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Infant botulism

MedGen UID:
68649
•Concept ID:
C0238027
•
Disease or Syndrome
Synonyms: Botulism, Infant; Botulism, Infantile; Infant Botulism; Infant Botulisms; Infantile Botulism
SNOMED CT: Infantile botulism (414488002)
 
Monarch Initiative: MONDO:0015804
Orphanet: ORPHA178478

Definition

A rare form of botulism, a rare acquired neuromuscular junction disease with descending flaccid paralysis caused by botulinum neurotoxins (BoNTs). It is due to intestinal colonization by <i>Clostridium botulinum</i> leading to toxin-mediated infection with toxemia. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfant botulism
Follow this link to review classifications for Infant botulism in Orphanet.

Professional guidelines

PubMed

Clinical Guidelines for Diagnosis and Treatment of Botulism, 2021.
Rao AK, Sobel J, Chatham-Stephens K, Luquez C
MMWR Recomm Rep 2021 May 7;70(2):1-30. doi: 10.15585/mmwr.rr7002a1. PMID: 33956777Free PMC Article
Medical treatment for botulism.
Chalk C, Benstead TJ, Keezer M
Cochrane Database Syst Rev 2011 Mar 16;(3):CD008123. doi: 10.1002/14651858.CD008123.pub2. PMID: 21412916
Botulism: the challenge of diagnosis and treatment.
Brook I
Rev Neurol Dis 2006 Fall;3(4):182-9. PMID: 17224901

Recent clinical studies

Etiology

Infant Botulism, Israel, 2007-2021.
Goldberg B, Danino D, Levinsky Y, Levy I, Straussberg R, Dabaja-Younis H, Guri A, Almagor Y, Tasher D, Elad D, Baider Z, Blum S, Scheuerman O
Emerg Infect Dis 2023 Feb;29(2):235-241. doi: 10.3201/eid2902.220991. PMID: 36692296Free PMC Article
Human Botulism in France, 1875-2016.
Rasetti-Escargueil C, Lemichez E, Popoff MR
Toxins (Basel) 2020 May 21;12(5) doi: 10.3390/toxins12050338. PMID: 32455538Free PMC Article
Microbiology and foodborne pathogens in honey.
Grabowski NT, Klein G
Crit Rev Food Sci Nutr 2017 Jun 13;57(9):1852-1862. doi: 10.1080/10408398.2015.1029041. PMID: 26176586
Infant botulism.
Brook I
J Perinatol 2007 Mar;27(3):175-80. doi: 10.1038/sj.jp.7211651. PMID: 17314986
Botulinum toxin as a biological weapon: medical and public health management.
Arnon SS, Schechter R, Inglesby TV, Henderson DA, Bartlett JG, Ascher MS, Eitzen E, Fine AD, Hauer J, Layton M, Lillibridge S, Osterholm MT, O'Toole T, Parker G, Perl TM, Russell PK, Swerdlow DL, Tonat K; Working Group on Civilian Biodefense
JAMA 2001 Feb 28;285(8):1059-70. doi: 10.1001/jama.285.8.1059. PMID: 11209178

Diagnosis

Infant Botulism, Israel, 2007-2021.
Goldberg B, Danino D, Levinsky Y, Levy I, Straussberg R, Dabaja-Younis H, Guri A, Almagor Y, Tasher D, Elad D, Baider Z, Blum S, Scheuerman O
Emerg Infect Dis 2023 Feb;29(2):235-241. doi: 10.3201/eid2902.220991. PMID: 36692296Free PMC Article
Clinical Guidelines for Diagnosis and Treatment of Botulism, 2021.
Rao AK, Sobel J, Chatham-Stephens K, Luquez C
MMWR Recomm Rep 2021 May 7;70(2):1-30. doi: 10.15585/mmwr.rr7002a1. PMID: 33956777Free PMC Article
Infant botulism.
Fenicia L, Anniballi F
Ann Ist Super Sanita 2009;45(2):134-46. PMID: 19636165
Botulism.
Sobel J
Clin Infect Dis 2005 Oct 15;41(8):1167-73. Epub 2005 Aug 29 doi: 10.1086/444507. PMID: 16163636
Botulinum toxin as a biological weapon: medical and public health management.
Arnon SS, Schechter R, Inglesby TV, Henderson DA, Bartlett JG, Ascher MS, Eitzen E, Fine AD, Hauer J, Layton M, Lillibridge S, Osterholm MT, O'Toole T, Parker G, Perl TM, Russell PK, Swerdlow DL, Tonat K; Working Group on Civilian Biodefense
JAMA 2001 Feb 28;285(8):1059-70. doi: 10.1001/jama.285.8.1059. PMID: 11209178

Therapy

Infant botulism: review and clinical update.
Rosow LK, Strober JB
Pediatr Neurol 2015 May;52(5):487-92. Epub 2015 Jan 21 doi: 10.1016/j.pediatrneurol.2015.01.006. PMID: 25882077
Infant botulism and indications for administration of botulism immune globulin.
Pifko E, Price A, Sterner S
Pediatr Emerg Care 2014 Feb;30(2):120-4; quiz 125-7. doi: 10.1097/PEC.0000000000000079. PMID: 24488164
Botulism.
Sobel J
Clin Infect Dis 2005 Oct 15;41(8):1167-73. Epub 2005 Aug 29 doi: 10.1086/444507. PMID: 16163636
Botulinum toxin as a biological weapon: medical and public health management.
Arnon SS, Schechter R, Inglesby TV, Henderson DA, Bartlett JG, Ascher MS, Eitzen E, Fine AD, Hauer J, Layton M, Lillibridge S, Osterholm MT, O'Toole T, Parker G, Perl TM, Russell PK, Swerdlow DL, Tonat K; Working Group on Civilian Biodefense
JAMA 2001 Feb 28;285(8):1059-70. doi: 10.1001/jama.285.8.1059. PMID: 11209178
Infant botulism.
Arnon SS
Annu Rev Med 1980;31:541-60. doi: 10.1146/annurev.me.31.020180.002545. PMID: 6772092

Prognosis

Infant Botulism, Israel, 2007-2021.
Goldberg B, Danino D, Levinsky Y, Levy I, Straussberg R, Dabaja-Younis H, Guri A, Almagor Y, Tasher D, Elad D, Baider Z, Blum S, Scheuerman O
Emerg Infect Dis 2023 Feb;29(2):235-241. doi: 10.3201/eid2902.220991. PMID: 36692296Free PMC Article
Human Botulism in France, 1875-2016.
Rasetti-Escargueil C, Lemichez E, Popoff MR
Toxins (Basel) 2020 May 21;12(5) doi: 10.3390/toxins12050338. PMID: 32455538Free PMC Article
Botulinum toxin.
Horowitz BZ
Crit Care Clin 2005 Oct;21(4):825-39, viii. doi: 10.1016/j.ccc.2005.06.008. PMID: 16168317
Recent advances in infant botulism.
Fox CK, Keet CA, Strober JB
Pediatr Neurol 2005 Mar;32(3):149-54. doi: 10.1016/j.pediatrneurol.2004.10.001. PMID: 15730893
Infant botulism.
Glatman-Freedman A
Pediatr Rev 1996 May;17(5):185-6. doi: 10.1542/pir.17-5-185. PMID: 8935918

Clinical prediction guides

Botulinum toxin as a biological weapon: medical and public health management.
Arnon SS, Schechter R, Inglesby TV, Henderson DA, Bartlett JG, Ascher MS, Eitzen E, Fine AD, Hauer J, Layton M, Lillibridge S, Osterholm MT, O'Toole T, Parker G, Perl TM, Russell PK, Swerdlow DL, Tonat K; Working Group on Civilian Biodefense
JAMA 2001 Feb 28;285(8):1059-70. doi: 10.1001/jama.285.8.1059. PMID: 11209178
Relapse of infant botulism.
Glauser TA, Maguire HC, Sladky JT
Ann Neurol 1990 Aug;28(2):187-9. doi: 10.1002/ana.410280214. PMID: 2221848
Infant botulism: clinical spectrum and epidemiology.
Thompson JA, Glasgow LA, Warpinski JR, Olson C
Pediatrics 1980 Dec;66(6):936-42. PMID: 7005856
The clinical spectrum of infant botulism.
Arnon SS, Chin J
Rev Infect Dis 1979 Jul-Aug;1(4):614-24. doi: 10.1093/clinids/1.4.614. PMID: 551512
Infant botulism. Epidemiological, clinical, and laboratory aspects.
Arnon SS, Midura TF, Clay SA, Wood RM, Chin J
JAMA 1977 May 2;237(18):1946-51. doi: 10.1001/jama.237.18.1946. PMID: 321825

Recent systematic reviews

Medical treatment for botulism.
Chalk CH, Benstead TJ, Pound JD, Keezer MR
Cochrane Database Syst Rev 2019 Apr 17;4(4):CD008123. doi: 10.1002/14651858.CD008123.pub4. PMID: 30993666Free PMC Article
Medical treatment for botulism.
Chalk CH, Benstead TJ, Keezer M
Cochrane Database Syst Rev 2014 Feb 20;(2):CD008123. doi: 10.1002/14651858.CD008123.pub3. PMID: 24558013
Medical treatment for botulism.
Chalk C, Benstead TJ, Keezer M
Cochrane Database Syst Rev 2011 Mar 16;(3):CD008123. doi: 10.1002/14651858.CD008123.pub2. PMID: 21412916
Honey and lozenges for children with non-specific cough.
Mulholland S, Chang AB
Cochrane Database Syst Rev 2009 Apr 15;2009(2):CD007523. doi: 10.1002/14651858.CD007523.pub2. PMID: 19370690Free PMC Article

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