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Chronic cutaneous lupus erythematosus

MedGen UID:
832656
•Concept ID:
CN226705
•
Disease or Syndrome
Synonyms: chronic cutaneous lupus erythematosus; cutaneous lupus erythematosus, chronic
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Non-Mendelian inheritance (Orphanet)
 
Monarch Initiative: MONDO:0015574
Orphanet: ORPHA163531

Definition

A form of cutaneous lupus erythematosus (CLE) that includes five different forms: discoid lupus erythematosus (DLE), chilblain lupus, hypertrophic or verrucous lupus erythematosus, lupus erythematosus tumidus, and lupus erythematosus panniculitis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic cutaneous lupus erythematosus
Follow this link to review classifications for Chronic cutaneous lupus erythematosus in Orphanet.

Professional guidelines

PubMed

Case series of anifrolumab for treatment of cutaneous lupus erythematosus and lupus-related mucocutaneous manifestations in patients with SLE.
Bao A, Petri MA, Fava A, Kang J
Lupus Sci Med 2023 Dec 19;10(2) doi: 10.1136/lupus-2023-001007. PMID: 38114267Free PMC Article
Cosmetic treatment in patients with autoimmune connective tissue diseases: Best practices for patients with lupus erythematosus.
Creadore A, Watchmaker J, Maymone MBC, Pappas L, Vashi NA, Lam C
J Am Acad Dermatol 2020 Aug;83(2):343-363. Epub 2020 Apr 28 doi: 10.1016/j.jaad.2020.03.123. PMID: 32360722
Cutaneous lupus erythematosus: diagnosis and treatment.
Okon LG, Werth VP
Best Pract Res Clin Rheumatol 2013 Jun;27(3):391-404. doi: 10.1016/j.berh.2013.07.008. PMID: 24238695Free PMC Article

Recent clinical studies

Etiology

Autoimmune Skin Conditions: Cutaneous Lupus Erythematosus.
Foulke G, Helm LA, Clebak KT, Helm M
FP Essent 2023 Mar;526:25-36. PMID: 36913660
Cutaneous Involvement in Systemic Lupus Erythematosus: A Review for the Rheumatologist.
Stull C, Sprow G, Werth VP
J Rheumatol 2023 Jan;50(1):27-35. Epub 2022 Sep 15 doi: 10.3899/jrheum.220089. PMID: 36109075Free PMC Article
Cutaneous lupus erythematosus in skin of color.
Nozile W, Adgerson CN, Cohen GF
J Drugs Dermatol 2015 Apr;14(4):343-9. PMID: 25844606
Lupus erythematosus: considerations about clinical, cutaneous and therapeutic aspects.
Moura Filho JP, Peixoto RL, Martins LG, Melo SD, Carvalho LL, Pereira AK, Freire EA
An Bras Dermatol 2014 Jan-Feb;89(1):118-25. doi: 10.1590/abd1806-4841.20142146. PMID: 24626656Free PMC Article
Lupus tumidus.
Dekle CL, Mannes KD, Davis LS, Sangueza OP
J Am Acad Dermatol 1999 Aug;41(2 Pt 1):250-3. doi: 10.1016/s0190-9622(99)70056-3. PMID: 10426896

Diagnosis

Autoimmune Skin Conditions: Cutaneous Lupus Erythematosus.
Foulke G, Helm LA, Clebak KT, Helm M
FP Essent 2023 Mar;526:25-36. PMID: 36913660
Fogo selvagem: endemic pemphigus foliaceus.
Hans-Filho G, Aoki V, Bittner NRH, Bittner GC
An Bras Dermatol 2018 Sep-Oct;93(5):638-650. doi: 10.1590/abd1806-4841.20188235. PMID: 30156612Free PMC Article
Lupus erythematosus: considerations about clinical, cutaneous and therapeutic aspects.
Moura Filho JP, Peixoto RL, Martins LG, Melo SD, Carvalho LL, Pereira AK, Freire EA
An Bras Dermatol 2014 Jan-Feb;89(1):118-25. doi: 10.1590/abd1806-4841.20142146. PMID: 24626656Free PMC Article
Cutaneous lupus erythematosus: diagnosis and treatment.
Okon LG, Werth VP
Best Pract Res Clin Rheumatol 2013 Jun;27(3):391-404. doi: 10.1016/j.berh.2013.07.008. PMID: 24238695Free PMC Article
Chronic cutaneous lupus erythematosus--clinical spectrum.
Pramatarov KD
Clin Dermatol 2004 Mar-Apr;22(2):113-20. doi: 10.1016/j.clindermatol.2003.12.016. PMID: 15234011

Therapy

Case series of anifrolumab for treatment of cutaneous lupus erythematosus and lupus-related mucocutaneous manifestations in patients with SLE.
Bao A, Petri MA, Fava A, Kang J
Lupus Sci Med 2023 Dec 19;10(2) doi: 10.1136/lupus-2023-001007. PMID: 38114267Free PMC Article
Autoimmune Skin Conditions: Cutaneous Lupus Erythematosus.
Foulke G, Helm LA, Clebak KT, Helm M
FP Essent 2023 Mar;526:25-36. PMID: 36913660
Cosmetic treatment in patients with autoimmune connective tissue diseases: Best practices for patients with lupus erythematosus.
Creadore A, Watchmaker J, Maymone MBC, Pappas L, Vashi NA, Lam C
J Am Acad Dermatol 2020 Aug;83(2):343-363. Epub 2020 Apr 28 doi: 10.1016/j.jaad.2020.03.123. PMID: 32360722
Cutaneous lupus erythematosus in skin of color.
Nozile W, Adgerson CN, Cohen GF
J Drugs Dermatol 2015 Apr;14(4):343-9. PMID: 25844606
Cutaneous lupus erythematosus: diagnosis and treatment.
Okon LG, Werth VP
Best Pract Res Clin Rheumatol 2013 Jun;27(3):391-404. doi: 10.1016/j.berh.2013.07.008. PMID: 24238695Free PMC Article

Prognosis

Cutaneous Involvement in Systemic Lupus Erythematosus: A Review for the Rheumatologist.
Stull C, Sprow G, Werth VP
J Rheumatol 2023 Jan;50(1):27-35. Epub 2022 Sep 15 doi: 10.3899/jrheum.220089. PMID: 36109075Free PMC Article
Lupus Erythematosus Tumidus Clinical Characteristics and Treatment: A Retrospective Review of 25 Patients.
Pona A, Cardenas-de la Garza JA, Broderick A, Sangueza OP, Niehaus AG, Bowers N, Pichardo RO
Cutis 2022 Jun;109(6):330-332. doi: 10.12788/cutis.0544. PMID: 35960984
A comprehensive review of immune-mediated dermatopathology in systemic lupus erythematosus.
Li Q, Wu H, Liao W, Zhao M, Chan V, Li L, Zheng M, Chen G, Zhang J, Lau CS, Lu Q
J Autoimmun 2018 Sep;93:1-15. Epub 2018 Jul 11 doi: 10.1016/j.jaut.2018.07.007. PMID: 30017673
The different faces of cutaneous lupus erythematosus.
Renner R, Sticherling M
G Ital Dermatol Venereol 2009 Apr;144(2):135-47. PMID: 19357621
Discoid lupus erythematosus.
Donnelly AM, Halbert AR, Rohr JB
Australas J Dermatol 1995 Feb;36(1):3-10; quiz 11-2. doi: 10.1111/j.1440-0960.1995.tb00916.x. PMID: 7763220

Clinical prediction guides

Comedogenic lupus: a rare variant of chronic cutaneous lupus erythematosus - case series.
Garcia LC, Morato IB, de Melo RFQ, Vale ECSD
An Bras Dermatol 2023 Mar-Apr;98(2):159-167. Epub 2023 Jan 25 doi: 10.1016/j.abd.2022.04.003. PMID: 36707354Free PMC Article
Cutaneous lupus erythematosus: factors related to cutaneous activity and damage in a cohort of 260 patients from A Coruña, Spain.
Arévalo-Bermúdez MDP, Paradela S, Balboa-Barreiro V, Fonseca E
Lupus 2020 Aug;29(9):1021-1030. Epub 2020 Jun 15 doi: 10.1177/0961203320930094. PMID: 32539659
Spectrum of cutaneous lupus erythematosus in South Africans with systemic lupus erythematosus.
Koch K, Tikly M
Lupus 2019 Jul;28(8):1021-1026. Epub 2019 Jun 19 doi: 10.1177/0961203319856091. PMID: 31215844
A comprehensive review of immune-mediated dermatopathology in systemic lupus erythematosus.
Li Q, Wu H, Liao W, Zhao M, Chan V, Li L, Zheng M, Chen G, Zhang J, Lau CS, Lu Q
J Autoimmun 2018 Sep;93:1-15. Epub 2018 Jul 11 doi: 10.1016/j.jaut.2018.07.007. PMID: 30017673
Chronic cutaneous lupus erythematosus presenting as atypical acneiform and comedonal plaque: case report and literature review.
Vieira ML, Marques ERMC, Leda YLA, Noriega LF, Bet DL, Pereira GAAM
Lupus 2018 Apr;27(5):853-857. Epub 2017 Aug 31 doi: 10.1177/0961203317726377. PMID: 28857716

Recent systematic reviews

Melanotic lupus erythematosus: A review of a newly described clinical form of chronic cutaneous lupus erythematosus.
Litaiem N, Rouai M, Slouma M, Rammeh S, Zeglaoui F
Clin Dermatol 2022 Nov-Dec;40(6):716-727. Epub 2022 Jul 28 doi: 10.1016/j.clindermatol.2022.07.009. PMID: 35907577
Emerging Skin Toxicities in Patients with Breast Cancer Treated with New Cyclin-Dependent Kinase 4/6 Inhibitors: A Systematic Review.
Silvestri M, Cristaudo A, Morrone A, Messina C, Bennardo L, Nisticò SP, Mariano M, Cameli N
Drug Saf 2021 Jul;44(7):725-732. Epub 2021 May 6 doi: 10.1007/s40264-021-01071-1. PMID: 33959899

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