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intermittent explosive disorder

MedGen UID:
7116
Concept ID:
C0021776
Mental or Behavioral Dysfunction
Synonyms: Disorders, Intermittent Explosive; Explosive Disorder, Intermittent; Intermittent Explosive Disorder; Intermittent Explosive Disorders
SNOMED CT: Intermittent explosive disorder (40987004)
 
Monarch Initiative: MONDO:0001521

Definition

A disorder characterized by recurrent episodes of serious assaultive acts or destruction of property due to a failure to resist aggressive impulses; the degree of aggression during these episodes is grossly out of proportion to any psychosocial provocation. The aggressive episodes are not etiologically linked to another mental disorder, a general medical condition, or substance use. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVintermittent explosive disorder

Professional guidelines

PubMed

Rizzi M, Gambini O, Marras CE
Handb Clin Neurol 2021;182:95-106. doi: 10.1016/B978-0-12-819973-2.00007-1. PMID: 34266615
Coccaro EF, Lee R, McCloskey MS
Compr Psychiatry 2014 Feb;55(2):260-7. Epub 2013 Oct 19 doi: 10.1016/j.comppsych.2013.09.007. PMID: 24321204
Olvera RL
CNS Drugs 2002;16(8):517-26. doi: 10.2165/00023210-200216080-00002. PMID: 12096933

Recent clinical studies

Etiology

Ciesinski NK, Drabick DAG, McCloskey MS
J Affect Disord 2022 Apr 1;302:367-375. Epub 2022 Jan 29 doi: 10.1016/j.jad.2022.01.099. PMID: 35101522
Silva B, Canas-Simião H, Cavanna AE
Psychiatr Clin North Am 2020 Jun;43(2):249-262. Epub 2020 Apr 8 doi: 10.1016/j.psc.2020.02.001. PMID: 32439020
Fahlgren MK, Puhalla AA, Sorgi KM, McCloskey MS
Psychiatry Res 2019 Mar;273:544-550. Epub 2019 Jan 14 doi: 10.1016/j.psychres.2019.01.046. PMID: 30710810
McCloskey MS, Ammerman BA
Curr Opin Psychol 2018 Aug;22:54-58. Epub 2017 Aug 9 doi: 10.1016/j.copsyc.2017.08.010. PMID: 28829989
Coccaro EF
Am J Psychiatry 2012 Jun;169(6):577-88. doi: 10.1176/appi.ajp.2012.11081259. PMID: 22535310

Diagnosis

Ciesinski NK, Drabick DAG, McCloskey MS
J Affect Disord 2022 Apr 1;302:367-375. Epub 2022 Jan 29 doi: 10.1016/j.jad.2022.01.099. PMID: 35101522
Coccaro EF
J Psychiatr Res 2019 Nov;118:38-43. Epub 2019 Aug 25 doi: 10.1016/j.jpsychires.2019.08.012. PMID: 31487607Free PMC Article
Fernandez E, Johnson SL
Clin Psychol Rev 2016 Jun;46:124-35. Epub 2016 Apr 27 doi: 10.1016/j.cpr.2016.04.012. PMID: 27188635
Coccaro EF
Am J Psychiatry 2012 Jun;169(6):577-88. doi: 10.1176/appi.ajp.2012.11081259. PMID: 22535310
Coccaro EF
Curr Psychiatry Rep 2000 Feb;2(1):67-71. doi: 10.1007/s11920-000-0045-z. PMID: 11122935

Therapy

Tahir T, Wong MM, Maaz M, Naufal R, Tahir R, Naidoo Y
Psychiatry Res 2022 May;311:114499. Epub 2022 Mar 7 doi: 10.1016/j.psychres.2022.114499. PMID: 35305343
Costa AM, Medeiros GC, Redden S, Grant JE, Tavares H, Seger L
Braz J Psychiatry 2018 Jul-Sep;40(3):316-319. Epub 2018 Mar 26 doi: 10.1590/1516-4446-2017-2262. PMID: 29590263Free PMC Article
Rosell DR, Siever LJ
CNS Spectr 2015 Jun;20(3):254-79. Epub 2015 May 4 doi: 10.1017/S109285291500019X. PMID: 25936249
Hollander E, Rosen J
J Psychopharmacol 2000;14(2 Suppl 1):S39-44. doi: 10.1177/02698811000142S106. PMID: 10888030
Finkel MJ
Clin Ther 1984;6(5):577-91. PMID: 6383610

Prognosis

Barra S, Turner D, Müller M, Hertz PG, Retz-Junginger P, Tüscher O, Huss M, Retz W
Eur Arch Psychiatry Clin Neurosci 2022 Mar;272(2):257-269. Epub 2020 Aug 11 doi: 10.1007/s00406-020-01181-4. PMID: 32780159Free PMC Article
Fahlgren MK, Puhalla AA, Sorgi KM, McCloskey MS
Psychiatry Res 2019 Mar;273:544-550. Epub 2019 Jan 14 doi: 10.1016/j.psychres.2019.01.046. PMID: 30710810
Coccaro EF, Shima CK, Lee RJ
J Psychiatr Res 2018 Nov;106:15-21. Epub 2018 Aug 10 doi: 10.1016/j.jpsychires.2018.08.013. PMID: 30240963
Fernandez E, Johnson SL
Clin Psychol Rev 2016 Jun;46:124-35. Epub 2016 Apr 27 doi: 10.1016/j.cpr.2016.04.012. PMID: 27188635
Coccaro EF, Lee R, McCloskey MS
Compr Psychiatry 2014 Feb;55(2):260-7. Epub 2013 Oct 19 doi: 10.1016/j.comppsych.2013.09.007. PMID: 24321204

Clinical prediction guides

Coccaro EF
J Psychiatr Res 2019 Nov;118:38-43. Epub 2019 Aug 25 doi: 10.1016/j.jpsychires.2019.08.012. PMID: 31487607Free PMC Article
Fahlgren MK, Puhalla AA, Sorgi KM, McCloskey MS
Psychiatry Res 2019 Mar;273:544-550. Epub 2019 Jan 14 doi: 10.1016/j.psychres.2019.01.046. PMID: 30710810
Coccaro EF, Shima CK, Lee RJ
J Psychiatr Res 2018 Nov;106:15-21. Epub 2018 Aug 10 doi: 10.1016/j.jpsychires.2018.08.013. PMID: 30240963
Medeiros GC, Seger L, Grant JE, Tavares H
Psychiatry Res 2018 Apr;262:209-212. Epub 2018 Feb 9 doi: 10.1016/j.psychres.2018.02.001. PMID: 29455060
Fernandez E, Johnson SL
Clin Psychol Rev 2016 Jun;46:124-35. Epub 2016 Apr 27 doi: 10.1016/j.cpr.2016.04.012. PMID: 27188635

Recent systematic reviews

Ali-Naqvi O, Alburak TA, Selvan K, Abdelmeguid H, Malvankar-Mehta MS
Psychiatr Q 2023 Mar;94(1):61-77. Epub 2023 Jan 24 doi: 10.1007/s11126-022-10013-8. PMID: 36690848
Tahir T, Wong MM, Maaz M, Naufal R, Tahir R, Naidoo Y
Psychiatry Res 2022 May;311:114499. Epub 2022 Mar 7 doi: 10.1016/j.psychres.2022.114499. PMID: 35305343
Jones RM, Arlidge J, Gillham R, Reagu S, van den Bree M, Taylor PJ
Br J Psychiatry 2011 Feb;198(2):93-8. doi: 10.1192/bjp.bp.110.083030. PMID: 21282779

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