free PMC Article

Therapy

Structure of the Ebola virus polymerase complex.
Yuan B, Peng Q, Cheng J, Wang M, Zhong J, Qi J, Gao GF, Shi Y
Nature 2022 Oct;610(7931):394-401. Epub 2022 Sep 28 doi: 10.1038/s41586-022-05271-2. PMID: 36171293Free PMC Article
Ebola.
Feldmann H, Sprecher A, Geisbert TW
N Engl J Med 2020 May 7;382(19):1832-1842. doi: 10.1056/NEJMra1901594. PMID: 32441897
Antivirals in medical biodefense.
Bugert JJ, Hucke F, Zanetta P, Bassetto M, Brancale A
Virus Genes 2020 Apr;56(2):150-167. Epub 2020 Feb 19 doi: 10.1007/s11262-020-01737-5. PMID: 32076918Free PMC Article
Ebola Virus: Pathogenesis and Countermeasure Development.
Furuyama W, Marzi A
Annu Rev Virol 2019 Sep 29;6(1):435-458. doi: 10.1146/annurev-virology-092818-015708. PMID: 31567063
Filovirus vaccines.
Bradfute SB, Dye JM Jr, Bavari S
Hum Vaccin 2011 Jun;7(6):701-11. Epub 2011 Jun 1 doi: 10.4161/hv.7.6.15398. PMID: 21519188Free PMC Article

Prognosis

Case fatality rate for Ebola disease, 1976-2022: A meta-analysis of global data.
Izudi J, Bajunirwe F
J Infect Public Health 2024 Jan;17(1):25-34. Epub 2023 Oct 27 doi: 10.1016/j.jiph.2023.10.020. PMID: 37992431
Repurposing Pyramax®, quinacrine and tilorone as treatments for Ebola virus disease.
Lane TR, Dyall J, Mercer L, Goodin C, Foil DH, Zhou H, Postnikova E, Liang JY, Holbrook MR, Madrid PB, Ekins S
Antiviral Res 2020 Oct;182:104908. Epub 2020 Aug 13 doi: 10.1016/j.antiviral.2020.104908. PMID: 32798602Free PMC Article
Can Ebola Virus Vaccines Have Universal Immune Correlates of protection?
Meyer M, Malherbe DC, Bukreyev A
Trends Microbiol 2019 Jan;27(1):8-16. Epub 2018 Sep 7 doi: 10.1016/j.tim.2018.08.008. PMID: 30201511Free PMC Article
Durability of single-dose rVSV-ZEBOV vaccine responses: what do we know?
Huttner A, Siegrist CA
Expert Rev Vaccines 2018 Dec;17(12):1105-1110. Epub 2018 Nov 15 doi: 10.1080/14760584.2018.1546582. PMID: 30422031
The Pathogenesis of Ebola Virus Disease.
Baseler L, Chertow DS, Johnson KM, Feldmann H, Morens DM
Annu Rev Pathol 2017 Jan 24;12:387-418. doi: 10.1146/annurev-pathol-052016-100506. PMID: 27959626

Clinical prediction guides

Drivers of African Filovirus (Ebola and Marburg) Outbreaks.
Stephens PR, Sundaram M, Ferreira S, Gottdenker N, Nipa KF, Schatz AM, Schmidt JP, Drake JM
Vector Borne Zoonotic Dis 2022 Sep;22(9):478-490. doi: 10.1089/vbz.2022.0020. PMID: 36084314Free PMC Article
Ebola virus disease.
Jacob ST, Crozier I, Fischer WA 2nd, Hewlett A, Kraft CS, Vega MA, Soka MJ, Wahl V, Griffiths A, Bollinger L, Kuhn JH
Nat Rev Dis Primers 2020 Feb 20;6(1):13. doi: 10.1038/s41572-020-0147-3. PMID: 32080199Free PMC Article
Can Ebola Virus Vaccines Have Universal Immune Correlates of protection?
Meyer M, Malherbe DC, Bukreyev A
Trends Microbiol 2019 Jan;27(1):8-16. Epub 2018 Sep 7 doi: 10.1016/j.tim.2018.08.008. PMID: 30201511Free PMC Article
Durability of single-dose rVSV-ZEBOV vaccine responses: what do we know?
Huttner A, Siegrist CA
Expert Rev Vaccines 2018 Dec;17(12):1105-1110. Epub 2018 Nov 15 doi: 10.1080/14760584.2018.1546582. PMID: 30422031
The Pathogenesis of Ebola Virus Disease.
Baseler L, Chertow DS, Johnson KM, Feldmann H, Morens DM
Annu Rev Pathol 2017 Jan 24;12:387-418. doi: 10.1146/annurev-pathol-052016-100506. PMID: 27959626

Recent systematic reviews

Marburg virus disease outbreaks, mathematical models, and disease parameters: a systematic review.
Cuomo-Dannenburg G, McCain K, McCabe R, Unwin HJT, Doohan P, Nash RK, Hicks JT, Charniga K, Geismar C, Lambert B, Nikitin D, Skarp J, Wardle J, Kont M, Bhatia S, Imai N, van Elsland S, Cori A, Morgenstern C; Pathogen Epidemiology Review Group
Lancet Infect Dis 2024 May;24(5):e307-e317. Epub 2023 Nov 28 doi: 10.1016/S1473-3099(23)00515-7. PMID: 38040006Free PMC Article
Neuropsychological long-term sequelae of Ebola virus disease survivors - A systematic review.
Lötsch F, Schnyder J, Goorhuis A, Grobusch MP
Travel Med Infect Dis 2017 Jul-Aug;18:18-23. Epub 2017 May 4 doi: 10.1016/j.tmaid.2017.05.001. PMID: 28478336
A systematic review and meta-analysis of seroprevalence surveys of ebolavirus infection.
Bower H, Glynn JR
Sci Data 2017 Jan 31;4:160133. doi: 10.1038/sdata.2016.133. PMID: 28140390Free PMC Article
Presence and Persistence of Ebola or Marburg Virus in Patients and Survivors: A Rapid Systematic Review.
Brainard J, Pond K, Hooper L, Edmunds K, Hunter P
PLoS Negl Trop Dis 2016 Feb;10(2):e0004475. Epub 2016 Feb 29 doi: 10.1371/journal.pntd.0004475. PMID: 26927697Free PMC Article
Time From Infection to Disease and Infectiousness for Ebola Virus Disease, a Systematic Review.
Velásquez GE, Aibana O, Ling EJ, Diakite I, Mooring EQ, Murray MB
Clin Infect Dis 2015 Oct 1;61(7):1135-40. Epub 2015 Jun 30 doi: 10.1093/cid/civ531. PMID: 26129757Free PMC Article

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