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Multicystic Mesothelioma

MedGen UID:
690123
•Concept ID:
C1266156
•
Neoplastic Process
Synonyms: Cystic Mesothelioma; Cystic mesothelioma, benign; Intermediate Mesothelioma; Multicystic mesothelioma, benign
SNOMED CT: Cystic mesothelioma, benign (128901009); Multicystic mesothelioma, benign (128901009)

Definition

A mesothelial neoplasm that arises from the peritoneum and rarely the pleura. It is characterized by the presence of multiple cysts lined by flattened or cuboidal mesothelial cells. There is no evidence of significant cytologic atypia or increased mitotic activity. It may reoccur. Rare cases of transformation to malignant mesothelioma have been reported. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMulticystic Mesothelioma

Professional guidelines

PubMed

Adenomatoid Tumor: A Review of Pathology With Focus on Unusual Presentations and Sites, Histogenesis, Differential Diagnosis, and Molecular and Clinical Aspects With a Historic Overview of Its Description.
Karpathiou G, Hiroshima K, Peoc'h M
Adv Anat Pathol 2020 Nov;27(6):394-407. doi: 10.1097/PAP.0000000000000278. PMID: 32769378
Long-term results of laparoscopic cytoreductive surgery and HIPEC for the curative treatment of low-grade pseudomyxoma peritonei and multicystic mesothelioma.
Mercier F, Jeremie G, Alyami M, Delphine V, Vahan K, Pascal R, Sylvie I, Guillaume P, Olivier G
Surg Endosc 2020 Nov;34(11):4916-4923. Epub 2019 Dec 2 doi: 10.1007/s00464-019-07280-1. PMID: 31792692
Benign multicystic mesothelioma and peritoneal inclusion cysts: are they the same clinical and histopathological entities? A systematic review to find an evidence-based management.
Rapisarda AMC, Cianci A, Caruso S, Vitale SG, Valenti G, Piombino E, Cianci S
Arch Gynecol Obstet 2018 Jun;297(6):1353-1375. Epub 2018 Mar 6 doi: 10.1007/s00404-018-4728-2. PMID: 29511797

Recent clinical studies

Etiology

Multicystic peritoneal mesothelioma treated with cytoreductive surgery followed or not by hyperthermic intraperitoneal chemotherapy: results from a large multicentric cohort.
Kepenekian V, Péron J, Goéré D, Sgarbura O, Delhorme JB, Eveno C, Benzerdjeb N, Bonnefoy I, Villeneuve L, Rousset P, Abboud K, Pocard M, Glehen O; On Behalf RENAPE (French Network for Rare Peritoneal Malignancies)
Int J Hyperthermia 2021;38(1):805-814. doi: 10.1080/02656736.2021.1903585. PMID: 34039244
Mesothelial Cysts.
Karpathiou G, Casteillo F, Dridi M, Peoc'h M
Am J Clin Pathol 2021 May 18;155(6):853-862. doi: 10.1093/ajcp/aqaa189. PMID: 33258870
Long-term results of laparoscopic cytoreductive surgery and HIPEC for the curative treatment of low-grade pseudomyxoma peritonei and multicystic mesothelioma.
Mercier F, Jeremie G, Alyami M, Delphine V, Vahan K, Pascal R, Sylvie I, Guillaume P, Olivier G
Surg Endosc 2020 Nov;34(11):4916-4923. Epub 2019 Dec 2 doi: 10.1007/s00464-019-07280-1. PMID: 31792692
Multicystic mesothelioma: Operative and long-term outcomes with cytoreductive surgery and hyperthermic intra peritoneal chemotherapy.
Nizri E, Baratti D, Guaglio M, Sinukumar S, Cabras A, Kusamura S, Deraco M
Eur J Surg Oncol 2018 Jul;44(7):1100-1104. Epub 2018 Mar 14 doi: 10.1016/j.ejso.2018.03.004. PMID: 29703622
Peritoneal inclusion cysts: a review.
Vallerie AM, Lerner JP, Wright JD, Baxi LV
Obstet Gynecol Surv 2009 May;64(5):321-34. doi: 10.1097/OGX.0b013e31819f93d4. PMID: 19386139

Diagnosis

Adenomatoid Tumor: A Review of Pathology With Focus on Unusual Presentations and Sites, Histogenesis, Differential Diagnosis, and Molecular and Clinical Aspects With a Historic Overview of Its Description.
Karpathiou G, Hiroshima K, Peoc'h M
Adv Anat Pathol 2020 Nov;27(6):394-407. doi: 10.1097/PAP.0000000000000278. PMID: 32769378
Benign multicystic mesothelioma and peritoneal inclusion cysts: are they the same clinical and histopathological entities? A systematic review to find an evidence-based management.
Rapisarda AMC, Cianci A, Caruso S, Vitale SG, Valenti G, Piombino E, Cianci S
Arch Gynecol Obstet 2018 Jun;297(6):1353-1375. Epub 2018 Mar 6 doi: 10.1007/s00404-018-4728-2. PMID: 29511797
Peritoneal mesothelioma: the site of origin matters.
Kindler HL
Am Soc Clin Oncol Educ Book 2013:182-8. doi: 10.14694/EdBook_AM.2013.33.182. PMID: 23714495
Peritoneal inclusion cysts: a review.
Vallerie AM, Lerner JP, Wright JD, Baxi LV
Obstet Gynecol Surv 2009 May;64(5):321-34. doi: 10.1097/OGX.0b013e31819f93d4. PMID: 19386139
Pathology of malignant mesothelioma.
Attanoos RL, Gibbs AR
Histopathology 1997 May;30(5):403-18. doi: 10.1046/j.1365-2559.1997.5460776.x. PMID: 9181361

Therapy

Mesothelioma in children and adolescents: the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT) contribution.
Orbach D, André N, Brecht IB, López Almaraz R, Ben-Ami T, Vermersch S, Carton M, Virgone C, Bisogno G, Schneider DT, Bajciova V, Reguerre Y, Galateau-Salle F, Stachowicz-Stencel T, Dvir R, Rees H, Bien E, Ferrari A, Ben Arush M
Eur J Cancer 2020 Nov;140:63-70. Epub 2020 Oct 10 doi: 10.1016/j.ejca.2020.09.011. PMID: 33049597
Multicystic mesothelioma: Operative and long-term outcomes with cytoreductive surgery and hyperthermic intra peritoneal chemotherapy.
Nizri E, Baratti D, Guaglio M, Sinukumar S, Cabras A, Kusamura S, Deraco M
Eur J Surg Oncol 2018 Jul;44(7):1100-1104. Epub 2018 Mar 14 doi: 10.1016/j.ejso.2018.03.004. PMID: 29703622
Peritoneal mesothelioma: the site of origin matters.
Kindler HL
Am Soc Clin Oncol Educ Book 2013:182-8. doi: 10.14694/EdBook_AM.2013.33.182. PMID: 23714495
Peritoneal inclusion cysts: a review.
Vallerie AM, Lerner JP, Wright JD, Baxi LV
Obstet Gynecol Surv 2009 May;64(5):321-34. doi: 10.1097/OGX.0b013e31819f93d4. PMID: 19386139
Pathology of malignant mesothelioma.
Attanoos RL, Gibbs AR
Histopathology 1997 May;30(5):403-18. doi: 10.1046/j.1365-2559.1997.5460776.x. PMID: 9181361

Prognosis

Mesothelial Cysts.
Karpathiou G, Casteillo F, Dridi M, Peoc'h M
Am J Clin Pathol 2021 May 18;155(6):853-862. doi: 10.1093/ajcp/aqaa189. PMID: 33258870
Long-term results of laparoscopic cytoreductive surgery and HIPEC for the curative treatment of low-grade pseudomyxoma peritonei and multicystic mesothelioma.
Mercier F, Jeremie G, Alyami M, Delphine V, Vahan K, Pascal R, Sylvie I, Guillaume P, Olivier G
Surg Endosc 2020 Nov;34(11):4916-4923. Epub 2019 Dec 2 doi: 10.1007/s00464-019-07280-1. PMID: 31792692
Peritoneal mesothelioma: the site of origin matters.
Kindler HL
Am Soc Clin Oncol Educ Book 2013:182-8. doi: 10.14694/EdBook_AM.2013.33.182. PMID: 23714495
Pathology of malignant mesothelioma.
Attanoos RL, Gibbs AR
Histopathology 1997 May;30(5):403-18. doi: 10.1046/j.1365-2559.1997.5460776.x. PMID: 9181361
Benign abdominal multicystic mesothelioma.
Kampschöer PH, Ubachs HM, Theunissen PH
Acta Obstet Gynecol Scand 1992 Oct;71(7):555-7. doi: 10.3109/00016349209041451. PMID: 1332379

Clinical prediction guides

Multicystic peritoneal mesothelioma treated with cytoreductive surgery followed or not by hyperthermic intraperitoneal chemotherapy: results from a large multicentric cohort.
Kepenekian V, Péron J, Goéré D, Sgarbura O, Delhorme JB, Eveno C, Benzerdjeb N, Bonnefoy I, Villeneuve L, Rousset P, Abboud K, Pocard M, Glehen O; On Behalf RENAPE (French Network for Rare Peritoneal Malignancies)
Int J Hyperthermia 2021;38(1):805-814. doi: 10.1080/02656736.2021.1903585. PMID: 34039244
Long-term results of laparoscopic cytoreductive surgery and HIPEC for the curative treatment of low-grade pseudomyxoma peritonei and multicystic mesothelioma.
Mercier F, Jeremie G, Alyami M, Delphine V, Vahan K, Pascal R, Sylvie I, Guillaume P, Olivier G
Surg Endosc 2020 Nov;34(11):4916-4923. Epub 2019 Dec 2 doi: 10.1007/s00464-019-07280-1. PMID: 31792692
Outcomes of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for peritoneal mesothelioma and predictors of survival.
Gilani SNS, Mehta A, Garcia-Fadrique A, Rowaiye B, Jenei V, Dayal S, Chandrakumaran K, Carr N, Mohamed F, Cecil T, Moran B
Int J Hyperthermia 2018 Aug;34(5):578-584. Epub 2018 Feb 12 doi: 10.1080/02656736.2018.1434902. PMID: 29431036
Well-differentiated papillary mesothelioma: a clinicopathological and immunohistochemical study of 18 cases with additional observation.
Chen X, Sheng W, Wang J
Histopathology 2013 Apr;62(5):805-13. doi: 10.1111/his.12089. PMID: 23530588
Multicystic mesothelioma. An analysis of pathologic findings and biologic behavior in 37 cases.
Weiss SW, Tavassoli FA
Am J Surg Pathol 1988 Oct;12(10):737-46. PMID: 3421410

Recent systematic reviews

Benign multicystic mesothelioma and peritoneal inclusion cysts: are they the same clinical and histopathological entities? A systematic review to find an evidence-based management.
Rapisarda AMC, Cianci A, Caruso S, Vitale SG, Valenti G, Piombino E, Cianci S
Arch Gynecol Obstet 2018 Jun;297(6):1353-1375. Epub 2018 Mar 6 doi: 10.1007/s00404-018-4728-2. PMID: 29511797

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