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Chorea gravidarum

MedGen UID:: 75545
•Concept ID:: C0264746
•: Disease or Syndrome

Synonyms:	Chorea Gravidarum; Chorea Gravidarums; Chorea, Pregnancy Induced; Chorea, Pregnancy-Induced; Choreas, Pregnancy-Induced; Choreoathetoses, Pregnancy-Associated; Choreoathetosis, Pregnancy Associated; Choreoathetosis, Pregnancy-Associated; Gravidarum, Chorea; Pregnancy-Associated Choreoathetoses; Pregnancy-Associated Choreoathetosis; Pregnancy-Induced Chorea; Pregnancy-Induced Choreas
SNOMED CT:	Chorea gravidarum (25113000)

Monarch Initiative:	MONDO:0001976

Definition

A rare movement disorder developed during pregnancy, characterized by involuntary jerky motion (chorea) and inability to maintain stable position of body parts (athetosis). rheumatic fever and collagen vascular disorders are frequently associated with this disease. Chorea may vary from mild to severe and occurs in approximately 1 per 2,000 to 3,000 pregnancies. (From Md Med J 1997 Sep;46(8):436-9) [from MONDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVChorea gravidarum

Fetal anomaly
- Congenital Systemic Disorder
  - Abnormality of the nervous system
    - Abnormal nervous system physiology
      - Abnormal central motor function
        Chorea
        Chorea gravidarum

Professional guidelines

PubMed

Treatment of Secondary Chorea: A Review of the Current Literature.

Feinstein E, Walker R
Tremor Other Hyperkinet Mov (N Y) 2020 Jul 16;10:22. doi: 10.5334/tohm.351. PMID: 32775036 Free PMC Article

The differential diagnosis of chorea.

Wild EJ, Tabrizi SJ
Pract Neurol 2007 Nov;7(6):360-73. doi: 10.1136/pn.2007.134585. PMID: 18024776

See all (2)

Recent clinical studies

Etiology

Pharmacotherapy for Sydenham's chorea: where are we and where do we need to be?

Bovenzi R, Conti M, Schirinzi T
Expert Opin Pharmacother 2023 May-Aug;24(11):1317-1329. Epub 2023 May 24 doi: 10.1080/14656566.2023.2216380. PMID: 37204415

Chorea.

Pandey S
J Assoc Physicians India 2013 Jul;61(7):471-4, 483. PMID: 24772751

Pregnancy in patients with Sydenham's Chorea.

Maia DP, Fonseca PG, Camargos ST, Pfannes C, Cunningham MC, Cardoso F
Parkinsonism Relat Disord 2012 Jun;18(5):458-61. Epub 2012 Jan 10 doi: 10.1016/j.parkreldis.2011.12.013. PMID: 22236583

Chorea gravidarum: a case report.

Karageyim AY, Kars B, Dansuk R, Aygun E, Unal O, Turan MC
J Matern Fetal Neonatal Med 2002 Nov;12(5):353-4. doi: 10.1080/jmf.12.5.353.354. PMID: 12607770

Lupus anticoagulant in pregnancy.

Lubbe WF, Butler WS, Palmer SJ, Liggins GC
Br J Obstet Gynaecol 1984 Apr;91(4):357-63. doi: 10.1111/j.1471-0528.1984.tb05923.x. PMID: 6424702

See all (9)

Diagnosis

Movement disorders in pregnancy.

Ba F, Miyasaki JM
Handb Clin Neurol 2020;172:219-239. doi: 10.1016/B978-0-444-64240-0.00013-1. PMID: 32768090

Chorea gravidarum: Case report and review of the literature.

Rengifo-Quintero LJ, Beltrán-Avendaño MA
Rev Colomb Obstet Ginecol 2019 Sep;70(3):189-194. doi: 10.18597/rcog.3251. PMID: 31738489

Chorea.

Pandey S
J Assoc Physicians India 2013 Jul;61(7):471-4, 483. PMID: 24772751

Chorea gravidarum.

Robottom BJ, Weiner WJ
Handb Clin Neurol 2011;100:231-5. doi: 10.1016/B978-0-444-52014-2.00015-X. PMID: 21496582

The differential diagnosis of chorea.

Wild EJ, Tabrizi SJ
Pract Neurol 2007 Nov;7(6):360-73. doi: 10.1136/pn.2007.134585. PMID: 18024776

See all (23)

Therapy

Treatment of Secondary Chorea: A Review of the Current Literature.

Feinstein E, Walker R
Tremor Other Hyperkinet Mov (N Y) 2020 Jul 16;10:22. doi: 10.5334/tohm.351. PMID: 32775036 Free PMC Article

Chorea gravidarum: Case report and review of the literature.

Rengifo-Quintero LJ, Beltrán-Avendaño MA
Rev Colomb Obstet Ginecol 2019 Sep;70(3):189-194. doi: 10.18597/rcog.3251. PMID: 31738489

The differential diagnosis of chorea.

Wild EJ, Tabrizi SJ
Pract Neurol 2007 Nov;7(6):360-73. doi: 10.1136/pn.2007.134585. PMID: 18024776

Chorea gravidarum.

Lewis BV, Parsons M
Lancet 1966 Feb 5;1(7432):284-6. doi: 10.1016/s0140-6736(66)90638-6. PMID: 4158893

Cortisone and ascorbic acid in chorea gravidarum (Sydenham's chorea).

SCHWARZ H, DE SAINT-VICTOR H
Can Med Assoc J 1952 Jun;66(6):583-5. PMID: 14945036 Free PMC Article

See all (20)

Prognosis

Pharmacotherapy for Sydenham's chorea: where are we and where do we need to be?

Bovenzi R, Conti M, Schirinzi T
Expert Opin Pharmacother 2023 May-Aug;24(11):1317-1329. Epub 2023 May 24 doi: 10.1080/14656566.2023.2216380. PMID: 37204415

Chorea gravidarum: Case report and review of the literature.

Rengifo-Quintero LJ, Beltrán-Avendaño MA
Rev Colomb Obstet Ginecol 2019 Sep;70(3):189-194. doi: 10.18597/rcog.3251. PMID: 31738489

Demonstration of choreic movements in a case of chorea gravidarum.

Pathania M, Lali BS, Yadav NK, Chaturvedi A
BMJ Case Rep 2013 Feb 15;2013 doi: 10.1136/bcr-2012-008234. PMID: 23417936 Free PMC Article

Consecutive pregnancy with chorea gravidarum associated with moyamoya disease.

Kim A, Choi CH, Han CH, Shin JC
J Perinatol 2009 Apr;29(4):317-9. doi: 10.1038/jp.2008.183. PMID: 19325553

Chorea gravidarum.

Cardoso F
Arch Neurol 2002 May;59(5):868-70. doi: 10.1001/archneur.59.5.868. PMID: 12020275

See all (6)

Clinical prediction guides

Gowers' Queen Square case notes on chorea: a 21st century re-appraisal.

Vale TC, Glass PG, Lees A, Cardoso F
Eur Neurol 2013;69(1):48-52. Epub 2012 Nov 3 doi: 10.1159/000343628. PMID: 23128056

Chorea gravidarum: a case report.

Karageyim AY, Kars B, Dansuk R, Aygun E, Unal O, Turan MC
J Matern Fetal Neonatal Med 2002 Nov;12(5):353-4. doi: 10.1080/jmf.12.5.353.354. PMID: 12607770

Chorea gravidarum and chorea associated with oral contraceptives--diseases due to antiphospholipid antibodies?

Omdal R, Roalsø S
Acta Neurol Scand 1992 Aug;86(2):219-20. doi: 10.1111/j.1600-0404.1992.tb05070.x. PMID: 1414234

Chorea gravidarum. Report of a fatal case with neuropathological observations.

Ichikawa K, Kim RC, Givelber H, Collins GH
Arch Neurol 1980 Jul;37(7):429-32. doi: 10.1001/archneur.1980.00500560059007. PMID: 7387488

See all (4)