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Metanephric Stromal Tumor

MedGen UID:
708025
•Concept ID:
C1285519
•
Neoplastic Process
Synonym: Metanephric stromal tumor
SNOMED CT: Metanephric stromal tumor (363658005)

Definition

A rare benign renal neoplasm composed of moderately cellular spindle cells. It occurs mostly in infancy and childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetanephric Stromal Tumor

Recent clinical studies

Etiology

Beyond Wilms tumor: imaging findings and outcomes of rare renal tumors in children.
Ayaz E, Ozcan HN, Oguz B, Haliloglu M
Pediatr Radiol 2022 Dec;52(13):2557-2567. Epub 2022 Jun 28 doi: 10.1007/s00247-022-05422-7. PMID: 35760918
Identification of a complex 17q rearrangement in a metanephric stromal tumor.
Toutain J, VuPhi Y, Doco-Fenzy M, Morice-Picard F, Stanislas S, Laharanne E, Cailley D, Vergnes P, Perel Y, Boccon-Gibod L, Deminiere C, Taine L
Cancer Genet 2011 Jun;204(6):340-3. doi: 10.1016/j.cancergen.2011.05.003. PMID: 21763632
The spectrum of metanephric adenofibroma and related lesions: clinicopathologic study of 25 cases from the National Wilms Tumor Study Group Pathology Center.
Arroyo MR, Green DM, Perlman EJ, Beckwith JB, Argani P
Am J Surg Pathol 2001 Apr;25(4):433-44. doi: 10.1097/00000478-200104000-00002. PMID: 11257617
Metanephric stromal tumor: report of 31 cases of a distinctive pediatric renal neoplasm.
Argani P, Beckwith JB
Am J Surg Pathol 2000 Jul;24(7):917-26. doi: 10.1097/00000478-200007000-00003. PMID: 10895814

Diagnosis

Beyond Wilms tumor: imaging findings and outcomes of rare renal tumors in children.
Ayaz E, Ozcan HN, Oguz B, Haliloglu M
Pediatr Radiol 2022 Dec;52(13):2557-2567. Epub 2022 Jun 28 doi: 10.1007/s00247-022-05422-7. PMID: 35760918
Reevaluation of metanephric stromal tumor two decades after it was named: A narrative review.
Zhang X, Yadav PK, Niu Q, Cheng H, Xiao Y, Wang Y, Gui H, Wang H, Rodriguez R, Wang Z
J Pediatr Urol 2020 Dec;16(6):822-829. Epub 2020 Aug 22 doi: 10.1016/j.jpurol.2020.08.011. PMID: 32893164
Metanephric stromal tumor with a rare incidence of squamous epithelium: A case report and a brief review of the literature.
Wang J, Jin W, Wu X
Pathol Res Pract 2017 Jul;213(7):863-867. Epub 2017 Mar 21 doi: 10.1016/j.prp.2017.03.009. PMID: 28554756
BRAF exon 15 mutations in pediatric renal stromal tumors: prevalence in metanephric stromal tumors.
Marsden L, Jennings LJ, Gadd S, Yu M, Perlman EJ, Cajaiba MM
Hum Pathol 2017 Feb;60:32-36. Epub 2016 Oct 18 doi: 10.1016/j.humpath.2016.09.025. PMID: 27769870
Cellular metanephric stromal tumor in a postmenopausal woman: a case report with review of the literature.
Chaudhri AA, Lee L, Das K
Int J Surg Pathol 2013 Apr;21(2):153-60. Epub 2012 Jul 25 doi: 10.1177/1066896912453851. PMID: 22832110

Therapy

Cellular metanephric stromal tumor in a postmenopausal woman: a case report with review of the literature.
Chaudhri AA, Lee L, Das K
Int J Surg Pathol 2013 Apr;21(2):153-60. Epub 2012 Jul 25 doi: 10.1177/1066896912453851. PMID: 22832110
Recurrent metanephric stromal tumor in an infant.
De Pasquale MD, Diomedi-Camassei F, Serra A, Boldrini R, Inserra A, Caione P, Jenkner A
Urology 2011 Dec;78(6):1411-3. Epub 2011 Jun 17 doi: 10.1016/j.urology.2011.04.029. PMID: 21683990

Prognosis

Beyond Wilms tumor: imaging findings and outcomes of rare renal tumors in children.
Ayaz E, Ozcan HN, Oguz B, Haliloglu M
Pediatr Radiol 2022 Dec;52(13):2557-2567. Epub 2022 Jun 28 doi: 10.1007/s00247-022-05422-7. PMID: 35760918
Metanephric stromal tumor with a rare incidence of squamous epithelium: A case report and a brief review of the literature.
Wang J, Jin W, Wu X
Pathol Res Pract 2017 Jul;213(7):863-867. Epub 2017 Mar 21 doi: 10.1016/j.prp.2017.03.009. PMID: 28554756
Primary renal sclerosing epithelioid fibrosarcoma: report of 2 cases with EWSR1-CREB3L1 gene fusion.
Argani P, Lewin JR, Edmonds P, Netto GJ, Prieto-Granada C, Zhang L, Jungbluth AA, Antonescu CR
Am J Surg Pathol 2015 Mar;39(3):365-73. doi: 10.1097/PAS.0000000000000338. PMID: 25353281Free PMC Article
Metanephric adenosarcoma: a rare case with immunohistochemistry and molecular analysis.
Su T, Yan F, Zhu P
Diagn Pathol 2014 Sep 30;9:179. doi: 10.1186/s13000-014-0179-7. PMID: 25267074Free PMC Article
Metanephric stromal tumor: report of 31 cases of a distinctive pediatric renal neoplasm.
Argani P, Beckwith JB
Am J Surg Pathol 2000 Jul;24(7):917-26. doi: 10.1097/00000478-200007000-00003. PMID: 10895814

Clinical prediction guides

Metanephric stromal tumor with a rare incidence of squamous epithelium: A case report and a brief review of the literature.
Wang J, Jin W, Wu X
Pathol Res Pract 2017 Jul;213(7):863-867. Epub 2017 Mar 21 doi: 10.1016/j.prp.2017.03.009. PMID: 28554756
Unclassified pediatric renal stromal tumor overlapping with metanephric stromal tumor and solitary fibrous tumor with diffuse S-100 protein expression.
Brancato F, Gurrera A, Bisceglia M, Alaggio R, Di Cataldo A, Di Benedetto V, Magro G
Pathol Res Pract 2011 Nov 15;207(11):707-11. Epub 2011 Sep 17 doi: 10.1016/j.prp.2011.07.008. PMID: 21925799
Myoid differentiation in mesoblastic nephroma: clinicopathologic and cytogenetic findings of a rare case.
Guschmann M, Tönnies H, Bührer C, Mau H, Vogel M
J Pediatr Surg 2002 Aug;37(8):E22. doi: 10.1053/jpsu.2002.34498. PMID: 12149722

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