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Immune System and Related Disorders

MedGen UID:
232638
Concept ID:
C1334156
Disease or Syndrome
Synonym: Immunodeficiency and Immunosuppression Disorders

Definition

A group of non-neoplastic and neoplastic disorders resulting from the deregulation and/or deficiency of immune system functions. It includes autoimmune disorders (e.g., lupus erythematosus, dermatomyositis, rheumatoid arthritis), congenital and acquired immunodeficiency syndromes including the acquired immune deficiency syndrome (AIDS), and neoplasms (e.g., lymphomas and malignancies secondary to transplantation). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImmune System and Related Disorders

Professional guidelines

PubMed

Ihnatowicz P, Drywień M, Wątor P, Wojsiat J
Ann Agric Environ Med 2020 Jun 19;27(2):184-193. Epub 2019 Oct 2 doi: 10.26444/aaem/112331. PMID: 32588591
Bassetti CLA, Adamantidis A, Burdakov D, Han F, Gay S, Kallweit U, Khatami R, Koning F, Kornum BR, Lammers GJ, Liblau RS, Luppi PH, Mayer G, Pollmächer T, Sakurai T, Sallusto F, Scammell TE, Tafti M, Dauvilliers Y
Nat Rev Neurol 2019 Sep;15(9):519-539. Epub 2019 Jul 19 doi: 10.1038/s41582-019-0226-9. PMID: 31324898
Brahmer JR, Lacchetti C, Schneider BJ, Atkins MB, Brassil KJ, Caterino JM, Chau I, Ernstoff MS, Gardner JM, Ginex P, Hallmeyer S, Holter Chakrabarty J, Leighl NB, Mammen JS, McDermott DF, Naing A, Nastoupil LJ, Phillips T, Porter LD, Puzanov I, Reichner CA, Santomasso BD, Seigel C, Spira A, Suarez-Almazor ME, Wang Y, Weber JS, Wolchok JD, Thompson JA; National Comprehensive Cancer Network
J Clin Oncol 2018 Jun 10;36(17):1714-1768. Epub 2018 Feb 14 doi: 10.1200/JCO.2017.77.6385. PMID: 29442540Free PMC Article

Recent clinical studies

Etiology

Wimalawansa SJ
Nutrients 2023 Sep 2;15(17) doi: 10.3390/nu15173842. PMID: 37686873Free PMC Article
Sîrbe C, Rednic S, Grama A, Pop TL
Int J Mol Sci 2022 Aug 29;23(17) doi: 10.3390/ijms23179784. PMID: 36077185Free PMC Article
Brauning A, Rae M, Zhu G, Fulton E, Admasu TD, Stolzing A, Sharma A
Cells 2022 Mar 17;11(6) doi: 10.3390/cells11061017. PMID: 35326467Free PMC Article
Olin A, Henckel E, Chen Y, Lakshmikanth T, Pou C, Mikes J, Gustafsson A, Bernhardsson AK, Zhang C, Bohlin K, Brodin P
Cell 2018 Aug 23;174(5):1277-1292.e14. doi: 10.1016/j.cell.2018.06.045. PMID: 30142345Free PMC Article
Estes ML, McAllister AK
Science 2016 Aug 19;353(6301):772-7. doi: 10.1126/science.aag3194. PMID: 27540164Free PMC Article

Diagnosis

Valent P, Klion AD, Roufosse F, Simon D, Metzgeroth G, Leiferman KM, Schwaab J, Butterfield JH, Sperr WR, Sotlar K, Vandenberghe P, Hoermann G, Haferlach T, Moriggl R, George TI, Akin C, Bochner BS, Gotlib J, Reiter A, Horny HP, Arock M, Simon HU, Gleich GJ
Allergy 2023 Jan;78(1):47-59. Epub 2022 Oct 19 doi: 10.1111/all.15544. PMID: 36207764Free PMC Article
Lian X, Yang K, Li R, Li M, Zuo J, Zheng B, Wang W, Wang P, Zhou S
Mol Cancer 2022 Jan 21;21(1):27. doi: 10.1186/s12943-021-01486-5. PMID: 35062950Free PMC Article
Zahorec R
Bratisl Lek Listy 2021;122(7):474-488. doi: 10.4149/BLL_2021_078. PMID: 34161115
Garcia-Cortes M, Robles-Diaz M, Stephens C, Ortega-Alonso A, Lucena MI, Andrade RJ
Arch Toxicol 2020 Oct;94(10):3381-3407. Epub 2020 Aug 27 doi: 10.1007/s00204-020-02885-1. PMID: 32852569
Kamisawa T, Zen Y, Pillai S, Stone JH
Lancet 2015 Apr 11;385(9976):1460-71. Epub 2014 Dec 4 doi: 10.1016/S0140-6736(14)60720-0. PMID: 25481618

Therapy

Correale J, Hohlfeld R, Baranzini SE
Nat Rev Neurol 2022 Sep;18(9):544-558. Epub 2022 Aug 5 doi: 10.1038/s41582-022-00697-8. PMID: 35931825
Biederstädt A, Rezvani K
Int J Hematol 2021 Nov;114(5):554-571. Epub 2021 Aug 28 doi: 10.1007/s12185-021-03209-4. PMID: 34453686Free PMC Article
Kaegi C, Wuest B, Schreiner J, Steiner UC, Vultaggio A, Matucci A, Crowley C, Boyman O
Front Immunol 2019;10:1990. Epub 2019 Sep 6 doi: 10.3389/fimmu.2019.01990. PMID: 31555262Free PMC Article
Tanaka TN, Bejar R
Blood 2019 Mar 7;133(10):1086-1095. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844670. PMID: 30670443
de Heredia FP, Gómez-Martínez S, Marcos A
Proc Nutr Soc 2012 May;71(2):332-8. Epub 2012 Mar 20 doi: 10.1017/S0029665112000092. PMID: 22429824

Prognosis

Schneider CV, Schneider KM, Teumer A, Rudolph KL, Hartmann D, Rader DJ, Strnad P
JAMA Intern Med 2022 Mar 1;182(3):291-300. doi: 10.1001/jamainternmed.2021.7804. PMID: 35040871Free PMC Article
Zhao J, Guo S, Schrodi SJ, He D
Front Immunol 2021;12:790122. Epub 2021 Nov 25 doi: 10.3389/fimmu.2021.790122. PMID: 34899757Free PMC Article
Zahorec R
Bratisl Lek Listy 2021;122(7):474-488. doi: 10.4149/BLL_2021_078. PMID: 34161115
Moosavi MM, Duncan A, Stowell SR, Roback JD, Sullivan HC
Transfus Med Rev 2020 Jul;34(3):178-187. Epub 2020 Jul 16 doi: 10.1016/j.tmrv.2020.06.004. PMID: 32826130
Olin A, Henckel E, Chen Y, Lakshmikanth T, Pou C, Mikes J, Gustafsson A, Bernhardsson AK, Zhang C, Bohlin K, Brodin P
Cell 2018 Aug 23;174(5):1277-1292.e14. doi: 10.1016/j.cell.2018.06.045. PMID: 30142345Free PMC Article

Clinical prediction guides

Sîrbe C, Rednic S, Grama A, Pop TL
Int J Mol Sci 2022 Aug 29;23(17) doi: 10.3390/ijms23179784. PMID: 36077185Free PMC Article
Zhao J, Guo S, Schrodi SJ, He D
Front Immunol 2021;12:790122. Epub 2021 Nov 25 doi: 10.3389/fimmu.2021.790122. PMID: 34899757Free PMC Article
Singh S, Anshita D, Ravichandiran V
Int Immunopharmacol 2021 Dec;101(Pt B):107598. Epub 2021 May 20 doi: 10.1016/j.intimp.2021.107598. PMID: 34233864Free PMC Article
Garcia-Cortes M, Robles-Diaz M, Stephens C, Ortega-Alonso A, Lucena MI, Andrade RJ
Arch Toxicol 2020 Oct;94(10):3381-3407. Epub 2020 Aug 27 doi: 10.1007/s00204-020-02885-1. PMID: 32852569
Olin A, Henckel E, Chen Y, Lakshmikanth T, Pou C, Mikes J, Gustafsson A, Bernhardsson AK, Zhang C, Bohlin K, Brodin P
Cell 2018 Aug 23;174(5):1277-1292.e14. doi: 10.1016/j.cell.2018.06.045. PMID: 30142345Free PMC Article

Recent systematic reviews

Liampas A, Parperis K, Erotocritou MF, Nteveros A, Papadopoulou M, Moschovos C, Akil M, Coaccioli S, Hadjigeorgiou GM, Hadjivassiliou M, Zis P
Eur J Neurol 2023 Jan;30(1):255-265. Epub 2022 Sep 23 doi: 10.1111/ene.15555. PMID: 36086910Free PMC Article
Barrio C, Arias-Sánchez S, Martín-Monzón I
Psychoneuroendocrinology 2022 Mar;137:105640. Epub 2021 Dec 17 doi: 10.1016/j.psyneuen.2021.105640. PMID: 34942539
Kaegi C, Wuest B, Schreiner J, Steiner UC, Vultaggio A, Matucci A, Crowley C, Boyman O
Front Immunol 2019;10:1990. Epub 2019 Sep 6 doi: 10.3389/fimmu.2019.01990. PMID: 31555262Free PMC Article
Adam EK, Quinn ME, Tavernier R, McQuillan MT, Dahlke KA, Gilbert KE
Psychoneuroendocrinology 2017 Sep;83:25-41. Epub 2017 May 24 doi: 10.1016/j.psyneuen.2017.05.018. PMID: 28578301Free PMC Article
Bordoni A, Danesi F, Dardevet D, Dupont D, Fernandez AS, Gille D, Nunes Dos Santos C, Pinto P, Re R, Rémond D, Shahar DR, Vergères G
Crit Rev Food Sci Nutr 2017 Aug 13;57(12):2497-2525. doi: 10.1080/10408398.2014.967385. PMID: 26287637

Supplemental Content

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