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Chronic cutaneous lupus erythematosus

MedGen UID:
832656
•Concept ID:
CN226705
•
Disease or Syndrome
Synonyms: chronic cutaneous lupus erythematosus; cutaneous lupus erythematosus, chronic
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Non-Mendelian inheritance (Orphanet)
 
Monarch Initiative: MONDO:0015574
Orphanet: ORPHA163531

Definition

A form of cutaneous lupus erythematosus (CLE) that includes five different forms: discoid lupus erythematosus (DLE), chilblain lupus, hypertrophic or verrucous lupus erythematosus, lupus erythematosus tumidus, and lupus erythematosus panniculitis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic cutaneous lupus erythematosus
Follow this link to review classifications for Chronic cutaneous lupus erythematosus in Orphanet.

Professional guidelines

PubMed

Lupus Erythematosus Tumidus Clinical Characteristics and Treatment: A Retrospective Review of 25 Patients.
Pona A, Cardenas-de la Garza JA, Broderick A, Sangueza OP, Niehaus AG, Bowers N, Pichardo RO
Cutis 2022 Jun;109(6):330-332. doi: 10.12788/cutis.0544. PMID: 35960984
Cosmetic treatment in patients with autoimmune connective tissue diseases: Best practices for patients with lupus erythematosus.
Creadore A, Watchmaker J, Maymone MBC, Pappas L, Vashi NA, Lam C
J Am Acad Dermatol 2020 Aug;83(2):343-363. Epub 2020 Apr 28 doi: 10.1016/j.jaad.2020.03.123. PMID: 32360722
Cutaneous lupus erythematosus: diagnosis and treatment.
Okon LG, Werth VP
Best Pract Res Clin Rheumatol 2013 Jun;27(3):391-404. doi: 10.1016/j.berh.2013.07.008. PMID: 24238695Free PMC Article

Recent clinical studies

Etiology

Autoimmune Skin Conditions: Cutaneous Lupus Erythematosus.
Foulke G, Helm LA, Clebak KT, Helm M
FP Essent 2023 Mar;526:25-36. PMID: 36913660
Cutaneous Involvement in Systemic Lupus Erythematosus: A Review for the Rheumatologist.
Stull C, Sprow G, Werth VP
J Rheumatol 2023 Jan;50(1):27-35. Epub 2022 Sep 15 doi: 10.3899/jrheum.220089. PMID: 36109075Free PMC Article
Cutaneous lupus erythematosus in skin of color.
Nozile W, Adgerson CN, Cohen GF
J Drugs Dermatol 2015 Apr;14(4):343-9. PMID: 25844606
Lupus erythematosus: considerations about clinical, cutaneous and therapeutic aspects.
Moura Filho JP, Peixoto RL, Martins LG, Melo SD, Carvalho LL, Pereira AK, Freire EA
An Bras Dermatol 2014 Jan-Feb;89(1):118-25. doi: 10.1590/abd1806-4841.20142146. PMID: 24626656Free PMC Article
Discoid lupus erythematosus.
Donnelly AM, Halbert AR, Rohr JB
Australas J Dermatol 1995 Feb;36(1):3-10; quiz 11-2. doi: 10.1111/j.1440-0960.1995.tb00916.x. PMID: 7763220

Diagnosis

Autoimmune Skin Conditions: Cutaneous Lupus Erythematosus.
Foulke G, Helm LA, Clebak KT, Helm M
FP Essent 2023 Mar;526:25-36. PMID: 36913660
Fogo selvagem: endemic pemphigus foliaceus.
Hans-Filho G, Aoki V, Bittner NRH, Bittner GC
An Bras Dermatol 2018 Sep-Oct;93(5):638-650. doi: 10.1590/abd1806-4841.20188235. PMID: 30156612Free PMC Article
Lupus erythematosus: considerations about clinical, cutaneous and therapeutic aspects.
Moura Filho JP, Peixoto RL, Martins LG, Melo SD, Carvalho LL, Pereira AK, Freire EA
An Bras Dermatol 2014 Jan-Feb;89(1):118-25. doi: 10.1590/abd1806-4841.20142146. PMID: 24626656Free PMC Article
Cutaneous lupus erythematosus: diagnosis and treatment.
Okon LG, Werth VP
Best Pract Res Clin Rheumatol 2013 Jun;27(3):391-404. doi: 10.1016/j.berh.2013.07.008. PMID: 24238695Free PMC Article
Chronic cutaneous lupus erythematosus--clinical spectrum.
Pramatarov KD
Clin Dermatol 2004 Mar-Apr;22(2):113-20. doi: 10.1016/j.clindermatol.2003.12.016. PMID: 15234011

Therapy

Autoimmune Skin Conditions: Cutaneous Lupus Erythematosus.
Foulke G, Helm LA, Clebak KT, Helm M
FP Essent 2023 Mar;526:25-36. PMID: 36913660
Cosmetic treatment in patients with autoimmune connective tissue diseases: Best practices for patients with lupus erythematosus.
Creadore A, Watchmaker J, Maymone MBC, Pappas L, Vashi NA, Lam C
J Am Acad Dermatol 2020 Aug;83(2):343-363. Epub 2020 Apr 28 doi: 10.1016/j.jaad.2020.03.123. PMID: 32360722
Cutaneous lupus erythematosus in skin of color.
Nozile W, Adgerson CN, Cohen GF
J Drugs Dermatol 2015 Apr;14(4):343-9. PMID: 25844606
Cutaneous lupus erythematosus: diagnosis and treatment.
Okon LG, Werth VP
Best Pract Res Clin Rheumatol 2013 Jun;27(3):391-404. doi: 10.1016/j.berh.2013.07.008. PMID: 24238695Free PMC Article
Discoid lupus erythematosus.
Donnelly AM, Halbert AR, Rohr JB
Australas J Dermatol 1995 Feb;36(1):3-10; quiz 11-2. doi: 10.1111/j.1440-0960.1995.tb00916.x. PMID: 7763220

Prognosis

Cutaneous Involvement in Systemic Lupus Erythematosus: A Review for the Rheumatologist.
Stull C, Sprow G, Werth VP
J Rheumatol 2023 Jan;50(1):27-35. Epub 2022 Sep 15 doi: 10.3899/jrheum.220089. PMID: 36109075Free PMC Article
Lupus Erythematosus Tumidus Clinical Characteristics and Treatment: A Retrospective Review of 25 Patients.
Pona A, Cardenas-de la Garza JA, Broderick A, Sangueza OP, Niehaus AG, Bowers N, Pichardo RO
Cutis 2022 Jun;109(6):330-332. doi: 10.12788/cutis.0544. PMID: 35960984
The different faces of cutaneous lupus erythematosus.
Renner R, Sticherling M
G Ital Dermatol Venereol 2009 Apr;144(2):135-47. PMID: 19357621
Lupus erythematosus tumidus.
Choonhakarn C, Poonsriaram A, Chaivoramukul J
Int J Dermatol 2004 Nov;43(11):815-8. doi: 10.1111/j.1365-4632.2004.02073.x. PMID: 15533063
Discoid lupus erythematosus.
Donnelly AM, Halbert AR, Rohr JB
Australas J Dermatol 1995 Feb;36(1):3-10; quiz 11-2. doi: 10.1111/j.1440-0960.1995.tb00916.x. PMID: 7763220

Clinical prediction guides

Comedogenic lupus: a rare variant of chronic cutaneous lupus erythematosus - case series.
Garcia LC, Morato IB, de Melo RFQ, Vale ECSD
An Bras Dermatol 2023 Mar-Apr;98(2):159-167. Epub 2023 Jan 25 doi: 10.1016/j.abd.2022.04.003. PMID: 36707354Free PMC Article
Cutaneous lupus erythematosus: factors related to cutaneous activity and damage in a cohort of 260 patients from A Coruña, Spain.
Arévalo-Bermúdez MDP, Paradela S, Balboa-Barreiro V, Fonseca E
Lupus 2020 Aug;29(9):1021-1030. Epub 2020 Jun 15 doi: 10.1177/0961203320930094. PMID: 32539659
Spectrum of cutaneous lupus erythematosus in South Africans with systemic lupus erythematosus.
Koch K, Tikly M
Lupus 2019 Jul;28(8):1021-1026. Epub 2019 Jun 19 doi: 10.1177/0961203319856091. PMID: 31215844
A comprehensive review of immune-mediated dermatopathology in systemic lupus erythematosus.
Li Q, Wu H, Liao W, Zhao M, Chan V, Li L, Zheng M, Chen G, Zhang J, Lau CS, Lu Q
J Autoimmun 2018 Sep;93:1-15. Epub 2018 Jul 11 doi: 10.1016/j.jaut.2018.07.007. PMID: 30017673
Chronic cutaneous lupus erythematosus presenting as atypical acneiform and comedonal plaque: case report and literature review.
Vieira ML, Marques ERMC, Leda YLA, Noriega LF, Bet DL, Pereira GAAM
Lupus 2018 Apr;27(5):853-857. Epub 2017 Aug 31 doi: 10.1177/0961203317726377. PMID: 28857716

Recent systematic reviews

Melanotic lupus erythematosus: A review of a newly described clinical form of chronic cutaneous lupus erythematosus.
Litaiem N, Rouai M, Slouma M, Rammeh S, Zeglaoui F
Clin Dermatol 2022 Nov-Dec;40(6):716-727. Epub 2022 Jul 28 doi: 10.1016/j.clindermatol.2022.07.009. PMID: 35907577
Emerging Skin Toxicities in Patients with Breast Cancer Treated with New Cyclin-Dependent Kinase 4/6 Inhibitors: A Systematic Review.
Silvestri M, Cristaudo A, Morrone A, Messina C, Bennardo L, Nisticò SP, Mariano M, Cameli N
Drug Saf 2021 Jul;44(7):725-732. Epub 2021 May 6 doi: 10.1007/s40264-021-01071-1. PMID: 33959899

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