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Inhalational botulism

MedGen UID:
731169
•Concept ID:
C1443900
•
Disease or Syndrome
Synonyms: Inhalation botulism; inhalation botulism; inhalational botulism
SNOMED CT: Inhalational botulism (409562009)
 
Monarch Initiative: MONDO:0016777
Orphanet: ORPHA254504

Definition

Inhalational botulism is a man-made form of botulism (see this term), a rare acquired neuromuscular junction disease with descending flaccid paralysis caused by botulinum neurotoxins (BoNTs). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInhalational botulism
Follow this link to review classifications for Inhalational botulism in Orphanet.

Professional guidelines

PubMed

Clinical Guidelines for Diagnosis and Treatment of Botulism, 2021.
Rao AK, Sobel J, Chatham-Stephens K, Luquez C
MMWR Recomm Rep 2021 May 7;70(2):1-30. doi: 10.15585/mmwr.rr7002a1. PMID: 33956777Free PMC Article
Botulism: cause, effects, diagnosis, clinical and laboratory identification, and treatment modalities.
Dembek ZF, Smith LA, Rusnak JM
Disaster Med Public Health Prep 2007 Nov;1(2):122-34. doi: 10.1097/DMP.0b013e318158c5fd. PMID: 18388640
Botulism: the challenge of diagnosis and treatment.
Brook I
Rev Neurol Dis 2006 Fall;3(4):182-9. PMID: 17224901

Recent clinical studies

Etiology

Human Botulism in France, 1875-2016.
Rasetti-Escargueil C, Lemichez E, Popoff MR
Toxins (Basel) 2020 May 21;12(5) doi: 10.3390/toxins12050338. PMID: 32455538Free PMC Article
Botulism: cause, effects, diagnosis, clinical and laboratory identification, and treatment modalities.
Dembek ZF, Smith LA, Rusnak JM
Disaster Med Public Health Prep 2007 Nov;1(2):122-34. doi: 10.1097/DMP.0b013e318158c5fd. PMID: 18388640

Diagnosis

Clinical Guidelines for Diagnosis and Treatment of Botulism, 2021.
Rao AK, Sobel J, Chatham-Stephens K, Luquez C
MMWR Recomm Rep 2021 May 7;70(2):1-30. doi: 10.15585/mmwr.rr7002a1. PMID: 33956777Free PMC Article
Human Botulism in France, 1875-2016.
Rasetti-Escargueil C, Lemichez E, Popoff MR
Toxins (Basel) 2020 May 21;12(5) doi: 10.3390/toxins12050338. PMID: 32455538Free PMC Article
Botulism: the challenge of diagnosis and treatment.
Brook I
Rev Neurol Dis 2006 Fall;3(4):182-9. PMID: 17224901
Botulinum toxin.
Horowitz BZ
Crit Care Clin 2005 Oct;21(4):825-39, viii. doi: 10.1016/j.ccc.2005.06.008. PMID: 16168317
Botulism.
Sobel J
Clin Infect Dis 2005 Oct 15;41(8):1167-73. Epub 2005 Aug 29 doi: 10.1086/444507. PMID: 16163636

Therapy

A Monoclonal Antibody Combination against both Serotypes A and B Botulinum Toxin Prevents Inhalational Botulism in a Guinea Pig Model.
Snow DM, Cobb RR, Martinez J, Finger-Baker I, Collins L, Terpening S, Syar ES, Niemuth N, Kobs D, Barnewall R, Farr-Jones S, Marks JD, Tomic MT
Toxins (Basel) 2021 Jan 5;13(1) doi: 10.3390/toxins13010031. PMID: 33466411Free PMC Article
Botulism: cause, effects, diagnosis, clinical and laboratory identification, and treatment modalities.
Dembek ZF, Smith LA, Rusnak JM
Disaster Med Public Health Prep 2007 Nov;1(2):122-34. doi: 10.1097/DMP.0b013e318158c5fd. PMID: 18388640
Descending polyneuropathy in an intravenous drug user.
O'Sullivan JM, McMahon G
Eur J Emerg Med 2005 Oct;12(5):248-50. doi: 10.1097/00063110-200510000-00010. PMID: 16175064
Botulism.
Sobel J
Clin Infect Dis 2005 Oct 15;41(8):1167-73. Epub 2005 Aug 29 doi: 10.1086/444507. PMID: 16163636
Biological agents as weapons 1: smallpox and botulism.
Whitby M, Street AC, Ruff TA, Fenner F
Med J Aust 2002 May 6;176(9):431-3. doi: 10.5694/j.1326-5377.2002.tb04486.x. PMID: 12056996

Prognosis

Human Botulism in France, 1875-2016.
Rasetti-Escargueil C, Lemichez E, Popoff MR
Toxins (Basel) 2020 May 21;12(5) doi: 10.3390/toxins12050338. PMID: 32455538Free PMC Article
Botulinum toxin.
Horowitz BZ
Crit Care Clin 2005 Oct;21(4):825-39, viii. doi: 10.1016/j.ccc.2005.06.008. PMID: 16168317

Clinical prediction guides

Descending polyneuropathy in an intravenous drug user.
O'Sullivan JM, McMahon G
Eur J Emerg Med 2005 Oct;12(5):248-50. doi: 10.1097/00063110-200510000-00010. PMID: 16175064

Supplemental Content

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