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Carcinoma, Lewis Lung

MedGen UID:: 67046
•Concept ID:: C0243038
•: Experimental Model of Disease; Neoplastic Process

Synonyms:

Lewis Lung Carcinoma; Lung Carcinoma, Lewis

Definition

A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy. [from MeSH]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVCarcinoma, Lewis Lung

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Epithelial neoplasm
        Carcinoma
        Carcinoma, Lewis Lung

Professional guidelines

PubMed

Lung-specific exosomes for co-delivery of CD47 blockade and cisplatin for the treatment of non-small cell lung cancer.

Cui Z, Ruan Z, Zeng J, Sun J, Ye W, Xu W, Guo X, Zhang L, Song L
Thorac Cancer 2022 Oct;13(19):2723-2731. Epub 2022 Aug 27 doi: 10.1111/1759-7714.14606. PMID: 36054073 Free PMC Article

Combined application of bevacizumab and PD-1 blockade displays durable treatment effects by increasing the infiltration and cytotoxic function of CD8(+) T cells in lung cancer.

Liu Y, Zhang T, Zhang L, Zhao C, Zhang Z, Wang Z, Gu M, Li W, Li B
Immunotherapy 2022 Jun;14(9):695-708. Epub 2022 May 16 doi: 10.2217/imt-2021-0196. PMID: 35574588

Evaluation of antitumor immunity by a combination treatment of high-dose irradiation, anti-PDL1, and anti-angiogenic therapy in murine lung tumors.

Chen JL, Pan CK, Huang YS, Tsai CY, Wang CW, Lin YL, Kuo SH, Shieh MJ
Cancer Immunol Immunother 2021 Feb;70(2):391-404. Epub 2020 Aug 6 doi: 10.1007/s00262-020-02690-w. PMID: 32761424

See all (26)

Recent clinical studies

Etiology

Obesity worsens mitochondrial quality control and does not protect against skeletal muscle wasting in murine cancer cachexia.

Cardaci TD, VanderVeen BN, Bullard BM, McDonald SJ, Unger CA, Enos RT, Fan D, Velázquez KT, Frizzell N, Spangenburg EE, Murphy EA
J Cachexia Sarcopenia Muscle 2024 Feb;15(1):124-137. Epub 2023 Dec 7 doi: 10.1002/jcsm.13391. PMID: 38062911 Free PMC Article

Modified Bushen Yiqi formula enhances antitumor immunity by reducing the chemotactic recruitment of M2-TAMs and PMN-MDSCs in Lewis lung cancer-bearing mice.

Kong Q, Zhu H, Gong W, Deng X, Liu B, Dong J
J Ethnopharmacol 2024 Jan 30;319(Pt 1):117183. Epub 2023 Sep 20 doi: 10.1016/j.jep.2023.117183. PMID: 37739106

EXT418, a novel long-acting ghrelin, mitigates Lewis lung carcinoma induced cachexia in mice.

Kerr HL, Krumm K, Lee II, Anderson B, Christiani A, Strait L, Breckheimer BA, Irwin B, Jiang AS, Rybachok A, Chen A, Caeiro L, Dacek E, Hall DB, Kostyla CH, Hales LM, Soliman TM, Garcia JM
J Cachexia Sarcopenia Muscle 2023 Jun;14(3):1337-1348. Epub 2023 Mar 21 doi: 10.1002/jcsm.13211. PMID: 36942661 Free PMC Article

Metabolomics and integrated network pharmacology analysis reveal Tricin as the active anti-cancer component of Weijing decoction by suppression of PRKCA and sphingolipid signaling.

Li JX, Li RZ, Sun A, Zhou H, Neher E, Yang JS, Huang JM, Zhang YZ, Jiang ZB, Liang TL, Ma LR, Wang J, Wang XR, Fan XQ, Huang J, Xie Y, Liu L, Tang L, Leung EL, Yan PY
Pharmacol Res 2021 Sep;171:105574. Epub 2021 Jul 25 doi: 10.1016/j.phrs.2021.105574. PMID: 34419228

Tumor-treating fields (TTFields) induce immunogenic cell death resulting in enhanced antitumor efficacy when combined with anti-PD-1 therapy.

Voloshin T, Kaynan N, Davidi S, Porat Y, Shteingauz A, Schneiderman RS, Zeevi E, Munster M, Blat R, Tempel Brami C, Cahal S, Itzhaki A, Giladi M, Kirson ED, Weinberg U, Kinzel A, Palti Y
Cancer Immunol Immunother 2020 Jul;69(7):1191-1204. Epub 2020 Mar 6 doi: 10.1007/s00262-020-02534-7. PMID: 32144446 Free PMC Article

See all (115)

Diagnosis

Opaganib (ABC294640) Induces Immunogenic Tumor Cell Death and Enhances Checkpoint Antibody Therapy.

Maines LW, Keller SN, Smith CD
Int J Mol Sci 2023 Nov 29;24(23) doi: 10.3390/ijms242316901. PMID: 38069222 Free PMC Article

Low- dose Apatinib promotes vascular normalization and hypoxia reduction and sensitizes radiotherapy in lung cancer.

Jiang S, Zhou Y, Zou L, Chu L, Chu X, Ni J, Li Y, Guo T, Yang X, Zhu Z
Cancer Med 2023 Feb;12(4):4434-4445. Epub 2022 Sep 6 doi: 10.1002/cam4.5113. PMID: 36065943 Free PMC Article

D‑allose enhances the efficacy of hydroxychloroquine against Lewis lung carcinoma cell growth by inducing autophagy.

Yamazaki K, Hoshi M, Tezuka H, Morita N, Hirayama M, Sato F, Yoshida S, Saito K
Oncol Rep 2022 Jun;47(6) Epub 2022 May 11 doi: 10.3892/or.2022.8328. PMID: 35543153 Free PMC Article

Time-dependent cytotoxicity of dichloroacetate and metformin against Lewis lung carcinoma.

Kolesnik DL, Pyaskovskaya ON, Yakshibaeva YR, Solyanik GI
Exp Oncol 2019 Mar;41(1):14-19. PMID: 30932416

Immunological hallmarks of cis-DDP-resistant Lewis lung carcinoma cells.

Fedorchuk O, Susak Y, Rudyk M, Senchylo N, Khranovska N, Skachkova O, Skivka L
Cancer Chemother Pharmacol 2018 Feb;81(2):373-385. Epub 2017 Dec 30 doi: 10.1007/s00280-017-3503-6. PMID: 29290023

See all (62)

Therapy

EXT418, a novel long-acting ghrelin, mitigates Lewis lung carcinoma induced cachexia in mice.

Inhibition of STAT6 with Antisense Oligonucleotides Enhances the Systemic Antitumor Effects of Radiotherapy and Anti-PD-1 in Metastatic Non-Small Cell Lung Cancer.

He K, Barsoumian HB, Puebla-Osorio N, Hu Y, Sezen D, Wasley MD, Bertolet G, Zhang J, Leuschner C, Yang L, Kettlun Leyton CS, Fowlkes NW, Green MM, Hettrick L, Chen D, Masrorpour F, Gu M, Maazi H, Revenko AS, Cortez MA, Welsh JW
Cancer Immunol Res 2023 Apr 3;11(4):486-500. doi: 10.1158/2326-6066.CIR-22-0547. PMID: 36700864 Free PMC Article

Metabolomics and integrated network pharmacology analysis reveal Tricin as the active anti-cancer component of Weijing decoction by suppression of PRKCA and sphingolipid signaling.

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8(+) T cell exhaustion.

Peng DH, Rodriguez BL, Diao L, Chen L, Wang J, Byers LA, Wei Y, Chapman HA, Yamauchi M, Behrens C, Raso G, Soto LMS, Cuentes ERP, Wistuba II, Kurie JM, Gibbons DL
Nat Commun 2020 Sep 9;11(1):4520. doi: 10.1038/s41467-020-18298-8. PMID: 32908154 Free PMC Article

Low-Dose Apatinib Optimizes Tumor Microenvironment and Potentiates Antitumor Effect of PD-1/PD-L1 Blockade in Lung Cancer.

Zhao S, Ren S, Jiang T, Zhu B, Li X, Zhao C, Jia Y, Shi J, Zhang L, Liu X, Qiao M, Chen X, Su C, Yu H, Zhou C, Zhang J, Camidge DR, Hirsch FR
Cancer Immunol Res 2019 Apr;7(4):630-643. Epub 2019 Feb 12 doi: 10.1158/2326-6066.CIR-17-0640. PMID: 30755403

See all (320)

Prognosis

Cell Therapy with Human Reprogrammed CD8(+) T-Cells Has Antimetastatic Effects on Lewis Lung Carcinoma in C57BL/6 Mice.

Skurikhin EG, Pershina O, Ermakova N, Pakhomova A, Zhukova M, Pan E, Sandrikina L, Widera D, Kogai L, Kushlinskii N, Kubatiev A, Morozov SG, Dygai A
Int J Mol Sci 2022 Dec 12;23(24) doi: 10.3390/ijms232415780. PMID: 36555420 Free PMC Article

Spatially fractionated radiotherapy: tumor response modelling including immunomodulation.

Asperud J, Arous D, Edin NFJ, Malinen E
Phys Med Biol 2021 Aug 24;66(17) doi: 10.1088/1361-6560/ac176b. PMID: 34298527

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8(+) T cell exhaustion.

Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis.

Li Z, Lin Y, Zhang S, Zhou L, Yan G, Wang Y, Zhang M, Wang M, Lin H, Tong Q, Duan Y, Du G
J Transl Med 2019 Mar 18;17(1):90. doi: 10.1186/s12967-019-1838-y. PMID: 30885207 Free PMC Article

Nicotine inhibits CD24 expression in Lewis lung carcinoma cells by upregulation of RAS expression.

Liu DH, An M, Bao BL, Ren F, Xia P
Int J Oncol 2018 Aug;53(2):815-822. Epub 2018 May 22 doi: 10.3892/ijo.2018.4415. PMID: 29845249

See all (71)

Clinical prediction guides

Modified Bushen Yiqi formula enhances antitumor immunity by reducing the chemotactic recruitment of M2-TAMs and PMN-MDSCs in Lewis lung cancer-bearing mice.

Kong Q, Zhu H, Gong W, Deng X, Liu B, Dong J
J Ethnopharmacol 2024 Jan 30;319(Pt 1):117183. Epub 2023 Sep 20 doi: 10.1016/j.jep.2023.117183. PMID: 37739106

EXT418, a novel long-acting ghrelin, mitigates Lewis lung carcinoma induced cachexia in mice.

Non-bone metastatic cancers promote osteocyte-induced bone destruction.

Pin F, Prideaux M, Huot JR, Essex AL, Plotkin LI, Bonetto A, Bonewald LF
Cancer Lett 2021 Nov 1;520:80-90. Epub 2021 Jul 4 doi: 10.1016/j.canlet.2021.06.030. PMID: 34233150 Free PMC Article

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8(+) T cell exhaustion.

Time-dependent cytotoxicity of dichloroacetate and metformin against Lewis lung carcinoma.

Kolesnik DL, Pyaskovskaya ON, Yakshibaeva YR, Solyanik GI
Exp Oncol 2019 Mar;41(1):14-19. PMID: 30932416

See all (187)

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Carcinoma, Lewis Lung

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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Table of contents

Practice guidelines

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