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Chronic autoimmune hepatitis

MedGen UID:
69144
Concept ID:
C0241910
Disease or Syndrome
Synonyms: Autoimmune Chronic Hepatitides; Autoimmune Chronic Hepatitis; Autoimmune Hepatitides; Autoimmune Hepatitis; Chronic Hepatitides, Autoimmune; Chronic Hepatitis, Autoimmune; Hepatitides, Autoimmune; Hepatitides, Autoimmune Chronic; Hepatitis, Autoimmune; Hepatitis, Autoimmune Chronic
SNOMED CT: Autoimmune chronic active hepatitis (197284004); Chronic autoimmune hepatitis (16098491000119109)

Definition

A chronic self-perpetuating hepatocellular INFLAMMATION of unknown cause, usually with HYPERGAMMAGLOBULINEMIA and serum AUTOANTIBODIES. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic autoimmune hepatitis
Follow this link to review classifications for Chronic autoimmune hepatitis in Orphanet.

Professional guidelines

PubMed

Díaz-González Á, Hernández-Guerra M, Pérez-Medrano I, Sapena V, Riveiro-Barciela M, Barreira-Díaz A, Gómez E, Morillas RM, Del Barrio M, Escudé L, Mateos B, Horta D, Gómez J, Conde I, Ferre-Aracil C, El Hajra I, Arencibía A, Zamora J, Fernández A, Salcedo M, Molina E, Soria A, Estévez P, López C, Álvarez-Navascúes C, García-Retortillo M, Crespo J, Londoño MC; ColHai Registry
Hepatology 2023 Apr 1;77(4):1095-1105. Epub 2023 Jan 3 doi: 10.1097/HEP.0000000000000018. PMID: 36626622
Olivas I, Cobreros M, Londoño MC, Díaz-González Á
Gastroenterol Hepatol 2022 Aug-Sep;45(7):561-570. Epub 2021 Dec 16 doi: 10.1016/j.gastrohep.2021.11.012. PMID: 34923033
Dusheiko GM
Aliment Pharmacol Ther 1994 Apr;8(2):229-53. doi: 10.1111/j.1365-2036.1994.tb00283.x. PMID: 8038356

Recent clinical studies

Etiology

Díaz-González Á, Hernández-Guerra M, Pérez-Medrano I, Sapena V, Riveiro-Barciela M, Barreira-Díaz A, Gómez E, Morillas RM, Del Barrio M, Escudé L, Mateos B, Horta D, Gómez J, Conde I, Ferre-Aracil C, El Hajra I, Arencibía A, Zamora J, Fernández A, Salcedo M, Molina E, Soria A, Estévez P, López C, Álvarez-Navascúes C, García-Retortillo M, Crespo J, Londoño MC; ColHai Registry
Hepatology 2023 Apr 1;77(4):1095-1105. Epub 2023 Jan 3 doi: 10.1097/HEP.0000000000000018. PMID: 36626622
Ferre-Aracil C, Riveiro-Barciela M, Trapero-Marugán M, Rodríguez-Perálvarez M, Llovet LP, Téllez L, Sánchez-Torrijos Y, Díaz-Fontenla F, Salcedo-Plaza M, Álvarez-López P, de la Mata M, Londoño MC, Bañares-Cañizares R, Calleja JL
Dig Dis Sci 2021 Aug;66(8):2826-2832. Epub 2020 Aug 29 doi: 10.1007/s10620-020-06569-9. PMID: 32860579
Yousefi A, Najafi M, Motamed F, Mahmoudi E, Bidoki AZ, Sadr M, Rahmani F, Farhmand F, Khodadad A, Fallahi G, Rezaei N
Ann Hepatol 2018 Oct 16;17(6):1021-1025. doi: 10.5604/01.3001.0012.7202. PMID: 30600293
Shen Y, Lu C, Men R, Liu J, Ye T, Yang L
Can J Gastroenterol Hepatol 2018;2018:3513206. Epub 2018 Mar 18 doi: 10.1155/2018/3513206. PMID: 29744332Free PMC Article
Schulz PO, Ferreira FG, Nascimento Mde F, Vieira A, Ribeiro MA, David AI, Szutan LA
World J Gastroenterol 2015 Jan 21;21(3):913-8. doi: 10.3748/wjg.v21.i3.913. PMID: 25624725Free PMC Article

Diagnosis

Ferre-Aracil C, Riveiro-Barciela M, Trapero-Marugán M, Rodríguez-Perálvarez M, Llovet LP, Téllez L, Sánchez-Torrijos Y, Díaz-Fontenla F, Salcedo-Plaza M, Álvarez-López P, de la Mata M, Londoño MC, Bañares-Cañizares R, Calleja JL
Dig Dis Sci 2021 Aug;66(8):2826-2832. Epub 2020 Aug 29 doi: 10.1007/s10620-020-06569-9. PMID: 32860579
Shen Y, Lu C, Men R, Liu J, Ye T, Yang L
Can J Gastroenterol Hepatol 2018;2018:3513206. Epub 2018 Mar 18 doi: 10.1155/2018/3513206. PMID: 29744332Free PMC Article
Schulz PO, Ferreira FG, Nascimento Mde F, Vieira A, Ribeiro MA, David AI, Szutan LA
World J Gastroenterol 2015 Jan 21;21(3):913-8. doi: 10.3748/wjg.v21.i3.913. PMID: 25624725Free PMC Article
Zeman MV, Hirschfield GM
Can J Gastroenterol 2010 Apr;24(4):225-31. doi: 10.1155/2010/431913. PMID: 20431809Free PMC Article
Koay LB, Tsai SL, Sun CS, Wu KT
Hepatogastroenterology 2008 Sep-Oct;55(86-87):1781-4. PMID: 19102393

Therapy

Díaz-González Á, Hernández-Guerra M, Pérez-Medrano I, Sapena V, Riveiro-Barciela M, Barreira-Díaz A, Gómez E, Morillas RM, Del Barrio M, Escudé L, Mateos B, Horta D, Gómez J, Conde I, Ferre-Aracil C, El Hajra I, Arencibía A, Zamora J, Fernández A, Salcedo M, Molina E, Soria A, Estévez P, López C, Álvarez-Navascúes C, García-Retortillo M, Crespo J, Londoño MC; ColHai Registry
Hepatology 2023 Apr 1;77(4):1095-1105. Epub 2023 Jan 3 doi: 10.1097/HEP.0000000000000018. PMID: 36626622
Olivas I, Cobreros M, Londoño MC, Díaz-González Á
Gastroenterol Hepatol 2022 Aug-Sep;45(7):561-570. Epub 2021 Dec 16 doi: 10.1016/j.gastrohep.2021.11.012. PMID: 34923033
Ferre-Aracil C, Riveiro-Barciela M, Trapero-Marugán M, Rodríguez-Perálvarez M, Llovet LP, Téllez L, Sánchez-Torrijos Y, Díaz-Fontenla F, Salcedo-Plaza M, Álvarez-López P, de la Mata M, Londoño MC, Bañares-Cañizares R, Calleja JL
Dig Dis Sci 2021 Aug;66(8):2826-2832. Epub 2020 Aug 29 doi: 10.1007/s10620-020-06569-9. PMID: 32860579
Meunier L, Ursic-Bedoya J, Pageaux GP, Larrey D
Liver Int 2018 Jun;38(6):995-999. Epub 2018 Mar 31 doi: 10.1111/liv.13737. PMID: 29532602
Hardtke-Wolenski M, Fischer K, Noyan F, Schlue J, Falk CS, Stahlhut M, Woller N, Kuehnel F, Taubert R, Manns MP, Jaeckel E
Hepatology 2013 Aug;58(2):718-28. Epub 2013 Jul 1 doi: 10.1002/hep.26380. PMID: 23475565

Prognosis

Yüksel M, Laukens D, Heindryckx F, Van Vlierberghe H, Geerts A, Wong FS, Wen L, Colle I
Int J Exp Pathol 2014 Oct;95(5):309-20. Epub 2014 Aug 12 doi: 10.1111/iep.12090. PMID: 25112417Free PMC Article
Núñez-Martínez O, De la Cruz G, Salcedo M, Molina J, De Diego A, Ripoll C, Calleja J, Alvarez E, Clemente G
Transplant Proc 2003 Aug;35(5):1857-8. doi: 10.1016/s0041-1345(03)00591-8. PMID: 12962824
Singh R, Nair S, Farr G, Mason A, Perrillo R
Am J Gastroenterol 2002 Oct;97(10):2670-3. doi: 10.1111/j.1572-0241.2002.06052.x. PMID: 12385459
Balakrishnan C, Mangat G, Kalke S, Desai D, Joshi A, Deshpande RB, Joshi VR
J Assoc Physicians India 1998 May;46(5):431-5. PMID: 11273283
Burgart LJ, Batts KP, Ludwig J, Nikias GA, Czaja AJ
Am J Surg Pathol 1995 Jun;19(6):699-708. doi: 10.1097/00000478-199506000-00010. PMID: 7755156

Clinical prediction guides

Díaz-González Á, Hernández-Guerra M, Pérez-Medrano I, Sapena V, Riveiro-Barciela M, Barreira-Díaz A, Gómez E, Morillas RM, Del Barrio M, Escudé L, Mateos B, Horta D, Gómez J, Conde I, Ferre-Aracil C, El Hajra I, Arencibía A, Zamora J, Fernández A, Salcedo M, Molina E, Soria A, Estévez P, López C, Álvarez-Navascúes C, García-Retortillo M, Crespo J, Londoño MC; ColHai Registry
Hepatology 2023 Apr 1;77(4):1095-1105. Epub 2023 Jan 3 doi: 10.1097/HEP.0000000000000018. PMID: 36626622
Shen Y, Lu C, Men R, Liu J, Ye T, Yang L
Can J Gastroenterol Hepatol 2018;2018:3513206. Epub 2018 Mar 18 doi: 10.1155/2018/3513206. PMID: 29744332Free PMC Article
Meunier L, Ursic-Bedoya J, Pageaux GP, Larrey D
Liver Int 2018 Jun;38(6):995-999. Epub 2018 Mar 31 doi: 10.1111/liv.13737. PMID: 29532602
Núñez-Martínez O, De la Cruz G, Salcedo M, Molina J, De Diego A, Ripoll C, Calleja J, Alvarez E, Clemente G
Transplant Proc 2003 Aug;35(5):1857-8. doi: 10.1016/s0041-1345(03)00591-8. PMID: 12962824
Theal RM, Scott K
Am Fam Physician 1996 May 1;53(6):2111-9. PMID: 8623723

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