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Carcinoma, Lewis Lung

MedGen UID:
67046
•Concept ID:
C0243038
•
Experimental Model of Disease; Neoplastic Process
Synonyms: Lewis Lung Carcinoma; Lung Carcinoma, Lewis

Definition

A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarcinoma, Lewis Lung

Professional guidelines

PubMed

Lung-specific exosomes for co-delivery of CD47 blockade and cisplatin for the treatment of non-small cell lung cancer.
Cui Z, Ruan Z, Zeng J, Sun J, Ye W, Xu W, Guo X, Zhang L, Song L
Thorac Cancer 2022 Oct;13(19):2723-2731. Epub 2022 Aug 27 doi: 10.1111/1759-7714.14606. PMID: 36054073Free PMC Article
Combined application of bevacizumab and PD-1 blockade displays durable treatment effects by increasing the infiltration and cytotoxic function of CD8(+) T cells in lung cancer.
Liu Y, Zhang T, Zhang L, Zhao C, Zhang Z, Wang Z, Gu M, Li W, Li B
Immunotherapy 2022 Jun;14(9):695-708. Epub 2022 May 16 doi: 10.2217/imt-2021-0196. PMID: 35574588
Evaluation of antitumor immunity by a combination treatment of high-dose irradiation, anti-PDL1, and anti-angiogenic therapy in murine lung tumors.
Chen JL, Pan CK, Huang YS, Tsai CY, Wang CW, Lin YL, Kuo SH, Shieh MJ
Cancer Immunol Immunother 2021 Feb;70(2):391-404. Epub 2020 Aug 6 doi: 10.1007/s00262-020-02690-w. PMID: 32761424Free PMC Article

Recent clinical studies

Etiology

Diet-induced obesity does not exacerbate cachexia in male mice bearing Lewis-lung carcinoma tumors.
Beaudry AG, Law ML, Gilley-Connor KR, Buley H, Dungan CM, Nascimento CMC, Vichaya EG, Wiggs MP
Am J Physiol Regul Integr Comp Physiol 2024 Mar 1;326(3):R254-R265. Epub 2024 Jan 22 doi: 10.1152/ajpregu.00208.2023. PMID: 38252513
Obesity worsens mitochondrial quality control and does not protect against skeletal muscle wasting in murine cancer cachexia.
Cardaci TD, VanderVeen BN, Bullard BM, McDonald SJ, Unger CA, Enos RT, Fan D, Velázquez KT, Frizzell N, Spangenburg EE, Murphy EA
J Cachexia Sarcopenia Muscle 2024 Feb;15(1):124-137. Epub 2023 Dec 7 doi: 10.1002/jcsm.13391. PMID: 38062911Free PMC Article
Modified Bushen Yiqi formula enhances antitumor immunity by reducing the chemotactic recruitment of M2-TAMs and PMN-MDSCs in Lewis lung cancer-bearing mice.
Kong Q, Zhu H, Gong W, Deng X, Liu B, Dong J
J Ethnopharmacol 2024 Jan 30;319(Pt 1):117183. Epub 2023 Sep 20 doi: 10.1016/j.jep.2023.117183. PMID: 37739106
Metabolomics and integrated network pharmacology analysis reveal Tricin as the active anti-cancer component of Weijing decoction by suppression of PRKCA and sphingolipid signaling.
Li JX, Li RZ, Sun A, Zhou H, Neher E, Yang JS, Huang JM, Zhang YZ, Jiang ZB, Liang TL, Ma LR, Wang J, Wang XR, Fan XQ, Huang J, Xie Y, Liu L, Tang L, Leung EL, Yan PY
Pharmacol Res 2021 Sep;171:105574. Epub 2021 Jul 25 doi: 10.1016/j.phrs.2021.105574. PMID: 34419228
Tumor-treating fields (TTFields) induce immunogenic cell death resulting in enhanced antitumor efficacy when combined with anti-PD-1 therapy.
Voloshin T, Kaynan N, Davidi S, Porat Y, Shteingauz A, Schneiderman RS, Zeevi E, Munster M, Blat R, Tempel Brami C, Cahal S, Itzhaki A, Giladi M, Kirson ED, Weinberg U, Kinzel A, Palti Y
Cancer Immunol Immunother 2020 Jul;69(7):1191-1204. Epub 2020 Mar 6 doi: 10.1007/s00262-020-02534-7. PMID: 32144446Free PMC Article

Diagnosis

Diet-induced obesity does not exacerbate cachexia in male mice bearing Lewis-lung carcinoma tumors.
Beaudry AG, Law ML, Gilley-Connor KR, Buley H, Dungan CM, Nascimento CMC, Vichaya EG, Wiggs MP
Am J Physiol Regul Integr Comp Physiol 2024 Mar 1;326(3):R254-R265. Epub 2024 Jan 22 doi: 10.1152/ajpregu.00208.2023. PMID: 38252513
Opaganib (ABC294640) Induces Immunogenic Tumor Cell Death and Enhances Checkpoint Antibody Therapy.
Maines LW, Keller SN, Smith CD
Int J Mol Sci 2023 Nov 29;24(23) doi: 10.3390/ijms242316901. PMID: 38069222Free PMC Article
Skeletal muscle analysis of cancer patients reveals a potential role for carnosine in muscle wasting.
Posa DK, Miller J, Hoetker D, Ramage MI, Gao H, Zhao J, Doelling B, Bhatnagar A, Wigmore SJ, Skipworth RJE, Baba SP
J Cachexia Sarcopenia Muscle 2023 Aug;14(4):1802-1814. Epub 2023 May 18 doi: 10.1002/jcsm.13258. PMID: 37199284Free PMC Article
D‑allose enhances the efficacy of hydroxychloroquine against Lewis lung carcinoma cell growth by inducing autophagy.
Yamazaki K, Hoshi M, Tezuka H, Morita N, Hirayama M, Sato F, Yoshida S, Saito K
Oncol Rep 2022 Jun;47(6) Epub 2022 May 11 doi: 10.3892/or.2022.8328. PMID: 35543153Free PMC Article
Immunological hallmarks of cis-DDP-resistant Lewis lung carcinoma cells.
Fedorchuk O, Susak Y, Rudyk M, Senchylo N, Khranovska N, Skachkova O, Skivka L
Cancer Chemother Pharmacol 2018 Feb;81(2):373-385. Epub 2017 Dec 30 doi: 10.1007/s00280-017-3503-6. PMID: 29290023

Therapy

Modified Bushen Yiqi formula enhances antitumor immunity by reducing the chemotactic recruitment of M2-TAMs and PMN-MDSCs in Lewis lung cancer-bearing mice.
Kong Q, Zhu H, Gong W, Deng X, Liu B, Dong J
J Ethnopharmacol 2024 Jan 30;319(Pt 1):117183. Epub 2023 Sep 20 doi: 10.1016/j.jep.2023.117183. PMID: 37739106
Opaganib (ABC294640) Induces Immunogenic Tumor Cell Death and Enhances Checkpoint Antibody Therapy.
Maines LW, Keller SN, Smith CD
Int J Mol Sci 2023 Nov 29;24(23) doi: 10.3390/ijms242316901. PMID: 38069222Free PMC Article
Inhibition of STAT6 with Antisense Oligonucleotides Enhances the Systemic Antitumor Effects of Radiotherapy and Anti-PD-1 in Metastatic Non-Small Cell Lung Cancer.
He K, Barsoumian HB, Puebla-Osorio N, Hu Y, Sezen D, Wasley MD, Bertolet G, Zhang J, Leuschner C, Yang L, Kettlun Leyton CS, Fowlkes NW, Green MM, Hettrick L, Chen D, Masrorpour F, Gu M, Maazi H, Revenko AS, Cortez MA, Welsh JW
Cancer Immunol Res 2023 Apr 3;11(4):486-500. doi: 10.1158/2326-6066.CIR-22-0547. PMID: 36700864Free PMC Article
Metabolomics and integrated network pharmacology analysis reveal Tricin as the active anti-cancer component of Weijing decoction by suppression of PRKCA and sphingolipid signaling.
Li JX, Li RZ, Sun A, Zhou H, Neher E, Yang JS, Huang JM, Zhang YZ, Jiang ZB, Liang TL, Ma LR, Wang J, Wang XR, Fan XQ, Huang J, Xie Y, Liu L, Tang L, Leung EL, Yan PY
Pharmacol Res 2021 Sep;171:105574. Epub 2021 Jul 25 doi: 10.1016/j.phrs.2021.105574. PMID: 34419228
Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8(+) T cell exhaustion.
Peng DH, Rodriguez BL, Diao L, Chen L, Wang J, Byers LA, Wei Y, Chapman HA, Yamauchi M, Behrens C, Raso G, Soto LMS, Cuentes ERP, Wistuba II, Kurie JM, Gibbons DL
Nat Commun 2020 Sep 9;11(1):4520. doi: 10.1038/s41467-020-18298-8. PMID: 32908154Free PMC Article

Prognosis

Tumor promoting effect of PDLIM2 downregulation involves mitochondrial ROS, oncometabolite accumulations and HIF-1α activation.
Yang JX, Chuang YC, Tseng JC, Liu YL, Lai CY, Lee AY, Huang CF, Hong YR, Chuang TH
J Exp Clin Cancer Res 2024 Jun 17;43(1):169. doi: 10.1186/s13046-024-03094-9. PMID: 38880883Free PMC Article
Cell Therapy with Human Reprogrammed CD8(+) T-Cells Has Antimetastatic Effects on Lewis Lung Carcinoma in C57BL/6 Mice.
Skurikhin EG, Pershina O, Ermakova N, Pakhomova A, Zhukova M, Pan E, Sandrikina L, Widera D, Kogai L, Kushlinskii N, Kubatiev A, Morozov SG, Dygai A
Int J Mol Sci 2022 Dec 12;23(24) doi: 10.3390/ijms232415780. PMID: 36555420Free PMC Article
Spatially fractionated radiotherapy: tumor response modelling including immunomodulation.
Asperud J, Arous D, Edin NFJ, Malinen E
Phys Med Biol 2021 Aug 24;66(17) doi: 10.1088/1361-6560/ac176b. PMID: 34298527
Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8(+) T cell exhaustion.
Peng DH, Rodriguez BL, Diao L, Chen L, Wang J, Byers LA, Wei Y, Chapman HA, Yamauchi M, Behrens C, Raso G, Soto LMS, Cuentes ERP, Wistuba II, Kurie JM, Gibbons DL
Nat Commun 2020 Sep 9;11(1):4520. doi: 10.1038/s41467-020-18298-8. PMID: 32908154Free PMC Article
Nicotine inhibits CD24 expression in Lewis lung carcinoma cells by upregulation of RAS expression.
Liu DH, An M, Bao BL, Ren F, Xia P
Int J Oncol 2018 Aug;53(2):815-822. Epub 2018 May 22 doi: 10.3892/ijo.2018.4415. PMID: 29845249

Clinical prediction guides

Diet-induced obesity does not exacerbate cachexia in male mice bearing Lewis-lung carcinoma tumors.
Beaudry AG, Law ML, Gilley-Connor KR, Buley H, Dungan CM, Nascimento CMC, Vichaya EG, Wiggs MP
Am J Physiol Regul Integr Comp Physiol 2024 Mar 1;326(3):R254-R265. Epub 2024 Jan 22 doi: 10.1152/ajpregu.00208.2023. PMID: 38252513
Hypothalamic-pituitary-adrenal axis activation and glucocorticoid-responsive gene expression in skeletal muscle and liver of Apc mice.
Martin A, Castells J, Allibert V, Emerit A, Zolotoff C, Cardot-Ruffino V, Gallot YS, Vernus B, Chauvet V, Bartholin L, Schaeffer L, Durieux AC, Hourdé C, Favier FB, Mazelin L, Freyssenet D
J Cachexia Sarcopenia Muscle 2022 Jun;13(3):1686-1703. Epub 2022 Mar 11 doi: 10.1002/jcsm.12939. PMID: 35277933Free PMC Article
Activation of Akt-mTORC1 signalling reverts cancer-dependent muscle wasting.
Geremia A, Sartori R, Baraldo M, Nogara L, Balmaceda V, Dumitras GA, Ciciliot S, Scalabrin M, Nolte H, Blaauw B
J Cachexia Sarcopenia Muscle 2022 Feb;13(1):648-661. Epub 2021 Nov 6 doi: 10.1002/jcsm.12854. PMID: 34741441Free PMC Article
Non-bone metastatic cancers promote osteocyte-induced bone destruction.
Pin F, Prideaux M, Huot JR, Essex AL, Plotkin LI, Bonetto A, Bonewald LF
Cancer Lett 2021 Nov 1;520:80-90. Epub 2021 Jul 4 doi: 10.1016/j.canlet.2021.06.030. PMID: 34233150Free PMC Article
Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8(+) T cell exhaustion.
Peng DH, Rodriguez BL, Diao L, Chen L, Wang J, Byers LA, Wei Y, Chapman HA, Yamauchi M, Behrens C, Raso G, Soto LMS, Cuentes ERP, Wistuba II, Kurie JM, Gibbons DL
Nat Commun 2020 Sep 9;11(1):4520. doi: 10.1038/s41467-020-18298-8. PMID: 32908154Free PMC Article

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