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Late latent syphilis

MedGen UID:
687555
•Concept ID:
C1260915
•
Disease or Syndrome
Synonyms: Late Latent Syphilis; late latent syphilis
SNOMED CT: Late latent syphilis (186903006)
 
Monarch Initiative: MONDO:0040923

Definition

Latent syphilis when infection was acquired more than twelve months previously. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLate latent syphilis

Professional guidelines

PubMed

Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Treatment of syphilis: a systematic review.
Clement ME, Okeke NL, Hicks CB
JAMA 2014 Nov 12;312(18):1905-17. doi: 10.1001/jama.2014.13259. PMID: 25387188Free PMC Article
Treatment of syphilis in HIV-infected subjects: a systematic review of the literature.
Blank LJ, Rompalo AM, Erbelding EJ, Zenilman JM, Ghanem KG
Sex Transm Infect 2011 Feb;87(1):9-16. Epub 2010 Oct 5 doi: 10.1136/sti.2010.043893. PMID: 20924048

Recent clinical studies

Etiology

Syphilis.
Peeling RW, Mabey D, Chen XS, Garcia PJ
Lancet 2023 Jul 22;402(10398):336-346. doi: 10.1016/S0140-6736(22)02348-0. PMID: 37481272
Clinical features associated with neurosyphilis in people living with HIV and late latent syphilis.
Martínez-Ayala P, Quiñonez-Flores A, González-Hernández LA, Ruíz-Herrera VV, Zúñiga-Quiñones S, Alanis-Sánchez GA, Cabrera-Silva RI, Amador-Lara F, Sánchez-Reyes K, Álvarez-Zavala M, Vázquez-Limón JC, Sánchez-Navarro JP, Andrade-Villanueva JF
Int J STD AIDS 2022 Mar;33(4):330-336. Epub 2022 Jan 3 doi: 10.1177/09564624211063091. PMID: 34978502Free PMC Article
Addressing the crisis of congenital syphilis: Key findings from an evaluation of the management of syphilis in pregnancy and the newborn in South-East Queensland.
Wu M, Seel M, Britton S, Dean JA, Lazarou M, Safa H, Griffin P, Nourse C
Aust N Z J Obstet Gynaecol 2022 Feb;62(1):91-97. Epub 2021 Aug 31 doi: 10.1111/ajo.13424. PMID: 34463955
Females treated for syphilis in Bialystok, Poland 2016-2020.
Serwin AB, Kaczyńska J, Flisiak I
Przegl Epidemiol 2021;75(4):494-501. doi: 10.32394/pe.75.46. PMID: 35543433
Efficacy of Doxycycline in the Treatment of Syphilis.
Dai T, Qu R, Liu J, Zhou P, Wang Q
Antimicrob Agents Chemother 2017 Jan;61(1) Epub 2016 Dec 27 doi: 10.1128/AAC.01092-16. PMID: 27795370Free PMC Article

Diagnosis

Syphilis.
Peeling RW, Mabey D, Chen XS, Garcia PJ
Lancet 2023 Jul 22;402(10398):336-346. doi: 10.1016/S0140-6736(22)02348-0. PMID: 37481272
Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Clinical features associated with neurosyphilis in people living with HIV and late latent syphilis.
Martínez-Ayala P, Quiñonez-Flores A, González-Hernández LA, Ruíz-Herrera VV, Zúñiga-Quiñones S, Alanis-Sánchez GA, Cabrera-Silva RI, Amador-Lara F, Sánchez-Reyes K, Álvarez-Zavala M, Vázquez-Limón JC, Sánchez-Navarro JP, Andrade-Villanueva JF
Int J STD AIDS 2022 Mar;33(4):330-336. Epub 2022 Jan 3 doi: 10.1177/09564624211063091. PMID: 34978502Free PMC Article
Addressing the crisis of congenital syphilis: Key findings from an evaluation of the management of syphilis in pregnancy and the newborn in South-East Queensland.
Wu M, Seel M, Britton S, Dean JA, Lazarou M, Safa H, Griffin P, Nourse C
Aust N Z J Obstet Gynaecol 2022 Feb;62(1):91-97. Epub 2021 Aug 31 doi: 10.1111/ajo.13424. PMID: 34463955
Females treated for syphilis in Bialystok, Poland 2016-2020.
Serwin AB, Kaczyńska J, Flisiak I
Przegl Epidemiol 2021;75(4):494-501. doi: 10.32394/pe.75.46. PMID: 35543433

Therapy

Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Efficacy of Doxycycline in the Treatment of Syphilis.
Dai T, Qu R, Liu J, Zhou P, Wang Q
Antimicrob Agents Chemother 2017 Jan;61(1) Epub 2016 Dec 27 doi: 10.1128/AAC.01092-16. PMID: 27795370Free PMC Article
Treatment of syphilis: a systematic review.
Clement ME, Okeke NL, Hicks CB
JAMA 2014 Nov 12;312(18):1905-17. doi: 10.1001/jama.2014.13259. PMID: 25387188Free PMC Article
Management of adult syphilis.
Ghanem KG, Workowski KA
Clin Infect Dis 2011 Dec;53 Suppl 3:S110-28. doi: 10.1093/cid/cir701. PMID: 22080265
Treatment of syphilis in HIV-infected subjects: a systematic review of the literature.
Blank LJ, Rompalo AM, Erbelding EJ, Zenilman JM, Ghanem KG
Sex Transm Infect 2011 Feb;87(1):9-16. Epub 2010 Oct 5 doi: 10.1136/sti.2010.043893. PMID: 20924048

Prognosis

Syphilis.
Peeling RW, Mabey D, Chen XS, Garcia PJ
Lancet 2023 Jul 22;402(10398):336-346. doi: 10.1016/S0140-6736(22)02348-0. PMID: 37481272
Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Clinical features associated with neurosyphilis in people living with HIV and late latent syphilis.
Martínez-Ayala P, Quiñonez-Flores A, González-Hernández LA, Ruíz-Herrera VV, Zúñiga-Quiñones S, Alanis-Sánchez GA, Cabrera-Silva RI, Amador-Lara F, Sánchez-Reyes K, Álvarez-Zavala M, Vázquez-Limón JC, Sánchez-Navarro JP, Andrade-Villanueva JF
Int J STD AIDS 2022 Mar;33(4):330-336. Epub 2022 Jan 3 doi: 10.1177/09564624211063091. PMID: 34978502Free PMC Article
Men treated for syphilis in Białystok, Poland,2014-2018.
Serwin AB, Grochowska A, Flisiak I
Przegl Epidemiol 2019;73(3):329-335. doi: 10.32394/pe.73.28. PMID: 31766830
Syphilis and HIV co-infection in an Israeli HIV clinic: incidence and outcome.
Agmon-Levin N, Elbirt D, Asher I, Gradestein S, Werner B, Sthoeger Z
Int J STD AIDS 2010 Apr;21(4):249-52. doi: 10.1258/ijsa.2009.009011. PMID: 20378895

Clinical prediction guides

Clinical features associated with neurosyphilis in people living with HIV and late latent syphilis.
Martínez-Ayala P, Quiñonez-Flores A, González-Hernández LA, Ruíz-Herrera VV, Zúñiga-Quiñones S, Alanis-Sánchez GA, Cabrera-Silva RI, Amador-Lara F, Sánchez-Reyes K, Álvarez-Zavala M, Vázquez-Limón JC, Sánchez-Navarro JP, Andrade-Villanueva JF
Int J STD AIDS 2022 Mar;33(4):330-336. Epub 2022 Jan 3 doi: 10.1177/09564624211063091. PMID: 34978502Free PMC Article
No improvement in serological response among serofast latent patients retreated with benzathine penicillin.
Ren RX, Wang LN, Zheng HY, Li J
Int J STD AIDS 2016 Jan;27(1):58-62. Epub 2015 Feb 16 doi: 10.1177/0956462415573677. PMID: 25691394
Syphilis and HIV co-infection in an Israeli HIV clinic: incidence and outcome.
Agmon-Levin N, Elbirt D, Asher I, Gradestein S, Werner B, Sthoeger Z
Int J STD AIDS 2010 Apr;21(4):249-52. doi: 10.1258/ijsa.2009.009011. PMID: 20378895
Is syphilis an incurable disease?
Ghinsberg RC, Nitzan Y
Med Hypotheses 1992 Sep;39(1):35-40. doi: 10.1016/0306-9877(92)90137-2. PMID: 1435390
Clinical survey of syphilis at the Dermatological Clinic of Nippon Medical School Hospital from 1984 to 1988, with special reference to the recent clinical manifestations and evaluation of IgM antibodies to Treponema pallidum.
Ishinaga M, Sasaki E
J Dermatol 1990 Oct;17(10):618-29. doi: 10.1111/j.1346-8138.1990.tb01705.x. PMID: 2273163

Recent systematic reviews

Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Treatment of syphilis: a systematic review.
Clement ME, Okeke NL, Hicks CB
JAMA 2014 Nov 12;312(18):1905-17. doi: 10.1001/jama.2014.13259. PMID: 25387188Free PMC Article
Treatment of syphilis in HIV-infected subjects: a systematic review of the literature.
Blank LJ, Rompalo AM, Erbelding EJ, Zenilman JM, Ghanem KG
Sex Transm Infect 2011 Feb;87(1):9-16. Epub 2010 Oct 5 doi: 10.1136/sti.2010.043893. PMID: 20924048

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