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Cancer-associated retinopathy

MedGen UID:
729915
•Concept ID:
C1321315
•
Disease or Syndrome
Synonyms: cancer-associated retinopathy; CAR syndrome; Paraneoplastic retinopathy; paraneoplastic retinopathy
SNOMED CT: Paraneoplastic retinopathy (404663008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019112
Orphanet: ORPHA71505

Definition

Cancer associated retinopathy (CAR) is a paraneoplastic disease of the eye associated with the presence of extraocular malignancy and circulating autoantibodies against retinal proteins. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCancer-associated retinopathy

Professional guidelines

PubMed

Management of autoimmune retinopathy treated with intravitreal dexamethasone implant.
Hou SM, Liu Q, Peng XY, Li YB, Li ZH, Zeng HY
Graefes Arch Clin Exp Ophthalmol 2023 May;261(5):1381-1389. Epub 2022 Dec 24 doi: 10.1007/s00417-022-05941-x. PMID: 36565329Free PMC Article
Clinical Utility of Antiretinal Antibody Testing.
Chen JJ, McKeon A, Greenwood TM, Flanagan EP, Bhatti MT, Dubey D, Pulido JS, Iezzi R, Smith WM, Sen HN, Gordon LK, Pittock SJ
JAMA Ophthalmol 2021 Jun 1;139(6):658-662. doi: 10.1001/jamaophthalmol.2021.0651. PMID: 33885761Free PMC Article
Paraneoplastic and non-paraneoplastic retinopathy and optic neuropathy: evaluation and management.
Rahimy E, Sarraf D
Surv Ophthalmol 2013 Sep-Oct;58(5):430-58. doi: 10.1016/j.survophthal.2012.09.001. PMID: 23969019

Recent clinical studies

Etiology

Paraneoplastic syndrome in neuroophthalmology.
Kang L, Wan C
J Neurol 2022 Oct;269(10):5272-5282. Epub 2022 Jul 2 doi: 10.1007/s00415-022-11247-z. PMID: 35779086
An update on autoimmune retinopathy.
Dutta Majumder P, Marchese A, Pichi F, Garg I, Agarwal A
Indian J Ophthalmol 2020 Sep;68(9):1829-1837. doi: 10.4103/ijo.IJO_786_20. PMID: 32823399Free PMC Article
Paraneoplastic syndromes in ophthalmology.
Bussat A, Langner-Lemercier S, Salmon A, Mouriaux F
J Fr Ophtalmol 2018 May;41(5):e181-e185. Epub 2018 May 18 doi: 10.1016/j.jfo.2018.03.002. PMID: 29784239
Paraneoplastic and non-paraneoplastic retinopathy and optic neuropathy: evaluation and management.
Rahimy E, Sarraf D
Surv Ophthalmol 2013 Sep-Oct;58(5):430-58. doi: 10.1016/j.survophthal.2012.09.001. PMID: 23969019
Cancer-associated retinopathy: update on pathogenesis and therapy.
Shildkrot Y, Sobrin L, Gragoudas ES
Semin Ophthalmol 2011 Jul-Sep;26(4-5):321-8. doi: 10.3109/08820538.2011.588657. PMID: 21958182

Diagnosis

Autoimmune Retinopathy: Intravenous Immunoglobulin Treatment versus Natural History.
Cox JT, Minkus CL, Li A, Han S, Liu R, Shah P, Stanwyck LK, Rizzo JF 3rd, Sobrin L
Ophthalmol Retina 2024 Jun;8(6):609-611. Epub 2024 Feb 28 doi: 10.1016/j.oret.2024.02.011. PMID: 38428458
Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy.
Weppelmann TA, Khalil S, Zafrullah N, Amir S, Margo CE
Cancer Control 2022 Jan-Dec;29:10732748221144458. doi: 10.1177/10732748221144458. PMID: 36473045Free PMC Article
An update on autoimmune retinopathy.
Dutta Majumder P, Marchese A, Pichi F, Garg I, Agarwal A
Indian J Ophthalmol 2020 Sep;68(9):1829-1837. doi: 10.4103/ijo.IJO_786_20. PMID: 32823399Free PMC Article
Autoimmune retinopathy.
Grange L, Dalal M, Nussenblatt RB, Sen HN
Am J Ophthalmol 2014 Feb;157(2):266-272.e1. Epub 2013 Sep 29 doi: 10.1016/j.ajo.2013.09.019. PMID: 24315290Free PMC Article
A curious case of glaucoma?
Pinney EL, Ferreyra HA, Frohman L
Surv Ophthalmol 2014 Mar-Apr;59(2):245-50. Epub 2013 Aug 1 doi: 10.1016/j.survophthal.2013.04.004. PMID: 23911153

Therapy

Autoimmune Retinopathy: Intravenous Immunoglobulin Treatment versus Natural History.
Cox JT, Minkus CL, Li A, Han S, Liu R, Shah P, Stanwyck LK, Rizzo JF 3rd, Sobrin L
Ophthalmol Retina 2024 Jun;8(6):609-611. Epub 2024 Feb 28 doi: 10.1016/j.oret.2024.02.011. PMID: 38428458
Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy.
Weppelmann TA, Khalil S, Zafrullah N, Amir S, Margo CE
Cancer Control 2022 Jan-Dec;29:10732748221144458. doi: 10.1177/10732748221144458. PMID: 36473045Free PMC Article
Anti-Interleukin-6 Antibodies for Autoimmune Retinopathy with Macular Edema.
Deaner JD, Jaffe GJ, Keenan RT, Carnago L, Grewal DS
Ophthalmol Retina 2022 Jan;6(1):91-93. Epub 2021 Aug 26 doi: 10.1016/j.oret.2021.08.008. PMID: 34454124
Neoplasia and intraocular inflammation: From masquerade syndromes to immunotherapy-induced uveitis.
Touhami S, Audo I, Terrada C, Gaudric A, LeHoang P, Touitou V, Bodaghi B
Prog Retin Eye Res 2019 Sep;72:100761. Epub 2019 May 12 doi: 10.1016/j.preteyeres.2019.05.002. PMID: 31091471
Cancer-associated retinopathy.
Goldstein SM, Syed NA, Milam AH, Maguire AM, Lawton TJ, Nichols CW
Arch Ophthalmol 1999 Dec;117(12):1641-5. doi: 10.1001/archopht.117.12.1641. PMID: 10604671

Prognosis

Paraneoplastic syndromes in ophthalmology.
Parrado-Carrillo A, Alcubierre R, Camós-Carreras A, Sanchez-Dalmau BF
Arch Soc Esp Oftalmol (Engl Ed) 2022 Jun;97(6):350-357. Epub 2022 Mar 12 doi: 10.1016/j.oftale.2022.03.006. PMID: 35292226
Autoimmune retinopathy.
Grange L, Dalal M, Nussenblatt RB, Sen HN
Am J Ophthalmol 2014 Feb;157(2):266-272.e1. Epub 2013 Sep 29 doi: 10.1016/j.ajo.2013.09.019. PMID: 24315290Free PMC Article
Autoimmune retinopathy.
Braithwaite T, Vugler A, Tufail A
Ophthalmologica 2012;228(3):131-42. Epub 2012 Jul 28 doi: 10.1159/000338240. PMID: 22846442
Cancer-associated retinopathy: update on pathogenesis and therapy.
Shildkrot Y, Sobrin L, Gragoudas ES
Semin Ophthalmol 2011 Jul-Sep;26(4-5):321-8. doi: 10.3109/08820538.2011.588657. PMID: 21958182
Cancer-associated retinopathy.
Goldstein SM, Syed NA, Milam AH, Maguire AM, Lawton TJ, Nichols CW
Arch Ophthalmol 1999 Dec;117(12):1641-5. doi: 10.1001/archopht.117.12.1641. PMID: 10604671

Clinical prediction guides

Tumors, tumor therapies, autoimmunity and the eye.
Wildner G
Autoimmun Rev 2021 Sep;20(9):102892. Epub 2021 Jul 3 doi: 10.1016/j.autrev.2021.102892. PMID: 34229046
Clinical Utility of Antiretinal Antibody Testing.
Chen JJ, McKeon A, Greenwood TM, Flanagan EP, Bhatti MT, Dubey D, Pulido JS, Iezzi R, Smith WM, Sen HN, Gordon LK, Pittock SJ
JAMA Ophthalmol 2021 Jun 1;139(6):658-662. doi: 10.1001/jamaophthalmol.2021.0651. PMID: 33885761Free PMC Article
Cancer-associated retinopathy preceding the diagnosis of cancer.
Hoogewoud F, Butori P, Blanche P, Brézin AP
BMC Ophthalmol 2018 Nov 3;18(1):285. doi: 10.1186/s12886-018-0948-2. PMID: 30390655Free PMC Article
Diagnosis difficulties in a patient with progressive loss of vision - a case report.
Cristescu TR
Rom J Ophthalmol 2017 Jan-Mar;61(1):60-64. doi: 10.22336/rjo.2017.11. PMID: 29450373Free PMC Article
Invasive thymoma with paraneoplastic retinopathy.
Yamada G, Ohguro H, Aketa K, Itoh T, Shijubo N, Takahashi H, Fujiwara O, Satoh M, Ohtsuka K, Abe S
Hum Pathol 2003 Jul;34(7):717-9. doi: 10.1016/s0046-8177(03)00183-7. PMID: 12874770

Recent systematic reviews

Treatment of Cancer-Associated Retinopathy: A Systematic Literature Review.
Brossard-Barbosa N, Dezard V, Margolin E
Ophthalmol Retina 2023 Sep;7(9):819-828. Epub 2023 May 7 doi: 10.1016/j.oret.2023.05.002. PMID: 37160190
Paraneoplastic ocular syndrome: a pandora's box of underlying malignancies.
Sarkar P, Mehtani A, Gandhi HC, Bhalla JS, Tapariya S
Eye (Lond) 2022 Jul;36(7):1355-1367. Epub 2021 Aug 3 doi: 10.1038/s41433-021-01676-x. PMID: 34345027Free PMC Article

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