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Cutaneous hamartoma

MedGen UID:
724285
•Concept ID:
C1302724
•
Neoplastic Process
Synonyms: Hamartoma of skin; Skin hamartoma
SNOMED CT: Hamartoma of skin (399921006); Cutaneous hamartoma (51697005)
 
HPO: HP:0031111

Definition

A hamartoma (tissue malformation consisting of an abnormal mixture of constitutive components) originating in the skin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous hamartoma

Professional guidelines

PubMed

An update on Becker's nevus: Pathogenesis and treatment.
Zhou YJ, Zheng DL, Hamblin MR, Xu YD, Wen X
Dermatol Ther 2022 Jul;35(7):e15548. Epub 2022 May 12 doi: 10.1111/dth.15548. PMID: 35502558
Tuberous sclerosis complex: review based on new diagnostic criteria.
Portocarrero LKL, Quental KN, Samorano LP, Oliveira ZNP, Rivitti-Machado MCDM
An Bras Dermatol 2018 Jun;93(3):323-331. doi: 10.1590/abd1806-4841.20186972. PMID: 29924239Free PMC Article
Cutaneous manifestations in neuro-oncology: clinically relevant tumor and treatment associated dermatologic findings.
Strowd RE, Strowd LC, Blakeley JO
Semin Oncol 2016 Jun;43(3):401-7. Epub 2016 Feb 23 doi: 10.1053/j.seminoncol.2016.02.029. PMID: 27178695

Recent clinical studies

Etiology

Nevus Lipomatosus Cutaneous Superficialis of Hoffmann and Zurhelle: a rare cutaneous hamartoma.
Kc S , Aryal A , Jha A , Karn D
Kathmandu Univ Med J (KUMJ) 2022 Apr-Jun;20(78):238-239. PMID: 37017173
Sclerotherapy for atypical oral manifestation of Cowden syndrome.
Cherkas E, Champion AF, Gates JC
Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Oct;130(4):e290-e293. Epub 2020 Jun 10 doi: 10.1016/j.oooo.2020.05.018. PMID: 32636168
Management of naevus sebaceous: a national survey of UK dermatologists and plastic surgeons.
Wali GN, Felton SJ, McPherson T
Clin Exp Dermatol 2018 Jul;43(5):589-591. Epub 2018 Feb 20 doi: 10.1111/ced.13422. PMID: 29460979
Nevus Lipomatosus Cutaneous Superficialis With Perifollicular Fibromas.
Anzai A, Halpern I, Rivitti-Machado MC
Am J Dermatopathol 2015 Sep;37(9):704-6. doi: 10.1097/DAD.0000000000000280. PMID: 25839891
Full-thickness surgical excision for the treatment of inflammatory linear verrucous epidermal nevus.
Lee BJ, Mancini AJ, Renucci J, Paller AS, Bauer BS
Ann Plast Surg 2001 Sep;47(3):285-92. doi: 10.1097/00000637-200109000-00011. PMID: 11562033

Diagnosis

Neurotropic melanoma arising from a neurocristic hamartoma.
Clements SA, Kelley BF, Rivera L, Greenway HT
J Cutan Pathol 2023 Mar;50(3):197-200. Epub 2023 Jan 5 doi: 10.1111/cup.14378. PMID: 36515639
Clinical, pathological, and molecular correlation of folliculocystic and collagen hamartoma: A new potential diagnostic criterion for tuberous sclerosis complex?
Apam-Garduño D, Cazarín-Barrientos J, Hernández-Martínez NL, Reyna-Fabián ME, Magaña M, Alcántara-Ortigoza MA, González-Del Angel A, Rivera-Vega MR
J Cutan Pathol 2023 Jun;50(6):481-486. Epub 2022 Nov 23 doi: 10.1111/cup.14340. PMID: 36229934
Nevus Lipomatosus Cutaneous Superficialis of Hoffmann and Zurhelle: a rare cutaneous hamartoma.
Kc S , Aryal A , Jha A , Karn D
Kathmandu Univ Med J (KUMJ) 2022 Apr-Jun;20(78):238-239. PMID: 37017173
Folliculosebaceous Cystic Hamartoma Arising in Miescher-Type Melanocytic Nevi.
Ishihara Y, Ogita A, Ito K, Saeki H, Ansai SI
Am J Dermatopathol 2022 Nov 1;44(11):817-821. Epub 2022 Sep 1 doi: 10.1097/DAD.0000000000002290. PMID: 36066121
Perifollicular fibroma.
Cho S, Hahm JH
J Eur Acad Dermatol Venereol 1999 Jul;13(1):46-9. PMID: 10565630

Therapy

Inflammatory linear verrucous epidermal nevus: why a combined laser therapy.
Conti R, Bruscino N, Campolmi P, Bonan P, Cannarozzo G, Moretti S
J Cosmet Laser Ther 2013 Aug;15(4):242-5. Epub 2013 Jun 21 doi: 10.3109/14764172.2013.807115. PMID: 23692514
Ultrapulse carbon dioxide laser treatment of porokeratotic eccrine ostial and dermal duct nevus.
Jain S, Sardana K, Garg VK
Pediatr Dermatol 2013 Mar-Apr;30(2):264-6. Epub 2012 Feb 16 doi: 10.1111/j.1525-1470.2011.01659.x. PMID: 22339989

Prognosis

Neuro-folliculo-sebaceous cystic hamartoma is a unique entity.
Samaka RM, Alrahabi N
Pol J Pathol 2015 Mar;66(1):77-9. doi: 10.5114/pjp.2015.51157. PMID: 26017884
A deep penetrating facial congenital melanocytic tumor with bone involvement and ipsilateral eye blindness.
Bergman R, Ben-Arush MW, Bar-Shalom R, Gilboa M, Simon E, Hershkovitz D, Sabo E, Maly A, Gerami P, Goldsher D
Am J Dermatopathol 2015 Jan;37(1):e5-e11. doi: 10.1097/DAD.0000000000000048. PMID: 25222197
Multicentric primary extramammary Paget disease: a Toker cell disorder?
Hashemi P, Kao GF, Konia T, Kauffman LC, Tam CC, Sina B
Cutis 2014 Jul;94(1):35-8. PMID: 25101342
Folliculosebaceous cystic hamartoma of the upper lip and labial mucosa.
Islam MN, Cohen DM, Bhattacharyya I
Quintessence Int 2011 Jun;42(6):e75-7. PMID: 21519579
Becker's nevus syndrome.
Angelo C, Grosso MG, Stella P, De Sio C, Passarelli F, Puddu P, Paradisi M
Cutis 2001 Aug;68(2):123-4. PMID: 11534913

Clinical prediction guides

Folliculosebaceous Cystic Hamartoma Arising in Miescher-Type Melanocytic Nevi.
Ishihara Y, Ogita A, Ito K, Saeki H, Ansai SI
Am J Dermatopathol 2022 Nov 1;44(11):817-821. Epub 2022 Sep 1 doi: 10.1097/DAD.0000000000002290. PMID: 36066121
Neuro-folliculo-sebaceous cystic hamartoma is a unique entity.
Samaka RM, Alrahabi N
Pol J Pathol 2015 Mar;66(1):77-9. doi: 10.5114/pjp.2015.51157. PMID: 26017884
Multicentric primary extramammary Paget disease: a Toker cell disorder?
Hashemi P, Kao GF, Konia T, Kauffman LC, Tam CC, Sina B
Cutis 2014 Jul;94(1):35-8. PMID: 25101342
Inflammatory linear verrucous epidermal nevus: why a combined laser therapy.
Conti R, Bruscino N, Campolmi P, Bonan P, Cannarozzo G, Moretti S
J Cosmet Laser Ther 2013 Aug;15(4):242-5. Epub 2013 Jun 21 doi: 10.3109/14764172.2013.807115. PMID: 23692514
Clinicopathologic analysis of 21 cases of nevus sebaceus: a retrospective study.
Simi CM, Rajalakshmi T, Correa M
Indian J Dermatol Venereol Leprol 2008 Nov-Dec;74(6):625-7. doi: 10.4103/0378-6323.45107. PMID: 19171988

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