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Haemophilus meningitis

MedGen UID:
7535
•Concept ID:
C0025292
•
Disease or Syndrome
Synonyms: Haemophilus Meningitides; Haemophilus Meningitis; Hemophilus Meningitides; Hemophilus Meningitis; Meningitides, Haemophilus; Meningitides, Hemophilus; Meningitis, Haemophilus; Meningitis, Hemophilus
SNOMED CT: Haemophilus meningitis (192643004)
 
Monarch Initiative: MONDO:0000889

Definition

Infections of the nervous system caused by bacteria of the genus haemophilus, and marked by prominent inflammation of the meninges. haemophilus influenzae type B is the most common causative organism. The condition primarily affects children under 6 years of age but may occur in adults. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHaemophilus meningitis

Professional guidelines

PubMed

Management of bacterial menigitis in 2016.
Javouhey E
Bull Acad Natl Med 2016 Jan;200(1):99-111. PMID: 29889417
Adjunctive dexamethasone treatment in acute bacterial meningitis.
Chaudhuri A
Lancet Neurol 2004 Jan;3(1):54-62. doi: 10.1016/s1474-4422(03)00623-9. PMID: 14693112
H. INFLUENZAE MENINGITIS: A CONTROLLED STUDY OF TREATMENT WITH AMPICILLIN.
THRUPP LD, LEEDOM JM, IVLER D, WEHRLE PF, BROWN JF, MATHIES AW, PORTNOY B
Postgrad Med J 1964 Dec;40(Suppl):SUPPL:119-26. doi: 10.1136/pgmj.40.suppl.119. PMID: 14246826Free PMC Article

Recent clinical studies

Etiology

Community-acquired Haemophilus influenzae meningitis in adults.
Chekrouni N, Koelman DLH, Brouwer MC, van der Ende A, van de Beek D
J Infect 2021 May;82(5):145-150. Epub 2021 Mar 25 doi: 10.1016/j.jinf.2021.03.016. PMID: 33774020
MenHibrix: a new combination meningococcal vaccine for infants and toddlers.
Hale SF, Camaione L, Lomaestro BM
Ann Pharmacother 2014 Mar;48(3):404-11. Epub 2013 Dec 18 doi: 10.1177/1060028013514375. PMID: 24353263
Bacterial meningitis post-PCV7: declining incidence and treatment.
Kowalsky RH, Jaffe DM
Pediatr Emerg Care 2013 Jun;29(6):758-66; quiz 767-8. doi: 10.1097/PEC.0b013e318294f709. PMID: 23736074
A prospective, population-based study of Haemophilus influenzae type b meningitis in The Gambia and the possible consequences.
Bijlmer HA, van Alphen L
J Infect Dis 1992 Jun;165 Suppl 1:S29-32. doi: 10.1093/infdis/165-supplement_1-s29. PMID: 1588170
Bacterial meningitis--1982.
Gold R
Am J Med 1983 Jul 28;75(1B):98-101. doi: 10.1016/0002-9343(83)90079-7. PMID: 6349348

Diagnosis

Diagnosis of bacterial meningitis in Ghana: Polymerase chain reaction versus latex agglutination methods.
Amidu N, Antuamwine BB, Addai-Mensah O, Abdul-Karim A, Stebleson A, Abubakari BB, Abenyeri J, Opoku AS, Nkukah JE, Najibullah AS
PLoS One 2019;14(1):e0210812. Epub 2019 Jan 17 doi: 10.1371/journal.pone.0210812. PMID: 30653582Free PMC Article
Management of bacterial menigitis in 2016.
Javouhey E
Bull Acad Natl Med 2016 Jan;200(1):99-111. PMID: 29889417
Recent advances in management of bacterial meningitis in neonates.
Klein JO
Infection 1984;12 Suppl 1:S44-51. doi: 10.1007/BF01641742. PMID: 6397449
Bacterial meningitis--1978.
Underman AE, Overturf GD, Leedom JM
Dis Mon 1978 Feb;24(5):1-63. doi: 10.1016/s0011-5029(78)80003-0. PMID: 376254
Bacterial meningitis.
Nankervis GA
Med Clin North Am 1974 May;58(3):581-92. doi: 10.1016/s0025-7125(16)32145-9. PMID: 4493707

Therapy

Glycoconjugate vaccines: an update.
Vella M, Pace D
Expert Opin Biol Ther 2015 Apr;15(4):529-46. Epub 2014 Dec 11 doi: 10.1517/14712598.2015.993375. PMID: 25496172
MenHibrix: a new combination meningococcal vaccine for infants and toddlers.
Hale SF, Camaione L, Lomaestro BM
Ann Pharmacother 2014 Mar;48(3):404-11. Epub 2013 Dec 18 doi: 10.1177/1060028013514375. PMID: 24353263
Chemoprophylaxis of meningitis.
Jones DM
Trans R Soc Trop Med Hyg 1991;85 Suppl 1:44-5. doi: 10.1016/0035-9203(91)90340-5. PMID: 1803697
Steroids in meningitis.
Tarlow MJ, McCracken GH
Br J Hosp Med 1989 Nov;42(5):358. PMID: 2597823
Bacterial meningitis: diagnosis and initial antibiotic therapy.
Dagbjartsson A, Ludvigsson P
Pediatr Clin North Am 1987 Feb;34(1):219-30. doi: 10.1016/s0031-3955(16)36190-9. PMID: 3543825

Prognosis

Management of bacterial menigitis in 2016.
Javouhey E
Bull Acad Natl Med 2016 Jan;200(1):99-111. PMID: 29889417
Bacterial meningitis post-PCV7: declining incidence and treatment.
Kowalsky RH, Jaffe DM
Pediatr Emerg Care 2013 Jun;29(6):758-66; quiz 767-8. doi: 10.1097/PEC.0b013e318294f709. PMID: 23736074
A prospective, population-based study of Haemophilus influenzae type b meningitis in The Gambia and the possible consequences.
Bijlmer HA, van Alphen L
J Infect Dis 1992 Jun;165 Suppl 1:S29-32. doi: 10.1093/infdis/165-supplement_1-s29. PMID: 1588170
Brain edema and increased intracranial pressure in the pathophysiology of bacterial meningitis.
Niemöller UM, Täuber MG
Eur J Clin Microbiol Infect Dis 1989 Feb;8(2):109-17. doi: 10.1007/BF01963892. PMID: 2498090
Bacterial meningitis.
Nankervis GA
Med Clin North Am 1974 May;58(3):581-92. doi: 10.1016/s0025-7125(16)32145-9. PMID: 4493707

Clinical prediction guides

Estimating the global and regional burden of meningitis in children caused by Haemophilus influenzae type b: A systematic review and meta-analysis.
Park JJ, Narayanan S, Tiefenbach J, Lukšić I, Ale BM, Adeloye D, Rudan I
J Glob Health 2022;12:04014. Epub 2022 Mar 5 doi: 10.7189/jogh.12.04014. PMID: 35265327Free PMC Article
Community-acquired Haemophilus influenzae meningitis in adults.
Chekrouni N, Koelman DLH, Brouwer MC, van der Ende A, van de Beek D
J Infect 2021 May;82(5):145-150. Epub 2021 Mar 25 doi: 10.1016/j.jinf.2021.03.016. PMID: 33774020
Haemophilus influenzae type b disease in the era of conjugate vaccines: critical factors for successful eradication.
Slack M, Esposito S, Haas H, Mihalyi A, Nissen M, Mukherjee P, Harrington L
Expert Rev Vaccines 2020 Oct;19(10):903-917. Epub 2020 Oct 10 doi: 10.1080/14760584.2020.1825948. PMID: 32962476
Haemophilus influenzae type b vaccination and anthropometric, cognitive, and schooling outcomes among Indian children.
Nandi A, Deolalikar AB, Bloom DE, Laxminarayan R
Ann N Y Acad Sci 2019 Aug;1449(1):70-82. Epub 2019 Jun 10 doi: 10.1111/nyas.14127. PMID: 31180594Free PMC Article
Haemophilus influenzae type b meningitis: manifestations and long term sequelae.
Sell SH
Pediatr Infect Dis J 1987 Aug;6(8):775-8. doi: 10.1097/00006454-198708000-00035. PMID: 3313239

Recent systematic reviews

Efficacy and Prolonged Safety of Haemophilus influenzae Type b Conjugate Vaccines.
Tripathi N, Mukherjee S
Infect Disord Drug Targets 2024;24(5):e150124225640. doi: 10.2174/0118715265269877231117070051. PMID: 38231056
Estimating the global and regional burden of meningitis in children caused by Haemophilus influenzae type b: A systematic review and meta-analysis.
Park JJ, Narayanan S, Tiefenbach J, Lukšić I, Ale BM, Adeloye D, Rudan I
J Glob Health 2022;12:04014. Epub 2022 Mar 5 doi: 10.7189/jogh.12.04014. PMID: 35265327Free PMC Article
Incidence and aetiology of bacterial meningitis among children aged 1-59 months in South Asia: systematic review and meta-analysis.
Ali M, Chang BA, Johnson KW, Morris SK
Vaccine 2018 Sep 18;36(39):5846-5857. Epub 2018 Aug 23 doi: 10.1016/j.vaccine.2018.07.037. PMID: 30145101
The effect of Haemophilus influenzae type B and pneumococcal conjugate vaccines on childhood meningitis mortality: a systematic review.
Davis S, Feikin D, Johnson HL
BMC Public Health 2013;13 Suppl 3(Suppl 3):S21. Epub 2013 Sep 17 doi: 10.1186/1471-2458-13-S3-S21. PMID: 24564188Free PMC Article

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