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Elevated cholesterol ester level

MedGen UID:
713473
Concept ID:
C1291155
Finding
Synonym: Increased cholesterol esters
SNOMED CT: Increased cholesterol esters (124054003); Cholesterol esters above reference range (124054003)
 
HPO: HP:0031211

Definition

An elevated concentration of circulating cholesterol esters, which are fatty acid esters of cholesterol and make up about two-thirds of total plasma cholesterol. [from HPO]

Professional guidelines

PubMed

Dybiec J, Baran W, Dąbek B, Fularski P, Młynarska E, Radzioch E, Rysz J, Franczyk B
Int J Mol Sci 2023 Aug 27;24(17) doi: 10.3390/ijms241713288. PMID: 37686091Free PMC Article
Kampangkaew J, Pickett S, Nambi V
Curr Opin Cardiol 2017 Jul;32(4):348-355. doi: 10.1097/HCO.0000000000000415. PMID: 28505047
Stroes ES, Thompson PD, Corsini A, Vladutiu GD, Raal FJ, Ray KK, Roden M, Stein E, Tokgözoğlu L, Nordestgaard BG, Bruckert E, De Backer G, Krauss RM, Laufs U, Santos RD, Hegele RA, Hovingh GK, Leiter LA, Mach F, März W, Newman CB, Wiklund O, Jacobson TA, Catapano AL, Chapman MJ, Ginsberg HN; European Atherosclerosis Society Consensus Panel
Eur Heart J 2015 May 1;36(17):1012-22. Epub 2015 Feb 18 doi: 10.1093/eurheartj/ehv043. PMID: 25694464Free PMC Article

Recent clinical studies

Therapy

Hosier H, Lipkind HS, Rasheed H, DeWan AT, Rogne T
Hypertension 2023 May;80(5):1067-1076. Epub 2023 Mar 8 doi: 10.1161/HYPERTENSIONAHA.122.20426. PMID: 36883459
Chapman MJ, Zamorano JL, Parhofer KG
Pharmacol Ther 2022 Sep;237:108172. Epub 2022 Mar 15 doi: 10.1016/j.pharmthera.2022.108172. PMID: 35304222
Johnson KE, Siewert KM, Klarin D, Damrauer SM; VA Million Veteran Program, Chang KM, Tsao PS, Assimes TL, Maxwell KN, Voight BF
PLoS Med 2020 Sep;17(9):e1003302. Epub 2020 Sep 11 doi: 10.1371/journal.pmed.1003302. PMID: 32915777Free PMC Article
Jang AY, Han SH, Sohn IS, Oh PC, Koh KK
Circ J 2020 May 25;84(6):867-874. Epub 2020 Apr 24 doi: 10.1253/circj.CJ-20-0051. PMID: 32336721
Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB, Doyle RT Jr, Juliano RA, Jiao L, Granowitz C, Tardif JC, Ballantyne CM; REDUCE-IT Investigators
N Engl J Med 2019 Jan 3;380(1):11-22. Epub 2018 Nov 10 doi: 10.1056/NEJMoa1812792. PMID: 30415628

Prognosis

Szarek M, Bhatt DL, Miller M, Brinton EA, Jacobson TA, Tardif JC, Ballantyne CM, Mason RP, Ketchum SB, Lira Pineda A, Doyle RT Jr, Steg PG; REDUCE-IT Investigators
J Am Coll Cardiol 2024 Apr 23;83(16):1529-1539. Epub 2024 Mar 25 doi: 10.1016/j.jacc.2024.02.016. PMID: 38530686
Ben Hassen C, Goupille C, Vigor C, Durand T, Guéraud F, Silvente-Poirot S, Poirot M, Frank PG
J Steroid Biochem Mol Biol 2023 Sep;232:106346. Epub 2023 Jun 13 doi: 10.1016/j.jsbmb.2023.106346. PMID: 37321513
Papadea P, Kalaitzopoulou E, Skipitari M, Varemmenou A, Papasotiriou M, Papachristou E, Goumenos D, Grune T, Georgiou CD
Redox Biol 2023 Aug;64:102762. Epub 2023 Jun 2 doi: 10.1016/j.redox.2023.102762. PMID: 37302344Free PMC Article
Jang AY, Han SH, Sohn IS, Oh PC, Koh KK
Circ J 2020 May 25;84(6):867-874. Epub 2020 Apr 24 doi: 10.1253/circj.CJ-20-0051. PMID: 32336721
Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB, Doyle RT Jr, Juliano RA, Jiao L, Granowitz C, Tardif JC, Ballantyne CM; REDUCE-IT Investigators
N Engl J Med 2019 Jan 3;380(1):11-22. Epub 2018 Nov 10 doi: 10.1056/NEJMoa1812792. PMID: 30415628

Clinical prediction guides

de Dios C, Abadin X, Roca-Agujetas V, Jimenez-Martinez M, Morales A, Trullas R, Mari M, Colell A
Transl Neurodegener 2023 Mar 9;12(1):10. doi: 10.1186/s40035-023-00343-3. PMID: 36895045Free PMC Article
Hosier H, Lipkind HS, Rasheed H, DeWan AT, Rogne T
Hypertension 2023 May;80(5):1067-1076. Epub 2023 Mar 8 doi: 10.1161/HYPERTENSIONAHA.122.20426. PMID: 36883459
Johnson KE, Siewert KM, Klarin D, Damrauer SM; VA Million Veteran Program, Chang KM, Tsao PS, Assimes TL, Maxwell KN, Voight BF
PLoS Med 2020 Sep;17(9):e1003302. Epub 2020 Sep 11 doi: 10.1371/journal.pmed.1003302. PMID: 32915777Free PMC Article
Langsted A, Nordestgaard BG
Curr Atheroscler Rep 2019 May 20;21(8):30. doi: 10.1007/s11883-019-0792-8. PMID: 31111240
Stroes ES, Thompson PD, Corsini A, Vladutiu GD, Raal FJ, Ray KK, Roden M, Stein E, Tokgözoğlu L, Nordestgaard BG, Bruckert E, De Backer G, Krauss RM, Laufs U, Santos RD, Hegele RA, Hovingh GK, Leiter LA, Mach F, März W, Newman CB, Wiklund O, Jacobson TA, Catapano AL, Chapman MJ, Ginsberg HN; European Atherosclerosis Society Consensus Panel
Eur Heart J 2015 May 1;36(17):1012-22. Epub 2015 Feb 18 doi: 10.1093/eurheartj/ehv043. PMID: 25694464Free PMC Article

Recent systematic reviews

Sahebkar A, Simental-Mendía LE, Guerrero-Romero F, Golledge J, Watts GF
Curr Pharm Des 2016;22(5):595-608. doi: 10.2174/1381612822666151125000035. PMID: 26601964
Talati R, Sobieraj DM, Makanji SS, Phung OJ, Coleman CI
J Am Diet Assoc 2010 May;110(5):719-26. doi: 10.1016/j.jada.2010.02.011. PMID: 20430133

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