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Sinusoidal Hemangioma

MedGen UID:
725857
•Concept ID:
C1304507
•
Neoplastic Process
Synonym: Sinusoidal hemangioma
SNOMED CT: Sinusoidal hemangioma (403965008); Sinusoidal hemangioma (699606005)

Definition

A rare hemangioma occurring mainly in middle-aged adults. The most common location is in the trunk. The lesions are small, asymptomatic, and bluish. They are composed of irregular, dilated, congested thin-walled vascular channels with scant smooth muscle in a sinusoidal or sieve-like pattern. (WHO 2018) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSinusoidal Hemangioma

Professional guidelines

PubMed

Genetic testing in the evaluation of individuals with clinical diagnosis of atypical Sturge-Weber syndrome.
Yeom S, Cohen B, Weiss CR, Montano C, Wohler E, Sobreira N, Hammill AM, Comi A
Am J Med Genet A 2023 Apr;191(4):983-994. Epub 2023 Jan 29 doi: 10.1002/ajmg.a.63106. PMID: 36710374
Cerebral cavernous malformations: natural history and clinical management.
Gross BA, Du R
Expert Rev Neurother 2015;15(7):771-7. Epub 2015 Jun 22 doi: 10.1586/14737175.2015.1055323. PMID: 26098013
Contemporary management of vascular malformations.
Colletti G, Valassina D, Bertossi D, Melchiorre F, Vercellio G, Brusati R
J Oral Maxillofac Surg 2014 Mar;72(3):510-28. Epub 2013 Oct 16 doi: 10.1016/j.joms.2013.08.008. PMID: 24139296

Recent clinical studies

Etiology

Intussusceptive angiogenesis and its counterpart intussusceptive lymphangiogenesis.
Díaz-Flores L, Gutiérrez R, Gayoso S, García MP, González-Gómez M, Díaz-Flores L Jr, Sánchez R, Carrasco JL, Madrid JF
Histol Histopathol 2020 Oct;35(10):1083-1103. Epub 2020 Apr 24 doi: 10.14670/HH-18-222. PMID: 32329808
Participation of Intussusceptive Angiogenesis in the Morphogenesis of Lobular Capillary Hemangioma.
Díaz-Flores L, Gutiérrez R, González-Gómez M, García MAP, Carrasco JL, Díaz-Flores L Jr, Madrid JF, Álvarez-Argüelles H
Sci Rep 2020 Mar 19;10(1):4987. doi: 10.1038/s41598-020-61921-3. PMID: 32193418Free PMC Article
Thrombotic Hemangioma With Organizing/Anastomosing Features: Expanding the Spectrum of GNA-mutated Hemangiomas With a Predilection for the Skin of the Lower Abdominal Regions.
Liau JY, Lee JC, Tsai JH, Chen CC, Wang YH, Chung YC
Am J Surg Pathol 2020 Feb;44(2):255-262. doi: 10.1097/PAS.0000000000001392. PMID: 31633489
Sinusoidal hemangioma and intravascular papillary endothelial hyperplasia: Interrelated processes that share a histogenetic piecemeal angiogenic mechanism.
Díaz-Flores L, Gutiérrez R, García MªP, González-Gómez M, Sáez FJ, Díaz-Flores L Jr, Carrasco JL, Madrid JF
Acta Histochem 2018 Apr;120(3):255-262. Epub 2018 Feb 25 doi: 10.1016/j.acthis.2018.02.007. PMID: 29486986
Spindle cell hemangioma.
Tomasini C, Aloi F, Soro E, Elia V
Dermatology 1999;199(3):274-6. doi: 10.1159/000018265. PMID: 10592415

Diagnosis

Sinusoidal hemangioma with secondary intravascular papillary endothelial hyperplasia.
Gurumurthy RY, Shankar NS, Mohan Raj CS, Sriram N
Indian J Pathol Microbiol 2020 Apr-Jun;63(2):279-281. doi: 10.4103/IJPM.IJPM_230_19. PMID: 32317533
Thrombotic Hemangioma With Organizing/Anastomosing Features: Expanding the Spectrum of GNA-mutated Hemangiomas With a Predilection for the Skin of the Lower Abdominal Regions.
Liau JY, Lee JC, Tsai JH, Chen CC, Wang YH, Chung YC
Am J Surg Pathol 2020 Feb;44(2):255-262. doi: 10.1097/PAS.0000000000001392. PMID: 31633489
Sinusoidal hemangioma and intravascular papillary endothelial hyperplasia: Interrelated processes that share a histogenetic piecemeal angiogenic mechanism.
Díaz-Flores L, Gutiérrez R, García MªP, González-Gómez M, Sáez FJ, Díaz-Flores L Jr, Carrasco JL, Madrid JF
Acta Histochem 2018 Apr;120(3):255-262. Epub 2018 Feb 25 doi: 10.1016/j.acthis.2018.02.007. PMID: 29486986
Role of MRI in the diagnosis and evaluation of cavernous hemangioma of the arm.
Ciurea ME, Bondari S, Stoica LE, Gheonea IA
J Med Life 2014 Mar 15;7(1):46-50. Epub 2014 Mar 25 PMID: 24653757Free PMC Article
Spindle cell hemangioma.
Tomasini C, Aloi F, Soro E, Elia V
Dermatology 1999;199(3):274-6. doi: 10.1159/000018265. PMID: 10592415

Prognosis

Thrombotic Hemangioma With Organizing/Anastomosing Features: Expanding the Spectrum of GNA-mutated Hemangiomas With a Predilection for the Skin of the Lower Abdominal Regions.
Liau JY, Lee JC, Tsai JH, Chen CC, Wang YH, Chung YC
Am J Surg Pathol 2020 Feb;44(2):255-262. doi: 10.1097/PAS.0000000000001392. PMID: 31633489
Sinusoidal hemangioma. A distinctive benign vascular neoplasm within the group of cavernous hemangiomas.
Calonje E, Fletcher CD
Am J Surg Pathol 1991 Dec;15(12):1130-5. PMID: 1746680

Clinical prediction guides

Intussusceptive Lymphangiogenesis in Lymphatic Malformations/Lymphangiomas.
Díaz-Flores L, Gutiérrez R, García MDP, Carrasco JL, Sáez FJ, Díaz-Flores L Jr, González-Gómez M, Madrid JF
Anat Rec (Hoboken) 2019 Nov;302(11):2003-2013. Epub 2019 Jul 8 doi: 10.1002/ar.24204. PMID: 31228317

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