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Late latent syphilis

MedGen UID:
687555
•Concept ID:
C1260915
•
Disease or Syndrome
Synonyms: Late Latent Syphilis; late latent syphilis
SNOMED CT: Late latent syphilis (186903006)
 
Monarch Initiative: MONDO:0040923

Definition

Latent syphilis when infection was acquired more than twelve months previously. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLate latent syphilis

Professional guidelines

PubMed

Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Efficacy of Doxycycline in the Treatment of Syphilis.
Dai T, Qu R, Liu J, Zhou P, Wang Q
Antimicrob Agents Chemother 2017 Jan;61(1) Epub 2016 Dec 27 doi: 10.1128/AAC.01092-16. PMID: 27795370Free PMC Article
Treatment of syphilis: a systematic review.
Clement ME, Okeke NL, Hicks CB
JAMA 2014 Nov 12;312(18):1905-17. doi: 10.1001/jama.2014.13259. PMID: 25387188Free PMC Article

Recent clinical studies

Etiology

Syphilis.
Peeling RW, Mabey D, Chen XS, Garcia PJ
Lancet 2023 Jul 22;402(10398):336-346. doi: 10.1016/S0140-6736(22)02348-0. PMID: 37481272
Clinical features associated with neurosyphilis in people living with HIV and late latent syphilis.
Martínez-Ayala P, Quiñonez-Flores A, González-Hernández LA, Ruíz-Herrera VV, Zúñiga-Quiñones S, Alanis-Sánchez GA, Cabrera-Silva RI, Amador-Lara F, Sánchez-Reyes K, Álvarez-Zavala M, Vázquez-Limón JC, Sánchez-Navarro JP, Andrade-Villanueva JF
Int J STD AIDS 2022 Mar;33(4):330-336. Epub 2022 Jan 3 doi: 10.1177/09564624211063091. PMID: 34978502Free PMC Article
Females treated for syphilis in Bialystok, Poland 2016-2020.
Serwin AB, Kaczyńska J, Flisiak I
Przegl Epidemiol 2021;75(4):494-501. doi: 10.32394/pe.75.46. PMID: 35543433
Efficacy of Doxycycline in the Treatment of Syphilis.
Dai T, Qu R, Liu J, Zhou P, Wang Q
Antimicrob Agents Chemother 2017 Jan;61(1) Epub 2016 Dec 27 doi: 10.1128/AAC.01092-16. PMID: 27795370Free PMC Article
Management of adult syphilis.
Ghanem KG, Workowski KA
Clin Infect Dis 2011 Dec;53 Suppl 3:S110-28. doi: 10.1093/cid/cir701. PMID: 22080265

Diagnosis

Syphilis.
Peeling RW, Mabey D, Chen XS, Garcia PJ
Lancet 2023 Jul 22;402(10398):336-346. doi: 10.1016/S0140-6736(22)02348-0. PMID: 37481272
Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Clinical features associated with neurosyphilis in people living with HIV and late latent syphilis.
Martínez-Ayala P, Quiñonez-Flores A, González-Hernández LA, Ruíz-Herrera VV, Zúñiga-Quiñones S, Alanis-Sánchez GA, Cabrera-Silva RI, Amador-Lara F, Sánchez-Reyes K, Álvarez-Zavala M, Vázquez-Limón JC, Sánchez-Navarro JP, Andrade-Villanueva JF
Int J STD AIDS 2022 Mar;33(4):330-336. Epub 2022 Jan 3 doi: 10.1177/09564624211063091. PMID: 34978502Free PMC Article
Females treated for syphilis in Bialystok, Poland 2016-2020.
Serwin AB, Kaczyńska J, Flisiak I
Przegl Epidemiol 2021;75(4):494-501. doi: 10.32394/pe.75.46. PMID: 35543433
Management of adult syphilis.
Ghanem KG, Workowski KA
Clin Infect Dis 2011 Dec;53 Suppl 3:S110-28. doi: 10.1093/cid/cir701. PMID: 22080265

Therapy

Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Efficacy of Doxycycline in the Treatment of Syphilis.
Dai T, Qu R, Liu J, Zhou P, Wang Q
Antimicrob Agents Chemother 2017 Jan;61(1) Epub 2016 Dec 27 doi: 10.1128/AAC.01092-16. PMID: 27795370Free PMC Article
Treatment of syphilis: a systematic review.
Clement ME, Okeke NL, Hicks CB
JAMA 2014 Nov 12;312(18):1905-17. doi: 10.1001/jama.2014.13259. PMID: 25387188Free PMC Article
Management of adult syphilis.
Ghanem KG, Workowski KA
Clin Infect Dis 2011 Dec;53 Suppl 3:S110-28. doi: 10.1093/cid/cir701. PMID: 22080265
Treatment of syphilis in HIV-infected subjects: a systematic review of the literature.
Blank LJ, Rompalo AM, Erbelding EJ, Zenilman JM, Ghanem KG
Sex Transm Infect 2011 Feb;87(1):9-16. Epub 2010 Oct 5 doi: 10.1136/sti.2010.043893. PMID: 20924048

Prognosis

Syphilis.
Peeling RW, Mabey D, Chen XS, Garcia PJ
Lancet 2023 Jul 22;402(10398):336-346. doi: 10.1016/S0140-6736(22)02348-0. PMID: 37481272
Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Clinical features associated with neurosyphilis in people living with HIV and late latent syphilis.
Martínez-Ayala P, Quiñonez-Flores A, González-Hernández LA, Ruíz-Herrera VV, Zúñiga-Quiñones S, Alanis-Sánchez GA, Cabrera-Silva RI, Amador-Lara F, Sánchez-Reyes K, Álvarez-Zavala M, Vázquez-Limón JC, Sánchez-Navarro JP, Andrade-Villanueva JF
Int J STD AIDS 2022 Mar;33(4):330-336. Epub 2022 Jan 3 doi: 10.1177/09564624211063091. PMID: 34978502Free PMC Article
Syphilis and HIV co-infection in an Israeli HIV clinic: incidence and outcome.
Agmon-Levin N, Elbirt D, Asher I, Gradestein S, Werner B, Sthoeger Z
Int J STD AIDS 2010 Apr;21(4):249-52. doi: 10.1258/ijsa.2009.009011. PMID: 20378895
Prognosis and treatment in late latent syphilis.
BARNETT CW
Stanford Med Bull 1959 May;17(2):61-73. PMID: 13659250

Clinical prediction guides

A network suspected infectious disease model for the development of syphilis transmission from 2015 to 2021 in Hubei province, China.
Zhang Y, Wang K, Zhu J, Wu J
J Appl Microbiol 2023 Dec 1;134(12) doi: 10.1093/jambio/lxad311. PMID: 38130214
Clinical features associated with neurosyphilis in people living with HIV and late latent syphilis.
Martínez-Ayala P, Quiñonez-Flores A, González-Hernández LA, Ruíz-Herrera VV, Zúñiga-Quiñones S, Alanis-Sánchez GA, Cabrera-Silva RI, Amador-Lara F, Sánchez-Reyes K, Álvarez-Zavala M, Vázquez-Limón JC, Sánchez-Navarro JP, Andrade-Villanueva JF
Int J STD AIDS 2022 Mar;33(4):330-336. Epub 2022 Jan 3 doi: 10.1177/09564624211063091. PMID: 34978502Free PMC Article
No improvement in serological response among serofast latent patients retreated with benzathine penicillin.
Ren RX, Wang LN, Zheng HY, Li J
Int J STD AIDS 2016 Jan;27(1):58-62. Epub 2015 Feb 16 doi: 10.1177/0956462415573677. PMID: 25691394
Syphilis and HIV co-infection in an Israeli HIV clinic: incidence and outcome.
Agmon-Levin N, Elbirt D, Asher I, Gradestein S, Werner B, Sthoeger Z
Int J STD AIDS 2010 Apr;21(4):249-52. doi: 10.1258/ijsa.2009.009011. PMID: 20378895
Is syphilis an incurable disease?
Ghinsberg RC, Nitzan Y
Med Hypotheses 1992 Sep;39(1):35-40. doi: 10.1016/0306-9877(92)90137-2. PMID: 1435390

Recent systematic reviews

Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Treatment of syphilis: a systematic review.
Clement ME, Okeke NL, Hicks CB
JAMA 2014 Nov 12;312(18):1905-17. doi: 10.1001/jama.2014.13259. PMID: 25387188Free PMC Article
Treatment of syphilis in HIV-infected subjects: a systematic review of the literature.
Blank LJ, Rompalo AM, Erbelding EJ, Zenilman JM, Ghanem KG
Sex Transm Infect 2011 Feb;87(1):9-16. Epub 2010 Oct 5 doi: 10.1136/sti.2010.043893. PMID: 20924048

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