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Paranasal Sinus Polyp

MedGen UID:
75536
•Concept ID:
C0264231
•
Neoplastic Process
Synonyms: Accessory Sinus Polyp; Nasal sinus polyp; Polyp of accessory sinus; Polyp of Accessory Sinus; Polyp of nasal sinus; Polyp of Paranasal Sinus; Polyp of the Accessory Sinus; Polyp of the Paranasal Sinus
SNOMED CT: Nasal sinus polyp (32307003); Polyp of nasal sinus (32307003); Polyp of accessory sinus (32307003)

Definition

A polyp that arises from the paranasal sinus mucosa. Causes include allergic rhinitis, chronic sinusitis, and cystic fibrosis. It is characterized by the presence of edematous tissue infiltrated by inflammatory cells, including eosinophils. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParanasal Sinus Polyp

Professional guidelines

PubMed

Current insight into treatment of chronic rhinosinusitis: Phenotypes, endotypes, and implications for targeted therapeutics.
Chapurin N, Wu J, Labby AB, Chandra RK, Chowdhury NI, Turner JH
J Allergy Clin Immunol 2022 Jul;150(1):22-32. Epub 2022 Apr 22 doi: 10.1016/j.jaci.2022.04.013. PMID: 35469844Free PMC Article
Clinical Consensus Statement: Balloon Dilation of the Sinuses.
Piccirillo JF, Payne SC, Rosenfeld RM, Baroody FM, Batra PS, DelGaudio JM, Edelstein DR, Lane AP, Luong AU, Manes RP, McCoul ED, Platt MP, Reh DD, Corrigan MD
Otolaryngol Head Neck Surg 2018 Feb;158(2):203-214. doi: 10.1177/0194599817750086. PMID: 29389303
Clinical practice guideline (update): adult sinusitis.
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PMID: 25832968

Recent clinical studies

Etiology

The influence of nasal microbiome diversity and inflammatory patterns on the prognosis of nasal polyps.
Gan W, Zhang H, Yang F, Liu S, Liu F, Meng J
Sci Rep 2021 Mar 18;11(1):6364. doi: 10.1038/s41598-021-85292-5. PMID: 33737534Free PMC Article
Pediatric Versus Adult Chronic Rhinosinusitis.
Snidvongs K, Sangubol M, Poachanukoon O
Curr Allergy Asthma Rep 2020 Jun 6;20(8):29. doi: 10.1007/s11882-020-00924-6. PMID: 32506185
Formation of nasal polyps: The roles of innate type 2 inflammation and deposition of fibrin.
Takabayashi T, Schleimer RP
J Allergy Clin Immunol 2020 Mar;145(3):740-750. doi: 10.1016/j.jaci.2020.01.027. PMID: 32145873Free PMC Article
Nasal polyps and rhinosinusitis.
Kwah JH, Peters AT
Allergy Asthma Proc 2019 Nov 1;40(6):380-384. doi: 10.2500/aap.2019.40.4252. PMID: 31690375
Systematic review and meta-analysis of total intravenous anesthesia and endoscopic sinus surgery.
DeConde AS, Thompson CF, Wu EC, Suh JD
Int Forum Allergy Rhinol 2013 Oct;3(10):848-54. Epub 2013 Jul 10 doi: 10.1002/alr.21196. PMID: 23843351

Diagnosis

Pheno-Endotyping Antrochoanal Nasal Polyposis.
Garaycochea O, Van Strahlen CR, Alobid I, Mullol J
Curr Allergy Asthma Rep 2023 Mar;23(3):165-180. Epub 2023 Feb 11 doi: 10.1007/s11882-023-01066-1. PMID: 36773125
Cost Utility Analysis of Dupilumab Versus Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyps.
Scangas GA, Wu AW, Ting JY, Metson R, Walgama E, Shrime MG, Higgins TS
Laryngoscope 2021 Jan;131(1):E26-E33. Epub 2020 Apr 3 doi: 10.1002/lary.28648. PMID: 32243622
Allergic fungal rhinosinusitis.
Dykewicz MS, Rodrigues JM, Slavin RG
J Allergy Clin Immunol 2018 Aug;142(2):341-351. doi: 10.1016/j.jaci.2018.06.023. PMID: 30080526
Chronic nasal dysfunction.
Jankowski R, Nguyen DT, Russel A, Toussaint B, Gallet P, Rumeau C
Eur Ann Otorhinolaryngol Head Neck Dis 2018 Feb;135(1):41-49. Epub 2017 Dec 14 doi: 10.1016/j.anorl.2017.11.006. PMID: 29249643
Sinonasal polyposis.
Drutman J, Babbel RW, Harnsberger HR, Sonkens JW, Braby D
Semin Ultrasound CT MR 1991 Dec;12(6):561-74. PMID: 1786179

Therapy

Nasal polyps and rhinosinusitis.
Kwah JH, Peters AT
Allergy Asthma Proc 2019 Nov 1;40(6):380-384. doi: 10.2500/aap.2019.40.4252. PMID: 31690375
Allergic fungal rhinosinusitis.
Dykewicz MS, Rodrigues JM, Slavin RG
J Allergy Clin Immunol 2018 Aug;142(2):341-351. doi: 10.1016/j.jaci.2018.06.023. PMID: 30080526
Different types of intranasal steroids for chronic rhinosinusitis.
Chong LY, Head K, Hopkins C, Philpott C, Burton MJ, Schilder AG
Cochrane Database Syst Rev 2016 Apr 26;4(4):CD011993. doi: 10.1002/14651858.CD011993.pub2. PMID: 27115215Free PMC Article
Clinical practice guideline (update): adult sinusitis.
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PMID: 25832968
Chronic rhinosinusitis.
Ocampo CJ, Grammer LC
J Allergy Clin Immunol Pract 2013 May-Jun;1(3):205-11; quiz 212-3. Epub 2013 Feb 6 doi: 10.1016/j.jaip.2012.12.001. PMID: 24565477

Prognosis

The influence of nasal microbiome diversity and inflammatory patterns on the prognosis of nasal polyps.
Gan W, Zhang H, Yang F, Liu S, Liu F, Meng J
Sci Rep 2021 Mar 18;11(1):6364. doi: 10.1038/s41598-021-85292-5. PMID: 33737534Free PMC Article
Maxillary Ameloblastoma: A Review With Clinical, Histological and Prognostic Data of a Rare Tumor.
Evangelou Z, Zarachi A, Dumollard JM, Peoc'h M, Komnos I, Kastanioudakis I, Karpathiou G
In Vivo 2020 Sep-Oct;34(5):2249-2258. doi: 10.21873/invivo.12035. PMID: 32871747Free PMC Article
Nasal polyps and rhinosinusitis.
Kwah JH, Peters AT
Allergy Asthma Proc 2019 Nov 1;40(6):380-384. doi: 10.2500/aap.2019.40.4252. PMID: 31690375
Chronic rhinosinusitis.
Ocampo CJ, Grammer LC
J Allergy Clin Immunol Pract 2013 May-Jun;1(3):205-11; quiz 212-3. Epub 2013 Feb 6 doi: 10.1016/j.jaip.2012.12.001. PMID: 24565477
Mycotic sinusitis.
Eloy P, Bertrand B, Rombeaux P, Delos M, Trigaux JP
Acta Otorhinolaryngol Belg 1997;51(4):339-52. PMID: 9444380

Clinical prediction guides

TIM-4 in macrophages contributes to nasal polyp formation through the TGF-β1-mediated epithelial to mesenchymal transition in nasal epithelial cells.
Qin D, Liu P, Zhou H, Jin J, Gong W, Liu K, Chen S, Huang J, Fan W, Tao Z, Xu Y
Front Immunol 2022;13:941608. Epub 2022 Aug 5 doi: 10.3389/fimmu.2022.941608. PMID: 35990621Free PMC Article
The influence of nasal microbiome diversity and inflammatory patterns on the prognosis of nasal polyps.
Gan W, Zhang H, Yang F, Liu S, Liu F, Meng J
Sci Rep 2021 Mar 18;11(1):6364. doi: 10.1038/s41598-021-85292-5. PMID: 33737534Free PMC Article
Cost Utility Analysis of Dupilumab Versus Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyps.
Scangas GA, Wu AW, Ting JY, Metson R, Walgama E, Shrime MG, Higgins TS
Laryngoscope 2021 Jan;131(1):E26-E33. Epub 2020 Apr 3 doi: 10.1002/lary.28648. PMID: 32243622
Different types of intranasal steroids for chronic rhinosinusitis.
Chong LY, Head K, Hopkins C, Philpott C, Burton MJ, Schilder AG
Cochrane Database Syst Rev 2016 Apr 26;4(4):CD011993. doi: 10.1002/14651858.CD011993.pub2. PMID: 27115215Free PMC Article
Chapter 7: Nasal polyps.
Georgy MS, Peters AT
Allergy Asthma Proc 2012 May-Jun;33 Suppl 1:22-23. doi: 10.2500/aap.2012.33.3537. PMID: 22794680

Recent systematic reviews

Sphenochoanal polyps in children - a systematic review (1995‒2021).
Tywoniuk K, Haber K, Mierzwiński J
Braz J Otorhinolaryngol 2022 Nov-Dec;88 Suppl 5(Suppl 5):S179-S187. Epub 2022 Mar 21 doi: 10.1016/j.bjorl.2022.02.006. PMID: 36127268Free PMC Article
Isolated sphenoid sinus opacifications: a systematic review and meta-analysis.
Moss WJ, Finegersh A, Jafari A, Panuganti B, Coffey CS, DeConde A, Husseman J
Int Forum Allergy Rhinol 2017 Dec;7(12):1201-1206. Epub 2017 Oct 12 doi: 10.1002/alr.22023. PMID: 29024448
Different types of intranasal steroids for chronic rhinosinusitis.
Chong LY, Head K, Hopkins C, Philpott C, Burton MJ, Schilder AG
Cochrane Database Syst Rev 2016 Apr 26;4(4):CD011993. doi: 10.1002/14651858.CD011993.pub2. PMID: 27115215Free PMC Article
Post-sinus surgery insertion of steroid-eluting bioabsorbable intranasal devices: A systematic review.
Rizan C, Elhassan HA
Laryngoscope 2016 Jan;126(1):86-92. Epub 2015 Jul 7 doi: 10.1002/lary.25460. PMID: 26154025
Systematic review and meta-analysis of total intravenous anesthesia and endoscopic sinus surgery.
DeConde AS, Thompson CF, Wu EC, Suh JD
Int Forum Allergy Rhinol 2013 Oct;3(10):848-54. Epub 2013 Jul 10 doi: 10.1002/alr.21196. PMID: 23843351

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