U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hypertrophic or verrucous lupus erythematosus

MedGen UID:
698156
Concept ID:
C1274838
Disease or Syndrome
Synonyms: hypertrophic or verrucous lupus erythematosus; Hypertrophic type discoid lupus erythematosus; Verrucous lupus erythematosus; Warty discoid lupus erythematosus; Warty lupus erythematosus
SNOMED CT: Hypertrophic type discoid lupus erythematosus (403492006); Warty lupus erythematosus (403492006); Warty discoid lupus erythematosus (403492006); Verrucous lupus erythematosus (403492006)
 
Monarch Initiative: MONDO:0019559
Orphanet: ORPHA90282

Definition

Hypertrophic or verrucous lupus erythematosus is a rare type of chronic cutaneous lupus erythematosus characterized by the appearance of lesions on sun-exposed areas (frequently the extensor surfaces of forearms, face, upper trunk) which vary from squamous violet, painful papules and blackish hyperkeratotic ulcers to depigmented atrophic plaques on the back, hyperkeratotic papules on upper extremities, and disseminated keratoacanthoma-like papulonodular verrucous lesions. Classic discoid lesions and squamous cell carcinoma may be associated. Histopathology reveals follicular plugging, liquefactive basal layer degeneration and a perivascular lymphocytic infiltrate. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypertrophic or verrucous lupus erythematosus

Professional guidelines

PubMed

Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, Romero D, Abdelmalek MF, Anstee QM, Arab JP, Arrese M, Bataller R, Beuers U, Boursier J, Bugianesi E, Byrne CD, Castro Narro GE, Chowdhury A, Cortez-Pinto H, Cryer DR, Cusi K, El-Kassas M, Klein S, Eskridge W, Fan J, Gawrieh S, Guy CD, Harrison SA, Kim SU, Koot BG, Korenjak M, Kowdley KV, Lacaille F, Loomba R, Mitchell-Thain R, Morgan TR, Powell EE, Roden M, Romero-Gómez M, Silva M, Singh SP, Sookoian SC, Spearman CW, Tiniakos D, Valenti L, Vos MB, Wong VW, Xanthakos S, Yilmaz Y, Younossi Z, Hobbs A, Villota-Rivas M, Newsome PN; NAFLD Nomenclature consensus group
Hepatology 2023 Dec 1;78(6):1966-1986. Epub 2023 Jun 24 doi: 10.1097/HEP.0000000000000520. PMID: 37363821Free PMC Article
Thenappan T, Ormiston ML, Ryan JJ, Archer SL
BMJ 2018 Mar 14;360:j5492. doi: 10.1136/bmj.j5492. PMID: 29540357Free PMC Article
Flynn JT, Kaelber DC, Baker-Smith CM, Blowey D, Carroll AE, Daniels SR, de Ferranti SD, Dionne JM, Falkner B, Flinn SK, Gidding SS, Goodwin C, Leu MG, Powers ME, Rea C, Samuels J, Simasek M, Thaker VV, Urbina EM; SUBCOMMITTEE ON SCREENING AND MANAGEMENT OF HIGH BLOOD PRESSURE IN CHILDREN
Pediatrics 2017 Sep;140(3) Epub 2017 Aug 21 doi: 10.1542/peds.2017-1904. PMID: 28827377

Recent clinical studies

Etiology

Curran L, de Marvao A, Inglese P, McGurk KA, Schiratti PR, Clement A, Zheng SL, Li S, Pua CJ, Shah M, Jafari M, Theotokis P, Buchan RJ, Jurgens SJ, Raphael CE, Baksi AJ, Pantazis A, Halliday BP, Pennell DJ, Bai W, Chin CWL, Tadros R, Bezzina CR, Watkins H, Cook SA, Prasad SK, Ware JS, O'Regan DP
Circ Genom Precis Med 2023 Dec;16(6):e004200. Epub 2023 Nov 28 doi: 10.1161/CIRCGEN.123.004200. PMID: 38014537Free PMC Article
Ahmad Z, Krüger K, Lautermann J, Lippert B, Tenenbaum T, Tigges M, Tisch M
HNO 2023 Aug;71(Suppl 1):67-72. Epub 2023 Jul 25 doi: 10.1007/s00106-023-01299-6. PMID: 37491540Free PMC Article
Pereira L, Monyror J, Almeida FT, Almeida FR, Guerra E, Flores-Mir C, Pachêco-Pereira C
Sleep Med Rev 2018 Apr;38:101-112. Epub 2017 Jun 14 doi: 10.1016/j.smrv.2017.06.001. PMID: 29153763
Ozaki H, Loenneke JP, Thiebaud RS, Abe T
Acta Physiol Hung 2015 Mar;102(1):1-22. doi: 10.1556/APhysiol.102.2015.1.1. PMID: 25804386
Teitelbaum BA, Hachey DL, Messner LV
J Am Optom Assoc 1997 Jun;68(6):373-6. PMID: 9190137

Diagnosis

Matias TB, Cordeiro RA, Duarte JA, de Jarry VM, Appenzeller S, Villarinho L, Reis F
Acad Radiol 2023 Nov;30(11):2696-2706. Epub 2023 Mar 6 doi: 10.1016/j.acra.2023.01.017. PMID: 36882352
Wang H, Wang Y, Wang R, Li Y, Wang P, Li J, Du J
Brain Res 2019 Sep 1;1718:53-63. Epub 2019 Apr 23 doi: 10.1016/j.brainres.2019.04.024. PMID: 31026459
Pereira L, Monyror J, Almeida FT, Almeida FR, Guerra E, Flores-Mir C, Pachêco-Pereira C
Sleep Med Rev 2018 Apr;38:101-112. Epub 2017 Jun 14 doi: 10.1016/j.smrv.2017.06.001. PMID: 29153763
Chi AC, Neville BW, Krayer JW, Gonsalves WC
Am Fam Physician 2010 Dec 1;82(11):1381-8. PMID: 21121523
Leung AK, Fong JH, Leong AG
J R Soc Promot Health 2002 Mar;122(1):24-7. doi: 10.1177/146642400212200111. PMID: 11989139

Therapy

Ebrahimi Z, Alimohamadi Y, Janani M, Hejazi P, Kamali M, Goodarzi A
J Tissue Eng Regen Med 2022 Oct;16(10):875-899. Epub 2022 Jul 6 doi: 10.1002/term.3338. PMID: 35795892
Pereira L, Monyror J, Almeida FT, Almeida FR, Guerra E, Flores-Mir C, Pachêco-Pereira C
Sleep Med Rev 2018 Apr;38:101-112. Epub 2017 Jun 14 doi: 10.1016/j.smrv.2017.06.001. PMID: 29153763
Schoenfeld BJ, Peterson MD, Ogborn D, Contreras B, Sonmez GT
J Strength Cond Res 2015 Oct;29(10):2954-63. doi: 10.1519/JSC.0000000000000958. PMID: 25853914
Ozaki H, Loenneke JP, Thiebaud RS, Abe T
Acta Physiol Hung 2015 Mar;102(1):1-22. doi: 10.1556/APhysiol.102.2015.1.1. PMID: 25804386
Fedorowicz Z, van Zuuren EJ, Schoones J
Cochrane Database Syst Rev 2013 Sep 9;2013(9):CD007510. doi: 10.1002/14651858.CD007510.pub3. PMID: 24018587Free PMC Article

Prognosis

Basso C, Michaud K, d'Amati G, Banner J, Lucena J, Cunningham K, Leone O, Vink A, van der Wal AC, Sheppard MN; Association for European Cardiovascular Pathology
Virchows Arch 2021 Jul;479(1):79-94. Epub 2021 Mar 19 doi: 10.1007/s00428-021-03038-0. PMID: 33740097Free PMC Article
Turini T, Weck Roxo AC, Serra-Guimarães F, Abreu ML, de Castro CC, Aboudib JH, Nahas FX
Plast Reconstr Surg 2018 Jan;141(1):87-92. doi: 10.1097/PRS.0000000000003921. PMID: 29280868
Marquez-Lara A, Luo TD, Senehi R, Aneja A, Beard HR, Carroll EA
J Orthop Trauma 2017 Aug;31 Suppl 3:S23-S25. doi: 10.1097/BOT.0000000000000905. PMID: 28697079
MacIver DH, Clark AL
J Card Fail 2016 Sep;22(9):731-7. Epub 2016 May 16 doi: 10.1016/j.cardfail.2016.03.020. PMID: 27090746
Gruen P, Kline DG
Neurosurg Focus 2007 Jun 15;22(6):E23. doi: 10.3171/foc.2007.22.6.24. PMID: 17613215

Clinical prediction guides

Basso C, Michaud K, d'Amati G, Banner J, Lucena J, Cunningham K, Leone O, Vink A, van der Wal AC, Sheppard MN; Association for European Cardiovascular Pathology
Virchows Arch 2021 Jul;479(1):79-94. Epub 2021 Mar 19 doi: 10.1007/s00428-021-03038-0. PMID: 33740097Free PMC Article
Bacharova L, Estes EH
J Electrocardiol 2017 Nov-Dec;50(6):906-908. Epub 2017 Jun 7 doi: 10.1016/j.jelectrocard.2017.06.006. PMID: 28651797
Phelan D, Collier P, Thavendiranathan P, Popović ZB, Hanna M, Plana JC, Marwick TH, Thomas JD
Heart 2012 Oct;98(19):1442-8. Epub 2012 Aug 3 doi: 10.1136/heartjnl-2012-302353. PMID: 22865865
Taylor SM, Molyneux ME, Simel DL, Meshnick SR, Juliano JJ
JAMA 2010 Nov 10;304(18):2048-56. Epub 2010 Nov 5 doi: 10.1001/jama.2010.1578. PMID: 21057136
Eftekharian A, Raad N, Gholami-Ghasri N
Int J Pediatr Otorhinolaryngol 2008 Apr;72(4):509-11. Epub 2008 Feb 20 doi: 10.1016/j.ijporl.2008.01.006. PMID: 18282616

Recent systematic reviews

Maron BJ, Desai MY, Nishimura RA, Spirito P, Rakowski H, Towbin JA, Rowin EJ, Maron MS, Sherrid MV
J Am Coll Cardiol 2022 Feb 1;79(4):372-389. doi: 10.1016/j.jacc.2021.12.002. PMID: 35086660
Carvalho L, Junior RM, Barreira J, Schoenfeld BJ, Orazem J, Barroso R
Appl Physiol Nutr Metab 2022 Apr;47(4):357-368. Epub 2022 Jan 11 doi: 10.1139/apnm-2021-0515. PMID: 35015560
Grgic J, Schoenfeld BJ, Orazem J, Sabol F
J Sport Health Sci 2022 Mar;11(2):202-211. Epub 2021 Jan 23 doi: 10.1016/j.jshs.2021.01.007. PMID: 33497853Free PMC Article
Schoenfeld BJ, Grgic J, Ogborn D, Krieger JW
J Strength Cond Res 2017 Dec;31(12):3508-3523. doi: 10.1519/JSC.0000000000002200. PMID: 28834797
Schoenfeld BJ, Ogborn D, Krieger JW
Sports Med 2016 Nov;46(11):1689-1697. doi: 10.1007/s40279-016-0543-8. PMID: 27102172

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...