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Benign connective and soft tissue neoplasm

MedGen UID:: 83866
•Concept ID:: C0347481
•: Neoplastic Process

Synonyms:	Benign Connective and Soft Tissue Neoplasm; benign connective and soft tissue neoplasm; Benign Connective and Soft Tissue Tumor; benign connective and soft tissue tumor; benign connective and soft tissue tumour; Benign Mesenchymal Cell Neoplasm; benign mesenchymal cell neoplasm; Benign Neoplasm of the Soft Tissue and Bone; benign neoplasm of the soft tissue and bone; Benign Tumor of the Soft Tissue and Bone; benign tumor of the soft tissue and bone; benign tumour of the soft tissue and bone; connective and soft tissue neoplasm, benign; connective tissue benign neoplasm; neoplasm of soft tissue; neoplasm of soft tissues; soft tissue benign neoplasm; tumor of the soft tissue; tumour of the soft tissue

Monarch Initiative:	MONDO:0000654

Definition

A neoplasm that arises from connective and soft tissue and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include lipoma, leiomyoma, fibroma, and osteoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign connective and soft tissue neoplasm

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Neoplasm by Special Category
        Benign neoplasm
        Benign connective and soft tissue neoplasm
        Benign chondrogenic neoplasm
        Bizarre Parosteal Osteochondromatous Proliferation
        Chondroblastoma
        Maxillofacial Chondroblastoma
        Chondroma
        Chondromatosis
        Enchondroma
        Laryngeal Chondroma
        Maxillofacial Chondroma
        Periosteal chondroma
        Soft tissue chondroma
        Chondromyxoid fibroma
        Maxillofacial Chondromyxoid Fibroma
        Sternal Chondromyxoid Fibroma
        Osteochondroma
        Multiple Osteochondromas
        Solitary Osteochondroma
        Osteochondromyxoma
        Subungual Exostosis
        Benign Fibrohistiocytic Neoplasm
        Benign Skin Fibrohistiocytic Neoplasm
        Dermatofibroma
        Histiocytoma
        Benign fibrous histiocytoma
        Malignant fibrous histiocytoma
        Tenosynovial giant cell tumor, diffuse type
        Tenosynovial giant cell tumor, localized type
        Benign lipomatous neoplasm
        Lipoblastoma
        Lipoblastomatosis
        Lipoma
        Angiolipoma
        Axillary lipoma
        Bone Lipoma
        Breast lipoma
        Cardiac lipoma
        Central nervous system lipoma
        Chest wall lipoma
        Chondroid lipoma
        Conventional lipoma
        Deep Lipoma
        Digestive System Lipoma
        Endobronchial lipoma
        External ear lipoma
        Fibrolipoma
        Fibromyxolipoma
        Frontal cutaneous lipoma
        Heart lipoma
        Hibernoma
        Kidney lipoma
        Lipomas of eyelids
        Mediastinal Lipoma
        Myolipoma
        Oral Cavity Lipoma
        Paratesticular lipoma
        Pleural lipoma
        Sacral lipoma
        Salivary Gland Lipoma
        Skin lipoma
        Spinal lipoma
        Spindle Cell/Pleomorphic Lipoma
        Tonsillar lipoma
        Vulvar Lipoma
        Multiple symmetric lipomatosis
        Diffuse lipomatosis
        Encephalocraniocutaneous lipomatosis
        HIV Lipodystrophy
        Lipomatosis of Nerve
        Mediastinal lipomatosis
        Pelvic lipomatosis
        Steroid lipomatosis
        Spindle cell liposarcoma
        Vulvar Lipoblastoma-Like Tumor
        Benign osteogenic neoplasm
        Osteoblastoma
        Cementoma
        Maxillofacial Osteoblastoma
        Osteoid osteoma
        Maxillofacial Osteoid Osteoma
        Osteoma
        Enostosis
        Ivory Exostosis
        Skull Osteoma
        Benign perivascular tumor
        Angioleiomyoma
        Cavernous Angioleiomyoma
        Intravascular angioleiomyoma
        Solid Angioleiomyoma
        Venous Angioleiomyoma
        Benign Glomus Tumor
        Glomangiomatosis
        Myofibroma
        Adult Myofibroma
        Infantile Myofibroma
        Myofibromatosis
        Infantile myofibromatosis
        Myofibromatosis, infantile, 1
        Myofibromatosis, infantile, 2
        Benign Phosphaturic Mesenchymal Tumor
        Benign soft tissue neoplasm
        Benign Central Nervous System Mesenchymal, Non-Meningothelial Neoplasm
        Central nervous system chondroma
        Central nervous system hemangioma
        Central nervous system leiomyoma
        Central Nervous System Myofibroblastoma
        Central Nervous System Rhabdomyoma
        Intracranial Fibrous Histiocytoma
        Benign Epithelioid Cell Type Gastrointestinal Stromal Tumor
        Benign Extrahepatic Bile Duct Soft Tissue Neoplasm
        Extrahepatic Bile Duct Fibroma
        Extrahepatic bile duct leiomyoma
        Extrahepatic bile duct lipoma
        Benign Extraskeletal Cartilaginous and Osseous Neoplasm
        Benign Fibroblastic Neoplasm
        Angiomyofibroblastoma
        Benign Skin Fibroblastic Neoplasm
        Calcifying fibrous tumor
        Elastofibroma dorsi
        EWSR1-SMAD3-Positive Fibroblastic Tumor
        Fibroma
        Fibromatosis Colli
        Fibroosseous pseudotumor of the digits
        Infantile digital fibromatosis
        Inflammatory Fibroid Polyp
        Myofibroblastoma
        Myositis ossificans
        Nodular fasciitis
        Proliferative fasciitis
        Proliferative myositis
        Benign Gastric Soft Tissue Neoplasm
        Benign Gastric Gastrointestinal Stromal Tumor
        Gastric hemangioma
        Gastric leiomyoma
        Gastric Lymphangioma
        Gastric Plexiform Fibromyxoma
        Lipoma of stomach
        Benign Gastrointestinal Stromal Tumor
        Benign Laryngeal Soft Tissue Neoplasm
        Laryngeal leiomyoma
        Subglottic hemangioma
        Benign Mediastinal Soft Tissue Neoplasm
        Mediastinal Chondroma
        Mediastinal Hemangioma
        Mediastinal Lymphangioma
        Mediastinal Rhabdomyoma
        Mediastinum leiomyoma
        Benign muscle neoplasm
        Benign Skeletal Muscle Neoplasm
        Benign smooth muscle neoplasm
        Infiltrating lipoma
        Intramuscular Myxoma
        Rhabdomyoma
        Benign Myoepithelioma
        Ectomesenchymal Chondromyxoid Tumor
        Lacrimal Gland Myoepithelioma
        Lung Myoepithelioma
        Mixed Tumor, Not Otherwise Specified
        Salivary Gland Myoepithelioma
        Skin Myoepithelioma
        Benign Oral Cavity Soft Tissue Neoplasm
        Gingival Angiofibroma
        Hemangioma of gingiva
        Oral Cavity Leiomyoma
        Pyogenic granuloma of oral mucosa
        Benign Pilar-Associated Mesenchyme Neoplasm
        Fibrofolliculoma
        Follicular Myxoma
        Perifollicular fibroma
        Pilar Leiomyoma
        Trichodiscoma
        Benign Sinonasal Soft Tissue Neoplasm
        Sinonasal Hemangioma
        Sinonasal Leiomyoma
        Benign Skin Vascular Neoplasm
        Skin hemangioma
        Skin lymphangioma
        Benign Soft Tissue Neoplasm of Uncertain Differentiation
        Acral Fibromyxoma
        Angiomyxoma
        Benign PEComa
        Ectopic Hamartomatous Thymoma
        Myxoma
        Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts
        Benign synovial neoplasm
        Synovial angioma
        Synovial chondromatosis
        Breast angiomatosis
        Breast hemangioma
        Breast capillary hemangioma
        Breast epithelioid hemangioma
        Endometrial stromal nodule
        Lung Myolipoma
        Paratesticular Hemangioma
        Penile Myointimoma
        Benign Vascular Neoplasm
        Benign blood vessel neoplasm
        Angiomatosis
        Hemangioma
        Benign Lymphatic Vessel Neoplasm
        Lymphangioma
        Benign Thyroid Gland Vascular Neoplasm
        Thyroid Gland Hemangioma
        Thyroid Gland Lymphangioma
        Musculoskeletal system benign neoplasm
        Bone benign neoplasm
        Aneurysmal bone cyst
        Benign neoplasm of lower jaw bone
        Benign Notochordal Cell Tumor
        Benign Osteoclastic Giant Cell-Rich Tumor of Bone
        Bone Hemangioma
        Bone Schwannoma
        Enchondromatosis
        Fibrous dysplasia
        Fibrous Histiocytoma of Bone
        Non-Ossifying Fibroma
        Periosteal Fibroma

Professional guidelines

PubMed

ACG Clinical Guideline: Diagnosis and Management of Gastrointestinal Subepithelial Lesions.

Jacobson BC, Bhatt A, Greer KB, Lee LS, Park WG, Sauer BG, Shami VM
Am J Gastroenterol 2023 Jan 1;118(1):46-58. Epub 2022 Sep 6 doi: 10.14309/ajg.0000000000002100. PMID: 36602835

EAA clinical practice guidelines-gynecomastia evaluation and management.

Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174

Uterine Fibroids: Diagnosis and Treatment.

De La Cruz MS, Buchanan EM
Am Fam Physician 2017 Jan 15;95(2):100-107. PMID: 28084714

See all (741)

Recent clinical studies

Etiology

Tenosynovial giant cell tumor.

Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897

Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates.

Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571

Cartilage-forming tumors.

Qasem SA, DeYoung BR
Semin Diagn Pathol 2014 Jan;31(1):10-20. Epub 2014 Jan 23 doi: 10.1053/j.semdp.2014.01.006. PMID: 24680178

Sarcoma.

Ceyssens S, Stroobants S
Methods Mol Biol 2011;727:191-203. doi: 10.1007/978-1-61779-062-1_11. PMID: 21331935

Lipoma excision.

Salam GA
Am Fam Physician 2002 Mar 1;65(5):901-4. PMID: 11898962

See all (5961)

Diagnosis

Lipoma and Its Doppelganger: The Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma.

Yee EJ, Stewart CL, Clay MR, McCarter MM
Surg Clin North Am 2022 Aug;102(4):637-656. doi: 10.1016/j.suc.2022.04.006. PMID: 35952693

Fibroepithelial tumours of the breast-a review.

Lerwill MF, Lee AHS, Tan PH
Virchows Arch 2022 Jan;480(1):45-63. Epub 2021 Sep 10 doi: 10.1007/s00428-021-03175-6. PMID: 34505197

Calcaneal Bone Tumors.

Temple EW, Prusa RD
Clin Podiatr Med Surg 2021 Apr;38(2):227-233. Epub 2021 Jan 26 doi: 10.1016/j.cpm.2020.12.007. PMID: 33745653

Tumor-Induced Osteomalacia.

Florenzano P, Hartley IR, Jimenez M, Roszko K, Gafni RI, Collins MT
Calcif Tissue Int 2021 Jan;108(1):128-142. Epub 2020 Jun 5 doi: 10.1007/s00223-020-00691-6. PMID: 32504138

Lipoma excision.

Salam GA
Am Fam Physician 2002 Mar 1;65(5):901-4. PMID: 11898962

See all (13923)

Therapy

Tenosynovial giant cell tumor.

Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897

Tumor-Induced Osteomalacia.

Florenzano P, Hartley IR, Jimenez M, Roszko K, Gafni RI, Collins MT
Calcif Tissue Int 2021 Jan;108(1):128-142. Epub 2020 Jun 5 doi: 10.1007/s00223-020-00691-6. PMID: 32504138

Surgical treatment of fibroids for subfertility.

Metwally M, Raybould G, Cheong YC, Horne AW
Cochrane Database Syst Rev 2020 Jan 29;1(1):CD003857. doi: 10.1002/14651858.CD003857.pub4. PMID: 31995657 Free PMC Article

Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials.

D'Angelo SP, Mahoney MR, Van Tine BA, Atkins J, Milhem MM, Jahagirdar BN, Antonescu CR, Horvath E, Tap WD, Schwartz GK, Streicher H
Lancet Oncol 2018 Mar;19(3):416-426. Epub 2018 Jan 19 doi: 10.1016/S1470-2045(18)30006-8. PMID: 29370992 Free PMC Article

Uterine fibroid management: from the present to the future.

Donnez J, Dolmans MM
Hum Reprod Update 2016 Nov;22(6):665-686. Epub 2016 Jul 27 doi: 10.1093/humupd/dmw023. PMID: 27466209 Free PMC Article

See all (1852)

Prognosis

Primary Soft-Tissue Lymphomas: MRI Features Help Discriminate From Other Soft-Tissue Tumors.

Spinnato P, Chiesa AM, Ledoux P, Kind M, Bianchi G, Tuzzato G, Righi A, Crombé A
Acad Radiol 2023 Feb;30(2):285-299. Epub 2022 Sep 7 doi: 10.1016/j.acra.2022.08.009. PMID: 36088202

Common Tumors and Tumor-like Lesions of the Shoulder.

Lee DH, Hills JM, Jordanov MI, Jaffe KA
J Am Acad Orthop Surg 2019 Apr 1;27(7):236-245. doi: 10.5435/JAAOS-D-17-00449. PMID: 30320728

Lipomatous Soft-tissue Tumors.

Johnson CN, Ha AS, Chen E, Davidson D
J Am Acad Orthop Surg 2018 Nov 15;26(22):779-788. doi: 10.5435/JAAOS-D-17-00045. PMID: 30192249

Neonatal soft tissue sarcomas.

Ferrari A, Orbach D, Sultan I, Casanova M, Bisogno G
Semin Fetal Neonatal Med 2012 Aug;17(4):231-238. Epub 2012 May 25 doi: 10.1016/j.siny.2012.05.003. PMID: 22633289

Desmoid tumours.

Shields CJ, Winter DC, Kirwan WO, Redmond HP
Eur J Surg Oncol 2001 Dec;27(8):701-6. doi: 10.1053/ejso.2001.1169. PMID: 11735163

See all (5246)

Clinical prediction guides

Fibroblastic and Myofibroblastic Soft-Tissue Tumors: Imaging Spectrum and Radiologic-Pathologic Correlation.

Haseli S, Mansoori B, Christensen D, Abadi A, Pooyan A, Shomal Zadeh F, Mau B, Khalili N, Murphey M, Chalian M
Radiographics 2023 Aug;43(8):e230005. doi: 10.1148/rg.230005. PMID: 37440448

Management of Stromal Lesions.

Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922

Epithelioid Fibrous Histiocytoma: A Concise Review.

Felty CC, Linos K
Am J Dermatopathol 2019 Dec;41(12):879-883. doi: 10.1097/DAD.0000000000001272. PMID: 30289773

Vascular lesions of the breast.

Baker GM, Schnitt SJ
Semin Diagn Pathol 2017 Sep;34(5):410-419. Epub 2017 May 30 doi: 10.1053/j.semdp.2017.05.013. PMID: 28676174

Malignant vascular tumors--an update.

Antonescu C
Mod Pathol 2014 Jan;27 Suppl 1:S30-8. doi: 10.1038/modpathol.2013.176. PMID: 24384851

See all (3656)

Recent systematic reviews

Management of phyllodes tumor: A systematic review and meta-analysis of real-world evidence.

Yu CY, Huang TW, Tam KW
Int J Surg 2022 Nov;107:106969. Epub 2022 Oct 31 doi: 10.1016/j.ijsu.2022.106969. PMID: 36328344

Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review.

Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127 Free PMC Article

Malignant phyllodes tumor of the breast: a systematic review.

Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723 Free PMC Article

Pachydermodactyly: a systematic review.

Vázquez Fernández R, Maneiro Fernández JR, Cervantes Pérez EC, Mera Varela A
Ir J Med Sci 2021 Aug;190(3):1005-1014. Epub 2020 Oct 1 doi: 10.1007/s11845-020-02378-1. PMID: 33006046

Surgical treatment of fibroids for subfertility.

Metwally M, Raybould G, Cheong YC, Horne AW
Cochrane Database Syst Rev 2020 Jan 29;1(1):CD003857. doi: 10.1002/14651858.CD003857.pub4. PMID: 31995657 Free PMC Article

See all (180)

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Benign connective and soft tissue neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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