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Paranasal Sinus Polyp

MedGen UID:
75536
•Concept ID:
C0264231
•
Neoplastic Process
Synonyms: Accessory Sinus Polyp; Nasal sinus polyp; Polyp of accessory sinus; Polyp of Accessory Sinus; Polyp of nasal sinus; Polyp of Paranasal Sinus; Polyp of the Accessory Sinus; Polyp of the Paranasal Sinus
SNOMED CT: Nasal sinus polyp (32307003); Polyp of nasal sinus (32307003); Polyp of accessory sinus (32307003)

Definition

A polyp that arises from the paranasal sinus mucosa. Causes include allergic rhinitis, chronic sinusitis, and cystic fibrosis. It is characterized by the presence of edematous tissue infiltrated by inflammatory cells, including eosinophils. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParanasal Sinus Polyp

Professional guidelines

PubMed

Current insight into treatment of chronic rhinosinusitis: Phenotypes, endotypes, and implications for targeted therapeutics.
Chapurin N, Wu J, Labby AB, Chandra RK, Chowdhury NI, Turner JH
J Allergy Clin Immunol 2022 Jul;150(1):22-32. Epub 2022 Apr 22 doi: 10.1016/j.jaci.2022.04.013. PMID: 35469844Free PMC Article
Clinical Consensus Statement: Balloon Dilation of the Sinuses.
Piccirillo JF, Payne SC, Rosenfeld RM, Baroody FM, Batra PS, DelGaudio JM, Edelstein DR, Lane AP, Luong AU, Manes RP, McCoul ED, Platt MP, Reh DD, Corrigan MD
Otolaryngol Head Neck Surg 2018 Feb;158(2):203-214. doi: 10.1177/0194599817750086. PMID: 29389303
Clinical practice guideline (update): adult sinusitis.
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PMID: 25832968

Recent clinical studies

Etiology

Yardstick for the medical management of chronic rhinosinusitis.
Borish L, Baroody FM, Kim MS, Lieberman JA, Peters A, Stevens WW, Bernstein JA
Ann Allergy Asthma Immunol 2022 Feb;128(2):118-128. Epub 2021 Oct 20 doi: 10.1016/j.anai.2021.10.014. PMID: 34687874
Pediatric Versus Adult Chronic Rhinosinusitis.
Snidvongs K, Sangubol M, Poachanukoon O
Curr Allergy Asthma Rep 2020 Jun 6;20(8):29. doi: 10.1007/s11882-020-00924-6. PMID: 32506185
Nasal polyps and rhinosinusitis.
Kwah JH, Peters AT
Allergy Asthma Proc 2019 Nov 1;40(6):380-384. doi: 10.2500/aap.2019.40.4252. PMID: 31690375
Systematic review and meta-analysis of total intravenous anesthesia and endoscopic sinus surgery.
DeConde AS, Thompson CF, Wu EC, Suh JD
Int Forum Allergy Rhinol 2013 Oct;3(10):848-54. Epub 2013 Jul 10 doi: 10.1002/alr.21196. PMID: 23843351
Chapter 4: Chronic rhinosinusitis.
Settipane RA, Peters AT, Chandra R
Am J Rhinol Allergy 2013 May-Jun;27 Suppl 1:S11-5. doi: 10.2500/ajra.2013.27.3925. PMID: 23711032

Diagnosis

Chronic Rhinosinusitis.
Keating MK, Phillips JC, Phillips J
Am Fam Physician 2023 Oct;108(4):370-377. PMID: 37843944
Pheno-Endotyping Antrochoanal Nasal Polyposis.
Garaycochea O, Van Strahlen CR, Alobid I, Mullol J
Curr Allergy Asthma Rep 2023 Mar;23(3):165-180. Epub 2023 Feb 11 doi: 10.1007/s11882-023-01066-1. PMID: 36773125
Allergic fungal rhinosinusitis.
Dykewicz MS, Rodrigues JM, Slavin RG
J Allergy Clin Immunol 2018 Aug;142(2):341-351. doi: 10.1016/j.jaci.2018.06.023. PMID: 30080526
Chronic nasal dysfunction.
Jankowski R, Nguyen DT, Russel A, Toussaint B, Gallet P, Rumeau C
Eur Ann Otorhinolaryngol Head Neck Dis 2018 Feb;135(1):41-49. Epub 2017 Dec 14 doi: 10.1016/j.anorl.2017.11.006. PMID: 29249643
EDITORIAL.
Kennedy DW
Int Forum Allergy Rhinol 2016 Jun;6(6):555-6. doi: 10.1002/alr.21806. PMID: 27342395

Therapy

Chronic Rhinosinusitis.
Keating MK, Phillips JC, Phillips J
Am Fam Physician 2023 Oct;108(4):370-377. PMID: 37843944
Nasal polyps and rhinosinusitis.
Kwah JH, Peters AT
Allergy Asthma Proc 2019 Nov 1;40(6):380-384. doi: 10.2500/aap.2019.40.4252. PMID: 31690375
Allergic fungal rhinosinusitis.
Dykewicz MS, Rodrigues JM, Slavin RG
J Allergy Clin Immunol 2018 Aug;142(2):341-351. doi: 10.1016/j.jaci.2018.06.023. PMID: 30080526
EDITORIAL.
Kennedy DW
Int Forum Allergy Rhinol 2016 Jun;6(6):555-6. doi: 10.1002/alr.21806. PMID: 27342395
Clinical practice guideline (update): adult sinusitis.
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PMID: 25832968

Prognosis

Update on allergic fungal rhinosinusitis.
Chua AJ, Jafar A, Luong AU
Ann Allergy Asthma Immunol 2023 Sep;131(3):300-306. Epub 2023 Feb 26 doi: 10.1016/j.anai.2023.02.018. PMID: 36854353
Nasal polyps and rhinosinusitis.
Kwah JH, Peters AT
Allergy Asthma Proc 2019 Nov 1;40(6):380-384. doi: 10.2500/aap.2019.40.4252. PMID: 31690375
Chronic rhinosinusitis.
Ocampo CJ, Grammer LC
J Allergy Clin Immunol Pract 2013 May-Jun;1(3):205-11; quiz 212-3. Epub 2013 Feb 6 doi: 10.1016/j.jaip.2012.12.001. PMID: 24565477
Osteitis and paranasal sinus inflammation: what we know and what we do not.
Georgalas C
Curr Opin Otolaryngol Head Neck Surg 2013 Feb;21(1):45-9. doi: 10.1097/MOO.0b013e32835ac656. PMID: 23299118
Mycotic sinusitis.
Eloy P, Bertrand B, Rombeaux P, Delos M, Trigaux JP
Acta Otorhinolaryngol Belg 1997;51(4):339-52. PMID: 9444380

Clinical prediction guides

The relationship of sinus opacification, olfaction and dupilumab efficacy in patients with CRSwNP.
Lee SE, Amin N, Mannent LP, Bachert C, Gross G, Cho SH, Praestgaard A, Siddiqui S, Nash S, Kamat S, Khan AH, Jacob Nara JA
Rhinology 2023 Dec 1;61(6):531-540. doi: 10.4193/Rhin22.220. PMID: 37453138
Isolated Sphenoid Sinus Disease in Children.
Kotowski M, Szydlowski J
Int J Environ Res Public Health 2023 Jan 2;20(1) doi: 10.3390/ijerph20010847. PMID: 36613169Free PMC Article
Exhalation Delivery Systems for Application of Intranasal Corticosteroids.
Kovacs AJ, Adappa ND, Kuan EC
Ear Nose Throat J 2021 Jun;100(5):309-313. Epub 2020 Dec 11 doi: 10.1177/0145561320980194. PMID: 33305974
Precision Medicine in Chronic Rhinosinusitis with Nasal Polyps.
Avdeeva K, Fokkens W
Curr Allergy Asthma Rep 2018 Mar 24;18(4):25. doi: 10.1007/s11882-018-0776-8. PMID: 29574586Free PMC Article
Systematic review and meta-analysis of total intravenous anesthesia and endoscopic sinus surgery.
DeConde AS, Thompson CF, Wu EC, Suh JD
Int Forum Allergy Rhinol 2013 Oct;3(10):848-54. Epub 2013 Jul 10 doi: 10.1002/alr.21196. PMID: 23843351

Recent systematic reviews

Surgery for nasal polyposis in cystic fibrosis.
Almeida PRL, Person OC, Puga ME, Atallah ÁN, Trevisani VF
Cochrane Database Syst Rev 2023 Dec 8;12(12):CD014084. doi: 10.1002/14651858.CD014084.pub2. PMID: 38063253Free PMC Article
Sphenochoanal polyps in children - a systematic review (1995‒2021).
Tywoniuk K, Haber K, Mierzwiński J
Braz J Otorhinolaryngol 2022 Nov-Dec;88 Suppl 5(Suppl 5):S179-S187. Epub 2022 Mar 21 doi: 10.1016/j.bjorl.2022.02.006. PMID: 36127268Free PMC Article
Isolated sphenoid sinus opacifications: a systematic review and meta-analysis.
Moss WJ, Finegersh A, Jafari A, Panuganti B, Coffey CS, DeConde A, Husseman J
Int Forum Allergy Rhinol 2017 Dec;7(12):1201-1206. Epub 2017 Oct 12 doi: 10.1002/alr.22023. PMID: 29024448
Post-sinus surgery insertion of steroid-eluting bioabsorbable intranasal devices: A systematic review.
Rizan C, Elhassan HA
Laryngoscope 2016 Jan;126(1):86-92. Epub 2015 Jul 7 doi: 10.1002/lary.25460. PMID: 26154025
Systematic review and meta-analysis of total intravenous anesthesia and endoscopic sinus surgery.
DeConde AS, Thompson CF, Wu EC, Suh JD
Int Forum Allergy Rhinol 2013 Oct;3(10):848-54. Epub 2013 Jul 10 doi: 10.1002/alr.21196. PMID: 23843351

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