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Cystocele

MedGen UID:
730551
Concept ID:
C1394494
Disease or Syndrome
Synonyms: Bladder cystocele; Bladder hernia; Bladder prolapse; Dropped bladder; Female cystocele; Prolapsed bladder; Vaginal cystocele
SNOMED CT: Vaginal cystocele (252005008); Female cystocele (252005008); Cystocele (252005008); Bladder cystocele (252005008)
 
HPO: HP:0100645

Definition

Anterior vaginal wall prolapse with bulging of the bladder into the vagina. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCystocele

Conditions with this feature

Ehlers-Danlos syndrome, type 4
MedGen UID:
82790
Concept ID:
C0268338
Disease or Syndrome
Vascular Ehlers-Danlos syndrome (vEDS) is characterized by arterial, intestinal, and/or uterine fragility; thin, translucent skin; easy bruising; characteristic facial appearance (thin vermilion of the lips, micrognathia, narrow nose, prominent eyes); and an aged appearance to the extremities, particularly the hands. Vascular dissection or rupture, gastrointestinal perforation, or organ rupture are the presenting signs in most adults with vEDS. Arterial rupture may be preceded by aneurysm, arteriovenous fistulae, or dissection but also may occur spontaneously. The majority (60%) of individuals with vEDS who are diagnosed before age 18 years are identified because of a positive family history. Neonates may present with clubfoot, hip dislocation, limb deficiency, and/or amniotic bands. Approximately half of children tested for vEDS in the absence of a positive family history present with a major complication at an average age of 11 years. Four minor diagnostic features – distal joint hypermobility, easy bruising, thin skin, and clubfeet – are most often present in those children ascertained without a major complication.
Aneurysm-osteoarthritis syndrome
MedGen UID:
462437
Concept ID:
C3151087
Disease or Syndrome
Loeys-Dietz syndrome (LDS) is characterized by vascular findings (cerebral, thoracic, and abdominal arterial aneurysms and/or dissections), skeletal manifestations (pectus excavatum or pectus carinatum, scoliosis, joint laxity, arachnodactyly, talipes equinovarus, cervical spine malformation and/or instability), craniofacial features (widely spaced eyes, strabismus, bifid uvula / cleft palate, and craniosynostosis that can involve any sutures), and cutaneous findings (velvety and translucent skin, easy bruising, and dystrophic scars). Individuals with LDS are predisposed to widespread and aggressive arterial aneurysms and pregnancy-related complications including uterine rupture and death. Individuals with LDS can show a strong predisposition for allergic/inflammatory disease including asthma, eczema, and reactions to food or environmental allergens. There is also an increased incidence of gastrointestinal inflammation including eosinophilic esophagitis and gastritis or inflammatory bowel disease. Wide variation in the distribution and severity of clinical features can be seen in individuals with LDS, even among affected individuals within a family who have the same pathogenic variant.

Professional guidelines

PubMed

Cohn JA, Smith AL
Curr Urol Rep 2019 Mar 30;20(5):23. doi: 10.1007/s11934-019-0885-5. PMID: 30929095
Tso C, Lee W, Austin-Ketch T, Winkler H, Zitkus B
Nurs Womens Health 2018 Jun;22(3):228-239. doi: 10.1016/j.nwh.2018.03.007. PMID: 29885711
Ichikawa M, Kaseki H, Akira S
Asian J Endosc Surg 2018 Feb;11(1):15-22. doi: 10.1111/ases.12478. PMID: 29485251

Recent clinical studies

Etiology

Başkiran Y, Uçkan K, Çeleğen İ, Tanoğlu FB
Medicine (Baltimore) 2023 Dec 22;102(51):e36720. doi: 10.1097/MD.0000000000036720. PMID: 38134086Free PMC Article
Karjalainen PK, Gillor M, Dietz HP
Aust N Z J Obstet Gynaecol 2021 Apr;61(2):263-269. Epub 2020 Dec 25 doi: 10.1111/ajo.13290. PMID: 33368207
Jan H, Ghai V, Thakar R
J Minim Invasive Gynecol 2018 Nov-Dec;25(7):1134. Epub 2018 Jan 31 doi: 10.1016/j.jmig.2018.01.014. PMID: 29371171
Maher C, Feiner B, Baessler K, Schmid C
Cochrane Database Syst Rev 2013 Apr 30;(4):CD004014. doi: 10.1002/14651858.CD004014.pub5. PMID: 23633316
Brieger GM, MacGibbon AL, Atkinson KH
Aust N Z J Obstet Gynaecol 1995 Feb;35(1):86-7. doi: 10.1111/j.1479-828x.1995.tb01839.x. PMID: 7772010

Diagnosis

Dietz HP, Chavez-Coloma L, Friedman T, Turel F
Aust N Z J Obstet Gynaecol 2022 Jun;62(3):420-425. Epub 2022 Jan 20 doi: 10.1111/ajo.13481. PMID: 35048356Free PMC Article
Iacobellis F, Reginelli A, Berritto D, Gagliardi G, Laporta A, Brillantino A, Renzi A, Scaglione M, Masselli G, Barile A, Romano L, Cappabianca S, Grassi R
Jpn J Radiol 2020 Jan;38(1):47-63. Epub 2019 Dec 16 doi: 10.1007/s11604-019-00903-6. PMID: 31845071
Dietz HP
Best Pract Res Clin Obstet Gynaecol 2019 Jan;54:12-30. Epub 2018 Jun 28 doi: 10.1016/j.bpobgyn.2018.06.006. PMID: 30082146
Capitano S, Castellani D
JAMA Surg 2018 Sep 1;153(9):856-857. doi: 10.1001/jamasurg.2018.0883. PMID: 29799922
Lamblin G, Delorme E, Cosson M, Rubod C
Int Urogynecol J 2016 Sep;27(9):1297-305. Epub 2015 Sep 4 doi: 10.1007/s00192-015-2832-4. PMID: 26337427

Therapy

Tso C, Lee W, Austin-Ketch T, Winkler H, Zitkus B
Nurs Womens Health 2018 Jun;22(3):228-239. doi: 10.1016/j.nwh.2018.03.007. PMID: 29885711
Jan H, Ghai V, Thakar R
J Minim Invasive Gynecol 2018 Nov-Dec;25(7):1134. Epub 2018 Jan 31 doi: 10.1016/j.jmig.2018.01.014. PMID: 29371171
Maher C
Int Urogynecol J 2013 Nov;24(11):1791-802. doi: 10.1007/s00192-013-2170-3. PMID: 24142055
Maher C, Feiner B, Baessler K, Schmid C
Cochrane Database Syst Rev 2013 Apr 30;(4):CD004014. doi: 10.1002/14651858.CD004014.pub5. PMID: 23633316
Brieger GM, MacGibbon AL, Atkinson KH
Aust N Z J Obstet Gynaecol 1995 Feb;35(1):86-7. doi: 10.1111/j.1479-828x.1995.tb01839.x. PMID: 7772010

Prognosis

Shah GS, Phillips C
Eur J Obstet Gynecol Reprod Biol 2023 Jul;286:118-120. Epub 2023 May 16 doi: 10.1016/j.ejogrb.2023.05.014. PMID: 37244000
Dubinskaya ED, Gasparov AS, Babichevа IA, Kolesnikova SN
J Gynecol Obstet Hum Reprod 2022 Feb;51(2):102278. Epub 2021 Nov 30 doi: 10.1016/j.jogoh.2021.102278. PMID: 34861425
Karjalainen PK, Gillor M, Dietz HP
Aust N Z J Obstet Gynaecol 2021 Apr;61(2):263-269. Epub 2020 Dec 25 doi: 10.1111/ajo.13290. PMID: 33368207
Anger JT, Raz S, Rodríguez LV
Curr Urol Rep 2007 Sep;8(5):394-8. doi: 10.1007/s11934-007-0037-1. PMID: 17880839
Raz S, Nitti VW, Bregg KJ
J Urol 1993 Apr;149(4):724-30. doi: 10.1016/s0022-5347(17)36193-1. PMID: 8455231

Clinical prediction guides

Haylen BT, Vu D, Wong A, Livingstone S
Neurourol Urodyn 2022 Aug;41(6):1293-1304. Epub 2022 Jun 22 doi: 10.1002/nau.24994. PMID: 35731184Free PMC Article
Dubinskaya ED, Gasparov AS, Babichevа IA, Kolesnikova SN
J Gynecol Obstet Hum Reprod 2022 Feb;51(2):102278. Epub 2021 Nov 30 doi: 10.1016/j.jogoh.2021.102278. PMID: 34861425
Karjalainen PK, Gillor M, Dietz HP
Aust N Z J Obstet Gynaecol 2021 Apr;61(2):263-269. Epub 2020 Dec 25 doi: 10.1111/ajo.13290. PMID: 33368207
Dietz HP
Best Pract Res Clin Obstet Gynaecol 2019 Jan;54:12-30. Epub 2018 Jun 28 doi: 10.1016/j.bpobgyn.2018.06.006. PMID: 30082146
Juliato CR, Santos Júnior LC, Haddad JM, Castro RA, Lima M, Castro EB
Rev Bras Ginecol Obstet 2016 Jul;38(7):356-64. Epub 2016 Jul 29 doi: 10.1055/s-0036-1585074. PMID: 27472812Free PMC Article

Recent systematic reviews

Ramage L, Simillis C, Yen C, Lutterodt C, Qiu S, Tan E, Kontovounisios C, Tekkis P
Tech Coloproctol 2017 Dec;21(12):915-927. Epub 2017 Nov 1 doi: 10.1007/s10151-017-1704-y. PMID: 29094218
Maher C, Feiner B, Baessler K, Christmann-Schmid C, Haya N, Brown J
Cochrane Database Syst Rev 2016 Nov 30;11(11):CD004014. doi: 10.1002/14651858.CD004014.pub6. PMID: 27901278Free PMC Article
Juliato CR, Santos Júnior LC, Haddad JM, Castro RA, Lima M, Castro EB
Rev Bras Ginecol Obstet 2016 Jul;38(7):356-64. Epub 2016 Jul 29 doi: 10.1055/s-0036-1585074. PMID: 27472812Free PMC Article
Maher C, Feiner B, Baessler K, Schmid C
Cochrane Database Syst Rev 2013 Apr 30;(4):CD004014. doi: 10.1002/14651858.CD004014.pub5. PMID: 23633316
Onwude JL
BMJ Clin Evid 2007 Mar 1;2007 PMID: 19454058

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